Browse > Article

A Case of Meningococcal Meningitis with Complement 9 Deficiency  

Choi, Sun-Mee (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Lee, Kyung-Yil (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Lee, Hyung-Shin (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Hong, Ja-Hyun (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Lee, Mi-Hee (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Lee, Byung-Cheol (Department of Pediatrics, College of Medicine, The Catholic University of Korea)
Publication Information
Clinical and Experimental Pediatrics / v.48, no.1, 2005 , pp. 101-103 More about this Journal
Abstract
Meningococcal disease is not rarely associated with abnormalities of the complement system. We experienced a case of C9 deficiency with meningococcal meningitis from a 12-year-old girl. Identification of complement deficiency has implications for management, including family studies, prophylaxis, vaccination, and altered threshold for infection screening and treatment.
Keywords
Meningococcus; Meningitis; Complement; C9;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Figen CA, Kuijper EJ, Dankert J, Daha MR, Caugant DA. Characterization of Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients. J Clin Microbiol 1998;36:2342-5
2 Fijen CA, Bredius RG, Kuijper EJ, Out TA, de Haas M, de Wit AP, et al. The role of Fc$\gamma$ receptor polymorphisms and C3 in the immune defence against Neisseria meningitidis in complement-deficient individiuals. Clin Exp Immunol 2000;120:338-45   DOI   PUBMED
3 Fine DP, Gewurz H, Griffiss M, Lint TF. Meninigococcal meningitis in a woman with inherited deficiency of the ninth component of complement. Clin Immunol Immunopathol 1983;28:414-7
4 Fijen CA, Kuijper EJ, Drogari-Apiranthitou M, van Leeuwen Y, Daha MR, Dankert J. Protection against meningococcal serogroup ACYW disease in complement-deficient individuals vaccinated with the tetravalent meningococcal capsular polysaccharide vaccine. Clin Exp Immunol 1998; 114:362-9   DOI   PUBMED
5 Borrow R, Richmond P, Kaczmarski EB, Iverson A, Martin SL, Findlow J, et al. Meninococcal serogroup C-specific IgG antibody responses and serum bactericidal titers in children following vaccination with a meningococcal A/C polysaccharide vaccine. FEMS Immunol Med Microbiol 2000;28:79-85   DOI   ScienceOn
6 Ernst T, Späth PJ, Aebi C, Schaad UB, Bianchetti MG. Screening for complement deficiency in bacterial meningitis. Acta Paediatr 1997;86:1009-10   DOI   ScienceOn
7 Woods CR. Neisseria meningitidis. In : Behrman RE, Klingman RM, Jenson HB, eds. Nelson textbook of pediatrics, 17th ed. Philadelphia : WB Saunders, 2004:896-9
8 Emonts M, Hazelzet JA, de Groot R, Hermans PW. Host genetic determinants of Neisseria meningitidis infections. Lancet Infect Dis 2003;3:565-77   DOI   ScienceOn
9 Tedesco F, Nurnberger W, Perisutti S. Inherited deficiencies of the terminal complement components. Int Rev Immunol 1993;10:57-63
10 Kusaba T, Kisu T, Inaba K, Sakai K, Okochi K, Yanase T. A pedigree of deficiency of the ninth component of complement(C9). Jinrui Idengaku Zasshi 1983;28:239-48   DOI   ScienceOn
11 Nakada M, Hara T, Aoki Y, Mizuno H, Akeda S, Inaba K, et al. Inherited deficiency of ninth component of complement : an increased risk of meningococcal meningitis. J Pediatr 1989;114:260-4   DOI   PUBMED
12 Mayatepek E, Grauer M, Hansch G, Sonntag HG. Deafness complement deficiencies and immunoglobulin status in patients with meningococcal diseases due to uncommon serotypes. Pediatr Infect Dis J 1993;12:808-11   DOI   ScienceOn
13 Ellison RT, Kohler PF, Curd JG, Judson FN, Reller LB. Prevalence of congenital or acquired complement deficiency in patients with sporadic meningococcal disease. N Engl J Med 1983;308:913-6   DOI   ScienceOn
14 Figueroa JE, Densen P. Infectious disease associated with complement deficiencies. Clin Microbiol Rev 1991;4:359-95
15 Hoare S, El-Shazali O, Clark JE, Fay A, Cant AJ. Investigation for complement deficiency following meningococcal disease. Arch Dis Child 2002;86:215-7   DOI   ScienceOn
16 Pollard AJ, Frasch C. Development of natural immunity to Neisseria meningitidis. Vaccine 2001;19:1327-46   DOI   ScienceOn
17 Overturf GD. Indications for the immunological evaluation of patients with meningitis. Clin Infect Dis 2003;36:189-94   DOI   ScienceOn