• Nuclear Medicine and Molecular Imaging
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• v.40 no.5
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• pp.275-278
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• 2006

We report the case of a 73-year-old man who had prostate cancer with bone metastases. Tc-99m HDP Whole body bone scan revealed multiple areas of increased bony uptake consistent with widespread bone metastases. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) demonstrated mild F-18 FDG uptake in the lymph nodes of neck, abdomen, and pelvis. However, abnormal F-18 FDG uptake was not seen in the skeletal system. Biopsy and immunohistochemical stains of left supraclavicular mass showed metastatic prostate adenocarcinoma. Currently, there are a few reported cases of F-18 FDG PET/CT evaluation of bone metastases in prostate cancer. We discuss the discrepancy between F-18 FDG PET/CT and bone scan in the detection of osseous metastases of prostate cancer.

• The Journal of Korean Physical Therapy
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• v.12 no.2
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• pp.29-37
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• 2000

본 연구의 목적은 힘판(Force plate)의 지면반발력(Ground reaction force)의 비교에 따라 발압력 측정계(F-메트와 F-스킨)의 상호 기계간의 신뢰성과 타당성을 연구하는 데에 목적을 두고 있으며 정상인과 리스프랑크(Lisfranc) 골절을 가지고 있는 환자를 대상으로 분석 연구하게 되었다. 힘판의 지면 반발력을 기준치로 설정하고 정상인과 환자의 각각 오른발과 왼발의 스텝에 대해 F 메트(F-mat) 와 F 스캔(F-scan) 시스템의 그래픽 비교 모식과 시간에따른 보령분석의 차이에 따라 이 논문에 대한 결과를 얻을 수 있었다. 본 연구에서는 F 스킨 시스템의 데이터 분석기인 새로운 버전 3.622와 마이크로 소프트웨어인 엑셀 97을 통해 새 시스템의 힘의 평균치와 그래픽을 통해 비교 분석하게 되었으며 다음과 같은 세가지 결론을 얻을 수 있었다. 첫 번째로 F스캔의 지면 반발력은 힘판과 비교되어질 때 통계학적으로 중요한 차이점을 얻을 수 없을 것이다. 두 번째, F 메트를 위한 지면 반발력 역시 힘판과 비교되어질 때 통계학적으로 중요한 차이점율 얻음 수 없을 것이다. 세 번째로 정상군과 실험군의 지면 반발력에 대해 중요한 차이점이 있을 것이라는 것이 밝혀졌다. 특히 정상군의 대상자는 실험군의 대상자와 비교되어질 때 각 발에 대해 증가된 지면 반발력을 나타내었다. 이상 본 연구에 대해 다음의 결론을 내릴 수가 있었고 기존의 F 스캔 시스템이 임상적으로 많이 쓰여졌지만 F 스캔의 센서에 대해 많은 이견 차이를 보였었다. 한편. F메트 시스템에서 F메트 센서의 일관성에 대해서는 어느 연구 논문도 나오지 않았고 이에 대해 F스캔(F-scan)과 힘판(Force plate)를 상호 비교하여 F메트 시스템에 대한 신뢰성과 타당성을 연구하는데 목적을 두게되었다.

• The Korean Journal of Nuclear Medicine
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• v.36 no.3
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• pp.147-154
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• 2002

The role of PET in the diagnosis and management of thyroid cancer is discussed. The major role of F-18 FDG PET is on patients with discordant negative I-131 scan and a positive serum thyroglobulin values. F-18 FDG PET scan localized metastatic sites in I-131 scan-negative thyroid carcinoma patients with high accuracy. F-18 PET is also valuable in medullary thyroid cancer with high calcitonin level. Focal thyroid uptake in patients with non-thyroidal diseas has high likelihood of thyroid cancer.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.sup1
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• pp.116-120
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• 2008

Prostate cancer is the second leading cause of cancer death of men in western countries and the death related to this disease in Korea is also getting increased. Although anatomic imaging tools such as transrectal US or MRI have been playing a great role in detection of primary prostate lesion, the evaluation of regional lymph node or distant organ metastasis using these modalities is not successful. $^{18}F-FDG-PET$ scan is emerging diagnostic tool for various malignancies. Considering the usual characteristics of prostate cancer such as slow growing and osteoblastic metastasis, the application of FDG PET scan to this disease might be limited. However, in advanced prostate cancer refractory to chemotherapy, FDG PET scan show strong FDG uptake and SUV changes in serial PET scan can be a good indicator of treatment response. Although FDG PET can be useful only in limited cases of prostate cancer, its indication can be widened in future owing to rapid technical improvement and accumulated experiences in this field.

• The Korean Journal of Nuclear Medicine Technology
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• v.18 no.2
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• pp.68-72
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• 2014

Purpose The nuclear medicine examination, there is a difficulty to carry out the inspection of both on the day of residual isotope due to the half-life. In this study, by studying the mutual influence and $^{18}F$-FDG of $^{99m}TcO_4{^-}$, I would like to explain the matters to be considered in the case of performing the same day. Materials and Methods With the NEMA-1994 Phantom, and experiments were performed 3 times. Create a 1: 4 Background ratio HOT and the $^{99m}TcO_4{^-}$ The first experiment: After underwent SPECT in INFINIA (GE Healthcare, MI, USA), and were injected with $^{18}F$-FDG 37 MBq in the Background area, 13 once for 60 minutes under the same conditions was time Scan. Create a 1: 4 Background ratio HOT and the $^{18}F$-FDG second is: The Scan in PET/CT Discovery 600 (GE Healthcare, MI, USA), and 148 MBq after injection $^{99m}TcO_4{^-}$ the Background area, once for 60 minutes, 6 under the same conditions was time Scan. Create a 1: 4 Background ratio HOT and the $^{18}F$-FDG experiments las, increments of 296 MBq and 148 MBq the 1 Bed Scan after $^{99m}TcO_4{^-}$, was 1 Bed Scan under the same conditions. Non BKG area and HOT, I was measured comparing the Total Counts and SNR or CNR. Results Showed a significant difference in the ratio CNR of enforcement during SPECT $^{18}F$-FDG is, (p>0.05). The $^{99m}TcO_4{^-}$ was no significant difference between the SNR ratio of PET / CT at the time of the effective date (p<0.05). I got the results $^{99m}TcO_4{^-}$ that reduce the Total Counts of PET / CT scan. Conclusion If you make a PET / CT scan, may affect the test using the $^{99m}TcO_4{^-}$ up to 12 hours, when it is performed before the $^{99m}TcO_4{^-}$, does not affect the SNR and SUV, PET / CT scan I reduced the detection efficiency. The inspection of day, we'd like to recommend a way to complement the detection efficiency to increase the inspection time of PET / CT in move forward the inspection using the $^{99m}TcO_4{^-}$.

• Progress in Medical Physics
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• v.13 no.3
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• pp.139-148
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• 2002

The measured attenuation correction with transmission (Tx) scans produced quantitatively accurate images. However, it was not clear for optimal emission (Ex) and Tx scan time in PET imaging. This study was to evaluate acceptable Ex and Tx scan time by simulating clinical situations using various phantoms. Cylindrical and NEMA phantom were used for $^{18}$ F-PET scan using 2D protocol in GE Advance PETTM scanner. Cylindrical phantom was filled with 136 MBq 18F, and five regions of interests (ROI) were drawn on 23 slices. NEMA phantom had three inserts containing water, air and polytetrafluoro-ethylene (PTFE). Outside of these inserts were filled with 309 MBq of $^{18}$ F, and total 12 ROIs were drawn on 23 slices. Scans were carried out according to five Ex scan times: 2, 5, 10, 15, and 30 min, and nine Tx scan times: 2, 3, 4, 5, 7, 10, 15, 20, and 30 min. Images were reconstructed using measured attenuation correction, and ROI analyses were performed for all images, and mean, standard deviation (SD), coefficient of variation and percent errors were calculated. For cylindrical phantom study, ROI mean and SD were decreased as Ex and Tx time increased. Coefficients of variation were kept constant, when Tx was greater than 10 min. The amount of error decreased for the increment of Ex time from 10 min to 15 min was almost the same to that from 15 min to 30 min. In NEMA phantom Tx 15 min showed the lowest er개r level when the percent errors for three inserts were summed for all of the Ex times. This study suggested that Ex 15 min and Tx 15 min were acceptable as optimal scan time for the scanning protocol and the dose of radiopharmaceuticals used in these phantom study.

• The Korean Journal of Nuclear Medicine Technology
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• v.16 no.1
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• pp.102-107
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• 2012

Purpose : Because of the rapid physical decay of the short half-lived radionuclide, counting of event for image is very limited. In this reason, long scan duration is applied for more accurate quantitative analysis in the relatively low sensitive examination. The aim of this study was to evaluate the difference according to scan duration and investigate the resonable scan duration using the radionuclide of 11C and 18F in PET scan. Materials and Methods : 1994-NEMA Phantom was filled with 11C of $30.08{\pm}4.22MBq$ and 18F of $40.08{\pm}8.29MBq$ diluted with distilled water. Dynamic images were acquired 20frames/1minute and static image was acquired for 20minutes with 11C. And dynamic images were acquired 20frames/2.5minutes and static image was acquired for 50minutes with 18F. All of data were applied with same reconstruction method and time decay correction. Region of interest (ROI) was set on the image, maximum radioactivity concentration (maxRC, kBq/mL) was compared. We compared maxRC with acquired dynamic image which was summed one bye one to increase the total scan duration. Results : maxRC over time of 11C was $3.85{\pm}0.45{\sim}5.15{\pm}0.50kBq/mL$ in dynamic image, and static image was $2.15{\pm}0.26kBq/mL$. In case of 18F, the maxRC was $9.09{\pm}0.42{\sim}9.48{\pm}0.31kBq/mL$ in dynamic image and $7.24{\pm}0.14kBq/mL$ in static. In summed image of 11C, as total scan duration was increased to 5, 10, 15, 20minutes, the maxRC were $2.47{\pm}0.4$, $2.22{\pm}0.37$, $2.08{\pm}0.42$, $1.95{\pm}0.55kBq/mL$ respectively. In case of 18F, the total scan duration was increased to 12.5, 25, 37.5, and 50minutes, the maxRC were $7.89{\pm}0.27$, $7.61{\pm}0.23$, $7.36{\pm}0.21$, $7.31{\pm}0.23kBq/mL$. Conclusion : As elapsed time was increased after completion of injection, the maxRC was increased by 33% and 4% in dynamic study of 11C and 18F respectively. Also the total scan duration was increased, the maxRC was reduced by 50% and 20% in summed image of 11C and 18F respectively. The percentage difference of each result is more larger in study using relatively shorter half-lived radionuclide. It appears that the accuracy of decay correction declined not only increment of scan duration but also increment of elapsed time from a starting point of acquisition. In study using 18F, there was no big difference so it's not necessary to consider error of quantitative evaluation according to elapsed time. It's recommended to apply additional decay correction method considering decay correction the error concerning elapsed time or to set the scan duration of static image less than 5minutes corresponding 25% of half life in study using shorter half-lived radionuclide as 11C.

• The Korean Journal of Nuclear Medicine
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• v.36 no.2
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• pp.143-145
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• 2002

A 49-year-old male patient with a carcinoma of the right pyriform sinus had a whole-body bone scan and gamma camera based F-18 FDG-PET for staging. Tc-99m MDP bone scan depicted diffuse increased uptake in the left femur due to chronic osteomyelitis but no skeletal metastasis. F-18-FDG-PET revealed increased focal bone uptake and uptake in the draining sinus due to chronic osteomyelitis in addition to visualization of the right pyriform sinus carcinoma and right neck nodal uptake. Fluorine-18 fluorodeoxyglucose-positron emission tomography is significantly more accurate than the bone scan in pinpointing chronic osteomyelitis focus and draining soft tissue infection.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.4
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• pp.253-258
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• 2009

Bone scintigraphy using $^{99m}$Tc-labeled phosphate agents has long been the standard evaluation method for whole skeletal system. However, recent shortage of $^{99m}$Tc supply and advanced positron emission tomography (PET) technology evoked the attention to surrogate radiopharmaceuticals and imaging modalities for bone. Actually, fluorine-18 ($^{18}$F) was the first bone seeking radiotracer before the introduction of $^{99m}$Tc-labeled agents even though its clinical application failed to become pervasive anymore after the rapid spread of Anger type gamma camera systems in early 1970s. However, rapidly developed PET technology made us refocus on the usefulness of $^{18}$F as a PET tracer. Early study comparing $^{18}$F-Na PET scan and planar bone scintigraphy reported that PET has higher sensitivity and specificity in the diagnosis of metastatic bone lesions than planar bone scan. Subsequent reports comparing between PET and both planar and SPECT bone image also revealed better results of PET scan in similar study groups. Rapid clinical application of PET/CT also accumulated considerable amount of experiences in skeletal evaluation and this modality is known to have better diagnostic power than stand alone PET system as well as bone scan. Furthermore $^{18}$F-Na PET/CT revealed better or at least equal results in detection of primary and metastatic bone lesions compared with CT and MRI. Therefore, it is obvious that $^{18}$F-Na PET/CT has potential to become new imaging modality for practical skeletal evaluation so continuous and careful evaluation of this modality and radiopharmaceutical must be required.

• Proceedings of the Optical Society of Korea Conference
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• 1997.08a
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• pp.65-65
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• 1997