• Journal of Acupuncture Research
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• 제25권4호
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• pp.171-181
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• 2008

Purpose : In order to estimate clinical effects of Oriental Medicine Treatment with acupotomy therapy of herniated lumbar intervertebral Disc patient needed operation. Methods : From 17th April, 2008 to 17th April, 2008, 1 female patient diagnosed as herniated lumbar intervertebral Disc at L4/5(right postero-lateral extrusion type)was treated with general oriental medicine therapy(acupuncture, moxibustion, cupping, physical therapy, herbal medication) and acupotomy. Results : The patient's chief complaints - Low back pain, both buttock pain, Right. leg paresthesia were remarkably improved. Conclusions : This study demonstrates that oriental medical treatment with acuputomy therapy has notable effect in improving functional disability and symptoms of lumbar radiculopathy. as though we had not wide experience in this treatment, more research is needed.

• 한국식품영양과학회지
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• 제45권3호
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• pp.380-385
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• 2016

압출성형공정과 효소처리가 신령버섯 추출물의 ${\beta}$-glucan 함량에 미치는 영향을 조사하였다. 스크루 회전속도 250 rpm, 원료 사입량 100 g/min, 사출구 3 mm 원형으로 고정하였으며, 수분 함량 20, 30%, 배럴 온도 130, $140^{\circ}C$로 조절하여 압출성형 신령버섯을 제조하였다. 수분 함량 20%, 배럴 온도 $130^{\circ}C$의 압출성형공정을 통한 신령버섯 추출혼합물은 ${\beta}$-glucan 함량이 16.91 mg/g으로 다른 공정들보다 증가하였다. 수분 함량 20%, 배럴 온도 $130^{\circ}C$의 압출성형 공정과 Rohament CL로 처리한 추출물의 ${\beta}$-glucan 함량은 같은 압출성형공정의 Viscozyme L 처리 추출물 17.35 mg/g과 Plantase TL 처리 추출물 17.51 mg/g보다 18.32 mg/g으로 가장 많이 증가하였다. 결론적으로 압출성형공정과 Rohament CL 처리한 추출물의 ${\beta}$-glucan 함량이 18.32 mg/g으로 압출성형공정과 효소처리를 하지 않은 대조구의 14.45 mg/g보다 약 26.7% 정도 증가함을 나타내었다. 이는 신령버섯 추출 시에 압출성형공정과 효소처리가 ${\beta}$-glucan 함량을 대조구에 비해 증가시킬 수 있다고 판단되었다.

• 대한치과보존학회:학술대회논문집
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• 대한치과보존학회 2006년도 Spring Scientific Meeting(the 125th) of Korean Academy of Conservative Dentistry
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• pp.235-235
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• 2006

• Applied Biological Chemistry
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• 제51권2호
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• pp.114-118
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• 2008

Ginseng treated with several treatment conditions of various acids to search hydrolysates on the basis of increased biological activity and modified structure. In the result of acid treatment, the conversion rate of ginsenoside Rg3, Rk1 and Rg5 was highest when ginseng treated with citric acid. After added citric acid to ginseng extract, boiled at l00$^{\circ}C$ for 1 hour and add enzyme, which is examined change by time. It compared with group which did not treated acid. Two groups became difference according to enzyme but the generation rate of ginsenoside Rg3, Rk1 and Rg5 did not show difference greatly. Also, the generation rate of ginsenoside Rg3, Rk1 and Rg5 by time passes did not show difference. The generation rate of ginsenoside Rg3, Rk1 and Rg5 increased when increased acid concentration, temperature and time. We did exclusion molding to shorten treatment time. In the result of ginseng treated with citric acid of various concentrations at various temperatures as time passes by extrusion molding, the generation rate of ginsenoside Rg3, Rk1 and Rg5 was highest when ginseng treated with 3% citric acid at l60$^{\circ}C$ for 20 minutes. In addition, total saponin amount of ginseng treated with 3% citric acid at 160$^{\circ}C$ for 20 minutes was about 11% higher than ginseng heated at 120$^{\circ}C$ for 3 hours. These results indicated that our exclusion molding process more effective, compared to traditional red ginseng manufacturing process.

• Reproductive and Developmental Biology
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• 제33권1호
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• pp.29-33
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• 2009

The brilliant cresyl blue (BCB) has been used to select the developmental competent oocytes in pigs, goats and cows. Growing oocytes have a higher level of active glucose-6-phosphate dehydrogenase(G6PDH) compare to mature oocytes and are rarely stained compared to mature oocytes, because G6PDH converts BCB to colorless. First polar body extrusion regard as a guideline of meoisis completion. Selection of polar body extrude oocyte is more developmental competent to blastocyst than unselected. This study was conducted to compare the BCB test to the polar body extrusion on selection of developmental competent porcine oocytes for the production of blastocyst. Cumulus-Oocytes complex were exposed to 26uM BCB stain diluted in NCSU-23 for 90 min. There was no significant difference embryo development to blastocysts between BCB treated and not treated($19.58{\pm}1.99$ vs $18.75{\pm}2.27%$), which means there was no detrimental effect of BCB exposure to oocytes. Normal fertilization is not differed among treatment groups from 70.0 to 78.4% development to blastocyst, beside polyspermy did not. To compare two different selection methods, BCB test and polar body extrusion, evaluate the developmental competent of IVP embryos. BCB+PB+(blue stained and polar body extruded, $20.71{\pm}0.45%$) and BCB-PB+(colorless and polar body extruded, $20.04{\pm}l.29%$) groups are significantly (p<0.05) higher developed than those of BCB+PB-(blue stained and no polar body, $13.24{\pm}0.73%$) and BCB-PB-(colorless and no poladbody, $7.25{\pm}0.77%$). These results showed that selection of polar body extruded oocytes method is more efficient than that of BCB test.

• 대한치과보철학회지
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• 제57권4호
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• pp.448-455
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• 2019

법랑모세포종은 치성 상피성 양성 종양으로 재발률이 높아 주변 조직의 광범위한 절제 및 결손부의 재건을 필요로 한다. 술 후 치아 결손 부위의 보철치료 시에 재건 부위의 해부학적 한계로 인해 임플란트 식립을 동반한 보철 치료가 추천된다. 본 증례에서는 법랑모세포종으로 인해 하악골 분절 절제술 및 장골을 이용한 하악골 재건술을 시행한 환자에서 재건 부위 상실치를 임플란트 고정성 보철물로 수복하였고 임플란트 보철물을 장착 완료 한 14개월 뒤 원인 미상의 인접치 정출로 인해 임플란트를 포함한 전방부 치아에서 1 mm 가량의 개방 교합이 발생하였다. 성인에서 상악 전치부 임플란트 식립 후 잔존 성장으로 인해 임플란트 저위 교합이 발생하는 경우는 보고된 바 있으나 본 증례는 구치부에서 인접한 자연치의 정출로 인해 임플란트 보철물을 포함한 전방 치열의 개방 교합이 발생한 것으로 그 유사 보고가 흔하지 않다. 이에 정출된 치아를 압하 하는 교정 치료를 동반한 전체 치료 과정을 보고하고 원인 미상의 자연치 정출이 발생한 원인에 대해 고찰해보고자 한다.

• Toxicological Research
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• 제19권3호
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• pp.181-187
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• 2003

Effects of repeated treatment with butylated hydroxyanisole (BHA) on the induction of glutathione S-transferases (GSTs) and teratogenicity of cyclophosphamide were investigated in rats. Pregnant rats were orally treated with BHA (50 mg/kg) for 7 days, from days 6 to 12 of gestation, and intraperitoneally challenged with cyclophosphamide (15 mg/kg) 2 hr after the final treatment. On day 20 of gestation, the maternal and fetal abnormalities were examined. Separately, a part of rats was sacrificed for the assay of hepatic and placental GSTs activities on day 12 of gestation following 7-day treatment with BHA. Cyclophosphamide, administered on day 12 of gestation, induced 43.2% of fetal death and resorption, and 100% of malformations in live fetuses, in contrast to low fetal resorption (8.7%) and malformations (8%) in control group. The malformations include cranial defect and exencephaly (100%), micrognathia and tongue extrusion (100%), limb defects (40%), renal pelvic dilatation (39%), and cleft palate (15%). Interestingly, BHA induced GSTs activities by 62% and 46% over the control in liver and placenta, respectively, and remarkably reduced the fetal resorption (13.9%) and malformations, resulting in 62% of cranial defect and exencephaly, 68% of micrognathia and tongue extrusion, 29% of limb defects, and 14% of renal pelvic dilatation. Taken together, it is suggested that a long-term pretreatment with BHA could substantially prevent fetuses from abortion and malformations following intrauterine exposure to teratogens including cyclophosphamide by inducing phase II antioxidant enzymes such as GSTs.

• Korea-Australia Rheology Journal
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• 제20권4호
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• pp.235-243
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• 2008

The aim of this study is to explore the possibility of incorporating supercritical carbon dioxide ($scCO_2$) into twin screw extrusion process for the production of polypropylene-clay nanocomposite (PPCN). The $CO_2$ is used as a reversible plasticizer which is expected to rapidly transport polymeric chains into the galleries of clay layers in its supercritical condition inside the extruder barrel and to expand the gallery spacings in its sub-critical state upon emerging from die. The structure and properties of the resulting PPCNs are characterized using wide-angle X-ray diffraction (WAXD), transmission electron microscopy (TEM), rheometry, thermogravimetry and mechanical testing. In the processing of the PPCNs with $scCO_2$, optimum $scCO_2$ concentration and screw speed which maximized the degree of intercalation of clay layers were observed. The WAXD result reveals that the PP/PP-g-MA/clay system treated with $scCO_2$ has more exfoliated structure than that without $scCO_2$ treatment, which is supported by TEM result. $scCO_2$ processing enhanced the thermal stability of PPCN hybrids. From the measurement of linear viscoelastic property, a solid-like behavior at low frequency was observed for the PPCNs with high concentration of PP-g-MA. The use of $scCO_2$ generally increased Young's modulus and tensile strength of PPCN hybrids.

• 한국주조공학회지
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• 제17권5호
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• pp.494-501
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• 1997

In order to manufacture large rod preforms of 2014 Al alloy with a good mechanical property by spray forming method, it was spray-formed at a droplet temperature of $715^{\circ}C$, a droplet flight distance of 400mm, and a spraying angle of $35^{\circ}$. The rod preforms were extruded at $397^{\circ}C$ with the die temperature of $420^{\circ}C$ under the hot extrusion ratio 21:1 and T6 heat treatment was performed. The 2014 Al alloys cast by hot top process were also extruded and heat-treated at the same condition as a reference material. Microstructural observation and tensile test were carried out to investigate the effects of extrusion on microstructure and mechanical property of spray-formed Al alloy. Spray-formed Al alloys had many porosities due to inappropriate process conditions such as long droplet flight distance and low droplet temperature but have fine equiaxed grain. These porosities were reduced with decreasing in grain size by hot extrusion. Ultimate tensile strength and yield strength of spray formed-extruded 2014 Al alloy were inferior to those of the normal cast-extruded 2014 Al alloy, but elongations were superior. The control of porosity was important to get spray formed preform with a good mechanical property.

• 대한심미치과학회지
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• 제29권1호
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• pp.54-61
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• 2020

교정적 정출술(Forced orthodontic eruption, FOE)은 각화 치은과 치조골량을 증가시키는 비침습적인 치료 방법이다. 정출력에 의해 치아가 정출되면 치은 섬유와 치주 인대가 신장되고 조골 세포의 유도가 촉진되어 새로운 골형성이 일어나게 된다. 또한 치은 변연이 치관 방향으로 이동되면서 부착 치은의 폭경이 증가된다. 반면, 점막 치은 경계는 일정하게 유지가 된다. 이러한 치료 효과들로 인해 교정적 정출술은 implant site development를 위해 사용될 수 있다. 본 증례 보고에서는 외상으로 인한 치관 파절로 수복이 불가능한 상악 전치부를 교정적 정출술로 연조직 증대를 이룬 후 치조골 이식술(block bone grafting)과 임플란트 식립을 통해 심미적으로 수복한 증례를 통해 교정적 정출술의 효과를 기술하고자 한다.