• 대한후두음성언어의학회지
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• 제30권1호
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• pp.12-14
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• 2019

Functional dysphonia (FD) is a disease entity which includes various voice disorders in the absence of structural or neurologic laryngeal pathology. Muscle tension dysphonia (MTD), psychogenic dysphonia are representative FD with completely different pathogenesis. Therefore there is no standard treatment modality for FD, the first step of treatment of FD is differentiating patient's voice symptoms from other organic voice disorders and other functional voice problems. MTD is a functional voice disorder caused by hyperfunction of intrinsic and extrinsic laryngeal musculature. Symptoms include increased vocal effort, roughness, fatigue and odynophonia. First line for MTD is indirect or direct voice therapy. Unfortunately, many patients with MTD improve with voice therapy alone. For these patients, various modalities tried; lidocaine application, surgical excision of the false vocal folds, and botulinum toxin injection, etc. Botulinum toxin injections are widely used in the field of otolaryngology, especially for spasmodic dysphonia. However, its use in FD or MTD has only been described in few case reports. The aim of this lecture is to evaluate the feasibility of botulinum toxin injection for FD, especially MTD.

• BMB Reports
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• 제55권9호
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• pp.429-438
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• 2022

Cervical cancer is the fourth most common malignancy in women worldwide. Although infection from human papillomavirus (HPV) has been the leading cause of cervical cancer, HPV-negative cervical cancer accounts for approximately 3-8% of all cases. Previous research studies on cervical cancer have focused on HPV-positive cervical cancer due to its prevalence, resulting in HPV-negative cervical cancer receiving considerably less attention. As a result, HPV-negative cervical cancer is poorly understood. Its etiology remains elusive mainly due to limitations in research methodology such as lack of defined markers and model systems. Moreover, false HPV negativity can arise from inaccurate diagnostic methods, which also hinders the progress of research on HPV-negative cervical cancer. Since HPV-negative cervical cancer is associated with worse clinical features, greater attention is required to understand HPV-negative carcinoma. In this review, we provide a summary of knowledge gaps and current limitations of HPV-negative cervical cancer research based on current clinical statistics. We also discuss future directions for understanding the pathogenesis of HPV-independent cervical cancer.

• Asian Journal for Public Opinion Research
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• 제9권1호
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• pp.48-82
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• 2021

This research article attempts to understand the current situation of fake news on social media in India. The study focused on four characteristics of fake news based on four research questions: subject matter, presentation elements of fake news, debunking tool(s) or technique(s) used, and the social media site on which the fake news story was shared. A systematic sampling method was used to select a sample of 90 debunked fake news stories from two Indian fact-checking websites, Alt News and Factly, from December 2019 to February 2020. A content analysis of the four characteristics of fake news stories was carefully analyzed, classified, coded, and presented. The results show that most of the fake news stories were related to politics in India. The majority of the fake news was shared via a video with text in which narrative was changed to mislead users. For the largest number of debunked fake news stories, information from official or primary sources, such as reports, data, statements, announcements, or updates were used to debunk false claims.

• 한국정보과학회논문지:데이타베이스
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• 제33권3호
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• pp.283-298
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• 2006

TPR-tree는 시간 함수 기반의 색인으로 위치 좌표와 속도 벡터 정보를 이용하여 이동체의 위치를 표현함으로써 현재 및 미래 위치 예측을 위한 질의에 사용된다. 그러나 이동체의 이동방향 및 속도가 특정 임계값을 벗어날 경우 매번 서버에 새로운 위치를 보고하기 때문에 차량과 같이 이동방향과 속도가 빈번하게 변하는 환경에 적용할 경우 서버로의 잦은 보고를 필요로 하게 되어 통신비용을 크게 증가시키는 문제가 있다. 통신비용을 일정하게 유지하기 위해서 이동체의 위치 보고를 일정한 시간 간격으로 수행하게 하는 방법이 있다. 그러나 일정한 시간 간격으로 보고되는 이동체의 위치를 저장하는 경우 보고 간격 사이에 속도와 방향이 변하게 되면 시간에 대한 선형적인 위치 예측 시에 오차가 발생하는 문제가 있다. 이 논문에서는 일정한 시간 간격으로 이동체의 위치보고가 이루어질 때 속도와 방향의 불확실성을 반영하여 이동체의 위치 예측을 하기 위해 도로네트워크 정보를 적용한 질의 처리 기법 및 데이타 저장 구조를 제시한다. 제시된 기법은 도로 네트워크 정보를 이용하여 이동체의 이동 방향을 도로 네트워크 세그먼트의 방향으로 제한함으로써 불확실 영역을 감소시키고 있으며 도로 네트워크 세그먼트의 종류별로 최대 속도를 설정하여 이동 속도와 변화에 대한 불확실성을 제거한다. 실험결과를 통하여 제안된 질의 처리 기법이 미래 위치에 대한 영역 질의 시에 False miss를 발생시키지 않으면서 False hit를 최소화 시키는 것을 확인함으로써 TPR-tree를 이용한 기존의 질의 처리 기법보다 질의 영역의 크기에 따라 최대 60% 이상 위치 예측 정확도가 향상됨을 알 수 있다.

• 대한두경부종양학회지
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• 제15권1호
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• pp.46-51
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• 1999

Background: Total thyroidectomy and postoperative radiodiodine ablation therapy in differentiated thyroid carcinomas enhance the reliability of serum thyroglobulin(Tg) levels and radioiodine scan in detecting recurrence or distant metastasis. There have been, however, some limitations in using these methods under certain conditions. Recently, several reports have indicated that thyroid peroxidase(TPO) could be used as an alternative tumor marker. We aimed to estimate the significance of serum TPO levels in differentiated thyroid carcinoma. Materials and Methods: Forty-eight patients who had undergone total thyroidectomy due to papillary thyroid carcinomas and who had been followed-up for at least 3 years were classified into two groups: 27 patients without any evidence of recurrence in group 1; and 20 patients with recurrence or distant metastasis in group 2. All patients were examined by radioiodine scans. Serum Tg, TSH, antithyroglobulin antibody, and TPO were measured and the relationships were statistically analyzed. The sensitivity and specificity of $^{131}I$ scan, serum Tg, and serum TPO were evaluated. Results: Serum Tg levels were $3.81{\pm}5.16ng/mL$ in group 1 and $147.02{\pm}193.75ng/mL$ in group 2. Only 2 patients in group 1 showed Tg levels exceeding 10ng/mL. In contrast, 4 patients in group 2 were under 10ng/mL. Serum antithyroglobulin antibody and TSH levels showed no statistical difference between the two groups. In group 1, 16 patients showed negative serum TPO results, and 4 patients in group 2 showed negative results. There was no correlation among serum Tg levels, antithyroglobulin antibody titers, and serum TPO levels in each group. In group 2, 4 patients with negative serum Tg levels showed positive TPO results and positive whole body scans. Two cases with false negative $^{131}I$ scans showed positive serum TPO and Tg results. In 4 cases showing false negative serum TPO levels, serum Tg levels and $^{131}I$ scans were positive. Conclusion: Serum Tg levels, radioiodine scans, and serum TPO levels can be clinically used as complementary methods in the diagnosis of recurrent or metastatic thyroid carcinomas. Serum TPO levels may be helpful when other methods fail to detect recurrences or distant metastasis in highly suspected patients.

• Clinical and Experimental Pediatrics
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• 제49권2호
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• pp.162-166
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• 2006

목 적: 소아의 경부 림프절 종대에서 세침 흡인 세포검사의 진단적 가치에 대한 자료를 분석한 보고는 국내에서 알려져 있지 않아, 이에 대한 분석을 보고하는 바이다. 방 법: 2001년에서 2005년까지 계명대학교 동산의료원 소아과에 내원하여 경부 림프절 종대가 있어 세침 흡인 세포검사를 시행하였던 환자 57례를 의무 기록을 통해 후향적으로 분석하였다. 세침 흡인 세포검사의 결과와 임상적 최종 진단 결과를 비교 관찰하였다. 결 과: 대상 환자 57례 중 비특이성 경부 림프절염이 52.5%로 가장 많았다. 악성질환은 모두 8례로 전체의 14.0%를 차지하였다. 세침 흡인 세포검사의 악성질환에 대한 진단적 효용성을 보았을 때 민감도 86%, 특이도 96%, 양성 예측률 75%, 음성예측률 98%였다. 위양성인 예는 랑게르한스 조직구증식증 1례와 전염성 단핵구증 1례이었고, 위음성이었던 예는 급성 림프구성백혈병 1례이었다. 세침 흡인 세포검사 후 개방 생검을 한 경우가 7례가 있었다. 검체가 충분하지 못했던 경우가 4례로 7.0%를 차지하였다. 결 론: 소아의 경부 종대는 양성인 반응성 림프절염에 의한 경우가 대부분이나 악성질환에 의한 것일 수도 있으므로 1차적으로 간편하게 시행할 수 있는 세침 흡인 세포검사를 적극적으로 이용하여야 하고 필요시 개방 생검도 실시하여야 하겠다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2519-2525
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• 2016

There are several existing reports of microarray chip use for assessment of altered gene expression in different diseases. In fact, there have been over 1.5 million assays of this kind performed over the last twenty years, which have influenced clinical and translational research studies. The most commonly used DNA microarray platforms are Affymetrix GeneChip and Quality Control Software along with their GeneChip Probe Arrays. These chips are created using several quality controls to confirm the success of each assay, but their actual impact on gene expression profiles had not been previously analyzed until the appearance of several bioinformatics tools for this purpose. We here performed a data mining analysis, in this case specifically focused on ovarian cancer, as well as healthy ovarian tissue and ovarian cell lines, in order to confirm quality control results and associated variation in gene expression profiles. The microarray data used in our research were downloaded from ArrayExpress and Gene Expression Omnibus (GEO) and analyzed with Expression Console Software using RMA, MAS5 and Plier algorithms. The gene expression profiles were obtained using Partek Genomics Suite v6.6 and data were visualized using principal component analysis, heat map, and Venn diagrams. Microarray quality control analysis showed that roughly 40% of the microarray files were false negative, demonstrating over- and under-estimation of expressed genes. Additionally, we confirmed the results performing second analysis using independent samples. About 70% of the significant expressed genes were correlated in both analyses. These results demonstrate the importance of appropriate microarray processing to obtain a reliable gene expression profile.

• Journal of Genetic Medicine
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• 제12권2호
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• pp.79-84
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• 2015

Purpose: We developed and validated a fetal trisomy detection method for use as a noninvasive prenatal test (NIPT) including a Clinical Laboratory Improvement Amendments (CLIA)-certified bioinformatics pipeline on a cloud-based computing system using both Illumina and Life Technology sequencing platforms for 221 Korean clinical samples. We determined the necessary proportions of the fetal fraction in the cell-free DNA (cfDNA) sample for NIPT of trisomies 13, 18, and 21 through a limit of quantification (LOQ) test. Materials and Methods: Next-generation sequencing libraries from 221 clinical samples and three positive controls were generated using Illumina and Life Technology chemistries. Sequencing results were uploaded to a cloud and mapped on the human reference genome (GRCh37/hg19) using bioinformatics tools. Based on Z-scores calculated by normalization of the mapped read counts, final aneuploidy reports were automatically generated for fetal aneuploidy determination. Results: We identified in total 29 aneuploid samples, and additional analytical methods performed to confirm the results showed that one of these was a false-positive. The LOQ test showed that the proportion of fetal fraction in the cfDNA sample would affect the interpretation of the aneuploidy results. Conclusion: Noninvasive chromosome examination (NICE), a CLIA-certified NIPT with a cloud-based bioinformatics platform, showed unambiguous success in fetus aneuploidy detection.

• Toxicological Research
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• 제26권1호
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• pp.21-28
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• 2010

As the frequency and the intensity of so called Asian dust (AD) events have increased, public concerns about the adverse health effects has spiked sharply over the last two decades. Despite the recent reports on the correlation between AD events and the risk for cardiovascular and respiratory disease, the nature of the toxicity and the degree of the risk are yet largely unknown. In the present study, we investigated the effects of the dichloromethane extract of AD (AD-X) and that of urban dust (NAD-X) collected during a non-AD period on gene expression in HL-60 cells using Illumina Sentrix HumanRef-8 Expression BeadChips. Global changes in gene expression were analyzed after 24 h of incubation with 50 or 100 ${\mu}g$/ml AD-X and NAD-X. By one-way analysis of variance (p < 0.05) and Benjamini-Hochberg multiple testing correction for false discovery rate of the results, 573 and 297 genes were identified as AD-X- and NAD-X-responsive, respectively. The genes were classified into three groups by Venn diagram analysis of their expression profile, i.e., 290 AD-X-specific, 14 NAD-X-specific, and 283 overlapping genes. Quantitative realtime PCR confirmed the changes in the expression levels of the selected genes. The expression patterns of five genes, namely SORL1, RABEPK, DDIT4, AZU1, and NUDT1 differed significantly between the two groups. Following rigorous validation process, these genes may provide information in developing biomarker for AD exposure.

• 한국의류학회지
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• 제19권3호
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• pp.483-503
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• 1995

The purpose of this study was to clarify the origin which have misused terms, analyze Its meanings and suggest the unified terms. The content of this study are as follows. The origin of the terms in western dress is different with the areas of cultural influence. Japanese occupied much more than other languages in the apparel industry after the civilization. and English has dominated in the educational filed since 1945 the Liberalization. French, German, Portuguese, Spanish, Dutch are added. These languages came to the clothing field via Japanese and English or directly from the countries. 망토(manteau프), 메리야스(medias스), 러닝셔츠(일) 라사(raxa네), 오트 쿠튀르(Haute Couture 프), 비로드(veludo 포), etc. However the words of foreign origin have misused or corrupted until now a days. 마이 (재킷, 상의), 노 슬립, 소데나시 (슬리브리스, 민소매) 넌라쟈(브래지어), 노타이, 노타이샤쓰(오픈칼라 셔츠, 넥타이를 매지 않은 셔츠) 와이샤쓰(드레스 ttu츠), etc. And also these terms are confused in using because of the word's diversity, the different nationality, change of the marking rules, and the difference between the education and production field terms. On the others hand, this study explained the differences between western costume and Korean costume as the clothing manufacture terms were translated to Korean. bodice-길, collar, neckline-깃, belt, sash-(허리)띠 And then the untied terms were suggested through the comparison production field and educational area (including schools and institutes). lapel, 라펠(학교용어) (학원용어), 가에리 (일) (의류산업 현장용어), 아랫깃(통일어) By the way, this study involved the origin of and misused teams in sewing and presented the unified terms. 미까시 (X)-미 카에시(일) - 안단($\bigcirc$), 이새(X)―홈줄임 ($\bigcirc$) As the above , the characteristics of clothing terms which have misused are Japans,;e, corrupt Japanese, false reports foreign words via Korean, Japanese, compound words of Korean and Japanese, compound words of English and Japanese. And also the words of foreign origin in clothing had the following tendency in the marking system. There are ellipsis of form, sex, timber, grammatical case '-ing', '-ed' in adjective and long vowels express to short vowels. We can see this phenomena as the rule of curtailment labor.