• 천문학회보
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• 제39권2호
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• pp.70.1-70.1
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• 2014

We analyze a newly discovered galaxy-galaxy scale gravitational lens system, FLS 1718+59 in the Spitzer First Look Survey (FLS) field. A background galaxy (z = 0.245) is severely distorted by a foreground galaxy (z = 0.08), via gravitational lensing. We analyze this system by several methods, including surface brightness fitting (Galfit and Ellipse), gravitational lens modeling (gravlens), and spectral energy distribution fitting (Magphys). From Galfit and Ellipse we measure properties of the lens galaxy, such as the effective radius and the average surface brightness inside it, the ellipticity, and the position angle. gravlens gives us the total mass inside the Einstein radius ($R_{Ein}$), and Magphys provides us an estimate of the stellar mass inside $R_{Ein}$. By comparing these obtained parameters, we confirm that the lens galaxy is an elliptical galaxy on the Fundamental Plane, and calculate the stellar mass function inside $R_{Ein}$, and discuss the implications of the results regarding the initial mass function.

• 동의생리병리학회지
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• 제19권6호
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• pp.1647-1655
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• 2005

Gamimahaenggamsuk-tang (GMHGST) is used for treatment of inflammatory diseases including rheumatoid arthritis (RA). Here, regulatory activity of GMHGST on RA-mediated inflammatory responses was investigated in cultured human fiDroblast-like synoviocytes (FLS), Levels of mRNAs encoding for inflammatory cytokines such as $IL-1{\beta}$, IL-6 and IL-8 and NOS-II enzyme, which had been induced by $TNF-{\alpha}$ and $IL-1{\beta}$ cotreatment, were decreased to the similar levels as those in cells treated with anti-inflammatory agent MTX. mRNA expressions of matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinases (TIMPs) as well as intercellular adhesion molecule (ICAM) were also downregulated by increasing doses of GMHGST in activated FLS. Moreover, GMHGST appeared to protect cells by decreasing NO levels, and inhibited cell proliferation which had been induced by inflammatory stimulation by $TNF-{\alpha}$ and IL-1. These results suggest that GMHGST is effective as an inhibitory agent for regulating inflammatory responses in activated FLS.

• Biomolecules & Therapeutics
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• 제31권5호
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• pp.536-543
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• 2023

Phytoceramide (Pcer) is found mainly in plants and yeast. It can be neuroprotective and immunostimulatory on various cell types. In this study, the therapeutic effect of Pcer was explored using the carrageenan/kaolin (C/K)-induced arthritis rat model and fibroblast-like synoviocytes (FLS). Pcer treatment (1, 10, and 30 mg/kg/day) were given to the arthritic rats for 6 days after disease induction. Weight distribution ration (WDR), knee thickness, squeaking score, serum levels of proinflammatory mediators, and histological analysis were measured and performed to evaluate arthritic symptoms in the rat model. In interleukin (IL)-1β-stimulated FLS, proinflammatory mediators were measured after Pcer (1-30 µM) treatment. Arthritic symptoms in rats with Pcer treatment were significantly decreased at days 4 to 6 after C/K arthritis induction. Inflammation in the knee joints were also significantly decreased in rats with Pcer treatment. Furthermore, in IL-1β-stimulated FLS, the expressions of proinflammatory mediators were also inhibited by Pcer. As shown by the results, Pcer has anti-arthritic effects in the C/K rat model and in synovial cells, suggesting that Pcer has the potential to be a useful agent in arthritis treatment.

• IMMUNE NETWORK
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• 제3권1호
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• pp.1-7
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• 2003

Type II collagen (CII), major component of hyaline cartilage, has been considered as an auto-antigen in rheumatoid arthritis (RA). However, the clinical and biological significances with regard to the CII autoimmunity need to be clarified in human RA. The presence of antibodies to CII has been identified in sera, synovial fluid, and cartilage of patients with RA. In our study, the increased titer of IgG anti-CII in sera was well correlated with C-reactive protein, suggesting that this antibody may reflect the inflammatory status of RA. The titer of anti-CII antibodies (anti-CII Abs) tended to be higher in early stages of diseases. In our extending study, among 997 patients with RA, 269 (27.0%) were positive for circulatory IgG antibody to CII, those levels were fluctuated over time. It is hard to assess the significant amount of T cell responses to CII and CII (255~274) in RA. By using a sensitive method of antigen specific mixed lymphocyte culture, we can detect the presence of CII-reactive T cells in peripheral blood mononuclear cells of RA patients. Sixty seven (46.9%) of 143 patients showed positive CII reactive T cell responses to CII or CII (255~274). The frequencies of CII reactive T cells were more prominent in inflamed synovial fluid (SF) than in peripheral blood. These T cells could be clonally expanded after consecutive stimulation of CII with feeding of autologous irradiated antigen presenting cells (APC). Moreover, the production of Th1-related cytokine, such as IFN-${\gamma}$, was strongly up-regulated by CII reactive T cells. These data suggest that T cells responding to CII, which are probably presenting the IFN-${\gamma}$ producing cells, may play an important role in the perpetuation of inflammatory process in RA. To evaluate the effector function of CII reactive T cells, we investigated the effect of CII reactive T cells and fibroblasts-like synoviocytes (FLS) interaction on the production of pro-inflammatory cytokines. When the CII reactive T cells were co-cultured with FLS, the production of IL-15 and TNF-${\alpha}$ from FLS were significantly increased (2 to 3 fold increase) and this increase was clearly presented in accord to the expansion of CII reactive T cells. In addition, the production of IFN-${\gamma}$ and IL-17, T cell derived cytokines, were also increased by the co-incubation of CII reactive T cells with FLS. We also examined the impact of CII reactive T cells on chemokines production. When FLS were co-cultured with CII stimulated T cells, the production of IL-8, MCP-1, and MIP-1${\alpha}$ were significantly enhanced. The increased production of these chemokines was strongly correlated with increase the frequency of CII reactive T cells. Conclusively, immune response to CII was frequently found in RA. Activated T cells in response to CII contributed to increase the production of proinflammatory cytokines and chemokines, which were critical for inflammatory responses in RA. The interaction of CII-reactive T cells with FLS further augmented this phenomenon. Taken together, our recent studies have suggested that autoimmunity to CII could play a crucial role not only in the initiation but amplification/perpetuation of inflammatory process in human RA.

• 한국식품저장유통학회지
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• 제15권6호
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• pp.909-914
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• 2008

복어식해(GLS), 가자미식해(FLS), 우럭식해(GAS) 및 골뱅이식해(WHS)의 발효 및 저장 중 미생물수의 변화와 관능적 품질을 평가하였다. 발효는 $10^{\circ}C$에서 4일간 행하였으며 저장은 $4^{\circ}C$에서 20일간 행하였다. 발효 저장 중 일반세균은 4일 동안 $10^{\circ}C$에서 저온 숙성시킨 후, $4^{\circ}C$로 이동시켜서 변온저장 하면서 미생물의 변화를 조사하였다. 일반세균수 조사에서 20일째 복어식해와 참가자미식해는 $10^2$이었으며, 우럭식해는 $10^5$, 골뱅이식해는 $10^4$까지 증식하였다. 유산균수는복어식해와 참가자미식해는 숙성기간 10일째 $10^8$으로 증식하였으며, 우럭식해는 15일째, 골뱅이식해는 20일째 각각 $10^8$으로 증식하였다. 미생물 증식은 참가자미식해>복어식해>우럭식해>골뱅이식해 순이었다. 효모조사에서는 복어식해와 참가자미식해는 발효저장 20일째 $10^4{\sim}10^5\;PFU/g$ 까지 증가하였으며, 우럭식해과 골뱅이식해는 0일째는 $10^2$ 이었으나 20일째는 각각 $10^5{\sim}10^4\;PFU/g$까지 증가하였다. 효모에서도 참가자미식해>복어식해>우럭식해>골뱅이식해 순으로 조사되어 균증식이 참가자미식해와 복어식해에서 높았다. 젖산균 조사에서 숙성기간 동안 젖산균수는 0일째 $10^3$으로 증식하였으나, lactobacillus는 발효저장 중 20일째 복어식해, 참가자미식해, 우럭식해, 골뱅이식해가 동일하게 $10^8$으로 증식하였으며, leuconostoc은 복어식해와 참가자미식해는 숙성 10일째 $10^8$ log cycle이상으로 증식되었고, 우럭식해는 15일째 $10^8$, 골뱅이식해는 $10^7$ log cycle로 측정되었다. 조사한 pH 는 복어식해, 참가자미식해는 4.42와 pH 4.56, 우럭식해와 골뱅이식해는 4.31과 pH 4.26으로 측정되었다. 조사한 4종류의 해산물 식해 산도는 1.55-1.85% 로 측정되었다. 관능평가 실험에서 복어식해와 참가자미식해는 종합평가에서 4.17-4.25, 우럭식해와 골뱅이식해는 3.59-3.79로 평가되었으며, 선호도는 참가자미식해>복어식해>우럭식해>골뱅이식해 순이었다.

• 월간양계
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• 제52권11호
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• pp.183-187
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• 2020

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2003년도 추계 학술대회 학술발표 논문집
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• pp.76-79
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• 2003

퍼지 로직 시스템(FLS)은 다양한 분야에서 성공적으로 사용되고 있다 퍼지 로직 시스템의 멤버십 함수와 규칙은 언어적인 정보나 수치적 데이터를 사용하여 표현된다. 또한 이러한 정보나 데이터에는 불확실성과 노이즈 등이 존재한다. 그러나 단순한 퍼지 로직 시스템으로노이즈가 포함된 불확실한 정보를 효과적으로 다루고 표현하는 데는 한계가 있다. 그러므로 노이즈가 포함된 정보를 효율적으로 처리하기 위해 본 논문에서는 type-2 FLS를 이용한다. 노이즈가 포함되어 불확실한 정도를 정확한 값으로 표현하기 어려울 때, type-2 FLS은 보다 정확하게 정보들을 다를 수 있음을 보인다. 비선형 시계열 시스템인 Box-Jenkins 데이터를 이용하여 singleton Type-1 FLS과 non-singleton type-1 FLS의 결과 값을 확인하고 이의 성능을 type-2 FLS과 비교, 분석한다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1845-1846
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• 2008

Type-2 퍼지 집합은 언어의 불확실성을 다루기 위하여 고안된 Type-1 퍼지집합의 확장이다. TSK 퍼지 로직 시스템(TSK Fuzzy Logic Systems; TSK FLS)은 Mamdani FLS과 함께 가장 널리 사용되는 퍼지 로직 시스템 모델이다. 본 논문에서는 Type-2 퍼지 집합을 이용하여 전반부 멤버쉽 함수를 구성하고 후반부 다항식 함수를 상수와 1차식, 2차식으로 확장한 다항식 Type-2 TSK FLS 설계한다. 다항식 Type-2 TSK FLS의 파라미터를 동정하기 위해 Back-propagation 방법을 사용한다. 제안된 다항식 Type-2 TSK FLS을 노이즈 섞인 비선형 시스템의 모델링에 적용하여 그 성능을 비교 분석한다.

• 제어로봇시스템학회논문지
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• 제7권2호
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• pp.125-130
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• 2001

This paper presents an indirect field-oriented (IFO) induction motor position servo drives which uses the model following adaptive controller with the artificial neural network(ANN)-based rotor resistance estimator. The model reference adaptive system(MRAS)-based 2-layer ANN estimates the rotor resistance on-line and a linear model-following position controller is designed by using the estimated the rotor resistance value. At the end, a fuzzy logic system(FLS) is added to make the position controller robust to the external disturbances and the parameter variations. The simulation results show the effectiveness of the proposed method.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2000년도 춘계학술대회 학술발표 논문집
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• pp.220-223
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• 2000

타입-2 퍼지집합을 이용하여 퍼지논리시스템(Fuzzy Logic System : FLS)을 구현하기 위한 연구들이 R. I John, N. Karnik, J. Mendel 등에 의해 현재 진행되고 있다. 타입-2 집합을 이용한 타입-2 FLS은 기존의 타입-1 FLS보다 제어규칙이나 소속함순가 가지고 있는 불확실성을 표현하는데 있어서 더 효과적이다. 그러나, 타입-2 FLS 역시 타입-1 FLS이 가지고 있는 문제점인 설계시 전문가에게 의존하여 시간과 비용이 많이 소요되고, 제어기의 구성요소들을 효율적으로 생성하기가 어렵다는 문제점을 더욱 심각하게 가지고 있다. 또한, 그 문제점을 해결하기 위한 연구들도 아직 미진한 상태이다. 본 논문에서는 타입-2 FLS의 설계를 위해 유전자 알고리즘을 사용하는 방법을 제안한다. 타입-2 FLS를 설계하기 위해서는 소속함수와 제어규칙을 생성하여야 한다. 본 논문에서는 유전자 알고리즘을 사용하여 타입-2 퍼지제어규칙과 소속함수를 설계하는 방법을 제안한다. 먼저, 유전자 알고리즘에서 사용할 수 있는 유전자의 형태로 타입-2 퍼지제어규칙과 소속함수를 표현하기 위한 인코딩방법을 제안하고, 각각의 염색체를 진화시키기 위한 교차 연산자와 돌연변이 연산자를 정의한다. 그리고, 제안된 방법을 함수근사문제에 적용하여 유효성과 성능을 평가, 검증한다.