• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2525-2528
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• 2013

The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in the differentiation and development for some tissues (e.g. muscle and nervous systems). The current studies showed that Homer3 abnormal expression changes in acute myeloid leukemia (AML). Forced expression of Homer3 in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by $As_2O_3$ through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetra decanoylphorbol-acetate (TPA). These results showed that Homer3 is a novel gene which plays a certain role in the occurrence and development of AML.

• 대한가정학회지
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• 제34권4호
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• pp.187-202
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• 1996

This study is to describl the child care system in Sweden and to understand how the progressive child care system has been developed. The sex categories of the child care issues were studied based on a review of the literature related to the Swedish child care, family welfare system and the socio-economic information on Sweden. Six categories were : (1) historical and socio-economic background of child care system, (2) supply of and demand for the child care service and the types of public and private child care, (3) child care program activities, (4) child care staff training system, (5) administration and financial support system for the child care, and (6) the family policy and the family support programs in Sweden. For the Korean child care system, this study on the Swedish child care implied that : (1) To provide a progressive system of the child care system in Korea will require serious discussion about concentration of the child care administration system which is currently distributed to Ministry of Education and Ministry of Health and Welfare. (2) The extensive family support programs such as the parental leave and flexible work conditions for women are needed for the infant care by parents at home. (3) to expand the child care services in Korea, public support should be primarily focused on the supply of the public day care centers even though the demands for the various child care services are to be met by public financial support. (4) Most of all, societal recognition that all children are the resposiblity of our society is needed to develop a progressive child care system in Korea.

• Asian-Australasian Journal of Animal Sciences
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• 제33권3호
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• pp.398-407
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• 2020

Objective: The Yip1 domain family (YIPF) proteins were proposed to function in endoplasmic reticulum (ER) to Golgi transport and maintenance of the morphology of the Golgi, which were homologues of yeast Yip1p and Yif1p. YIPF3, the member 3 of YIPF family was a homolog of Yif1p. The aim of present study was to investigate the expression and regulation mechanism of porcine YIPF3. Methods: Quantitative realtime polymerase chain reaction (qPCR) was used to analyze porcine YIPF3 mRNA expression pattern in different tissues and pig kidney epithelial (PK15) cells stimulated by polyinosine-polycytidylic acid (poly [I:C]). Site-directed mutations combined with dual luciferase reporter assays and electrophoretic mobility shift assay (EMSA) were employed to reveal transcription regulation mechanism of porcine YIPF3. Results: Results showed that the mRNA of porcine YIPF3 (pYIPF3) was widely expressed with the highest levels in lymph and lung followed by spleen and liver, while weak in heart and skeletal muscle. Subcellular localization results indicated that it expressed in Golgi apparatus and plasma membranes. Upon stimulation with poly (I:C), the level of this gene was dramatically up-regulated in a time- and concentration-dependent manner. pYIPF3 core promoter region harbored three cis-acting elements which were bound by ETS proto-oncogene 2 (ETS2), zinc finger and BTB domain containing 4 (ZBTB4), and zinc finger and BTB domain containing 14 (ZBTB14), respectively. In which, ETS2 and ZBTB4 both promoted pYIPF3 transcription activity while ZBTB14 inhibited it, and these three transcription factors all played important regulation roles in tumorigenesis and apoptosis. Conclusion: The pYIPF3 mRNA expression was regulated by ETS2, ZBTB4, and ZBTB14, and its higher expression in immune organs might contribute to enhancing ER to Golgi transport of proteins, thus adapting to the immune response.

• 가족자원경영과 정책
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• 제12권3호
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• pp.81-101
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• 2008

The purpose of this study is to examine support policies regarding work and family reconciliation, to suggest plans to improve workplace policies, and to suggest directions for further studies. This study looks at OECD's work-life reconciliation policies as well as family friendly workplace policies in Korea to find a way to enhance business' receptiveness and implementation of the policies. By examining women's labor conditions, this study finds that family friendly workplace policies are necessarily imminent in our society of low fertility and ageing. Along with the evaluation of benefit level and the effectiveness of current policies, this study uses data from interviews with working mothers who have had the experience of family friendly benefits. The results of the analyses suggest that the government should focus on improving the workplace environment in companies that do not show bias against the use of family friendly policies. In order to farm more successful policies, future studies are needed to analyze the changes of fertility, working conditions, support programs, and benefits.

• 기독교교육논총
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• 제65권
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• pp.103-131
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• 2021

본 연구는 교육사역에서 모델이 되는 교회를 규모별로 선택하여 코로나 시기에 실시한 사역을 조사함으로 미래 교회사역의 방향을 규명하는 것을 목적으로 한다. 연구방법은 4개 교회 목회자의 사역 경험이 자료의 주된 출처가 된 사례연구를 활용했다. 교회마다 독특한 사역이 실행되었지만, 새벽 특별기도회, 가족예배, 가족단위 별 여름성경학교, 성경쓰기 또는 읽기 프로그램, 온라인 제자훈련 프로그램 등이 일반적이었다. 이 밖에도 각 교회에서는 토크쇼, 번개팅, 보이는 라디오, 전교인의 성경 필사본 제작 등 교회의 특징 및 필요 그리고 코로나 시기의 특성을 반영한 특별 프로그램을 실시하였다. 이러한 결과를 바탕으로 교회의 목회철학을 반영한 목회 프로그램 실시, 공동체 의식 강화, 가족의 영적 기능 회복, 온라인 교수법 활용, 소외계층에 대한 심리적 지원 등이 교육목회 방향으로 제시되었다. 이 외에도 기독교의 공공성 회복과 교단이나 전문기관의 도움을 받아 시대의 요구를 반영한 프로그램과 온라인 자료를 개발할 수 있는 방안이 제시되었다.

• Asian-Australasian Journal of Animal Sciences
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• 제18권4호
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• pp.458-462
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• 2005

The study was aimed at detecting polymorphism of the fifth intron in lipoprotein lipase (LPL) gene and analyzing association between the polymorphism and productive traits. A pair of primers was designed for amplifying the fifth intron. Sequence analysis indicated that a G1171C substitution existed in Large White breed. The mutation was detected by PCR-AfaI-RFLP. Polymorphism analysis in a pig resource family showed that there existed significant effects on carcass and meat quality traits. Thoraxwaist fat thickness of BB genotype was significantly higher (14.2%, p<0.05) than that of AA on carcass traits, while BB genotype was significantly lower (3.6% p<0.01, 4.1% p<0.01; 2.3% p<0.01, 1.9% p<0.01; 1.8% p<0.01, 1.4% p<0.05) than AA and AB genotype in pH of m. Longissimus Dorsi (LD), m. Biceps Femoris (BF), m. Semipinali Capitis (SC). The allelic frequencies were also significantly different between indigenous Chinese breeds and exotic breeds. Data analyzed revealed that the mutation locus affected production traits mostly by additive effects. Based on these results, it is necessary to do more studies on LPL gene before making the LPL locus into the application of marker-assisted selection (MAS) programs.

• 기독교교육논총
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• 제74권
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• pp.81-106
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• 2023

연구 목적 : 본 연구는 회중론적 관점에서 한국교회의 3040세대에 대한 보다 비판적이고 통전적인 이해를 통하여 3040세대 회중을 향한 보다 합당한 목양를 실천할 수 있는 교육목회적 함의점들을 발견하는데 목적이 있다. 연구 내용 및 방법 : 먼저, 회중론과 교육목회와의 연계성에 대한 성서적, 신학적, 교육적 근거들을 살펴보았다. 그리고 3040세대에 대한 연령 발달적, 신앙발달적, 사회문화적 접근을 통해 3040세대의 회중론적 이해와 특징들을 기술하였고, 회중론적 관점에서 본 3040세대에 대한 교육목회적 함의점들을 제시하였다. 결론 및 제언 : 본 연구는 한국교회 3040세대의 특징과 세대간 역동성을 주목하며 회중론적 관점에서 네가지 교육목회적 함의로서 1) 다양한 가정유형을 고려한 가정친화적 교육목회로의 전환, 2) 복음과 삶의 이슈가 만나는 전생애주기적 제자양육으로의 강화, 3) 올라인 목회(all-line ministry)를 기반으로 하는 협업형 소그룹의 강화, 4) 더 나은 세상을 향한 창의적이고 복음적인 ESG 사역의 개발과 실천을 제언하였다.

• 가정과삶의질연구
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• 제34권2호
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• pp.51-64
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• 2016

Family education service for healthy families has increased steadily over the past ten years since the Healthy Family Act was enacted. The Purpose of this study aims to investigate the current state of family education professionals such as family life educators and healthy family specialists, and also suggest a management plan for them. The data used was collected from literature regarding family life educators and healthy family specialists, reports and home pages of Ministry of Gender Equality and Family, Korean Institute for Healthy Family, Healthy Family Support Center in Seoul and Gyeonggi-do, Korean Association of Family Relations, etc. The major suggestions are as follows: 1) empowerment of family education professionals, 2) development of the workplace for family education professionals, 3) development and promotion of various education programs for families, 4) improvement of the capability of family education professionals response to a low fertility-ageing society, 5) collaborative networking between family life educators and healthy family specialists. This study contributes to provide insights on how to train and manage family education professionals.

• 한국사회복지학
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• 제57권4호
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• pp.225-251
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• 2005

본 연구는 최근 사회적으로 관심이 고조되고 있는 가족복지정책을 중심으로 제기되고 있는 가족복지 서비스 전달체계에 관한 모형을 정립해 가는데 고려해야 할 원칙과 방향에 대하여 논의하고 있다. 이를 위해 본 연구는 가족복지정책의 패러다임 전환과 보건복지부에서 여성가족부로 가족업무가 이관되는 변천과정을 개괄하였다. 이를 통해 전환기에 서 있는 가족복지정책이 담보해야 할 내용성을 제시하고 이를 실현하기 위한 전달체계의 구축원칙을 기존 사회복지전달체계와의 연관성과 가족복지서비스 전달체계의 특성을 결합하여 제시하였다. 마지막 부분에서는 2004년도 시범사업을 수행한 기관들의 프로그램을 살펴보면서 가족복지서비스 전달체계 구조상 가장 지역사회 가족과 맞닿아 있는 가족지원 센터의 모형을 설계하는데 기본적으로 고려할 사항을 제안하였다. 가족복지서비스 전달체계의 구축원칙으로는 우선 가족구성원이 일과 가정의 양립을 통해 가족의 안정성을 강화하며, 어떠한 형태의 가족이든 사회적로 배제되지 않고 기본적인 생활기반을 유지해 나갈 수 있도록 지원하는 가족복지정책의 목표를 실현가능한 것으로 전환시키는 전달체계이어야 한다는 것이다. 또한 사회복지전달체계에서 요구되고 있는 통합성, 지속성, 효율성, 접근성의 강화가 동시에 요구된다. 특히 가족복지서비스의 구체적 현장단위인 가족지원센터는 민주적이고 평등한 가족관계 증진을 위한 교육 및 상담 프로그램 등과 같은 직접적 서비스 제공과 함께 구체적이고 다양한 욕구를 지닌 가족구성원에게 필요한 정보를 제공하고 지역사회의 가족관련 기관들을 활용할 수 있게 지원하는 모형으로 정착할 수 있는 방안이 고려되어야 하겠다.

• 가족자원경영과 정책
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• 제12권4호
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• pp.1-13
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• 2008

The purpose of this study is to analyze and assess the family policy of the Lee administration and to suggest agendas for sustainable future family policy. Traditionally, families are a unique unit of production and reproduction of family members and social laborers. In addition, families are the social safety net help people survive in a society. Therefore, family policies play an important role in contemporary society. In this context, we review the literature related to family and social policy, and the contents of Ministry for Health, Welfare and Family Affairs, which is the main authority in Korea. The results are as follow: Firstly, the Lee administration ignored the data showing that family policy should be a unique policy, and not a sub-division of welfare policy. Secondly, there is no difference between the active welfare policy of the Lee administration and policies of past administrations. Finally, this study suggests that subjects of future oriented family policy should focus on co-developing programs for the individual, family, and society, to develop problem-prevention and family needs- ordered policy, and to make integrated family policy through laws and delivery systems such as Healthy Family Centers.