• The Journal of Korean Physical Therapy
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• 제25권5호
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• pp.288-296
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• 2013

Purpose: This study was conducted in order to determine whether mechanical horseback-riding training depending on velocity can improve vestibular function and static postural balance on standing in healthy adults. Methods: For evaluation of vestibular function, electrooculography (EOG) of vertical and horizontal was performed for identification of the motion of eyes. For evaluation of static postural balance, COP distance, time spent on the sharpened Romberg test with neck extension (SRNE) were measured. Measurements were performed three times before training, three weeks after training, and six weeks after training. Participants were randomly assigned to three groups: fast velocity-mechanical horse -riding training (FV-MHRT, n=12), moderate velocity-mechanical horse-riding training (MV-MHRT, n=12), and slow velocity-mechanical horse-riding training (SV-MHRT, n=12). Results: According to the result for vertical, horizontal EOG, there was significant interaction in each group in accordance with the experiment time (p<0.05). The FV-MHRT group showed a significant decrease compared with the MV- MHRT, SV-MHRT groups (p<0.05). According to the result for static postural balance, the time spent, COP distance in SRNE showed significant interaction in each group in accordance with the experiment time (p<0.05). The time spent on the SRNE showed a significant increas in FV-MHRT, SV-MHRT (p<0.05). The COP distance of SRNE showed a significant increase in MV-MHRT (p<0.05). Conclusion: The MHRT velocity activated mechanism of vestibular spinal reflex (VSR), vestibular ocular reflex (VOR), also helped to strengthen vestibular function and static postural balance. In addition, it should be applied to different velocity of MHRT according to the specific purpose.

• 셀메드
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• 제10권3호
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• pp.25.1-25.7
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• 2020

Allergic Rhinitis (AR) is an IgE (immunoglobin-E) mediated inflammatory condition of upper respiratory tract; main clinical features involve runny nose, sneezing, nasal obstruction, itching and watery eyes. AR is a global problem and has large variations in incidences, currently affects up to 20% - 40% of the population worldwide. It may not be a life-threatening disease per se but indisposition from the condition can be severe and has the potential to adversely affect the daily functioning of life. Classical yoga literature indicates that, components of yoga have been used to treat numerous inflammatory conditions including upper respiratory tract. A few yoga intervention studies reported improvement in lung capacity, Nasal air flow and symptoms of allergic rhinitis. This review examined various anti-inflammatory pathways mediated through Yoga that include downregulation of pro-inflammatory cytokines and upregulation of anti-inflammatory cytokines. The hypothalaminic-pitutary-adrenal (HPA) axis and vagal efferent stimulation has been reported to mediate anti-inflammatory effect. A significant reduction is also reported in other inflammatory biomarkers like- TNF-alpha, nuclear factor kappa B (NF-κB), plasma CRP and Cortisol level. Neti, a yogic nasal cleansing technique, reported beneficial effect on AR by direct physical cleansing of thick mucus, allergens, and inflammatory mediator from nasal mucosa resulting in improved ciliary beat frequency. We do not find any study showing effect of yoga on neurogenic inflammation. In summary, Integrated Yoga Therapy may have beneficial effect in reducing symptoms and improving quality of life for patients with allergic rhinitis. Yoga may reduce inflammation through mediating neuro-endocrino-immunological network. Future studies are needed to explore the mechanism how yoga might modulate immune inflammation cascade and neurogenic inflammation at the cellular level in relevance to allergic rhinitis; the effects of kriyas (yogic cleansing techniques) also need to be evaluated in early and late phase of AR. So the proposed model could guide future research.

• 한국임상수의학회지
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• 제18권4호
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• pp.324-328
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• 2001

This study was performed to evaluate the effects of $AS_2O_3$ upon antiangiogenesis in rat cornea, to examine it\`s possible application as an anticancer drug and to provide basic data for further studies of antiangiogenetic mechanism of $AS_2O_3$ . Angiogenesis was induced by cornea micropocket assay, as previously described. Sixteen of forty-eight eyes of Sprague-Dawley rats were randomly assigned to one of three groups, namely, only a bFGF group(control group), and a group treated by $AS_2O_3$ ($AS_2O_3$ group). After pellet implantation, we measured the number of new vessels, vessel length and clock hour of neovascularization, and area of neovascularization was determined using a mathematical formula. New vessels growing began at day 3, number of vessels in $AS_2O_3$ group were significantly more less than those in control group (p<0.05). The length of vessels of $AS_2O_3$ group was significantly shorter than that of control group after day 3(p<0.05). The clock hours of all group were slowly increased at all days but $AS_2O_3$ group was inhibited more than control group. Neovascularization areas of $AS_2O_3$ group were more significantly inhibited than those of control group (p<0.05). This study showed that $AS_2O_3$ had powerful antiangiogenetic effects and it would be useful in the choice of anticancer drug.

• 한국정보통신학회논문지
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• 제7권8호
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• pp.1823-1830
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• 2003

본 논문에서는 동공 검출 기술을 이용한 얼굴 검출 방법을 제안하고자 한다. 동공 검출기는 눈의 역 반사 특성을 이용한 능동적 조명을 사용하여 검출을 용이하도록 하였고. 제안된 방법의 검출 범위는 소형 컴퓨터나 무인 정보 단말기 등의 활용에 적합하도록 하였다. 동공 후보 영역을 계산하여 검출한 후, 학습 규칙을 사용하여 얼굴에 대응하는 두 개의 지점을 선택하도록 하였다. 얼굴 검출 성능을 증명하기 위하여, 얼굴의 최대 돌출 부위를 지정 할 수 있는 이중 모드의 얼굴 추적 장치를 개발하였다. 추정치 와 복합 얼굴 검출기의 측정치를 결합하여 특징 관계를 추적함으로 처리의 안정성을 높이었다. 또한, 실시간으로 서보의 제어장치를 원격 조정하여 항상 카메라가 이미지의 중앙을 추적하도록 함으로서 얼굴의 위치를 추정할 수 있도록 하였다.

• 융합신호처리학회논문지
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• 제18권2호
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• pp.31-36
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• 2017

이 연구는 비동기 매커니즘을 바탕으로 닫힌 눈(eye-closed) 및 이중 블링크 (double-blinking) EEG를 사용하여 BCI를 개발하는 것을 목표한다. 제안된 시스템은 신호 처리 모듈과 그래픽 사용자 인터페이스 (VK-가상 키보드)로 구성되어 있으며 26개의 영문자와 특수 기호로 구성됩니다. "눈 닫기"이벤트는 "선택"(select)명령을 유발하는 반면, "이중 블링크"(DB) 이벤트는 "실행 취소"(undo) 명령에 따라 실행합니다. 3개의 이벤트 그룹 ("열린 눈"(eye-open, "닫힌 눈" (eye-closed)및 "이중 블링크"(double-blinking)에 대한 EEG 신호 분석과 관련된 3 등급 벡터 보조 분류 (SVM) 기계가 제안되었습니다. 결과는 제안된 BCI가 평균 92.6 %의 전체 정확도와 5 글자 / 분의 맞춤법 비율을 달성 할 수 있음을 보여주었습니다. 전반적으로 이 연구는 실제 BCI 맞춤법을 구현하기의 실현 가능성과 신뢰성으로 인해 정확도와 철자 비율의 향상을 보여주었습니다.

• Journal of Ginseng Research
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• 제45권6호
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• pp.676-682
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• 2021

Background: Red ginseng has been found to improve ocular perfusion and dry eye syndrome in glaucomatous eyes; however, its effects on visual function and vision-related quality of life have not been investigated. This study sought to evaluate the effects of red ginseng on visual function and vision-related quality of life in glaucoma patients using contrast sensitivity and a questionnaire. Methods: Participants were randomly assigned to two groups in this prospective, randomized, double-blind study: in one group, red ginseng was taken first, followed by a placebo, and in the other, placebo was taken first, followed by red ginseng. We measured and compared changes in contrast sensitivity and vision-related quality of life between the two groups. Contrast sensitivity was measured using OPTEC® 6500P, and vision-related quality of life was evaluated using the 25-item National Eye Institute Visual Function Questionnaire. One-way and two-way repeated measure analyses of variance were used for the comparison. Relationships between respective changes in dry eye syndrome and contrast sensitivity were also analyzed. Results: Daytime contrast sensitivity and ocular pain improved after the administration of red ginseng. Nighttime contrast sensitivity was improved in early or moderate glaucoma. Improved contrast sensitivity was not associated with improvement in dry eye syndrome. Conclusion: Red ginseng could improve contrast sensitivity and ocular pain in patients with glaucoma. The mechanism underlying improvement in contrast sensitivity appears to be associated with enhanced retinal perfusion or retinal ganglion cell function, but not dry eye syndrome.

• 사상체질면역의학회지
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• 제34권3호
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• pp.1-20
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• 2022

Objective The Constitutional Seong-Jeong therapy is one of the important ways to prevent Sasang constitutional symptomatology. But, there are various interpretations and unclear aspects of the content and meaning, so there are many difficulties in applying it concretely in actual clinical practice. The purpose of this study is to clarify the physiology, pathology, treatment mechanism and its specific meaning. Method The pathology associated with constitutional symptomatology is known as Deepening-Seong and Exploding-Jeong. Therefore, related pathologies and corresponding treatment and prevention mechanisms were reviewed, focusing on the related contents of Donguisusebowon, and their specific meanings were considered. Results and Conclusions 1. Constitutional Seong-Jeong therapy is a regimen to prevent and manage Deepening-Seong and Exploding-Jeong. 2. Deepening-Seong and Exploding-Jeong are the inappropriate occurrences of Seong and Jeong in the poor area of the Heavenly-frame recognition and in the vulnerable area of Humanly-activity practice, and the antecedent cause is covetous desire. 3. Deepening-Seong and Exploding-Jeong cause the weakening in the power of ears-eyes-nose-mouth to perceive Heavenly frame and the power of lung-spleen-liver-kidney to practice Humanly activity in the four constitution's weak system, which lead to the Interruption in processing of four Qi in each weak system. 4. The four constitutions must be careful about the occurrence of covetous desire in the process of recognizing Heavenly frame and doing Humanly activity so that intellectual and behavioral abilities can be exerted to overcome the poor area of the recognition of Heavenly frame and the formation of Humanly activity to prevent deepening-Seong and exploding-Jeong from occurring.

• The Korean Journal of Physiology and Pharmacology
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• 제18권2호
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• pp.89-94
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• 2014

DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal and conjunctival cells, suggesting that it might be considered as a drug for the treatment of dry eye. However, whether DA-6034 induces $Ca^{2+}$ signaling and its underlying mechanism in epithelial cells are not known. In the present study, we investigated the mechanism for actions of DA-6034 in $Ca^{2+}$ signaling pathways of the epithelial cells (conjunctival and corneal cells) from human donor eyes and mouse salivary gland epithelial cells. DA-6034 activated $Ca^{2+}$-activated $Cl^-$ channels (CaCCs) and increased intracellular calcium concentrations ($[Ca^{2+}]_i$) in primary cultured human conjunctival cells. DA-6034 also increased $[Ca^{2+}]_i$ in mouse salivary gland cells and human corneal epithelial cells. $[Ca^{2+}]_i$ increase of DA-6034 was dependent on the $Ca^{2+}$ entry from extracellular and $Ca^{2+}$ release from internal $Ca^{2+}$ stores. Interestingly, these effects of DA-6034 were related to ryanodine receptors (RyRs) but not phospholipase C/inositol 1,4,5-triphosphate ($IP_3$) pathway and lysosomal $Ca^{2+}$ stores. These results suggest that DA-6034 induces $Ca^{2+}$ signaling via extracellular $Ca^{2+}$ entry and RyRs-sensitive $Ca^{2+}$ release from internal $Ca^{2+}$ stores in epithelial cells.

• 인터넷정보학회지
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• 제14권3호
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• pp.78-85
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• 2013

The revelations made possible by Edward Snowden, a contractor of the US intelligence service NSA, are a sobering reminder that the Internet is not an 'anonymous' means of communication. In fact, the Internet has never been conceived with anonymity in mind. If anything, the Internet and networking technologies provide far more detailed and traceable information about where, when, with whom we communicate. The content of the communication can also be made available to third parties who obtain encryption keys or have the means of exploiting vulnerabilities (either by design or by oversight) of encryption software. Irrebuttable evidence has emerged that the US and the UK intelligence services have had an indiscriminate access to the meta-data of communications and, in some cases, the content of the communications in the name of security and protection of the public. The conventional means of judicial scrutiny of such an access turned out to be ineffectual. The most alarming attitude of the public and some politicians is "If you have nothing to hide, you need not be concerned." Where individuals have nothing to hide, intelligence services have no business in the first place to have a peek. If the public espouses the groundless assumption that State organs are benevolent "( they will have a look only to find out whether there are probable grounds to form a reasonable suspicion"), then the achievements of several hundred years of struggle to have the constitutional guarantees against invasion into privacy and liberty will quickly evaporate. This is an opportune moment to review some of the basic points about the protection of privacy and freedom of individuals. First, if one should hold a view that security can override liberty, one is most likely to lose both liberty and security. Civilized societies have developed the rule of law as the least damaging and most practicable arrangement to strike a balance between security and liberty. Whether we wish to give up the rule of law in the name of security requires a thorough scrutiny and an informed decision of the body politic. It is not a decision which can secretly be made in a closed chamber. Second, protection of privacy has always depended on human being's compliance with the rules rather than technical guarantees or robustness of technical means. It is easy to tear apart an envelope and have a look inside. It was, and still is, the normative prohibition (and our compliance) which provided us with protection of privacy. The same applies to electronic communications. With sufficient resources, surreptitiously undermining technical means of protecting privacy (such as encryption) is certainly 'possible'. But that does not mean that it is permissible. Third, although the Internet is clearly not an 'anonymous' means of communication, many users have a 'false sense of anonymity' which make them more vulnerable to prying eyes. More effort should be made to educate the general public about the technical nature of the Internet and encourage them to adopt user behaviour which is mindful of the possibilities of unwanted surveillance. Fourth, the US and the UK intelligence services have demonstrated that an international cooperation is possible and worked well in running the mechanism of massive surveillance and infiltration into data which travels globally. If that is possible, it should equally be possible to put in place a global mechanism of judicial scrutiny over a global attempt at surveillance.

• 한국체육학회지인문사회과학편
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• 제58권6호
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• pp.449-459
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• 2019

이 연구의 목적은 외발서기 동작 시 취득한 운동역학데이터로부터 주파수분석의 기법을 통하여 인체 운동명령신호가 어떻게 자세조절 과정에 영향을 미치는지를 규명하는 자세역학의 토대연구이다. 이를 위하여 체조경력 10년 이상의 운동신경이 우수한 국가대표상비군(n=6)과 일반인(n=6)을 대상으로 발바닥 압력중심점(CoP)의 궤적데이터를 FFT신호처리기법에 의한 저주파대역Rambling (RM)과 고주파대역 Trembling (TR)의 주파수분석을 탐색하였다. 본 연구결과에 따르면 눈뜨고 외발서기와 눈감고 외발서기 동작을 중심으로 두 집단 간 자세조절능력의 안정화지수 평가에서 독립표본 t검증에서 유의한 차이가 나타났으며(p<.05), 이러한 차이는 저주파대역 RM의 주요주파수 f1과 고주파대역 TR의 주요 주파수 f2의 최대진폭의 출력 차이로 밝혀졌다(p<.05). 특히 자세송환피드백에 관여하는 고유주파수인 저주파수대역에서는 주요주파수가 8-9 Hz 대역에서 뇌지시 하 안정적 자세조절의 운동기전을 행하는 운동명령으로 확인하였으며, 120-135 Hz의 고주파수대역에서는 자세 흔들림을 최소화하기 위한 반사적 근반응의 적응성을 보이는 것으로 연구되었다. 자세조절의 중추신경계 운동조절에 관여하는 고유주파수와 최대진폭에서 유의한 차이가 발견됨으로서 외발서기 시 발바닥 압력조절에 의한 신호파형의 운동명령이 자세조절에 영향을 미치는 것으로 해석되었다.