• Annual Conference of KIPS
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• 2014.04a
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• pp.858-860
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• 2014

최근 영상처리 기법과 하드웨어의 발달로 의학 분야에서는 질병의 진단에 다양한 영상 시스템을 활용하고 있다. 특히 OCT 기술은 인체조직의 고해상도 이미지 획득과 혈류속도 측정을 동시에 할 수 있어 의료분야에 다양하게 적용이 가능하여 많은 관심을 받고 있다. 이에 더욱더 선명한 OCT 영상을 획득하기 위해 다양한 알고리즘과 필터를 사용함에 따라 빠른 프로세스 처리가 요구되고 있는 실정이다. 본 논문에서는 듀얼 코어 이상급의 CPU 를 탑재한 시스템에서 데이터 처리 모듈과 렌더링 모듈을 트리플 버퍼를 통해 비동기식으로 멀티스레드화 하였고, GPU 기반의 병렬처리를 통한 데이터 처리를 하여 속도를 향상시켰다. 이에 광학 카메라 촬영 시 선명한 실시간 OCT 영상을 확인할 수 있었다.

• Proceedings of the Optical Society of Korea Conference
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• 2006.07a
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• pp.101-102
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• 2006

• The Transactions of The Korean Institute of Electrical Engineers
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• v.61 no.4
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• pp.639-642
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• 2012

Optical coherence tomography(OCT) can provide real-time and non-invasive subsurface imaging with ultra-high resolution of micrometer scale. However, conventional OCT systems generally have a limited imaging depth range within a depth of only 1-2 mm. To overcome the limitation, we have proposed an active surface tracking algorithm used in common-path Fourier-domain OCT system in order to extend the imaging depth range. The surface tracking algorithm based on the threshold and Savitzky-Golay filter of A-scan data was applied to real-time tracking. The algorithm has controlled a moving stage according to the sample's surface variance in real time. An OCT image obtained by the algorithm clearly show an extended imaging depth range. Consequently, the proposed algorithm demonstrated the potential for improving the conventional OCT systems with limitary depth range.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.6
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• pp.1117-1121
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• 2007

We demonstrate a wavelength swept mode-locked ring laser for the frequency domain optical coherence tomography(FD OCT). A laser is constructed by using a semiconductor optical amplifier, fiber Fabry-Perot tunable filter and 2.6 km fiber ring cavity. Mode-locking is implemented by 2.6 km fiber ring cavity for matching the fundamental or harmonic of cavity roundtrip time to a sweep period. The wavelength sweeps are repetitively generated with the repetition period of 77.2 kHz which is the parallel resonance frequency of Fabry-Perot tunable filter for the low driving current consumption of the fiber Fabry-Perot tunable filter. The wavelength tuning range of the laser is more than FWHM of 61 nm centered at the wavelength of 1320 nm and the linewidth of the source is $0.014{\pm}0.002$ nm.

• Journal of the Optical Society of Korea
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• v.15 no.3
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• pp.293-299
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• 2011

In this study, we demonstrated Fourier-domain/swept-source optical coherence tomography (FD/SS-OCT) at a center wavelength of 800 nm for in vivo human retinal imaging. A wavelength-swept source was constructed with a semiconductor optical amplifier, a fiber Fabry-Perot tunable filter, isolators, and a fiber coupler in a ring cavity. Our swept source produced a laser output with a tuning range of 42 nm (779 to 821 nm) and an average power of 3.9 mW. The wavelength-swept speed in this configuration with bidirectionality is 2,000 axial scans per second. In addition, we suggested a modified zero-crossing method to achieve equal sample spacing in the wavenumber (k) domain and to increase the image depth range. FD/SS-OCT has a sensitivity of ~89.7 dB and an axial resolution of 10.4 ${\mu}m$ in air. When a retinal image with 2,000 A-lines/frame is obtained, an acquisition speed of 2.0 fps is achieved.

• Current Optics and Photonics
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• v.3 no.1
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• pp.54-65
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• 2019

To develop a biomarker predicting tumor treatment efficacy is helpful to reduce time, medical expenditure, and efforts in oncology therapy. In clinics, microvessel density using immunohistochemistry has been proposed as an indicator that correlates with both tumor size and metastasis of cancer. In the preclinical study, we hypothesized that vascular morphometrics using optical coherence tomography angiography (OCTA) could be potential indicators to estimate the treatment efficacy of breast cancer. To verify this hypothesis, a 13762-MAT-B-III rat breast tumor was grown in a dorsal skinfold window chamber which was applied to a nude mouse, and the change in vascular morphology was longitudinally monitored during tumor growth and metronomic cyclophosphamide treatment. Based on the daily OCTA maximum intensity projection map, multiple vessel parameters (vessel skeleton density, vessel diameter index, fractal dimension, and lacunarity) were compared with the tumor size in no tumor, treated tumor, and untreated tumor cases. Although each case has only one animal, we found that the vessel skeleton density (VSD), vessel diameter index and fractal dimension (FD) tended to be positively correlated with tumor size while lacunarity showed a partially negative correlation. Moreover, we observed that the changes in the VSD and FD are prior to the morphological change of the tumor. This feasibility study would be helpful in evaluating the tumor vascular response to treatment in preclinical settings.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.7
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• pp.1393-1397
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• 2009

A high-speed wavelength swept laser, which is based on oscillation characteristics of a fiber Fabry-Perot tunable filter, is described. The laser is constructed by using a semiconductor optical amplifier, a fiber Fabry-Perot tunable filter, and 3.348 km fiber ring cavity. The wavelength sweeps are repeatatively generated with the repetition period of 61 kHz which is the first parallel oscillation frequency of the Fabry-Perot tunable filter for the low power consumption. Mode-locking is implemented by 3.348 km fiber ring cavity for matching the fundamental of cavity roundtrip time to the sweep period. The wavelength tuning range of the laser is 87 nm(FWHM) and the average output power is 1.284 mW.