• Maxillofacial Plastic and Reconstructive Surgery
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• 제23권1호
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• pp.77-81
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• 2001

경안명 괴사성 근막염은 높은 사망률을 가진 치명적인 질환이나 혈류가 풍부한 두경부에서는 거의 발생하지 않고 피부에 괴사를 보이지 않는 경우도 많아 두경부에 발생한 감염증의 진단시에 그 가능성을 고려하지 않는 오류를 범하기 쉽다. 따라서, 일단 발생한 경우 오진 또는 뒤늦은 진단으로 환자의 생명을 위협하게 될 수 있다. 이의 진단에는 임상적 검사상 촉진시 느껴지는 염발음이 가장 중요하고 이환 부위의 종창, 악취, 지저분하고 창백하며 붉은 빛을 띠는 피부 표면의 모습, 절개 시 회색빛의 구정물과 같은 삼출물 등이 참고자료가 될 수 있으며, 컴퓨터 단층사진의 촬영을 통해 피하조직의 공기 방울이나 공기 주머니를 확인하고 hemolytic Streptococci등의 균배양 결과를 종합적으로 판단함으로써 더욱 정확한 진단이 가능해지고, 치료방법으로는 빠르고 광범위한 외과적 처치와 대량의 항생제 투여가 가장 중요하고 고압산소요법 등 기타 보조적 처치법을 적절히 시행한다면 좋은 결과를 얻을 수 있을 것으로 사료되었다.

• 한국운동역학회지
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• 제21권5호
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• pp.653-660
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• 2011

The purpose of this study was to compare selected kinematic variables between male medalists and a Korean male javelin thrower at the IAAF World Championships, Daegu 2011. The three medalists and one Korean javelin thrower that participated in the Championships were videotaped using three high-speed cameras (300 frames/s, EX-F1 Exilim, Casio, Japan). The results showed that the release and attitude angles of the Korean male javelin thrower (KMJT) were greater than that of the medalists, whereas the attack angle of the KMJT was smaller than that of the medalists. This study also found that the KMJT clearly had a lower release height than the medalists. As a possible adaptation of his physique to the skill, the KMJT used a small trunk inclination angle and produced greater inclination angles at his upper extremities. These results may be linked to an increase in the release angle of the KMJT. There were some difference between the KMJT and the medalists in terms of the length and duration of the delivery phase. In harmony with the shorter length of the delivery phase, its duration was shorter for the KMJT in comparison to the medalists. Because the delivery stride is considered to be a primary generator of endpoint speed, this decrease in the delivery phase time would decrease the javelin velocity at release. The amount of time taken in the delivery phase may be a critical factor to enhance a javelin thrower's performance. Thus, rhythmic movement training specifically designed for the KMJT will help him attain an optimal throwing position.

• 대한소아치과학회지
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• 제32권4호
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• pp.682-686
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• 2005

색소실조증(Incontinentia pigmenti)은 신생아기에 체간과 사지에 소수포가 발생하여 1세경이 되면 수포는 더 이상 생기지 않고 갈색반점이 나타나는 특징을 보이는 아주 드문 질환이다. Bloch-Sulzberger syndrome이라고 불리는 이 질환은 반성 우성 유전질환으로 대부분 여성에게 나타나며, 외배엽, 중배엽 기원 조직들인 눈, 치아, 피부, 손톱, 가슴, 머리카락, 신경계 등에 이상을 동반한다. 본 증례는 유치의 선천적 결손을 주소로 내원한 환아의 문진 중 색소실조증의 사실을 발견하고 검사한 결과, 다수의 유치와 영구치의 선천적 결손과 치아의 형태이상, 상악의 열성장, 치아의 형태이상과 악골 성장의 부조화 등으로 인한 교합불안정을 보이고 있었다. 전신적으로는 망막이상을 보여 수술을 시행한 상태이며, 피부에는 특징적 인 갈색반점을 보였다. 현재 치아결손부의 공간관리와, 심미적, 심리적인 문제의 해결, 그리고 기능의 회복을 위해 가철식 부분의치를 장착해주었으며, 계속적인 관찰을 하고 있다.

• Journal of Yeungnam Medical Science
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• 제28권1호
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• pp.70-76
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• 2011

Rhabdomyosarcomas are soft tissue sarcomas; while extremely rare in adults, they are one of the most common neoplasms in children and adolescents. Histologically, they can be classified into embryonal (ERMS), alveolar (ARMS), pleomorphic, and undifferentiated types. The ARMS type is very rare, and is associated with a poor prognosis. Common primary sites of ARMS are the trunk and extremities. We report on a case of paraaortic, supraclavicular, and axillary lymph node metastasis from paratesticular ARMS treated with VAC (vincristine, dactinomycin, cyclophosphamide)/ IE(ifosfamide, etoposide) chemotherapy in a young adult. Administration of six cycles of chemotherapy with VAC/IE resulted in complete remission. The patient has maintained complete remission over the past 27 months.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.279-289
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• 1995

This study was designed 1) to develop a hypertensive animal model in which the blood pressures (BPs) of symmetric regions (right and left upper extremities) are significantly different and 2) to test the effect of BP per se on the contractility and endothelium-dependent relaxation of vascular smooth muscle. Rabbits were anesthetized with sodium pentobarbital and ventilated with room air via animal respirator. The transverse aorta was exposed through the left second intercostal space and the lumen of the aorta was narrowed partially by ligation using 3-0 silk and a probe at a point between the origins of the brachiocephalic trunk and the left subclavian artery. Four to eight weeks postoperatively, BPs were measured in the carotid artery as the high BP area (proximal to coactation site) and in the femoral artery as the low BP area (distal to coarctation site). In the animal model, pressure-overload hypertension was developed and the BP of the right subclavian artery was higher than that of the left subclavian artery. The concentrations of circulating epinephrine, norepinephrine, angiotensin I, and angiotensin II were measured. The right and left subclavian arteries and their branches were used for isometric tension recording in organ baths and their responsiveness to phenylephrine, serotonin, acetylcholine, and sodium nitroprusside were examined. The BPs of carotid and femoral artery in control animals were $116{\pm} 12/75{\pm}9\;mmHg (mean ${\pm}SEM$) and $130{\pm}16/68{\pm}9\;mmHg$ respectively, while those of carotid and femoral artery in the hypetensive animals were $172{\pm}6/111{\pm}10\;mmHg$ and 136{\pm} 4/100 {\pm}9\;mmHg$ respectively. There were no significant differences in the concentrations of circulating epinephrine, norepinephrine, angiotensin I, and angiotensin II between controls and the animal models. No significant differences were found in the vascular sensitivities to phenylephrine and serotonin between the high pressure-exposed vessels and the low pressure-exposed vessels. However, the endothelium-dependent relaxation to acetylcholine and nitroprusside-induced relaxation showed significant differences between the high pressure-exposed and the low pressure-exposed subclavian arteries. From the above results, we suggest that the contractility of vascular smooth muscle is unchanged by the elevated pressure per se. However, the endothelium-dependent relaxation to acetylcholine and the nitroprusside-induced relaxation are attenuated by pressure.

• Journal of Chest Surgery
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• 제32권5호
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• pp.456-460
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• 1999

배경: 다한증에 대한 흉부교감신경절제술은 흉강경기구 및 수술술기 발달로 효과적인 치료방법으로 인식되고 있으나 보상성 다한증으로 그 만족도가 떨어지고 있다. 따라서 저자들은 수술결과 및 보상성 다한증을 분석하고자 하였으며 수술전후 손과 발의 온도 차이 그리고 상지와 하지의 혈류량을 측정하였다. 대상 및 방법: 1995년 12월부터 1998년 7월까지 강남성모병원에서 총 47명의 다한증환자를 흉강경하에 교감신경절제술을 시행하였다. 수술전후로 손가락 및 발가락에서 온도변화를 측정하였고, 혈류량 측정은 도플러 초음파검사로 손가락동맥, 요골동맥, 그리고 족배동맥에서 측정하였다. 결과: 수술사망은 없었으며, 기흉 7건, 재발 3건, 안검하수 1건등의 합병증이 있었다. 보상성 다한증은 수술한 환자의 95%에서 있었으며 이중 5명이 수술을 후회하였다. 족부 다한증은 흉부교감신경절제술후 46%에서 향상되었고, 수술전후 온도변화는 우측 손에서 1$^{\circ}C$, 좌측 손에서 1.9$^{\circ}C$였고 통계적으로 의미있게 증가하였다. 그러나 족부 다한증에서는 의미있는 온도차이가 없었다. 혈류량은 손에서 의미있게 증가하였으나 발에서는 차이가 없었다. 결론: 다한증의 흉부 교감신경절제술은 안전하고 효과적인 치료이지만 그 만족도는 보상성 다한증에 의해 감소하고 있으므로 수술전에 보상성 다한증에 대하여 충분히 설명하는 것이 중요하다. 족부 다한증은 생리적 변화에 의한 것이라기 보다는 정신적 안정에 의한 것으로 보인다.

• 대한한방내과학회지
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• 제45권2호
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• pp.208-218
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• 2024

We report a case of generalized dystonia that developed from oromandibular dystonia and improved following Korean medicine treatment. The patient was hospitalized for 18 days and treated with herbal medicine, mainly Hyeongbangsabaek-san and Soyangbowi-tang, acupuncture, electroacupuncture, pharmacopuncture, cupping, and moxibustion. To evaluate the clinical effects of the treatment, we used the Unified Dystonia Rating Scale (UDRS) and Global Dystonia Severity Rating Scale (GDS) and checked dyskinesia occurrence in a diary recorded by the patient's guardian. After 18 days of hospitalization, the UDRS for the trunk, upper extremities, and lower face improved by more than 50%, and the GDS for the whole region, except the larynx and lower face, also improved. In addition, the maximum duration of dystonia decreased from 6 hours to 3 hours, and the pain and numbness associated with dystonia disappeared. This case suggests that Korean medicine treatment is effective in treating generalized dystonia.

• Archives of Plastic Surgery
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• 제34권5호
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• pp.659-662
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• 2007

Purpose: Multiple skin leiomyoma and uterine myoma bearing autosomal dominant traits are benign smooth muscle tumors which originate in skin or female uterus. Skin leiomyoma occurs after gene mutation originating from arrector pili muscle of hair follicle where its clinical manifestations vary significantly from person to person. Our department hereby reports the histological findings and genetic evaluations of this very rare disease. Methods: A 57-year-old woman presented in our institute with multiple tumors in the left and central parts of her back that started to appear since 19 years ago. The patient was diagnosed as having uterine myoma 15 years ago and underwent hysterectomy. Biopsy has been done on the specimen, and genomic DNA was separated from Fumarate hydratase gene for it to go through PCR amplification. The results of PCR amplification were aligned by sequencer. Results: According to the results of biopsy, tumor cells were spindle-shaped and were aligned in a bundle where there was no dysplasia or mitosis. Moreover, these cells had abundant eosinophilic cytoplasm with elongated nucleus, and benign leiomyoma that showed positive reactions to SMA stain were found. In genetic examination, mutations such as heterozygous single nucleotide substitutions were found in alignments of amplified DNA. Conclusion: Multiple skin leiomyoma and uterine myoma are relatively uncommon diseases that are transmitted through autosomally dominant traits from genetic mutations. When a patient's chief complaint lies upon skin-colored or brown masses that occur in multiples appearing in the trunk or extremities with characteristic clinical symptoms and histological findings, and when the patient's family history is acknowledged such as skin or uterine leiomyoma or renal tumor, necessary genetic examination on multiple skin leiomyoma and uterine myoma could be done, and thereby precise diagnosis could also be made.

• Archives of Reconstructive Microsurgery
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• 제8권1호
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• pp.35-43
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• 1999

저자들은 1988년부터 1998년까지 시행한 252예의 유리피판술 중 9예에서 미세혈관 문합부의 혈전 등의 이유로 실패하였으며, 이들 중 두경부 및 하지의 7예에서는 첫 수술 4-16일 사이에 제 2의 유리피판술을 성공적으로 시행하여 환부를 치유시키고, 처음에 계획하였던 수술적 목표를 달성하였다. 수부의 2예는 환자 및 보호자와 충분한 상의하여 원거리 피판과 피부이식 등 고식적인 치료 방법을 선택하였다. 수부의 경우는 다른 부위보다 고식적 치료 방법이 덜 부담되었던 것으로 생각되었으며, 두경부와 하지는 환부의 특성상 제 2의 유리 피판술이 최선의 선택으로 생각되었다. 유리 피판술이 실패한 환부에서 계속된 제 2의 유리 피판술을 시행하는 것은, 처음의 수술보다 면밀한 술전 계획과 준비, 완벽한 수술, 수술후의 철저한 환자 관리가 요구되었으나, 이들 환부의 처치에 매우 효과적이고 환자의 기대에 부응할 수 있는 방법이라고 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.81-85
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• 2016

Globally, the burden of breast cancer (BC) continues to increase. BC related lymphedema (BCRL) is currently non curable and as a life time risk it affects at least 25% of BC patients. Knowing more about BCRL and appropriate control of its modifiable risk factors can improve quality of life (QOL) of the affected patients. In this case control study to detect factors, 400 women with BCRL (as the case group) and 283 patients with BC without lymphedema (as the control group) that were referred to Shiraz University of Medical Sciences affiliated BC clinic center were assessed. The data were analyzed in SPSS. The mean age of the case group was $52.3{\pm}11.0years$ and of the control group was $50.1{\pm}10.9years$. In patients with BCRL, 203(50.7%) had left (Lt) side BC and in non- lymphedema group 151 (53.3%) had Lt side BC. Out of all BCRL patients, 204 (51%) had lymphedema in all parts of their affected upper extremities, 100 (25%) had swelling in the arm and forearm and 23 (5.7%) had edema in both the upper extremity and trunk. Edema, heaviness, concern about changing body image, pain and paresthesia were the most common signs/symptoms among patients with BCRL. In BCRL patients, the difference of circumference between the affected upper limb and non-affected limb was $4.4{\pm}2.5cm$ and the difference in volume displacement was $528.7{\pm}374.4milliliters$. Multiple variable analysis showed that moderate to severe activity (OR; odds ratio =14, 95% CI :2.6-73.3), invasiveness of BC (OR =13.7, 95% CI :7.3-25.6), modified radical mastectomy (OR=4.3, 95% CI :2.3-7.9), BMI =>25 (OR=4.2, 95% CI :2-8.7), radiotherapy (OR=3.9, 95% CI :1.8-8.2), past history of limb damage (OR=1.7, 95% CI :0.9-3.1) and the number of excised lymph nodes (OR=1.06, 95% CI :1.02-1.09) were the significant predictors of lymphedema in women with BC. Modifiable risk factors of BCRL such as non-guided moderate to severe physical activity, high BMI and trauma to the limb should be controlled as early as possible in BC patients to prevent development of BCRL and improve QOL of these patients.