• Journal of the korean academy of Pediatric Dentistry
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• v.38 no.1
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• pp.95-100
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• 2011

Fibrodysplasia ossificans progressiva(FOP) is characterized by episodes of permanent heterotopic ossifications of soft tissues throughout the body. FOP is inherited in an autosomal dominant pattern, but most cases result from new mutations in the ACVR1 gene. Even minimal trauma can cause permanent ossifications of soft tissues and give rise to complications following routine dental care. Dental block anesthesia, severe stretching of the jaw and biopsies are all contraindicated in children with FOP. There is no effective treatment. Since the prevalence of FOP is very low and most patients with FOP are misdiagnosed during childhood, they undergo dangerous and unnecessary treatment that can lead to permanent harm. For patients with FOP, early diagnosis and prevention of complications are most important. This study aims at contemplating the characteristic features and consideration factors for the dental treatment of FOP patients in relation to the case of an eight years-and-one month old boy who was referred to Pediatric Dentistry due to prolonged retention of mandibular right and left deciduous central incisors after being diagnosed with sporadic FOP at Pediatric Orthopaedics, Seoul National University Hospital, and received dental treatment without the exacerbation of the FOP symptoms.

• The Korean Journal of Food And Nutrition
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• v.28 no.4
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• pp.620-627
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• 2015

The present study was carried out to investigate the biological activity of ethanol extracts from fermented Opuntia humifusa with 3 different mushroom mycelia: Phellinus linteus, Lentinula edodes, and Pleurotus ostreatus. Fermented Opuntia humifusa by Phellinus linteus (FOP) and Lentinula edodes (FOL) showed more DPPH and ABTS radical scavenging activities than non-fermented Opuntia humifusa (NFO) and fermented Opuntia humifusa by Pleurotus ostreatus (FOPO). At a concentration of 250 ppm, the ABTS radical scavenging activities of the FOP and FOL were similar to that of BHA, a synthetic antioxidant. The total polyphenol content had a similar tendency to that of the radical scavenging activity. However, the flavonoid content was increased in the order of NFO, FOL, FOPO, and FOP. At all concentrations, the tyrosinase inhibitory activity of FOP and FOPO were significantly higher than that of kojic acid. During adipocyte differentiation, NFO and FOL showed no significant difference in lipid accumulation in 3T3-L1 cells. FOP and FOPO showed a higher fat accumulation inhibitory effect than NFO and FOL. These results provide baseline data for Opuntia humifusa as a novel functional food.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.25 no.6
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• pp.100-107
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• 2011

Since transmission and distribution neutral wires are connected with a substation grounding grid, it is very difficult to measure grounding resistance of isolated substation grounding grid after the substation is energized. It is impractical to isolate the grounding grid from other parallel connections such as distribution line neutrals and overhead ground wires for grounding resistance measurement only. In this paper, we proposed and demonstrated a novel measurement method of grounding resistance of isolated substation grounding grid. For this method, grounding current division factor and conventional FOP(Fall-Of-Potential) profiles were measured at power supplying 154[kV] substation. The obtained FOP profile was processed with the measured grounding current division factor to produce the grounding resistance of isolated grounding grid. Simulated FOP profile agreed well with the measured one showing the validity of the proposed method.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.55 no.5
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• pp.195-201
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• 2006

Tower footing resistance and fault current division factor are important design factors for evaluation of the lightning performance of the transmission line and/or design of the grounding electrode system. The periodic measurement of those factors are also important to verify that the grounding performance of the towers has been maintained good. However, the direct measurement of those factors in operating or energized condition is very difficult because of many practical reasons, such as the difficulty of disconnecting overhead groundwires from the tower under test. With supports by GECOL (General Electricitiy Company of Libya), we had a special chance to conduct Fall-Of-Potential (FOP) test on the energized 220 kV transmission towers before and after disconnecting the overhead groundwires from the towers under test. In this paper, the FOP test results on the towers and the fault current division factors estimated from the comparision of the FOP tests with and without overhead groundwires were presented. The computer models for the FOP test simulations were also constructed to find that the simulated results agreed very well with the measured ones.

• Nuclear Engineering and Technology
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• v.33 no.5
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• pp.514-525
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• 2001

Optimum characteristics of digital X-ray sensor components were analyzed to develop intra- oral dental digital X-ray image sensor using indirect method. Parametric analysis was carried out to optimize the phosphor thickness and the fiber optic plate (FOP) coupling to charge coupled device (CCD). X-ray absorption and light diffusion in the phosphor layer were analyzed by the Monte Carlo method. Real time X-ray image was obtained with prototype X- ray image sensor using general CCD camera with 1∼10 Ip/mm resolution. It has been previously shown that large resolution degradation in X-ray images was caused by miss alignment of FOP to CCD and optical adhesive selection. In this study, we reported that X-ray image quality was greatly improved by using optimized characteristics of alignment device and phosphor thickness.

• The korean journal of orthodontics
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• v.28 no.2 s.67
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• pp.255-268
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• 1998

This study was investigated to assess the difference of facial height and occlusal plane inclination between normal occlusion group and class II malocclusion group. The subjects consisted of 50 normal occlusion (male 25, female 25) and 50 class II(male 25, female 25) malocclusion patients. All subjects are adult. lateral cephalogram was taken with standard method traced, and digitized for each subjects. The computerized statiscal analysis was carried out with SPSS program. The results were as follows 1. In class II malocclusion group, variables significant different from normal occlusion group were as follows ; SN-FOP, FH-BOP, MP-BOP, AB-BOP, AB-FOP, Facial plane-BOP, FP-FOP 2. In class II malocclusion group, the posterior facial height -especially posterior lower facial height-was significantly smaller than normal occlusion group.(P<0.05) 3. In class II malocclusion group, the angles between occlusal plane and upper and lower incisor, the angle between upper molar and bisected occlusal plane were significantly larger than those of normal occlusion group. (P<0.05) 4. L1 to Mandibular plane (mm) was a unique factor of occlusal plane position that showed significant difference in class II malocclusion group. 5. The correlation between overbite and occlusal plane inclination existed in class II malocclusion group, but the correlation didn't exist in normal occlusion group.

• Journal of Microbiology and Biotechnology
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• v.28 no.1
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• pp.157-164
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• 2018

Francisella tularensis (FT), a highly infectious pathogen, is considered to be a potential biological weapon owing to the current lack of a human vaccine against it. Tul4 and FopA, both outer membrane proteins of FT, play an important role in the bacterium's immunogenicity. In the present study, we evaluated the immune response of mice - humanized with human CD34+ cells (hu-mice) - to a cocktail of recombinant Tul4 and FopA (rTul4 and rFopA), which were codon-optimized and expressed in Escherichia coli. Not only did the cocktail-immunized hu-mice produce a significant human immunoglobulin response, they also exhibited prolonged survival against an attenuated live vaccine strain as well as human T cells in the spleen. These results suggest that the cocktail of rTul4 and rFopA had successfully induced an immune response in the hu-mice, demonstrating the potential of this mouse model for use in the evaluation of FT vaccine candidates.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.1494-1498
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• 2009

세계기상기구(WMO)에 의하여 홍수예경보시스템의 평가를 위하여 개발된 MOFFS Ver.3의 개선을 위하여 특정유역의 홍수방어체계의 취약성을 평가하고 홍수방어시스템의 완성도를 높이기위한 DSS-FOP를 개발하였다. DSS-FOP는 지점별, 홍수사상별로 예보시스템 운영결과를 간단한 평가양식에 나타내는 시스템이며, 홍수방어구조물(Flood control infra)과 홍수조절운영(Flood control operation)으로 분류한다. 홍수방어구조물은 수문관측, 홍수방어구조물, 홍수조절지휘소로, 홍수조절 운영은 자료처리 및 전송, 홍수예측모형, 예경보발령의 총 6가지 주요평가항목과 하부의 23가지 세부평가항목으로 구성하였다. 점수부여체계는 최대점수, 목표점수, 성과점수, 부족점수, 취약점수의 산정을 통하여 구조물인프라와 운영측면에서의 시스템취약부분을 평가 진단할 수 있도록 하였다. 개발된 DSS-FOP를 이용하여 국내의 한강유역과 UN/ESCAP 태풍위원회의 회원국인 태국의 Khlong U-Taphao 유역을 대상으로 적용하고 그 결과를 비교 평가하였다. 한강유역의 경우 하천정보센터 신설 및 조직강화로 인적자원측면에서 높은 성과점수를 보였으며, 향후 수문레이더 설치 등으로 관측분야에서의 개선이 기대된다. 태국의 Khlong U-Taphao 유역의 경우 목표수준을 다소 조정할 필요가 있으며, 비상행동계획의 마련이 시급하다. 더불어 홍수방어구조물에 대한 지속적인 투자가 필요한 상황이다. 이러한 DSS-FOP의 평가결과는 국가별, 유역별, 호우사상별로 관리되며, 태풍위원회 회원국의 적용 및 기술지침의 작성을 위해 많은 평가 및 조사가 축적되어야 한다.

• Journal of Microbiology and Biotechnology
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• v.26 no.9
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• pp.1613-1619
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• 2016

Francisella tularensis is a highly virulent pathogen of humans and other mammals. Moreover, F. tularensis has been designated a category A biothreat agent, and there is growing interest in the development of a protective vaccine. In the present study, we determine the in vitro and in vivo immune responses of a subunit vaccine composed of recombinant peptides Tul4 and FopA from epitopes of the F. tularensis outer membrane proteins. The recombinant peptides with adjuvant CpG induced robust immunophenotypic change of dendritic cell (DC) maturation and secretion of inflammatory cytokines (IL-6, IL-12). In addition, the matured DCs enabled ex vivo proliferation of naive splenocytes in a mixed lymphocyte reaction. Lastly, we determined the in vivo immune response by assessment of antibody production in C57BL/6 mice. Total IgG levels were produced after immunization and peaked in 6 weeks, and moreover, Tul4-specific IgG was confirmed in the mice receiving peptides with or without CpG. Based on these results, we concluded that the recombinant peptides Tul4 and FopA have immunogenicity and could be a safe subunit vaccine candidate approach against F. tularensis.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.2
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• pp.49-54
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• 2005

Measuring ground resistance is a typical way of performance evaluation of a grounding electrode. Among various ground resistance measurement methods, FOP (Fall-Of-Potential) method has been widely used, especially in case of a relatively large grounding electrode such as a substation grounding mesh grid Since FOP measurement line has to be increased as the size of grounding electrode increases, however, it is often that securing long enough FOP-line is practically impossible. In this paper, a sophisticated interpretation method of FOP measurement ma which is applicable to large grounding electrode networks, is presented.