• The Journal of Korean Medicine
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• v.22 no.4
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• pp.37-44
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• 2001

Objectives : Cellular death by apoptosis is an active process, depending on gene transcription and protein synthesis. It was reported that nitric oxide can induce apoptosis in several cancer cell-lines. We have previously observed that proliferation of Ll210 cells was inhibited by the administration of Gleditsiae Spina water extract (GE). In this present study, the mechanism of inhibitory action on the proliferation of L l210 cells was examined. Methods : The cell proliferation was determined by MTT assay and DNA fragmentation was determined by a flow cytometry. Results : The administration of GE decreased proliferation of L1210 cells and enhanced DNA fragmentation in vivo system. DNA fragmentation of L1210 cells was enhanced by co-culture of peritoneal macrophages obtained from GE-administered mice in vitro and it was partly inhibited by L-NMMA, nitric oxide synthetase inhibitor. In addition, GE increased nitric oxide production from peritoneal macrophages of L1210-transplanted mice. Conclusions : These results suggest that the inhibitory action of GE on proliferation of transplanted-L1210 cells is partly caused by an induction of apoptosis via production of nitric oxide in macrophages.

• Mass Spectrometry Letters
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• v.6 no.3
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• pp.65-70
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• 2015

N-Alkyl/benzyl substituted isatin derivatives are intermediates and synthetic precursors for the preparation of biological active heterocycles. N-alkyl/benzyl isatins have showed various biological activities, such as cytotoxicity, antiviral, caspase inhibition, cannabinoid receptor 2 agonists for the treatment of neuropathic pain, etc. In this study, N-alkyl/benzyl isatin derivatives were synthesized from isatin and alkyl/benzyl halides in presence of K₂CO₃ in DMF and excellent to quantitative yields (~95%) were obtained. Isatins and benzyl-isatins were condensed with fluorescein hydrazide to form fluorescein hydrazone. All the compounds were subjected to their fragmentation behavior study using LC/MSⁿ. N-Alkyl substituted isatin derivatives fragmented at nitrogen-carbon (N-C) bond, hence gave daughter ion as [RN+H]⁺. Whereas, N-benzyl substituted isatin derivatives fragmented at carbon-carbon (C-C) bond of alkyl chain which linked with nitrogen molecules, therefore gave N-methyl fragments [RNCH₂]⁺. This study demonstrated that, isatin moiety present in a small/large molecule or in a matrix of reaction mixture with/without N-alkyl/benzyl substituents can be identified by mass spectroscopic fragmentation behavior study.

• Bulletin of the Korean Chemical Society
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• v.30 no.2
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• pp.459-463
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• 2009

Furoxanaldehydes possessing phenyl or alkenyl groups at the 3- or 4-position of the furoxan ring were designed for alkyne formation on a solid surface. Furoxans 2 and 3 were prepared from the corresponding alkenes 2a and 3a by the reaction with NaN$O_2$ in acetic acid. Furoxan 4, in which the furoxan ring is conjugated with a double bond, was prepared from bis(bromomethyl)benzene 4a in 5 steps using the Wittig reaction of aldehyde 1 as the key step. The electron beam-mediated fragmentation of furoxanaldehydes 1-4 in a mass spectrometer was exploited by focusing on alkyne formation on the solid surface. The fragmentation of furoxan 3 possessing diaryl groups afforded diarylacetylene at high efficiency, suggesting that the aryl group conjugated with the furoxan ring could facilitate alkyne formation with the evolution of NO.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2000.11a
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• pp.79-83
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• 2000

Interfacial and microfailure properties of carbon liber/bismaleimide (BMI) composites were evaluated using both tensile fragmentation and compressive Broutman tests with acoustic emission (AE). Since BMI is rather difficult matrix to apply for the conventional fragmentation test because of its too low elongation and too brittle and high modulus properties, dual matrix composite system was applied. After carbon fiber/BMI composite was prepared for rod shape by controlling differing curing stage, composites rod was embedded in toughened epoxy as outer matrix. The typical microfailure modes including fiber break, matrix cracking, and interlayer failure were observed during tensile testing, whereas the diagonal slippage in fiber ends was observed during compressive test. On the other hand, AE amplitudes of BMI matrix fracture were higher than carbon fiber tincture under tensile test because BMI matrix has very brittle and high modulus. The waveform of signals coming from BMI matrix fractures was consistent with AE amplitude result under tensile tests.

• Interaction and multiscale mechanics
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• v.6 no.2
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• pp.173-195
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• 2013

Meshfree methods are known to have the capability to overcome the strict regularization requirements and numerical instabilities that encumber the finite element method (FEM) in large deformation problems. They are also more naturally suited for problems involving material perforation and fragmentation. To take advantage of the high efficiency of FEM and high accuracy of meshfree methods, a coupled finite element (FE) and reproducing kernel (RK, one of the meshfree approximations) formulation is described in this paper. The coupling of FE and RK approximation is implemented in an evolutionary fashion, where the extent and location of the evolution is dependent on a triggering criteria provided by the material constitutive laws. To enhance computational efficiency, Gauss quadrature is applied to integrate both FE and RK domains so that no state variable transfer is required when mesh conversion is performed. To control the hourglassing that might occur with 1-point integrated hexahedral grids, viscous type hourglass control is implemented. Meanwhile, the FEM version of the K&C concrete (KCC) model was modified to make it applicable in both FE and RK formulations. Results using this code and the KCC model are shown for the modeling of concrete responses under quasi-static, blast and impact loadings. These analyses demonstrate that fragmentation phenomena of the sort commonly observed under blast and impact loadings of concrete structures was able to be realistically captured by the coupled formulation.

• Analytical Science and Technology
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• v.10 no.1
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• pp.9-17
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• 1997

Nitrophenols are a group of important priority pollutants classified by the US Environmental Protection Agency. Reverse-phase liquid chromatographic method combined with mass spectromethy employing atmospheric pressure chemical ionization(APCI) interface is utilized to determine a mixture of nitrophenols in water matrix without any pretreatment. The sensitivity and selectivity for the identification of different kind of nitrophenols is enhanced by the use of selected ion monitoring and cone voltage fragmentation. The fragmentation patterns of nitrophenols are compared with those obtained from the collision induced dissociation(CID) MS/MS technique.

• Journal of Korea Multimedia Society
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• v.24 no.11
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• pp.1526-1537
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• 2021

Due to the difference between the underwater communication environment and the terrestrial communication environment, the radio communication mainly used on the ground cannot be used in underwater. For this reason, in the underwater communication environment, various communication media such as acoustic waves, infrared rays, light and so on has been studied, but there exist several difficulties in operating them individually due to their physical limitations. The concept for overcoming these difficulties is the very underwater multi-media communication, a method to select a communication medium best suitable for the current underwater environment among underwater communication multimedia whenever there occurs underwater communication failure. In this paper, we present an underwater multi-media communication network based on star topology and a fragmentation and reassembly technique to solve the problems caused by the different MTU (Maximum Transmission Unit) sizes among different underwater communication media. We also present the estimations and analysis on processing times in each of fragmentation and reassembly and the total data amount for transmitting fragments in our proposed underwater multi-media communication network.

• Geomechanics and Engineering
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• v.33 no.6
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• pp.567-581
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• 2023

The prediction and achievement of a proper rock fragmentation size is the main challenge of blasting operations in surface mines. This is because an optimum size distribution can optimize the overall mine/plant economics. To this end, this study attempts to develop four improved artificial intelligence models to predict rock fragmentation through cascaded forward neural network (CFNN) and radial basis function neural network (RBFNN) models. In this regards, the CFNN was trained by the Levenberg-Marquardt algorithm (LMA) and Conjugate gradient backpropagation (CGP). Further, the RBFNN was optimized by the Dragonfly Algorithm (DA) and teaching-learning-based optimization (TLBO). For developing the models, the database required was collected from the Midouk copper mine, Iran. After modeling, the statistical functions were computed to check the accuracy of the models, and the root mean square errors (RMSEs) of CFNN-LMA, CFNN-CGP, RBFNN-DA, and RBFNN-TLBO were obtained as 1.0656, 1.9698, 2.2235, and 1.6216, respectively. Accordingly, CFNN-LMA, with the lowest RMSE, was determined as the model with the best prediction results among the four examined in this study.

• Journal of KIISE
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• v.43 no.6
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• pp.627-635
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• 2016

When many processes issue write operations alternately on Log-structured File System (LFS), the created files can be fragmented on the file system layer although LFS sequentially allocates new blocks of each process. Unfortunately, this file fragmentation degrades read performance because it increases the number of block I/Os. Additionally, read-ahead operations which increase the number of data to request at a time exacerbates the performance degradation. In this paper, we suggest a new cleaning method on LFS that minimizes file fragmentation. During a cleaning process of LFS, our method sorts valid data blocks by inode numbers before copying the valid blocks to a new segment. This sorting re-locates fragmented blocks contiguously. Our cleaning method experimentally eliminates 60% of file fragmentation as compared to file fragmentation before cleaning. Consequently, our cleaning method improves sequential read throughput by 21% when read-ahead is applied.

• The Transactions of the Korea Information Processing Society
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• v.4 no.6
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• pp.1625-1635
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• 1997

An extension of the weighted buddy system, called the extended-weighted buddy system, for dynamic memory allocation in an object-oriented computer is presented. The extended-weighted buddy system allows block sizes of $2^k,\;3*2^k,\;5*2^k,\;7*2^k$, whereas the original weighted buddy system allowed block sizes of $2^k\;and\;3*2^k$. This extension is achieved at only the cost of additional 3 bits per block for memory management unit. Simulation results are presented which compare our method with the weighted buddy system. These results indicate that, for uniform request distributions, our system has less internal memory fragmentation than the weighted buddy system(approximately 60%). And, for exponential request distributions, it has less internal memory fragmentation than the weighted buddy method (approximately 50%). The external fragmentation is greater for this system than the weighted buddy system. But, our system has less total memory fragmentation for exponential request distributions, and two systems take a similar total memory fragmentation for uniform request distributions, so we can substitutes the extended-weighted buddy system for weighted buddy system.