• Title/Summary/Keyword: Failure ratio

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Socio-economic Status Plays Important Roles in Childhood Cancer Treatment Outcome in Indonesia

  • Mostert, Saskia;Gunawan, Stefanus;Wolters, Emma;van de Ven, Peter;Sitaresmi, Mei;van Dongen, Josephine;Veerman, Anjo;Mantik, Max;Kaspers, Gertjan
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.12
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    • pp.6491-6496
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    • 2012
  • Background: The influence of parental socio-economic status on childhood cancer treatment outcome in low-income countries has not been sufficiently investigated. Our study examined this influence and explored parental experiences during cancer treatment of their children in an Indonesian academic hospital. Materials and Methods: Medical charts of 145 children diagnosed with cancer between 1999 and 2009 were reviewed retrospectively. From October 2011 until January 2012, 40 caretakers were interviewed using semi-structured questionnaires. Results: Of all patients, 48% abandoned treatment, 34% experienced death, 9% had progressive/relapsed disease, and 9% overall event-free survival. Prosperous patients had better treatment outcome than poor patients (P<0.0001). Odds-ratio for treatment abandonment was 3.3 (95%CI: 1.4-8.1, p=0.006) for poor versus prosperous patients. Parents often believed that their child's health was beyond doctor control and determined by luck, fate or God (55%). Causes of cancer were thought to be destiny (35%) or God's punishment (23%). Alternative treatment could (18%) or might (50%) cure cancer. Most parents (95%) would like more information about cancer and treatment. More contact with doctors was desired (98%). Income decreased during treatment (55%). Parents lost employment (48% fathers, 10% mothers), most of whom stated this loss was caused by their child's cancer (84% fathers, 100% mothers). Loss of income led to financial difficulties (63%) and debts (55%). Conclusions: Treatment abandonment was most important reason for treatment failure. Treatment outcome was determined by parental socio-economic status. Childhood cancer survival could improve if financial constraints and provision of information and guidance are better addressed.

Biomechanical Analysis of Different Thoracolumbar Orthosis Designs using Finite Element Method (유한요소 해석을 이용한 정형용 흉·요추 보조기의 형태에 따른 생체역학적 분석)

  • Kim, Y.H.;Jun, S.C.;Jung, D.Y.;Lee, S.J.
    • Journal of rehabilitation welfare engineering & assistive technology
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    • v.6 no.1
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    • pp.45-50
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    • 2012
  • Thoracolumbar orthosis has been used for the rehabilitation of the patients with senile kyphosis. Recently, a number of different thoracolumbar orthosis designs have been introduced but its biomechanical effectiveness still remain unknown. In this study, we compared the pressure distribution on the surface of the trunk and stresses on the orthosis in relation to changes in connecting frame designs (Type 1, one-connecting frame type; Type 2, two-connecting frame type; Type 3, all-in-one type) using finite element (FE) models under different motions of the trunk. The results showed that Type 3 distributed the pressure on the trunk most evenly followed by Type 2 and Type 1 and the difference between Type 1 and Type 2 was negligible. ROM was limited most effectively by Type 3 ($8.5{\sim}9.4^{\circ}$), followed by Type 2 ($11.3{\sim}13.9^{\circ}$) and Type 1 ($12.1{\sim}15.4^{\circ}$). The ratio between the peak von Mises stress and yield strength of each material remained less than 20% regardless of orthosis type indicating low likelihood of component failure. In conclusion, our study found that all-in-one type of orthosis was the most effective design for the conservative treatment of spinal deformity in terms of function and comfort.

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Change of Bending Properties of 2×4 Larch Lumber According to Span Length in the Four Point Bending Test (4점 휨 시험에서 지간 거리에 따른 2×4 낙엽송 제재목의 휨 성능 변화)

  • Kim, Chul-Ki;Kim, Kwang-Mo;Lee, Sang-Joon;Park, Moon-Jae
    • Journal of the Korean Wood Science and Technology
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    • v.46 no.5
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    • pp.486-496
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    • 2018
  • This study was conducted to confirm an effect of span length on bending properties of larch dimensional lumber in the four point bending test. The size of specimen in this study was 38 (width) ${\times}$ 89 (depth) ${\times}$ 3,600 (length) $mm^3$, and average air-dry density and moisture content of the specimens was $543.5kg/m^3$ and 10.5%, respectively. Visually graded No. 1 dimensional lumbers of 248 were divided by two groups to compare modulus of rupture (MOR) and modulus of elasticity (MOE). One group was tested in the four point bending test with span length of 1,650 mm, and other was tested with span length of 3,000 mm. While MOE was not different according to span length in 5% significance level, MOR was different in accordance with span lengths and was in inverse proportion to change of span length. Fifth percentiles of MOR in span length of 1,650 and 3,000 mm were 28.65 and 25.70 MPa, respectively. It was confirmed that the difference between MORs in each case increased as normalized rank increased. This is because of size effect in Weibull weakest link failure theory. Therefore, KS F 2150, in which there is only regulation about span to depth ratio of 15 or more, is needed to be revised to contain a method considering size effect for MOR. From the method, various results of bending test with different size of lumber could be used to determine design value of lumber.

Long-Term Result of Tricuspid Valve Replacement (삼첨판막 치환술의 장기성적)

  • Lim, Cheong;Kang, Moon-Chul;Kim, Kyung-Hwan;Kim, Ki-Bong;Ahn, Hyuk
    • Journal of Chest Surgery
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    • v.34 no.9
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    • pp.680-685
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    • 2001
  • Background: Tricuspid valve replacement is very rarely performed procedure and its long-term result is not yet satisfactory. Moreover, it is not well known whether bioprosthesis or mechanical prosthesis is the best selection for artificial valve. We reviewed 72 cases of tricuspid valve replacements in 71 patients between January 1989 and December 1998, trying to analyze the overall results and risk factors for mortality and morbidity. Material and Method: Average age of the patients at the time of operation was 42$\pm$13 years(range 16 to 65 years) and the sex ratio of male versus female was 32/39. Primary diagnosis consisted of 50 cases of aquired valvular heart disease and 18 cases of congenital heart disease, such as Ebstein’s anomaly. 4 cases had isolated tricuspid valve regurgitation. Implanted valves were 69 mechanical prosthesis and 3 bioprosthesis. Concomitant mitral or aortic valve replacements were performed in 50 cases. One patient received concomittant pulmonary valve replacement. Result: There were 7(9.72%) operative deaths and 7(13.0%) late deaths. Actuarial survival at 10 years was 59.2$\pm$7.2%. Prosthetic tricuspid valve thrombosis occurred 11 times in 5 patients. Reoperation for prosthetic tricuspid valve failure was performed in 1 patient. In this case, examination of the explanted prostheses showed that the tricuspid stenosis was the result of valve thrombosis. Among the 47 survivors, 46 patients(98%) were in functional class I or II. Conclusion: In our ten-year experience of tricuspid valve replacement, mortality and morbidity were satisfactory. Mechanical prosthesis in tricuspid position showed comparable clinical results as bioprosthesis.

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Predicting Mortality in Patients with Tuberculous Destroyed Lung Receiving Mechanical Ventilation

  • Kim, Won-Young;Kim, Mi-Hyun;Jo, Eun-Jung;Eom, Jung Seop;Mok, Jeongha;Kim, Ki Uk;Park, Hye-Kyung;Lee, Min Ki;Lee, Kwangha
    • Tuberculosis and Respiratory Diseases
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    • v.81 no.3
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    • pp.247-255
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    • 2018
  • Background: Patients with acute respiratory failure secondary to tuberculous destroyed lung (TDL) have a poor prognosis. The aim of the present retrospective study was to develop a mortality prediction model for TDL patients who require mechanical ventilation. Methods: Data from consecutive TDL patients who had received mechanical ventilation at a single university-affiliated tertiary care hospital in Korea were reviewed. Binary logistic regression was used to identify factors predicting intensive care unit (ICU) mortality. A TDL on mechanical Ventilation (TDL-Vent) score was calculated by assigning points to variables according to ${\beta}$ coefficient values. Results: Data from 125 patients were reviewed. A total of 36 patients (29%) died during ICU admission. On the basis of multivariate analysis, the following factors were included in the TDL-Vent score: age ${\geq}65$ years, vasopressor use, and arterial partial pressure of oxygen/fraction of inspired oxygen ratio <180. In a second regression model, a modified score was then calculated by adding brain natriuretic peptide. For TDL-Vent scores 0 to 3, the 60-day mortality rates were 11%, 27%, 30%, and 77%, respectively (p<0.001). For modified TDL-Vent scores 0 to ${\geq}3$, the 60-day mortality rates were 0%, 21%, 33%, and 57%, respectively (p=0.001). For both the TDL-Vent score and the modified TDL-Vent score, the areas under the receiver operating characteristic curve were larger than that of other illness severity scores. Conclusion: The TDL-Vent model identifies TDL patients on mechanical ventilation with a high risk of mortality. Prospective validation studies in larger cohorts are now warranted.

Investigation of Lateral Resistance of Short Pile by Large-Scale Load Tests (실물 재하시험을 통한 짧은말뚝의 횡방향 저항거동 평가)

  • Lee, Su-Hyung;Choi, Yeong-Tae;Lee, Il-Wha;Yoo, Min-Taek
    • Journal of the Korean Geotechnical Society
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    • v.33 no.8
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    • pp.5-16
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    • 2017
  • When a lateral load is applied to a short pile whose embedded depth is relatively smaller than its diameter, an overturning failure occurs. To investigate the behavior of laterally loaded short piles, several model tests in laboratory scales had been carried out, however the behavior of large moment carrying piles for electric poles, traffic sign and road lamp, etc. have not been revealed yet. This paper deals with the real-scale load tests for 750 mm diameter short piles. To simulate the actual loading condition, very large moment was mobilized by applying lateral loads to the location 8 m away from the pile head. Three load tests changing the pile embedded lengths to 2.0 m, 2.5 m, and 3.0 m were carried out. The test piles overturned abruptly with very small displacement and rotation before the failures. These brittle failures are in contrast with the ductile failures shown in the former model tests with the relatively smaller moment to lateral load ratio. Comparisons of the test results with three existing methods for the estimation of the ultimate lateral capacity show that the method assuming the rotation point at pile tip matches well when the embedded depth is small, however, as the embedded depth increases the other two methods assuming the inversion of soil pressure with respect to rotation points in pile length match better.

A Clinical Study on Children with Delayed Language Development - Especially Focussing on Causes - (소아 언어발달지연의 연구 - 특히 원인을 중심으로 -)

  • Kim, Jeong-Ho;Moon, Han-Ku;Hah, Jeong-Ok
    • Journal of Yeungnam Medical Science
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    • v.8 no.2
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    • pp.24-34
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    • 1991
  • Delayed emergence of speech or language are frequent causes for concern about development during early childhood. Dealy in evaluation and proper management until school entry in more likely to result in frustration, anxiety and school failure. Many language disturbances and their attendant behavior disorders respond to intensive language therapy. Authors analyzed the medical recoreds of 52 children with delayed language development evaluated during 30 months from January 1986 through June 1988. The results were as follows : 1. The majority of cases were evaluated at the age of 2-2.9 year old(16 cases, 30.8%) and 3-3.9 year old(11 cases, 21.2%) 2. Male to female ratio was 3 : 1 3. The most common cause was mental retardation(53.8%), followed by developmental language disorder(23.1%) and autism(13.5%) 4. The most common associated condition was dysarticulation(17.3%), followed by strabismus(9.6%) and seizures(7.7%) 5. Special education was recommended in cases of 23(44.2%), speech therapy in 12 cases(23.1%) and consultation to child psychiatry in 7 cases (13.5%). Making diagnosis of underlying disorders is not simple because assessment of intelligence in young children is difficult and only a few tests are standardized. More detailed study on children with delayed language development and development of psychometric tests for the handicapped children are necessary, especially in Korea.

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Congenital Ileal Atresia in Newborn (신생아 선천성 회장 폐쇄증)

  • Huh, Young-Soo;Kim, Chang-Sig;Shin, Son-Moon
    • Journal of Yeungnam Medical Science
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    • v.11 no.1
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    • pp.35-41
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    • 1994
  • Newborns with ileal atresia freqently present with abdominal distension, bilious vomiting. and failure to pass meconium. Diagnosis is usually established on plain x-ray of the abdomen by the findings of distended small bowel loops and air-fluid levels. In the period of October 1988 to February 1994, 8 patients with congenital ileal atresia were operated and the following results were obtained. 1. Eight patients were comprised of 4 males and 4 females, the ratio of male and female was 1 : 1. 2. Six patients(75%) had been admittted to our hospital during three days of life. 3. Congenital ileal atresia was in 8 cases : Type I in two(25%), Type II in two(25%), Type IIIa in three(37.5%), Type IIIb in one(12.5%). 4. There was one premature patient who was small for gestational age. 5. Overall, abdominal distension and bilious vomiting occurring in seven patients, were frequent presenting complaints. 6. Diagnosis was possible with clinical symptom and simple abdomen. 7. Operative treatment was undertaken as soon as the diagnosis was made. In seven cases a primary end-to-end anastomosis was performed after resection of dilated proximal loop. 8. A total of four associated congenital anomalies were found in one patient. 9. Postoperative complications occurred in three cases(37.5%).

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Determination of the Critical Buckling Loads of Shallow Arches Using Nonlinear Analysis of Motion (비선형 운동해석에 의한 낮은 아치의 동적 임계좌굴하중의 결정)

  • Kim, Yun Tae;Huh, Taik Nyung;Kim, Moon Kyum;Hwang, Hak Joo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.12 no.2
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    • pp.43-54
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    • 1992
  • For shallow arches with large dynamic loading, linear analysis is no longer considered as practical and accurate. In this study, a method is presented for the dynamic analysis of shallow arches in which geometric nonlinearity must be considered. A program is developed for the analysis of the nonlinear dynamic behavior and for evaluation of critical buckling loads of shallow arches. Geometric nonlinearity is modeled using Lagrangian description of the motion. The finite element analysis procedure is used to solve the dynamic equation of motion and Newmark method is adopted in the approximation of time integration. A shallow arch subject to radial step loads is analyzed. The results are compared with those from other researches to verify the developed program. The behavior of arches is analyzed using the non-dimensional time, load, and shape parameters. It is shown that geometric nonlinearity should be considered in the analysis of shallow arches and probability of buckling failure is getting higher as arches are getting shallower. It is confirmed that arches with the same shape parameter have the same deflection ratio at the same time parameter when arches are loaded with the same parametric load. In addition, it is proved that buckling of arches with the same shape parameter occurs at the same load parameter. Circular arches, which are under a single or uniform normal load, are analyzed for comparison. A parabolic arch with radial step load is also analyzed. It is verified that the developed program is applicable for those problems.

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Seismic Behavior and Estimation for Base Isolator Bearings with Self-centering and Reinforcing Systems (자동복원 및 보강 시스템과 결합된 면진받침의 지진거동과 평가)

  • Hu, Jong Wan
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.35 no.5
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    • pp.1025-1037
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    • 2015
  • Flexible base isolation bearings that separate superstructure from ground have been widely used in the construction field because they make a significant contribution to increasing the fundamental period of the structure, thereby decreasing response acceleration transmitted into the superstructure. However, the established bearing devices installed to uphold the whole building give rise to some problems involved with failure and collapse due to lack of the capacity as modern structures are getting more massive and higher. Therefore, this study suggests new isolation bearings assembled with additional restrainers enabled to reinforcing and recentering, and then evaluates their performance to withstand the seismic load. The superelastic shape memory alloy (SMA) bars are installed into the conventional lead-rubber bearing (LRB) devices in order to provide recentering forces. These new systems are modeled as component spring models for the purpose of conducting nonlinear dynamic analyses with near fault ground motion data. The LRB devices with steel bars are also designed and analyzed to compare their responses with those of new systems. After numerical analyses, ultimate strength, maximum displacement, permanent deformation, and recentering ratio are compared to each model with an aim to investigate which base isolation models are superior. It can be shown that LRB models with superelastic SMA bars are superior to other models compared to each other in terms of seismic resistance and recentering effect.