• Journal of the Korean Home Economics Association
• /
• v.44 no.8
• /
• pp.101-116
• /
• 2006

"The Healthy Family Act" was established in 2004. It prevents problems of the family and increases the healthy characteristic of general family. According to this Act, Healthy Family Support Centers appeared to a new part of family welfare institution. This study is to search Programs and PR strategy of Healthy Family Support Center. The results of this study were as follows. First, Education program ranked highest in selecting important programs operated by the healthy family support center. Among education programs, they were the education of husband and wife relationships and the parents education that ranked on top. Second, The government further strengthen publicity relation(PR) about the HFSC. A deficiency of budget and manpower problems were major obstacles for PR activities. TV, news paper and magazine are useful medium. Management of PR activities in the HFSC is consider as one of the main factor to decide development and survival in social community.

• Clinical and Experimental Pediatrics
• /
• v.56 no.10
• /
• pp.417-423
• /
• 2013

Vitamin D is an essential component of bone and mineral metabolism; its deficiency causes growth retardation and skeletal deformities in children and osteomalacia and osteoporosis in adults. Hypovitaminosis D (vitamin D insufficiency or deficiency) is observed not only in adults but also in infants, children, and adolescents. Previous studies suggest that sufficient serum vitamin D levels should be maintained in order to enhance normal calcification of the growth plate and bone mineralization. Moreover, emerging evidence supports an association between 25-hydroxyvitamin D (25[OH]D) levels and immune function, respiratory diseases, obesity, metabolic syndrome, insulin resistance, infection, allergy, cancers, and cardiovascular diseases in pediatric and adolescent populations. The risk factors for vitamin D insufficiency or deficiency in the pediatric population are season (winter), insufficient time spent outdoors, ethnicity (non-white), older age, more advanced stage of puberty, obesity, low milk consumption, low socioeconomic status, and female gender. It is recommended that all infants, children, and adolescents have a minimum daily intake of 400 IU ($10{\mu}g$) of vitamin D. Since the vitamin D status of the newborn is highly related to maternal vitamin D levels, optimal vitamin D levels in the mother during pregnancy should be maintained. In conclusion, given the important role of vitamin D in childhood health, more time spent in outdoor activity (for sunlight exposure) and vitamin D supplementation may be necessary for optimal health in infants, children, and adolescents.

• Journal of Genetic Medicine
• /
• v.9 no.1
• /
• pp.38-41
• /
• 2012

A 32-year-old female patient and her sister show high levels of high density lipoprotein (HDL) cholesterol in regular health checkups, since female patient was 11 years old. The patient's serum total cholesterol was 285 mg/dL and HDL cholesterol was 113 mg/dL. Her sister's total cholesterol was 240 mg/dL and the HDL cholesterol measured to be 90 mg/dL. Lipoprotein pattern and cholesteryl ester transfer activity gene analysis were examined in these patients. We found c.1321+1G>A (IVS14+1G/A) hetero mutation in cholesteryl ester transfer protein (CETP) genes. Generally, CETP mediates transfer and exchange of triglycerides and cholesteryl ester between plasma lipoproteins. Also we investigated a key role of HDL-CE and Apo A-1 metabolism. Patients with low levels of CETP have increased serum HDL levels. We hereby report two Korean cases of CETP deficiency in a family. Brief literature review ensues with the cases.

• Korean Journal of Family Medicine
• /
• v.39 no.6
• /
• pp.370-374
• /
• 2018

Background: Iron is an essential element for women of reproductive age, especially in the period before and during the pregnancy. This study investigates the consumption of iron to prevent iron deficiency anemia among pregnant women visiting Neyshabur healthcare centers based on the theory of planned behavior. Methods: In this experimental study, data were collected through a questionnaire survey. It included 160 pregnant women who were receiving maternity services at twelve healthcare centers in the city of Neyshabur in Iran between 2015 and 2017. The participants' demographic and anthropometric characteristics, Using the theory of planned behavior, and blood lab examination results, including ferritin levels were measured and the data were analyzed using IBM SPSS ver. 22.0 (IBM Corp., Armonk, NY, USA). Results: The average scores of knowledge, attitude, perceived behavioral control, subjective norms, and intention categories for the intervention group were meaningfully increased after the participants received education on iron supplementation (P<0.05). However, these changes were not found to be significant in the control group (P>0.05). No statistically significant difference was obtained in the subjective norms category between the two groups after the education intervention (P=0.92). Conclusion: Based on the experimental effects of education encouraging iron supplementation in pregnant women, it is suggested that workshops promoting iron supplementation should be conducted in health centers with the aim of preventing widespread iron deficiency anemia.

• Korean Journal of Psychosomatic Medicine
• /
• v.7 no.2
• /
• pp.247-251
• /
• 1999

Background : Iron deficiency anemia(IDA) is a very common condition, and its underlying causes are diverse. Gastrointestinal blood loss, pregnancy, menorrhagia are known as common causes of IDA. However, especially in the IDA case of unknown origin, we must consider the culture specific cause of IDA as a possible cause of IDA. As I found an unusual cause of IDA related to a cultural behavior, I would like to report two cases of IDA occurred by negative therapy in Korea. It is possible to explain these cases by explanatory model. Case 1 : With a chief complaint of dyspnea, a 27-year-old woman visited our clinic. She had multiple treatment histories of negative therapy for her psoriasis. The blood loss during this procedure is the cause of present IDA. Case 2 : A 70-year-old man visited our clinic complaining of anorexia and dizziness. The history of treatment showed that he had an IDA 9 month ago. The IDA developed again because of repeated negative therapy after previous treatment of IDA. He has used the negative therapy intermittently to treat tinea pedis for 5 years. Conclusion : We must consider the negative therapy as a possible cause of IDA in Korea.

• Journal of Families and Better Life
• /
• v.10 no.1 s.19
• /
• pp.229-238
• /
• 1992

According as the modern form of the family becomes nuclearized, inevitable is the isolation of the family. The relationship of the neighborhood and the kinsmen are being dissolved, making the isolated and unsteady nuclear family. We need a community in the modern society, for we are facing a lot of social problems as the nuclear family. The problems are as follows ; the rearing of the children, the alienation of a woman and the woman's roles in the society. In addition to those problems, there are also such some other problems as the alienation of the old man and the social roles of them. That is to say, the community appeared as a kind of attempt to overcome the above-mentioned problems, Kibbutz may be itself called and enlarged family to function as one family even though it is not just a blood relationship. The American commune is a large family community as a group to overcome the alienation and solitude of the nuclear family. On the other hand, the urban community is the small-scaled and cooperative family to solve the problem that the modern nuclear family is a unit living solitarily and unsteadily. But in fact, even in such a community, there are much tension and conflict against its establishing purpose. In my opinion, if those communities have to surmount the tension and conflict which are derived from the process in a bid to overcome the troubles like the alienation and solitude of the nuclear family. The bond of family must be consolidated among all the members of the community. And then community may be co-existed with the traditional family as the alternative family in the future, which can supply the deficiency of the unsteady unclear family.

• Journal of Genetic Medicine
• /
• v.20 no.1
• /
• pp.25-29
• /
• 2023

The CYP11A1 gene encodes for the cholesterol side-chain cleavage enzyme (P450scc), which initiates steroid hormone biosynthesis. Defective P450scc activity results in severe glucocorticoid and mineralocorticoid deficiencies. We describe a case of P450scc deficiency due to a novel homozygous CYP11A1 variant inherited from the mother with a possibility of uniparental disomy (UPD). The patient was a female, had no family history of endocrine disease, and showed adrenal insufficiency at 13 days of age. Hormonal analysis with an adrenocorticotropic hormone stimulation test showed both glucocorticoid and mineralocorticoid deficiencies, presumed to be a defect of the early stage of steroidogenesis. Exome sequencing reported a novel homozygous frameshift variant of CYP11A1 (c.284_285del, p.Asn95Serfs*10), which was inherited from the mother. Additionally, homozygosity in 15q22.31q26.2, which included CYP11A1, was identified using a chromosomal microarray. It was suggested that the possibility of maternal UPD was involved as the cause of a P450scc deficiency by unmasking the maternally derived affected allele. To our understanding, P450scc deficiency associated with UPD encompassing CYP11A1 had not been reported in Korea before. Genetic analysis can help diagnose rare causes of primary adrenal insufficiency, including P450scc deficiency.

• Clinical and Experimental Pediatrics
• /
• v.48 no.1
• /
• pp.101-103
• /
• 2005

Meningococcal disease is not rarely associated with abnormalities of the complement system. We experienced a case of C9 deficiency with meningococcal meningitis from a 12-year-old girl. Identification of complement deficiency has implications for management, including family studies, prophylaxis, vaccination, and altered threshold for infection screening and treatment.

• Microbiology and Biotechnology Letters
• /
• v.49 no.4
• /
• pp.594-602
• /
• 2021

The NLRP3 (nucleotide-binding domain, leucine-rich repeat family pyrin domain containing 3) inflammasome plays an important role in the initiation of inflammatory responses, through the recognition of pathogen-associated molecular patterns and tumor progression, including tumor growth and metastasis. In this study, we examined the effects of defective NLRP3 on the growth, migration, and invasiveness of hepatocellular carcinoma (HCC) SK-Hep1 cell. First, HCC SK-Hep1 cells were transfected with human NLRP3 targeting LentiCRISPRv2 vector using the CRISPR-Cas9 system, and NLRP3 deficiency was confirmed by RT-qPCR and western blotting. NLRP3 deficient SK-Hep1 cells showed delayed cell growth and decreased protein expression of PI3K, p-AKT, and pNF-κB when compared to NLRP3 complete SK-Hep1 cells. In addition, NLRP3 deficiency arrested the cell cycle at G1 phase through an increase in p21 and a reduction in CDK6. NLRP3 deficient SK-Hep1 cells also showed significantly delayed cell migration, invasion, and wound healing. The expression of epithelial-mesenchymal transition signaling molecules, such as N-cadherin and MMP-9, was found to be dramatically decreased in NLRP3 deficient SK-Hep1 cells compared to NLRP3 complete SK-Hep1 cells.

• Molecules and Cells
• /
• v.43 no.2
• /
• pp.176-181
• /
• 2020

The RUNX transcription factors serve as master regulators of development and are frequently dysregulated in human cancers. Among the three family members, RUNX3 is the least studied, and has long been considered to be a tumor-suppressor gene in human cancers. This idea is mainly based on the observation that RUNX3 is inactivated by genetic/epigenetic alterations or protein mislocalization during the initiation of tumorigenesis. Recently, this paradigm has been challenged, as several lines of evidence have shown that RUNX3 is upregulated over the course of tumor development. Resolving this paradox and understanding how a single gene can exhibit both oncogenic and tumor-suppressive properties is essential for successful drug targeting of RUNX. We propose a simple explanation for the duality of RUNX3: p53 status. In this model, p53 deficiency causes RUNX3 to become an oncogene, resulting in aberrant upregulation of MYC.