• Korean Journal of Food Science and Technology
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• v.43 no.3
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• pp.375-380
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• 2011

This study was performed to investigate cholesterol improvement effects of adding fermented defatted soybean grit (FD) and FD added to 5 or 10% Corchorus olitorius (FDC). Cholesterol adsorption in the FD and FDC group was more than 70%. Apolipoprotein AI and CIII improved in HepG2 cells, and a greater improvement effect was shown in FDC than that in FD. We also investigated the effect of FDC on body lipid metabolism and a high-fat diet for 4 weeks. Rats were divided into control (Con), high-fat (HF), HF treated with 20% FD (HF-FD), and HF treated with 20% FDC (HF-FDC) groups. Plasma total cholesterol and low density lipoprotein-cholesterol concentrations, hepatic total cholesterol, and triglyceride contents were significantly lower in the HF-FDC group than those in the HF group. Additionally, fecal total cholesterol and triglyceride contents increased in rats treated with FDC. Hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activities were significantly lower in the HF-FDC group than those in the HF group.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.4A
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• pp.337-342
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• 2010

Generally most sluice gates are closed and opened by a mechanical winch, a winch using an oil-pressure, or a winch mixing both. Because of their size and structure, they should be safely operated with more than two pulling devices helping each other. At the moment of their opening and closing, there usually occur some additional loads to the structure which cannot be exactly measurable at the stage of designing. Such additional loads can cause the sluice gate to be unbalanced and make it hard to open and close the gate, and by also overloading a winch, they can inflict a significant damage to the safety of the sluice gate. This paper explains a FDC(Force-Displacement Control) system which simultaneously considered the oil-pressure and displacement in order to evenly distribute the force and make a winch balanced at the opening and closing motion. This FDC system was implemented by means of the PID(Proportional Integral Derivative) function of XG 5000 program. It was experimented on a model of the sluice gate winch with the hydraulic oil pressure cylinder. The experiments showed that the developed FDC system made the winch of hydraulic oil pressure cylinder open and close cooperatively in spite of various external loads. Therefore the FDC system is proven effective when it is applied to a winch of sluice gate.

• Journal of Korean Society on Water Environment
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• v.35 no.6
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• pp.481-496
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• 2019

The Ministry of Environment has measured streamflow at eight-day intervals for the estimation of standard flow of the Total Maximum Daily Loads (TMDL) system. This study identified the availability of the partially measured the eight-day interval data for estimating standard flow and found the optimal extension techniques of standard flow. The study area was selected for the Nakbon-A watershed in the Nakdong River, and four streamflow record extension techniques of standard flow were considered: extension, percentile, drainagearea, and regional regression methods. The flow duration curve (FDC) using the eight-day interval streamflow data indicated very high Nash and Sutcliffe Efficiency (NSE) values above 90 % from FDC-II to FDC-VII compared to FDC-VIII, the standard FDC. This result demonstrates that FDC using daily data of three-six cumulative years could represent standard FDC fairly well. For the streamflow record extension techniques of standard flow, the percentile method was selected as the optimal alternative, showing the minimal difference from FDC-VIII. These results validate the availability of the eight-day interval streamflow data in the standard flow estimation and the application of extension techniques. It seems that these results could reduce the uncertainty of partially measured streamflow data for water quantity and quality management.

• Journal of Korean Society on Water Environment
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• v.29 no.3
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• pp.343-353
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• 2013

Flow duration curve (FDC) can be developed by linking the daily flow data of stream flow monitoring network to 8-day interval flow data of the unit watersheds for the management of Total Maximum Daily Loads. This study investigated the applicable method for the development of long term FDC with the selection of the stream flow reference sites, and suggested the development of the FDC in 4 river basins. Out of 142 unit watersheds in 4 river basins, 107 unit watersheds were shown to estimate daily flow data for the unit watersheds from 2006 to 2010. Short term FDC could be developed in 64 unit watersheds (45%) and long term FDC in 43 unit watersheds (30%), while other 35 unit watersheds (25%) were revealed to have difficulties in the development of FDC itself. Limits in the development of the long term FDC includes no stream monitoring sites in certain unit watersheds, short duration of stream flow data set and missing data by abnormal water level measurements on the stream flow monitoring sites. To improve these limits, it is necessary to install new monitoring sites in the required areas, to keep up continuous monitoring and make normal water level observations on the stream flow monitoring sites, and to build up a special management system to enhance data reliability. The development of long term FDC for the unit watersheds can be established appropriately with the normal and durable measurement on the selected reference sites in the stream flow monitoring network.

• Journal of Korean Society on Water Environment
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• v.28 no.2
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• pp.224-231
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• 2012

It is necessary to develop flow duration curve (FDC) on each unit watershed in order to analyze flow conditions in the stream for the management of Total Maximum Daily Loads (TMDLs). This study investigated a simple method to develop FDC for the general use of the curve. A simple equation for daily flow estimation was derived from the regression analysis between the 8-day interval flow data of a unit watershed and the daily flow monitoring data of an adjacent upstream region. FDC can be prepared with the calculation of daily flow by the equation for each unit watershed. An annual and a full-period FDC were drawn for each unit watershed in Guem river basin. Standard flow such as low and ordinary flow can be obtained from the annual FDC. Major percentile of flow such as 10, 25, 50, 75 or 90% can be obtained from the full-period FDC. It is considered that this simple method of developing FDC can be utilized more widely for the calculation of standard flow and the assessment of water quality in the process of TMDLs.

• Journal of Wetlands Research
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• v.20 no.2
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• pp.136-144
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• 2018

The Ministry of the Environment conducts a water environment management plan and TMDL(Total Maximum Daily Load) for integrated watershed management, and determines whether the target water quality is achieved using water quality monitoring data. The concentration of monitoring points located in the downstream of the watershed is the outcome of complicated mechanisms such as influx of pollutants from the tributaries of the watershed and self-purification of river water. The purpose of this study is to analyze the effect of main stream and tributary water quality on the target water quality point using the water pollution source tracking and exceedance rate of watershed. In this study, FDC and exceedance rate analysis were performed on six water quality items including BOD and T-P, which are the targets of TMDL. Water quality items and points affecting the target water quality point were derived from flow rate. In this study, the pollution source tracking through FDC analysis and exceedance rate analysis will be able to establish more efficiently the water quality management strategy for each branch to achieve the target water quality.

• Korean Journal of Clinical Pharmacy
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• v.32 no.1
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• pp.13-19
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• 2022

Background: The use of combination therapy and fixed-dose combination therapy is increasing for the treatment of type 2 diabetes. Sodium glucose cotransporter-2 inhibitor (SGLT2i) is a drug class used in combination with metformin. Methods: Type 2 diabetes patients on SGLT2i/metformin combination therapy were extracted from the 2019 Health Insurance Review & Assessment Service-National Patients Sample. On July 1, 2019, SGLT2i and metformin fixed-dose combination (SGLT2i/metformin FDC) and two-pill combination (TPC) groups were identified, and a chi-square test and multiple logistic regression were performed. Results: Of total 2,992 patients, 1,077 (36%) were prescribed SGLT2i/metformin FDC and 1,915 (64%) were prescribed TPC. We found that the most common comorbidities were in the order of dyslipidemia, gastrointestinal disease, and hypertension. Multiple logistic regression analysis showed that the use of SGLT2i/metformin FDC was lower than TPC in patients with diabetic neuropathy (OR=0.76, p=0.008). Clinic (OR=2.09, p<0.001) and general hospital (OR=1.40, p=0.019) showed higher tendency to prescribe SGLT2i/metformin FDC compared to tertiary hospital. The tendency of prescribing SGLT2i/metformin FDC was lower in Kyeonggi (OR=0.79, p=0.037), Gyeongsang (OR=0.77, p=0.025) and Chungcheong (OR=0.68, p=0.007) than Seoul. Conclusion: Factors related to the use of SGLT2i/metformin FDC in patients with type 2 diabetes were complication, medical institution and region. The tendency to prescribe SGLT2i/metformin FDC was relatively higher in clinics than in tertiary general hospitals and in Seoul than in other regions.

• IMMUNE NETWORK
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• v.3 no.3
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• pp.176-181
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• 2003

Background: The molecular basis of follicular dendritic cells (FDC)-germinal center (GC) B cell interaction is largely unknown, although this cellular interaction is thought to be important for the whole process of GC B cell differentiation. Methods: Using FDC-like cells, HK, and highly purified GC B cells, we attempted to identify the molecules that play critical roles in the interactions between FDC and B cells. GC B cells were co-cultured with HK cells and soluble CD154 in the presence or absence of various function-blocking monoclonal antibodies to examine their effect on GC B cell binding to HK cells and B cell proliferation. Results: Anti-CD11a and anti-CD54 antibodies inhibited GC B cell binding to HK cells while anti-CD49d and anti-CD106 antibodies did not. GC B cell proliferation was not impaired by the disruption of GC B cell-HK cell adherence. Conclusion: Our results suggest that CD11a/CD18-CD54 interactions play an important roles in the initial binding of GC B cells to FDC and diffusible growth factors from FDC may be responsible the massive proliferation of GC B cells.

• Journal of Korean Society on Water Environment
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• v.35 no.6
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• pp.497-509
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• 2019

After the Total Maximum Daily Loads(TMDLs) was applied, it became beyond the limit of concentration management. However, it does not adequately reflect the characteristics of various watersheds, and causes problems with local governments because of the standard flow set. Thus, in this study, the Han River system is organized into four groups in estimating the Pollution Contribution by applying the Flow Duration Curve(FDC) created by the daily flow of data from the HSPF. And the method of this study is expected to be valuable as basic data for the TMDLs. As a result, Group I contains the main watersheds with no large hydraulic structures and tributary watersheds. There is no specificity in the FDC and the Pollution Contribution is estimated as rainfall runoff. Group II contains watersheds near the city where the FDC is maintained above a certain level during the Low Flow Conditions and the Pollution Contribution is estimated as the discharge flow of large scale point pollution facilities. Group III contains the main watersheds in which the large hydraulic structures are installed and FDC is curved in the Low Flow Conditions. So the Pollution Contribution is estimated as the water quality of the large hydraulic structures. Group IV contains the upstream in mainstream watersheds in which the large hydraulic structures are installed and the FDC is disabled before the Low Flow Conditions. As the flow is concentrated in the High Flow Conditions, the non-point pollution sources are estimated as the Pollution Contribution.

• The Transactions of the Korean Institute of Power Electronics
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• v.27 no.1
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• pp.26-32
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• 2022

This paper proposes a power system that includes a 120k W fuel cell DC-DC converter (FDC) and 30 kW bidirectional DC-DC converter (BHDC) for a 150 kW fuel-cell vehicle. With a high DC link voltage of 800 V, the efficiency and power density of the power electronic components are improved. Through the modular design of FDC and BHDC, electric components are shared, resulting in reduced mass production costs. The switching frequency of 30 kHz of full SiC devices and optimal design of coupled inductor reduce the volume, achieving a power density of 8.3 kW/L. Furthermore, a synergetic operation strategy using variable limiter control of FDC and BHDC was proposed to efficiently operate the fuel cell vehicle considering the fuel cell stack efficiency according to the load. Finally, the performance of the prototype was verified by Highway Fuel Economy Driving Schedule testing, EMI test, and the linked operation between FDC and BHDC. The full load efficiencies of the FDC and BHDC prototypes are 98.47% and 98.74%, respectively.