• Journal of Dental Anesthesia and Pain Medicine
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• 제19권6호
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• pp.343-351
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• 2019

Background: Preterm labor and miscarriage may occur in stressful situations, such as a surgical operation or infection during pregnancy. Pharyngeal and buccal abscess and facial bone fractures are inevitable dental surgeries in pregnant patients. Remifentanil is an opioid analgesic that is commonly used for general anesthesia and sedation. Nonetheless, no study has investigated the effects of remifentanil on amniotic epithelial cells. This study evaluated the effects of remifentanil on the factors related to uterine contraction and its mechanism of action on amniotic epithelial cells. Methods: Amniotic epithelial cells were preconditioned at various concentrations of remifentanil for 1 h, followed by 24-h lipopolysaccharide (LPS) exposure. MTT assays were performed to assess the cell viability in each group. The effects of remifentanil on factors related to uterine contractions in amniotic epithelial cells were assessed using a nitric oxide (NO) assay, western blot examinations of the expression of nuclear factor-kappa B (NF-κB), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE₂), and RT-PCR examinations of the expression of the proinflammatory cytokines interleukin (IL)-1β and tumor necrosis factor-alpha (TNF-α). Results: Remifentanil did not affect viability and nitric oxide production of amniotic epithelial cells. Western blot analysis revealed that remifentanil preconditioning resulted in decreased expressions of NF-κB and PGE2 in the cells in LPS-induced inflammation, and a tendency of decreased COX2 expression. The results were statistically significant only at high concentration. RT-PCR revealed reduced expressions of IL-1β and TNF-α. Conclusions: Preconditioning with remifentanil does not affect the viability of amniotic epithelial cells but reduces the expression of factors related to uterine contractions in situations where cell inflammation is induced by LPS, which is an important inducer of preterm labor. These findings provide evidence that remifentanil may inhibit preterm labor in clinical settings.

• 대한치과교정학회지
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• 제28권5호
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• pp.763-774
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• 1998

골격성 III급 부정교합자의 두개안면골격형태가 하악이부형태와 하악전치의 위치에 미치는 영향을 알아보고자 연구를 시행하였다. 전후방적인 악골부조화가 나타나지 않고 교정치료의 경험이 없는 만 20세 이상의 성인남녀(정상군)와, 하악전돌의 악골부조화를 보이며 교정치료의 경험이 없 만 20세 이상의 성인남녀(하악전돌군)를 비교하여, 두개안면골격형태에 따른 하악이부형태와 하악전치의 위치에 관하여 다음과 같은 결론을 얻었다. 1. 두개안면골격형태의 비교에서 하악에 관련된 ${\angle}SN-Mn,\;{\angle}FMA,\;{\angle}Pal-Mn,\;{\angle}LFH$은 하악전돌군이 정상군에 비하여 크게 나타났지만,(p<0.05) 상악에 관련된 항목은 차이를 나타내지 아니하였다(p>0.n). 2. 하악전치를 둘러 싸고 있는 치조돌기는 하악전돌군이 정상군에 비해서 수평적으로 좁고,수직적으로 긴 형태를 나타내었다(p<0.05). 하악이부의 형태에서도 수평적으로는 하악전돌군이 정상군에 비해서 좁게 나타났으나, 수직적으로는 차이를 나타내지 아니하였다(p>0.05). 3. 하악전돌군의 두개안면골격형태와 이부계측항목과의 상관관계에서 두개저와 하악하연에 기인하는 수직적인 악골부조화가 증가할수록 LaABH, LiACBW, LaACBW, LiABBW, SW, ${\angle}LISA$가 감소하는 역상관관계를 나타냈지만 (p<0.05), 전후방적인 악골부조화와는 별다른 상관관계가 나타나지 않았다(p>0.05). 4. 하악전돌군에서 수직적인 두개안면골격형태를 나타내는 ${\angle}SN-Mn,\;{\angle}FMA,\;{\angle}Pal-Mn,\;{\angle}LFH$ 와 하악이부의 계측 항목인 LiACBW, LiABBW, SW, ${\angle}LISA$ 사이에 높은 상관관계가 존재하여, 수직적인 악골부조화로 하악이부의 형태와 하악전치의 경사도를 예측할 수 있었다(p<0.001).

• Restorative Dentistry and Endodontics
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• 제21권1호
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• pp.321-338
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• 1996

The purpose of this study was to evaluate the effect of moistening and air-drying of acid conditioned dentin and enamel on the marginal microleakage. In this study, Class V cavity were prepared on both buccal and lingual surface of sixty extracted human premolars with cementum margin. These specimens were randomly devided into three groups and three dentin adhesives(Scotchbond Multi-Purpose, All bond 2, Prisma Universal Bond 3) were applied to each group. The specimens in each group were subdevided into four groups (Wet/primed, Dry/primed, Wet/not primed, Dry/not primed) and the etched dentin and enamel surface were treated these four surface treatments prior to the placement of a bonding agent or adhesive. Wet/primed group was simply blot-dried with a damp facial tissue before primer placement ; Dry/primed group was air dried for 30 seconds before the placement of a primer ; Wet/not primed group and Dry/not primed group were not primed after blot dried and air dried for 30 seconds each group. The bonding agent and composite resin were applied for each group. All specimens were exposed to 500 cycle of thermal stress. Specimens were placed in a silver nitrate solution and then sectioned buccolingually through the center of the restoration. The dye penetrations of the specimens were observed with a stereo microscope. The statistical test were applied to the results using a one way analysis variance (ANOVA) and Duncan's multiple range test. The aspects of silver ion penetration into the resin/dentin interface were examined under scanning electron microscopy. The results were as follows. 1. In all groups, the enamel margin showed significantly lower leakage value than the cementum margin (p<0.05). 2. Regardless of various surface treatment and dentin adhesives, there was no significant difference at the enamel margins (p>0.05). 3. At the dentin margins, the leakage values of Dry/not primed group showed significantly higher than that of the other groups (p<0.05). The leakage values of Wet/primed group showed significantly lower than that of the other groups, but, there was no significant difference between Wet group and Dry group. 4. There was no significantly difference between the dentin adhesives regarding the surface treatments in all groups(p>0.05). 5. On the backscatterd scanning electron microscopy observation, the penetration of the silver ion occured at the bonding resin/dentin interface. In the Wet/primed group, resindentin hybrid zone and resin penetration into the dentin was observed. The resin tags were compactively formed to a thickness of $3\sim4{\mu}m$ at the upper part of dentinal tubules. In the Dry/primed group, the thickness of the hybrid zone and the diameter, depth of the resin tags diminished. In the Non-primed groups, the hybrid zone was not identified and few resin tag was observed. There was the gap formation in the resin/dentin interface.

• Journal of Korean Neurosurgical Society
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• 제63권3호
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• pp.397-405
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• 2020

Objective : We retrospectively evaluated the efficacy of Gamma Knife radiosurgery (GKS) for recurrent nasopharyngeal carcinoma (NPC) in patients who previously underwent radiotherapy, and analyzed the treatment outcomes over 14 years. Methods : Ten patients with recurrent NPC who had previously received radiotherapy underwent stereotactic radiosurgery using a Gamma Knife^® (Elekta Inc, Atlanta, GA, USA) between 2005 and 2018. The median target volume was 8.2 ㎤ (range, 1.7-17.8), and the median radiation dose to the target was 18 Gy (range, 12-30). The median follow-up period was 18 months (range, 6-76 months). Overall and local failure-free survival rates were determined using the Kaplan-Meier method. Results : The NPCs recurred at the primary cancer site in seven patients (70%), as distant brain metastasis in two (20%), and as an extension into brain in one (10%). The recurrent tumors in seven of the 10 patients (70%) were found on the routine follow-up imaging studies. Two patients presented with headache and one with facial pain. Local failure after GKS occurred in five patients (50%) : two of whom died eight and 6 months after GKS, respectively. No adverse radiation effects were noted after GKS. The 1- and 3-year overall survival rates after GKS were 90% and 77%, respectively. The local failure-free survival rates at 6 months, 1 year, and 3 years after GKS were 80%, 48%, and 32%, respectively. The median interval from GKS to local failure was 8 months (range, 6-12). Univariate analysis revealed that using co-registration with positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI) was associated with a lower local failure rate of recurrent NPC (p=0.027). Conclusion : GKS is an acceptable salvage treatment option for patients with recurrent NPC who previously received radiation therapy. PET-CT and MRI co-registration for dose planning can help achieve local control of recurrent NPC.

• 대한정형외과스포츠의학회지
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• 제9권1호
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• pp.58-64
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• 2010

목적: 최근 교통 수단 및 레저 수단으로써 자전거 이용이 증가함에 따라 자전거 관련 수상 환자도 증가하는 추세이다. 본 저자들은 자전거 사고로 인해 입원 치료를 시행한 환자들의 사고 유형에 대해 분석하였다. 대상 및 방법: 본 연구는 2008년 01월 01일부터 2009년 05월 31일까지 자전거 주행중 사고로 인해 본원에 입원한 75명의 환자 중 추시 가능하였던 71명을 대상으로 하였다. 남자 54명 및 여자 17명이었고 평균 나이는 36.7세였다. 수상 정도, 수상 부위, 수상 기전, 수상 장소, 자전거 종류, 자전거 이용 목적, 동반 탑승 혹은 화물 적재 여부, 계절 그리고 보호구 착용 여부 등을 Injury Severity Score( ISS)를 이용하여 분석하였다. 결과: Injury Severity Score 는 1점이 11례, 4점이 41례, 5점이 2례, 9점이 13례, 13점이 1례,16점이 2례 및 29점이 1례였다. 상지 및 하지의 골절 46례중 수술적 치료를 필요로 하였던 환자는 36례였고, 이는 전체 환자의 50.7 %였으며, 척추체 골절, 안면부 손상 및 복부장기 손상으로 인해 수술적 치료를 시행한 환자는 각각 2례,8례 및 1례였다. 두부 손상은 전체 10례였는데, 이중 중환자실 치료를 필요로 할 정도로 심각한 손상은 3례로 전체 환자의 4.2%였다. 결론: 자전거 사고를 방지하기 위해서는 자전거 전용 도로 확충, 안전 교육 및 헬멧을 포함한 상지 및 하지 보호대 착용 등의 사고 예방 노력이 필요할 것으로 사료된다.

• 대한한방내과학회지
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• 제28권4호
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• pp.816-829
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• 2007

Objectives : This study investigated warning signs and stroke presymptoms and their relationship with acute stroke patients in each stroke type. Methods : 217 patients with first-ever acute stroke within 2 weeks as the case group, 146 people without four major risk factors (hypertension, diabetes mellitus, hyperlipidemia and ischemic heart disease) as the healthy control group (Normals), and 160 people as the general control group (Controls) were recruited at the Stroke Medical Center in Daejeon University Oriental Medicine Hospital from July 2005 to March 2007 for this case-control study. We analyzed the odds ratio of each warning sign or presymptom by multivariate logistic analysis and evaluated each stroke type, as well as general characteristics such as age, sex, etc. Results : Paralysis or weakness of the face and limbs, visual field disorder or loss of vision or blurred and double vision in eyes or both eyes, and sudden difficulty in speaking or dysarthria showed significant increase respectively in each stroke type. In contrast, numbness or tingling sensation or lowering sensation of the face and limbs, numbness or dead sensation of 1st and 2nd fingers, tension at cervical lesion, blepharospasm, facial spasm, etc. had no significant relation with stroke occurrence. Conclusions : In this study we demonstrated that each presymptom have an influence on each stroke type and have different odds ratio for stroke. We believe this may contribute to interpreting the importance of warning signs or presymptoms for each type of stroke, and more prospective studies are needed.

• Archives of Plastic Surgery
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• 제32권2호
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• pp.155-160
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• 2005

The aim of this study is to establish anatomical dimension of the lip in young population in Korean, using specially designed soft ware with photographic image. We measure 13 anatomical dimensions of lips in 2,229 young people. (917 male, 1312 female, Aged from 18-33 years. Average age 19.7). Statistical analysis of these measurements of large population could offer useful information in facial plastic surgery. The mean measurements are as follows 1. Lengths (male/female) Widths of philtrum: $1.11{\pm}0.19cm/1.02{\pm}0.21cm$ Heights of philtrum: $1.6{\pm}0.24cm/1.47{\pm}0.21cm$ Heights of cupid bow: $0.88{\pm}0.16cm/0.83{\pm}0.16cm$ Height of upper vermilion: $0.74{\pm}0.16cm/0.70{\pm}0.15cm$ Height of lower vermilion: $1.08{\pm}0.17cm/1.02{\pm}0.15cm$ Height of upper lip(Rt.): $1.24{\pm}0.2cm/1.23{\pm}0.2cm$ Height of upper lip(Lt.): $1.24{\pm}0.2cm/1.17{\pm}0.19cm$ Half horizontal length of lip: $2.2{\pm}0.26cm/2.11{\pm}0.2cm$ Horizontal length of lip: $4.41{\pm}0.4cm/4.25{\pm}0.36cm$ Height of lower face: $7.1{\pm}0.58cm/6.52{\pm}0.6cm$ 2. Angles Nasolabial angle: $97.77{\pm}11.97^{\circ}/95.5{\pm}11.34^{\circ}$ Mentolabial angle: $133.88{\pm}14.65^{\circ}/129.27{\pm}13.67^{\circ}$ Angle of Cupid's bow: $111.65{\pm}13.99^{\circ}/116.75{\pm}16.2^{\circ}$ Previous reported photogrammetric measurements was difficult to implement to surgical practice. Because these were printed photographies of the same size. Therefore, in this study, we can measure a lot of objects and items more conveniently and correctly by using proportional program on computer after taking a digital photograph. Consequently, proportional measurements with photogrammetry of lip could be useful and corrective substitute for anthropometrical measuring. These data could be useful reference for preoperative consultation, surgical planning and learning anatomical measurement of lips and adjacent structures.

• 감성과학
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• 제22권3호
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• pp.35-46
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• 2019

인공지능기술은 사용자의 언어, 목소리 톤, 표정을 인지하고 학습하여 다양한 맥락에서 사용자의 감정에 대응할 수 있도록 발전하고 있다. 여러 인공지능 기반 서비스 중에서 특히 사용자와의 커뮤니케이션이 중요한 서비스 다수는 감정을 표현하는 인터랙션을 제공한다. 그러나 인공지능 시스템의 감정을 표현하는 수단으로서의 비언어적 인터랙션에 관한 연구는 아직 미비하다. 이에 조명효과 중 특히 색상과 깜빡임 운동을 중심으로 인공지능 디바이스의 감성 인터랙션을 연구하였다. 본 연구에서 구현한 인공지능 디바이스 프로토타입은 red, yellow, green, blue, purple, white 6가지의 조명 색상과 느림, 중간, 빠른 세 단계 속도의 깜빡임 효과로 감정을 표현한다. 프로토타입을 활용하여 20대부터 30대 남녀 50명을 대상으로 인공지능 디바이스의 색상별, 속도별 조명 효과가 표현하고 있는 감정에 응답하는 실험을 진행하였다. 실험 결과 각 조명 색상은 기존 색채감성연구에서 드러난 감성적 이미지와 대체로 유사한 감정을 나타내는 것으로 평가되었다. 조명의 깜빡임 속도는 감정의 각성과 밸런스의 변화에 영향을 주었으며, 이때 각성의 변화 양상은 모든 색상에서 유사한 기조를 보였다. 밸런스 변화 양상은 기존 색채감성연구의 감성적 이미지와 어느 정도 관련이 있지만 색상 별 차이가 있는 것으로 관찰되었다. 인공지능 시스템을 탑재한 사물의 종류와 인공지능 디바이스가 점점 다양해지는 현 시점에서, 본 연구결과는 조명을 통한 인공지능의 감성 인터랙션을 설계할 때 기여할 수 있을 것으로 기대된다.

• 한국멀티미디어학회논문지
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• 제11권11호
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• pp.1501-1514
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• 2008

깊이 값에 따른 얼굴의 형상은 사람의 특징을 나타내는 중요한 요소 중의 하나로서 각 사람마다 다른 모양을 가지고 있다. 다른 형상을 가진 얼굴 영상으로부터 분리한 주파수 성분은 동일 얼굴에 대한 또 다른 중요 특징 성분의 하나가 될 수 있다. 본 논문은 3차원 얼굴 영상에서 등고선 값을 따라 추출된 영역에 대하여 각 영역별로 주파수 분리를 이용하여 특징을 추출한다. 그리고 이 주파수에 대한 수정된 퍼지 군집화를 적용한 얼굴 인식 알고리즘을 제안한다. 먼저 객체와 배경을 분리하여 얼굴을 추출한 후 얼굴에서 가장 두드러진 형태인 코끝을 찾는다. 이를 이용하여 회전된 얼굴에 대해 정규화를 실시한다. 얼굴의 등고선 영역은 코끝을 기준으로 깊이 값에 따라 영역이 추출되며 이는 사람마다 서로 다른 형상 특징을 가진다. 등고선에 따라 획득된 3차원 얼굴 영상으로부터 이산 웨이블릿 변환을 이용하여 4가지의 주파수 성분을 추출하여 특징정보로 사용한다. 각각의 웨이블릿 주파수 성분을 추출한 등고선 영역에 대해 차원의 감소를 위하여 고유얼굴 추출과 특징 공간상에서 클래스간의 분리를 최대화시키기 위해 선형 판별 분석 알고리즘을 이용하여 유사도를 비교하였다. 본 논문에서는 클래스간의 분별 정보를 향상시키고자 각각의 등고선 영역과 각 영역의 주파수별로 수정된 퍼지 군집화 알고리즘을 적용하여 인식률을 향상 시켰으며, 코끝으로부터 깊이 값이 60인 영역의 경우 98.3%의 인식률을 나타내었다.

• Journal of Korean Neurosurgical Society
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• 제40권5호
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• pp.336-341
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• 2006

Objective : The authors conducted a retrospective study to evaluate the preservation rates of serviceable hearing and to determine its prognostic factors after gamma knife stereotactic radiosurgery[GK SRS] in the patient with vestibular schwannomas. Methods : Between December 1997 and March 2005, 54 patients with a sporadic vestibular schwannoma and serviceable hearing [Gardner Robertson grade I-II] were enrolled in this study. Electronic database of medical records and radiological examinations before and after GK SRS were investigated to the last follow up. The mean marginal dose was $12.3{\pm}0.7Gy$. The mean maximum dose delivered to the tumor center was 24.7Gy [$22{\sim}30Gy$]. The median tumor volume was 2cc [$0.1{\sim}9.1cc$]. The median follow-up period of magnetic resonance[MR] imaging was 31 months [$6{\sim}99\;months$], and the mean follow-up period of audiometry was 24 months [$4{\sim}70\;months$]. Results : The tumor control rate was 100% in the patients with the follow up period more than 2 years. The trigeminal and facial nerve preservation rates were 98% and 100%, respectively. Twenty-eight [52%] of the 54 patients preserved serviceable hearing and 16 [30%] patients retained their pre-GK G-R grade level after GK SRS. In the univariate and multivariate analysis, there was no significant prognostic factor in preservation of the serviceable hearing. Conclusion : The hearing preservation rate is still unsatisfactory compared with the results of other cranial nerve preservation and tumor control in the treatment of vestibular schwannoma by GK SRS. More sophisticated strategy during and after GK SRS is necessary to improve long-term hearing preservation.