• Communications for Statistical Applications and Methods
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• 제24권6호
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• pp.663-671
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• 2017

Some genetic association tests include an unidentifiable nuisance parameter under the null hypothesis of no association. When the mode of inheritance (MOI) is not specified in a case-control design, the Cochran-Armitage (CA) trend test contains an unidentifiable nuisance parameter. The transmission disequilibrium test (TDT) in a family-based association study that includes the unaffected also contains an unidentifiable nuisance parameter. The hypothesis tests that include an unidentifiable nuisance parameter are typically performed by taking a supremum of the CA tests or TDT over reasonable values of the parameter. The p-values of the supremum test statistics cannot be obtained by a normal or chi-square distribution. A common method is to use a Davies's upper bound of the p-value instead of an exact asymptotic p-value. In this paper, we provide a unified sine-cosine process expression of the CA trend test that does not specify the MOI and the TDT that includes the unaffected. We also present a closed form expression of the exact asymptotic formulas to calculate the p-values of the supremum tests when the score function can be written as a linear form in an unidentifiable parameter. We illustrate how to use the derived formulas using a pharmacogenetics case-control dataset and an attention deficit hyperactivity disorder family-based example.

• 생명과학회지
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• 제10권2호
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• pp.210-217
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• 2000

A kinetic profile of the catalytic domain of stromelysin-1 (SCD) using the fluorescent peptide substrate has been determined by the stopped-flow technique. The pH profile has a pH optimum of about 5.5 with an extended shoulder above pH 7. Three pKa values, 5.0, 5.7, and 9.8 are found for the free enzyme state and two pH independent Kcat/Km values of 4.1$\times$104 M-1 s-1 and 1.4$\times$104 M-1 s-1 at low and high pH, respectively. The profile is quite different in shape with other MMP family which has been reported, having broad pH optimum with two pKa values. The substrate specificity of SCD towards fluorescent heptapeptide substrates has been also examined by thin layer chromatography. The cleavage sites of the substrates have been identified using reverse-phase HPLC method.SCD cleaves Dns-PLA↓L↓WAR and Dns-PLA↓L↓FAR at two positions. However, the Dns-PLA↓LRAR, Dns-PLE↓LFAR, adn Dns-PLSar↓LFAR are cleaved exclusively at one bond. The double cleavages of Dns-PLALWAR and Dns-PLALFAR by SCD are in marked contrast to the close structurally related matrilysin. A notable feature of SCD catalysis agrees with the structural data that the S1' pocket of SCD is deeper than that of matriysin. The differences observed between SCD and matrilysin may form the basis of understanding the structural relationships and substrate specificities of the MMP family in vivo.

• 대한가정학회지
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• 제47권8호
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• pp.37-52
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• 2009

The purpose of this study was to examine Korean-Chinese parent-child relationship values through Korean proverbs on parent-child relationships. A total of 233 Korean-Chinese who reside in Yungil, China participated in this study. The participants were recruited through Korean-Chinese preschools and elementary schools. They completed a questionnaire which asked to what extent they agreed or disagreed with Korean proverbs. The items were classified into four categories: filial piety (duty), child-care and education, childrearing practices, and traditional son preference (and daughter discrimination). The results showed that, although the participants highly agreed to the meaning of the proverbs, they seldom used Korean proverbs in their daily lives. The findings concluded that the participants generally manifested a traditional value of filial piety or duty. Also, the findings showed that more fathers acclaimed the value of traditional son preference (and daughter discrimination) than mothers. Finally, the degree of familiarity with Korean culture was found to be a major factor in explaining differences in levels of agreement or disagreement to the proverbs. Since Korean-Chinese ethnic minority groups in China tend to adhere to traditional Korean values, they might encounter more challenges assimilating into the mainstream Chinese culture.

• 한국주거학회논문집
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• 제14권3호
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• pp.9-18
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• 2003

This study is designed to explore the relationship between the level of housing satisfaction and housing values, as well as family characteristics and characteristics of residence. Questionnaires are administered to 526 adolescents from the four residential areas in Kwangju. Most of the adolescents are satisfied with their housing environment, especially indoors, however, they show a lower level of satisfaction toward the appearance and organization of the unit plan. It is found that the level of the safety, comfortability and social values predicted a meaningful variance in the level of housing satisfaction. Those with a higher degree of safety and social values tend to be associated with stronger housing satisfaction, whereas those with lower comfortability values are more associated with stronger housing satisfaction. Groups with higher household incomes are more likely to be satisfied with their housing environment. Groups living within a younger and larger house are more likely to be satisfied with their housing environment. Also, owners tend to show a stronger degree of housing satisfaction than renters.

• Asian Journal for Public Opinion Research
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• 제2권3호
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• pp.140-171
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• 2015

As China's economic development brings the country out of poverty and into modernity, a long-lasting debate concerns whether the Chinese public's value system is also changing toward the so-called "modern values," or whether some distinctly traditional Chinese values remain unchanged. Using empirical data collected at three points in time during the 1990s and the first two decades of the 21st Century (1993, 2002, and 2011), I found that Chinese citizens who benefitted from urbanization, rising levels of education and employment in non-farm, knowledge-based industries displayed stronger modern values. People with stronger modern values are more likely to emphasize individual autonomy, competition, gender equality, and market transaction, among others. Some characteristics of the Chinese people, most importantly family values, however, seem to remain stable amidst rapid social changes.

• Journal of Crop Science and Biotechnology
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• 제11권1호
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• pp.69-74
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• 2008

This work aimed to evaluate 11 potato families for insect resistance horticultural traits. The families were derived from crosses between introduced insect resistant and adapted genotypes. A randomized complete block design, with three replications was used. The plot consisted of 25 genotypes of a family, summing up to 75 genotypes tested per family. Two susceptible cultivars were included in the experiment as checks. The genotypes were evaluated for insect resistance, tuber yield traits, tuber appearance and tuber skin smoothness. The genetic value for the intensity of insect attack in the leaves and in the tubers was lower(higher resistance) in the 11 families than in the checks. For yield traits, there was no predominant effect among the families regarding the origin of the resistant donor species(Solanum berthaultii and/or S. chacoense). However, there was a large contribution of the C-1485-16-87 recurrent parent in crosses with resistant genotypes for tuber yield and tuber number. In relation to tuber appearance, only the family derived form the C-1485-16-87/ ND140(S. berthaultii) cross did not differ from the checks. had genetic value tuber skin smoothness, it was identified that families derived from S. berthaultii resistant parents showed higher genetic values than the check cultivars. For tuber skin smoothness, the genetic values of the families neither differed significantly from each other nor from the checks.

• 한국물환경학회지
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• 제35권2호
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• pp.152-164
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• 2019

In this study, a Benthic Macroinvertebrates Family Index (BMFI) was developed using 100 indicator groups (99 families including Chironomidae with 2 phena). Families were assigned a score between 1 and 10 depending on their sensitivity to organic pollution. The BMFI was composed of the sensitivity and relative abundance of the indicator taxa. Sensitivity values of each group were generally similar to Biological Monitoring Working Party (BMWP) scores or Walley, Hawkes, Paisley, Trigg (WHPT) scores of UK, Japanese BMWP scores, and the FBI tolerance values of North America. However, sensitivity values of some taxa were significantly different from those of foreign countries, which seemed to have resulted from discrepancy in species composition, difference of taxonomic classification system, or methodological difference for estimation of sensitivity. As an annual average level, BMFI showed significant correlation with concentration of 5-day biochemical oxygen demand (BOD5) (correlation coefficient r = -0.80, n = 569 sites), total suspended solids (r = -0.68), and total phosphorus (r = -0.79). In addition, BMFI revealed strong correlation with Shannon-Weaver's species diversity (r = 0.85), Margalef's species richness (r = 0.85) and McNaughton's dominance (r = -0.84). Correlation between BMFI and water quality parameters or community indices such as species diversity did not show significant difference compared to that of species-level indices such as BMI (Benthic Macroinvertebrates Index). This means that BMFI is a more useful indicator in terms of easy identification of organisms. BMFI was used to assess the environmental status of 3,017 sites of Stream Ecosystem Survey conducted by the Korean Ministry of Environment between 2016 and 2018. As a result, about half of all sites appeared to be in good condition, and a quarter in poor condition.

• 한국생활과학회지
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• 제21권3호
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• pp.453-468
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• 2012

The number of Healthy Family Support Centers has dramatically increased during the past eight years since the Framework Act on Healthy Families was enacted. This phenomenal growth is largely credited to Certified Healthy Family Specialists (CHFSs). Despite their contributions, the job and working conditions of the CHFSs have rarely been explored from the insiders' perspective. In this study, we aim to delineate CHFSs' job and working conditions from their own narratives in order to improve an understanding of CHFSs' profession and work environment. We conducted in-depth interviews with nine CHFSs and a focus-group interview with five CHFSs. Our findings revealed that CHFSs took pride in their professions, internalized their professional mission of enhancing family strengths, and highlighted CHFSs' unique professional role in comparison to other human services professionals. In conclusion, CHFSs showed a strong professional identity consisting of rich professional knowledge, solid career goals, and integrated socio-political values. Contrary to the positive perception of the CHFSs' job, CHFSs expressed challenges in their working conditions in terms of small-scale organizations at local Healthy Family Support Centers, a heavy workload, hierarchical relationships with local government officers, and the unsatisfactory payroll and promotion system. This study contributes to a better understanding of CHFSs' job and their working conditions and provides insights on how to enhance professionalism among CHFSs and their work environment. As for policy implications, we suggest advancing qualifications for CHFSs, improving professional training programs for current CHFSs, and expanding small-scale organizations.

• International Journal of Internet, Broadcasting and Communication
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• 제15권4호
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• pp.215-222
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• 2023

In this paper, we examine the roles, mutual relationships, and guidelines for a healthy life as exemplified by the characters Santiago and Manolin in Ernest Hemingway's novel "The Old Man and the Sea" and use this content to compare the happy home life of elderly couples in Korea. Through a metaphorical exploration of the lives of elderly husbands and wives in Korean society, the study examines their significance as the core of the family, particularly during their senior years. Ernest Hemingway's "The Old Man and the Sea" portrays Santiago as a unique embodiment of virtue and humanity. As an elderly male fisherman, he symbolizes a profound connection with the sea, as well as qualities such as courage, patience, and unwavering passion. His story underscores the importance of pursuing new goals and maintaining hope even in old age. The relationship between Santiago and Manolin provides insights into the dynamics of elderly husbands and wives in their domestic lives. Manolin's unwavering support for Santiago and his understanding of Santiago's dreams exemplify the significance of mutual support and the establishment of common goals for elderly couples. These characters serve as exemplary models for understanding and supporting one another within a family setting. Within the context of family life, applying these exemplary models and relationship dynamics fosters mutual respect, collaboration, emotional expression, and effective communication. Supporting each other and working towards common goals can enhance the family atmosphere, resolve conflicts, and enrich domestic life. Furthermore, when elderly couples share common goals and enjoy activities together, they strengthen their bond and create a more fulfilling family life. These shared activities deepen the affection between elderly husbands and wives and contribute to a thriving household. Through the characters of Santiago and Manolin in "The Old Man and the Sea," we present in this study a deeper understanding of the values and roles within the domestic lives and affection of elderly husbands and wives. Mutual respect, collaboration, emotional expression, communication, mutual support, common goals, hope, and shared domestic activities all play pivotal roles in maintaining a healthy family life and establishing happiness and well-being within the family. We expect this study to offer valuable insights into the fields of family studies, elderly welfare, and sociology.

• 가족자원경영과 정책
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• 제10권1호
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• pp.33-51
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• 2006

Today, the Korean society is experiencing an increase in serious problems, such as child abuse, unmarried mothers, single mothers, which cannot be overlooked as simply trivial family matters. The increase in these problems is caused by the rapid change that has taken place within our society, which has emasculated the power of our traditional values and behavior patterns to cope with contemporary life styles. Premarital Preparation Education is starting to gain attention as a preventive measure that can overcome this serious family crisis. Although the importance of the Premarital Preparation Education program cannot be overemphasized, there are only few cases where engaged couples and unmarried men and women are exposed to this type of program and actually experience its benefits. In other words, there is an urgent need to revitalize and increase the effects of the Premarital Preparation Education Program. This research was conducted in order to find a way to revitalize and to increase the effects of the program, so that more and more people can participate and receive benefits from it. First, we have analyzed the program's contents and the current condition on how the program is actually conducted. Then we have compared real case examples of the program and analyzed the current situation and its problems.