• Archives of Pharmacal Research
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• v.17 no.5
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• pp.381-382
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• 1994

Administration route dependency on the distribution of PEGylated recombinant human turor necrosis factor binding protein (rhTNFbp-PEG20K dimer) was observed following a subcutaneous (sc) and an intravenous (iv) administrationin rats. ehTNFbp-PEG20K dimer is composed of two rhTNGbp molecules (molecular weight 18, 278 daltons each) joined by polyethylene glycol 2000(PEG30K). The steady state distribution volume of rhTNFbp-PEG20K was 55 m/kg and 359 ml/kg following the i.v. and s.c. administrations, respectively. These results suggest that the distribution of ehTNFbp-PEG20K is limited within the cpillary space after i.v. administration, while rhTNFbp-PEG20K can distribute into a space (35.9% of body weight) which is between extracellylar space and total body water. A lymphatic absorption may paly a role in the distribution of rhTNFbp-PEF20K dimer following the sc administration. The present study suggests that the administration route of a lartge protein molecule should be determined depedning upon target sites.

• KIEAE Journal
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• v.16 no.5
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• pp.87-92
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• 2016

Purpose: The objective of this research is to investigate and analyze the relationship between physical residential conditions and occupants' responses in apartment buildings by POE(Post-Occupancy Evaluation). The analysis results from this research will help to identify the indoor residential problems and find design solutions for improving overall residential indoor residential environment. Method: The occupant survey was conducted at four different apartment complex area at Cheongju City, Chungbuk Province, Korea. Combination of unbalanced indoor environmental conditions in residential building had difference of occupants' responses according to occupants' characteristics, such as gender, age, and so on. The survey collected data regarding the occupants' EQ(Environmental Quality) priorities to determine the weight of each environmental-quality factor (lighting, acoustic, thermal and indoor air quality). A paired comparison method was used to determine the weight by comparing the relative importance of the two factors based on occupant's survey response. Result: The output from this research is useful to understand the residential environment, occupants' satisfaction, preference, and identifies the current residential problems and finds an architectural solution in apartment buildings.

• Journal of Power Electronics
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• v.11 no.1
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• pp.105-111
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• 2011

By having accurate knowledge of the magnetic field distribution and the thrust calculation in linear synchronous motors, assessing the performance and optimization of the motor design are possible. In this paper, after carrying out a performance analysis of a single-sided wound secondary linear synchronous motor by varying the motor design parameters in a layer model and a d-q model, machine single- and multi-objective design optimizations are carried out to improve the thrust density of the motor based on the motor weight and the motor efficiency multiplied by its power factor by defining various objective functions including a flexible objective function. A genetic algorithm is employed to search for the optimal design. The results confirm that an overall improvement in the thrust mean, efficiency multiplied by the power factor, and thrust to the motor weight ratio are obtained. Several design conclusions are drawn from the motor analysis and the design optimization. Finally, a finite element analysis is employed to evaluate the effectiveness of the employed machine models and the proposed optimization method.

• Journal of the Korean Society of Clothing and Textiles
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• v.23 no.8
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• pp.1228-1239
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• 1999

This research analyzes characterisation and classification of body types for the Chinese women and to compare the differences of body type with Korea women in university. The measurement has gauged in 1998 at Yeon-Gil University in China. One hundred of the Chosunjok college women aged 17 and 24 in China were measured for this research. In the results of frequency analysis a comparison of the anthropometric categories of the chinese women with those of the Koreans revealed that the Chinese women were shorter and more fat in body. In the results of factor analysis Both two groups factor 1 represented the degree of abesity while factor 2 indicated the stature and the arm length. For the Chosunjok the body types are classified into eight types but Korean has four types by cluster analysis The stature and weight varied according to types leading to a classification focusing on the body size determened by stature and weight factors.

• Journal of the Korean Society of Clothing and Textiles
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• v.37 no.8
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• pp.1107-1116
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• 2013

This study examined the use of cutinase and lipase to process cotton/polyester blend fabric. Optimum treatment conditions for cutinase and lipase were investigated for cotton/polyester blend fabric. The properties of enzyme-treated fabrics were evaluated and compared in optimal treatment conditions. In addition, the possibility to provide an enzymatic finishing on blend fabrics using mixed enzymes in a two-step process were studied. The weight loss of cotton/polyester blend fabrics with Triton X-100 was 0.8% and the dyeing property of blend fabrics with calcium chloride increased by a factor of 1.2. The use of two enzymes in combination with cutinase and lipase in the presence of auxiliaries resulted in a cotton/polyester blend fabric weight loss of 0.8%. In addition, the dyeing properties of cotton/polyester blend fabrics improved by a factor of 1.5 and the moisture regain of cotton/polyester blend fabrics improved by a factor of 1.16. However, no marked loss was observed in tensile strength. The surface morphology of cotton/polyester blend fabrics is modified through a two-enzyme treatment. The treatment of cotton/polyester blend fabrics with cutinase and lipase maintains cotton strength and improves the moisture regain of polyester fabrics.

• Biomedical Science Letters
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• v.27 no.4
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• pp.248-254
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• 2021

Ulcerative colitis (UC), chronic inflammatory bowel disease, is characterized by severe inflammation in the colon. Tea is one of the most popular beverages consumed worldwide. Pu-erh tea, a unique Chinese tea produced by microbial activities, possesses a broad range of health-promoting effects, including anti-aging, anti-Alzheimer's disease, antioxidation and anti-obesity. However, the inhibitory effect of Pu-erh tea on intestinal inflammation and the underlying mechanism remain unclear. The present study was designed to evaluate the regulatory effect of Pu-erh tea extract (PTE) on dextran sulfate sodium (DSS)-induced colitis clinical signs by analyzing the weight loss and colon length in mice. The inhibitory effects of PTE on inflammatory mediators, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, and the activation of nuclear factor-κB (NF-κB) were also determined in DSS-treated colitis tissue. We observed that PTE treatment significantly inhibited the DSS-induced clinical symptoms of weight loss, decrease,in colon length, and colon tissue damage in mice. Moreover, PTE attenuated the DSS-induced levels of IL-6 and TNF-α in colon tissue. We also demonstrated the anti-inflammatory mechanism of PTE by suppressing the activation of NF-κB in DSS-treated colon tissues. Collectively, the findings provide experimental evidence that PTE may be effective in preventing and treatment of intestinal inflammatory disorders, including UC.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.5 no.2
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• pp.73-84
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• 2007

This study aims to examine changes from differences in the lumbar scoliosis angle and iliac crest height due to abnormal and habitual posture shown in unilateral weight load at standing posture and suggest data for preventing and treating lumbago. The subjects of this study are 16 lumbago patients between twenties and forties with chronic lumbago over six months, but without neurological symptoms. As a result of photographing front and back with three conditions such as weight load on both sides and left or right unilateral weight load posture in order to examine changes of lumbar scoliosis and iliac crest according to changes of posture at unilateral weight load, while scoliosis angle and iliac crest height by habitual unilateral support were increased, those by opposite support were decreased. In conclusion, it was found that habitual unilateral weight load may cause continuous distortion of spinal angle and change of iliac crest height and these may be a factor of lumbago. Therefore, if habitual unilateral weight load state is kept continuously, distortion of lumbar angle and iliac crest height may be greater and common efforts to change habitual unilateral weight load are needed.

• Korean Journal of Human Ecology
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• v.24 no.1
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• pp.111-122
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• 2015

The purpose of this study was to identify the shoes satisfaction and selection criteria according to women's BMI. Data was collected from 323 women in their 20-40's. Factor analysis, one-way ANOVA, Chi-square test, and multi regression analysis were done. Women were segmented into the under weight group, the regular weight group, and the over weight group according to their BMI. The factors of shoes selection criteria were fit and practicality, appearance, fashion and brand, materials and sewing, comfort and economy, and size. Generally most women were satisfied with the styles of shoes but dissatisfied with materials and size. The underweight group's foot was shorter and narrower, shoes was shorter and heel height was higher but the over weight group was opposite. The under weight group were satisfied with higher heel and comfort and practical shoes. The regular weight group were satisfied with higher heel and comfort and economy shoes but the over weight group was dissatisfied with higher heel and comfort and economy shoes.

• Journal of the Korean Society of Food Culture
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• v.18 no.4
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• pp.396-405
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• 2003

The purpose of this study was to investigate the changes of obesity and depression level of obese children on body weight control program. The body weight control program included nutrition education, psychotherapy and exercise for weekly session during 9 months. The results from this study were as follows. A total of 27 obese children participated in this study. The average age of children was 11.7 years, 70% of children had regular exercise. Average exercise time was 1.2 hours and watching television time was 1.8 hours. Children's serum composition were within normal ranges. Rohrer index(RI) was significantly decreased to 163 from 167(p<0.001) and BMI was significantly decreased to 23.9 from 24.5(p<0.01) after body weight control program. There was not significant difference in depression score after body weight control program and there was not significant correlation between obesity and depression level. The response tendency of depression items indicated obese children had negative depression feelings and couldn't have hopeful mind to the future. But there were significant increase(p<0.05) in depression and hopeful mind in factor analysis. The suggestion and limitations of this study were discussed. These results suggest that body weight control program including nutrition education, exercise and psychotherapy may be effective for helping obese children.

• Journal of Korean Academy of Nursing
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• v.13 no.3
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• pp.51-60
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• 1983

Currently changing trends of child health care is demand total health assessment of child including growth and development. This study concentrates on the growth & developmental status of low birth weight infant for help their growth & development. Thus it can be provide a direction for scientific health education and counseling materials by investigating factor of growth & development. The subjects for this study were made up of 40 low birth weight infant who attended the well baby clinic of E university Hospital. The study method used was a questionnaire ＆ anthropometric assessment and DDST for normative data of development. The period for data collection was from July 1st to August 31th, 1982. Analysis of the data was done using percentages, $\chi$$^2$-test Stepwise Multiple Regression. The results of study were as follows. 1. The mean weight of birth was 2,068gm and mean of gestational period was 35.65 weeks. 2. The age at which weight ; 32.5%, head circumference : 67,5% chest circumference : 55.0%, height : 50. 0％ was normal range of physical growth. 3. The reverse age at which social development ; 87.5%, fine motor & adaptive development ; 70.0%, gross motor development ; 72.5% of children Passed by DDST to determine of normal range of development. 4. In the among variables, it was found that the infant who were the higher emotional & verbal response of mother and stimulus environment was the more normal range of weight & development than who was not. 5. The stepwise Multiple Regression between developmental status and predictors-birth order, weight at birth, sex, antenatal care, gestational period-are accounts for 34.1%.