• Title/Summary/Keyword: FSG

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Antioxidative, Antimicrobial and Anticytotoxic Activities of Seungmagalgeuntang and Fermented Seungmagalgeuntang (승마갈근탕과 발효 승마갈근탕에 의한 항산화, 항미생물 및 항세포독성 효과)

  • In, Jae Pyung;Shin, Jung Mi;Hur, Sun Jin;Lee, Si Kyung
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.43 no.7
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    • pp.980-988
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    • 2014
  • Seungmagalgeuntang (SG) is broadly used in traditional Oriental medicine especially in Korea, China, and Japan, for its many pharmacological effects. This study was carried out to investigate the antioxidative, antimicrobial, and anticytotoxic activities of SG and fermented seungmagalgeuntang (FSG). DPPH radical scavenging activities of SG and FSG were 70% and 74%, respectively, which increased slightly by fermentation. Nitrite scavenging activities were strongly altered at pH 1.2, (36.4% in SG and 38.3% in FSG) by addition of $200{\mu}g/g$. Superoxide dismutase-like activities were from 21.5% to 23.3% at a concentration of 0.4 mg/mL, and the highest value were observed in FSG. Total flavonoid contents of SG and FSG were 47.1 and $52.1{\mu}g/L$, respectively which shows an increase upon fermentation. In the antimicrobial activity test, $MIC_{50}$ values of SG and FSG were $800{\mu}g/mL$ for Candida albicans and 3,200 and $1,600{\mu}g/mL$ for Staphylococcus epidermidis and Staphylococcus aureus, respectively. Antibacterial effects were higher in FSG compared to SG. Anticytotoxic cadmium toxicities ranged from 63.5% to 76.1% at $10{\mu}g/mL$ of SG and FSG, and the highest value was observed in FSG. In the sensory evaluation, color, flavor, and overall preference values were higher in FSG.

Fluorine Penetration Characteristics on Various FSG Capping Layers (FSG Capping 레이어들에서의 플루오르 침투 특성)

  • Lee, Do-Won;Kim, Nam-Hoon;Kim, Sang-Yong;Eom, Joon-Chul;Chang, Eui-Goo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2004.04b
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    • pp.26-29
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    • 2004
  • High density plasma fluorinated silicate glass (HDP FSG) is used as a gap fill film for metal-to-metal space because of many advantages. However, FSG films can cause critical problems such as bonding issue of top metal at package, metal contamination, metal peel-off, and so on. It is known that these problems are caused by fluorine penetration out of FSG film. To prevent it, FSG capping layers such like SRO (Silicon Rich Oxide) are needed. In this study, their characteristics and a capability to block fluorine penetration for various FSG capping layers are investigated. Normal stress and High stress due to denser film. While heat treatment to PETEOS caused lower blocking against fluorine penetration, it had insignificant effect on SiN. Compared with other layers, SRO using ARC chamber and SiN were shown a better performance to block fluorine penetration.

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Study on Fluorine Penetration of Capping Layers using FTIR analysis (FTIR을 이용한 캐핑레이어의 플루오르 침투 특성 연구)

  • Lee, Do-Won;Kim, Nam-Hoon;Kim, Sang-Yong;Kim, Tae-Hyoung;Chang, Eui-Goo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2004.07a
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    • pp.300-303
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    • 2004
  • To fill the gap of films for metal-to-metal space High density plasma fluorinated silicate glass (HDP FSG) is used due to various advantages. However, FSG films can have critical drawbacks such as bonding issue of top metal at package, metal contamination, metal peel-off, and so on. These problems are generally caused by fluorine penetration out of FSG film. Hence, FSG capping layers such like SRO(Silicon Rich Oxide) are required to prevent flourine penetration. In this study, their characteristics and a capability to block fluorine penetration for various FSG capping layers are investigated through FTIR analysis. FTIR graphs of both SRO using ARC chamber and SiN show that clear Si-H bonds at $2175{\sim}2300cm^{-1}$. Thus, Si-H bond at $2175{\sim}2300cm^{-1}$ of FSG capping layers lays a key role to block fluorine penetration as well as dangling bond.

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The Quality Characteristics of Cookies Prepared with Different Forms of Shredded Garlics (다진 마늘의 첨가 형태에 따른 쿠키의 품질 특성)

  • Choi, Duck-Joo;Shin, Jung-Hye;Lee, Soo-Jung;Lee, Hyun-Ji;Kwon, O-Chen
    • The Korean Journal of Food And Nutrition
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    • v.20 no.3
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    • pp.282-288
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    • 2007
  • The quality characteristics of cookies between fresh shredded garlic(FSG) and heat-treated($150^{\circ}C$, 5 min) shredded garlic (HT-SG) were comparatively analyzed based on different content additions. The levels investigated were 0, 0.5, 1, 2, 4 and 6% for both shredded garlics. Dough pH was lower in the FSG-added cookies than in the HT-SG-added cookies. The spread factor decreased with the addition of shredded garlic compared to the control($10.63{\pm}0.57$), but differences were insignificant within each group. Cookies hardness was highest at 2% garlic content, and it was higher for HT-SG than FSG. Compared to the measured L-value of the control, the L-values of the test samples decreased with increasing garlic contents. With increasing garlic contents, the a-value increased, but the b-value remained mostly unchanged, with less significant difference compared to the control. The color of the HT-SG group tended to be brown as the garlic content increased. The degree of browning was more pronounced for HT-SG than FSG. Surface cracking of the cookies tended to be higher in the FSG samples than in HT-SG. Compared to the control, garlic taste and flavor increased remarkably with increasing garlic content, and they were stronger for the FSG cookies. The overall acceptability of HT-SG was relatively high, and it was highest for the HT-SG cookies with a 0.5~2% garlic contents than for the control cookies.

Design of New Channel Adaptive Equalizer for Digital TV (디지털 TV에 적합한 새로운 구조의 채널 적응 등화기 설계)

  • Baek, Deok-Soo;Lee, Wan-Bum;Kim, Hyeoung-Kyun
    • Journal of the Institute of Electronics Engineers of Korea TE
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    • v.39 no.2
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    • pp.17-28
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    • 2002
  • Recently, the study on non-linear equalization, self-recovering equalization using the neural Network structure or Fuzzy logic, is lively in progress. In this thesis, if the value of error difference is large, coefficient adaptation rate is bigger, and if being small, it is smaller. We proposed the new FSG(Fuzzy Stochastic Gradient)/CMA algorithm combining TS(Tagaki-Sugeno) fuzzy model having fast convergence rate and low mean square error(MSE) and CMA(Constant Modulus Algorithm) which is prone to ISI and insensitive to phase alteration. As a simulation result of the designed channel adaptive equalizer using the proposed FSG/CMA algorithm, it is shown that SNR is improved about 3.5dB comparing to the conventional algorithm. 

Pathology and Classification of Focal Segmental Glomerulosclerosis (초점성 분절성 사구체 경화증의 병리와 분류)

  • Kim, Yong-Jin
    • Childhood Kidney Diseases
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    • v.16 no.1
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    • pp.21-31
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    • 2012
  • Focal segmental glomerulosclerosis (FSGS) is the name of the primary glomerular disease as well as the terminology to describe the secondary phenomena of any other glomerular diseases. It is characterized by sclerosis, hyalinosis, foam cell infiltration, vacuolar change of podocytes, and halo formation in the glomerulus. Throughout the interstitium, lymphocytes infiltration, tubular atrophy and vascular changes are accompanied. Occasionally, IgM and/or C3 depositions are noted in the sclerotic areas. Electron microscopically, diffuse effacement of foot processes are seen in non-sclerotic area like minimal change disease. Podocyte injury patterns including vacuolar changes are frequently examined. Recently, Columbia group has suggested morphologic classification of FSGS and they demonstrated very good prognosis of tip lesion and poor prognosis of both collapsing and cellular types. However, the pathogenetic classification has been suggested by others; hyperfilteration, podocyte injury, genetic lesions etc. Further studies are necessary to understand and treat this disease.

Transcriptome Profiling of Kidney Tissue from FGS/kist Mice, the Korean Animal Model of Focal Segmental Glomerulosclerosis (국소성 분절성 사구체 신병증의 동물 모델 (FGS/kist 생쥐) 신 조직의 유전자 발현 양상)

  • Kang, Hee-Gyung;Lee, Byong-Sop;Lee, Chul-Ho;Ha, Il-Soo;Cheong, Hae-Il;Choi, Yong
    • Childhood Kidney Diseases
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    • v.15 no.1
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    • pp.38-48
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    • 2011
  • Purpose: Focal segmental glomerulosclerosis (FSGS) is the most common glomerulopathy causing pediatric renal failure. Since specific treatment targeting the etiology and pathophysiology of primary FSGS is yet elusive, the authors explored the pathophysiology of FSGS by transcriptome analysis of the disease using an animal model. Methods: FGS/kist strain, a mouse model of primary FSGS, and RFM/kist strain, as control and the parent strain of FGS/kist, were used. Kidney tissues were harvested and isolated renal cortex was used to extract mRNA, which was run on AB 1700 mouse microarray chip after reverse transcription to get the transcriptome profile. Results: Sixty two genes were differentially expressed in FGS/kist kidney tissue compared to the control. Those genes were related to cell cycle/cell death, immune reaction, and lipid metabolism/vasculopathy, and the key molecules of their networks were TNF, IL-6/4, IFN${\gamma}$, TP53, and PPAR${\gamma}$. Conclusion: This study confirmed that renal cell death, immune system activation with subsequent fibrosis, and lipid metabolism-related early vasculopathy were involved in the pathophysiology of FSGS. In addition, the relevance of methodology used in this study, namely transcriptome profiling, and Korean animal model of FGS/kist was validated. Further study would reveal novel pathophysiology of FSGS for new therapeutic targets.

Podocytopathy and Morphologic Changes in Focal Segmental Glomerulosclerosis (초점분절사구체경화증에서 발세포병증과 형태 변화)

  • Jeong, Hyeon Joo
    • Childhood Kidney Diseases
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    • v.17 no.1
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    • pp.13-18
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    • 2013
  • Podocytopathy is glomerular lesions characterized by podocyte injury. It is observed in various glomerular diseases, but minimal change disease and focal segmental glomerulosclerosis (FSGS) are the prototypes. In this review, morphologic features of podocyte injury and subtypes of FSGS will be reviewed briefly. Effacement of podocyte foot processes is the most common feature of podocyte injury. As podocytic injury progresses, intracytoplasmic vacuoles, subpodocytic cyst, detachment of podocytes from the glomerular basement membrane and apoptosis develop. Glomerular capillary loops in epithelium-denuded area undergo capillary collapse. Synechia and hyalinosis may accompany this lesion. To manifest segmental sclerosis, podocyte loss above a threshold level may be required. Injured podocytes can injure neighboring intact podocytes, and thereby spread injury within the same lobule. FSGS can be categorized into five subtypes by morphologic characteristics; not otherwise specified (NOS), perihilar, cellular, tip, and collapsing types. Each subtype has been reported to show different clinical courses and associated conditions, but there are controversies on its significance. With recent progress in the discovery of genetic abnormalities causing FSGS and plasma permeability factors, we expect to unravel pathophysiology of FSGS and to understand histological sequences leading to FSGS in near future.

A comparative study of lower extremity muscle activity in adults in their 20s with flat foot that applied low-dye taping and foot intrinsic muscle strengthening exercise (Low-dye 테이핑과 발 내재근육 강화 운동을 적용한 편평발을 가진 20대 성인의 하지 근육활성도 비교 연구)

  • Yoo, Kyung-Tae
    • Journal of Industrial Convergence
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    • v.19 no.5
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    • pp.103-110
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    • 2021
  • The purpose of this study was to investigate effect of low-dye taping and foot intrinsic muscle strengthening exercise on the muscle activity of the tibialis anterior, calf muscles, and long calf muscles during one-foot standing in subjects with flat feet. The subjects were 16 adults in their 20s with flat feet, and they were divided into low-dye taping (LTG; n=8) and foot intrinsic muscle strengthening exercise (FSG; n=8) groups. Each group underwent the appropriate intervention twice a week for 6 weeks. The muscle activity of the tibialis anterior, long calf muscle, and medial calf muscle was measured. Repeated two-way ANOVA was performed to compare changes in muscle activity before and after the intervention. As a result of muscle activity measurement, LTG significantly decreased between before and after the experiment in all muscles (p<.05). In FSG, only the tibialis anterior significantly decreased between before and after the experiment (p<.05). Therefore, low-dye taping and foot intrinsic muscle strengthening exercises will be helpful for efficient the lower extremity muscle activity of flat foot.

Design of Equalizer using Fussy Stochastic Gradient Algorithm (퍼지 확률 기울기 알고리즘을 이용한 등화기 설계)

  • Park, Hyoung-Keun;Ra, Yoo-Chan
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.9 no.1
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    • pp.152-159
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    • 2005
  • For high-speed data communication in band-limited channels, main of the bit error are fading and ISI(Inter-Symbol Interference). The common way of dealing with ISI is using equalization in the receiver. In this thesis, channel adaptive equalizer which uses Fuzzy Stochastic Gradient(FSG) and Constant Modulus Algorithm(CMA) is nonlinear equalizer, or Blind equalizer, that works directly on the signals with no training sequences required. This equalizer employs Takagi-Sugeno's fuzzy model that uses the FSG algorithm, to automatically regulate the step size of the descent gradient vector, combining fast convergence rate and low mean square error(MSE), and the CMA which is a special case of Godard's algorithm, to having multiple dispersion constants($R_p$).