Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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The Conversion of Ginsenosides by Extrusion Molding

압출성형에 의한 ginsenoside의 변환

  • Ryu, Jae-Hyung (Department of Molecular Biotechnology, Kangwon National University) ;
  • Li, Chun-Ying (Department of Molecular Biotechnology, Kangwon National University) ;
  • Ahn, Moon-Sub (Gangwon Provincial Agricultural Research & Extension Services) ;
  • Kim, Jang-Won (Department of Molecular Biotechnology, Kangwon National University) ;
  • Kang, Wie-Soo (Department of Agricultural Engineering, Kangwon National University) ;
  • Rhee, Hae-Ik (Department of Molecular Biotechnology, Kangwon National University)
  • Published : 2008.06.30
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Abstract

Ginseng treated with several treatment conditions of various acids to search hydrolysates on the basis of increased biological activity and modified structure. In the result of acid treatment, the conversion rate of ginsenoside Rg3, Rk1 and Rg5 was highest when ginseng treated with citric acid. After added citric acid to ginseng extract, boiled at l00$^{\circ}C$ for 1 hour and add enzyme, which is examined change by time. It compared with group which did not treated acid. Two groups became difference according to enzyme but the generation rate of ginsenoside Rg3, Rk1 and Rg5 did not show difference greatly. Also, the generation rate of ginsenoside Rg3, Rk1 and Rg5 by time passes did not show difference. The generation rate of ginsenoside Rg3, Rk1 and Rg5 increased when increased acid concentration, temperature and time. We did exclusion molding to shorten treatment time. In the result of ginseng treated with citric acid of various concentrations at various temperatures as time passes by extrusion molding, the generation rate of ginsenoside Rg3, Rk1 and Rg5 was highest when ginseng treated with 3% citric acid at l60$^{\circ}C$ for 20 minutes. In addition, total saponin amount of ginseng treated with 3% citric acid at 160$^{\circ}C$ for 20 minutes was about 11% higher than ginseng heated at 120$^{\circ}C$ for 3 hours. These results indicated that our exclusion molding process more effective, compared to traditional red ginseng manufacturing process.

Keywords

References

  1. Jeon, H. K., Kim, S. C. and Jung, N. P. (1991) Effects of ginseng saponin fraction and cyclophosphamide on the tumoricidal activity of mouse macrophage and the antitumor effect. Korean J. Ginseng Sci. 105, 15-99
  2. Kim, M. J. and Jung, N. P. (1987) The effect of ginseng saponin on the mouse immune system. Korean J. Ginseng Sci. 11, 130-135
  3. Kang, S. Y. and Kim, N. D. (1992) The antihypertensive effect of red ginseng saponin and the endothelium-derived vascular relaxation. Korean J. Ginseng Sci. 16, 130-135
  4. Joo, C. N and Kim, J. H. (1992) Study on the hypoglycemic action of ginseng saponin on streptozotocin induced diabetic rats( I ). Korean J. Ginseng Sci. 16, 190-197
  5. Oliveira, A. C. C., Perez, A. C., Merino, G., Prietp, J. G. and Alvarez, A. I. (2001) Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise. Comparative Biochemistry and Physiology Part C. 130, 369-377
  6. Kim, J. S. and Kim, K. W. (1996) Screening of antioxidative components from red ginseng saponin. Korean J. Ginseng Sci. 20, 173-178
  7. Hasegawa, H., Sung, J. H., Matsumiya, S. and Uchiyama, M. (1996) Main Ginseng Saponin Metabolites Formed by Intestinal Bacteria. Planta Medica. 62, 453-457 https://doi.org/10.1055/s-2006-957938
  8. Karikura, M., Miyase, T., Tanizawa, H., Taniyama, T. and Takino, Y. (1991) Studies on absorption, distribution, excretion and metabolism of ginseng saponins. . The decomposition products of ginsenoside Rh2 in the stomach of rats. Chem. Pharm. Bull. 39, 400-404 https://doi.org/10.1248/cpb.39.400
  9. Tawab, M. A., Bahr, U., Karas, M., Wurglice, M. and Schubert-Zsilavecz, M. (2003) Degradation of ginsenosides in hymans after oral administration. Drug Metab. Dispos. 31, 1065-1071 https://doi.org/10.1124/dmd.31.8.1065
  10. Hasegawa, H., Sung, J. H. and Benno, Y. (1997) Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta Medica 63, 436-440 https://doi.org/10.1055/s-2006-957729
  11. Hasegawa H. and Uchiyama M. (1998) Antimetastatic efficacy of orally administered ginsenoside Rb1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite. Planta Medica 64, 696-700 https://doi.org/10.1055/s-2006-957560
  12. Akao, T., Kanaoka, M. and Kobashi, K. (1998) Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration measurement of compound K by enzyme immunoassay. Biol. Pharm. Bull. 21, 245-249 https://doi.org/10.1248/bpb.21.245
  13. Han, B. H., Park, M. H., Han, Y. N., Woo, L. K. Sankawa, U. and Tanaka, O. (1982) Degradation of ginseng saponins under mild acidic conditions. Planta Med. 44, 146-149 https://doi.org/10.1055/s-2007-971425
  14. Jeong, H. P. (2004) Sun Ginseng-A new processed ginseng with fortified activity. Food Industry and Nutrition. 9, 23-27
  15. C.M. Lai, S.P. Li, H. Yu, J. B. Wan, K. W. Kan, Y. T. Wang (2006) A rapid HPLC-SI-MS/MS for qualitative and quantitative analysisof saponins in 'XUESETONG' injection. J. Pham and Bio analysis 40, 669-678 https://doi.org/10.1016/j.jpba.2005.11.003