• 대한한의학회지
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• 제21권3호
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• pp.225-230
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• 2000

In a complete oculomotor nerve palsy, patients show ptosis(paresis of the levator), abduction(paresis of the medial rectus and compensatory overaction of the lateral rectus) and dilated pupils. In oculomotor nerve palsy, the functions of four of the six extraocular muscles are compromised and its treatment is the most difficult problem in the paralytic strabismus. Currently, if the condition of the oculomotor nerve palsy is not improved within a year, surgical correction can be attempted. We experienced an improved case of the oculomotor nerve palsy in a Benedikt's syndrome patient treated with oriental medicine. We used herbal medicine and acupuncture. Based on this experience, it is considered that oriental medicine can be applied to the treatment of the oculomotor nerve palsy. Oculomotor nerve, Palsy, Ptosis, Abduction, Benedikt's syndrome.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권6호
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• pp.677-680
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• 2000

Orbital injuries are common with facial trauma. Direct injuries to the globe are not rare but it can result in complications such as chemosis, subconjunctival hemorrhage and hyphema. Periorbital trauma or injuries to the extraocular muscles and blow-out fracture may result in lid edema, ecchymosis & ptosis and diplopia or limitation of ocular motion respectively. Indirect injuries to the optic nerve come up without any injuries but its complication is irreversible and severe such as loss of vision. The aim of this study is to review the literature on blindness or ptosis following facial trauma and present the cases of blindness after facial trauma and ptosis after mandibular fracture without specific clinical findings.

• 동의신경정신과학회지
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• 제12궈1호
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• pp.201-207
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• 2001

Oculomotor nerve is the third cranial nerve, controlls four of the six extraocular muscles(superior rectus muscle, medial rectus muscle, inferior rectus muscle and inferior oblique muscle), levator palpebrae superioris muscle, cilliary muscle and muscle sphincter pupillae. In the oculomotor nerve palsy, limited oculogyration, diplopia, blepharoptosis, accomodation paralysis and mydriasis can be occured. We experienced an improved case of the oculomotor nerve palsy patient treated with oriental medicine for 25days. We used herbal medicine and acupuncture. Based on this experience, it is considered that oriental medicine can be applied to the treatment of the oculomotor nerve palsy.

• Annals of Clinical Neurophysiology
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• 제8권1호
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• pp.78-80
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• 2006

Miller-Fisher syndrome, Guillain-Barre syndrome with ophthalmoplegia, Bickerstaff s brainstem encephalitis and acute ophthalmoplegia share some clinical features, and common anti-GQ1b IgG antibody and these are introduced as anti-GQ1b antibody syndrome. These syndromes mostly present with paralysis of extraocular muscles and internal ophthalmoplegia rarely occurs. We report a case of acute isolated bilateral internal ophthalmoplegia associated with anti-GQ1b IgG antibody.

• 대한유전성대사질환학회지
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• 제22권2호
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• pp.37-45
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• 2022

Inherited metabolic disorders (IMD) are a large group of rare disorders affecting normal biochemical pathways. The ophthalmic involvement can be very varied affecting any part of the eye, including abnormalities of cornea, lens dislocation and cataracts, retina and the optic nerve, and extraocular muscles. Eye disorders can be initial symptoms of some IMD and can be clue for diagnosis of IMD. However, eye disorders can evolve later in the natural history of an already diagnosed metabolic disorder. Awareness of IMDs is important to facilitate early diagnosis and in some cases instigate early treatment if a patient presents with eye involvement suggestive of a metabolic disorder. Ophthalmological interventions are also an important component of the multisystem holistic approach to treating patients with metabolic disorders.

• 대한두개안면성형외과학회지
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• 제13권2호
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• pp.99-103
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• 2012

Purpose: Many surgical methods for reconstruction of orbital floor fracture have been reported, which include subciliary approach, transconjunctival approach, transantral and transnasal endoscopic approach, etc. The purpose of this study is to demonstrate a surgical technique and analyze the results of transnasal endoscopic approach with Foley catheter ballooning without implantation of artificial surgical material through subciliary approach. Methods: Between February 2007 and November 2010, 29 orbital floor fracture patients, who had no herniated muscles through bone fragments, were treated through transnasal endoscopic approach with Foley catheter ballooning. Under the endoscopic view, the operator identified the opening of maxillary sinus. After widening of the opening using forceps, the operator reduced the fragmented bone with curved suction tip. Thereafter, 18-Fr Foley catheter was inserted. Four weeks after the operation, the catheter was removed. Results: Preoperatively, 6 patients had diplopias, 4 patients had limitations of extraocular motions and 3 patients had enophthalmos. After removal of the Foley catheter 4 weeks after the operation, 2 patients had diplopias, 1 patient had a limitation of extraocular motion, 1 patient has an enophthalmos and 1 patient had numbness on the cheek. These symptoms were resolved about 6 months after the surgery. Conclusion: The operative technique of Foley catheter ballooning through transnasal endoscopic approach without implantation of the artificial surgical material through subciliary approach can be considered one of the appropriate techniques for orbital floor fracture.

• The Korean Journal of Physiology
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• 제2권2호
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• pp.75-81
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• 1968

According to recent observations of Cohen et al. the patterns of vestibular eye movements of rabbits are different from those of cats. However, the causes of such difference of the reflex eye movements in these species are not wholly explained. While the accumulated data obtained from cats appear to be established, experimental evidences in rabbits are rather meager. The author had re-examined the reflex eye movements of rabbits and attempted to find a mechanism which causes such difference in the reflex eye movements between two species. In anesthesized rabbit, unilateral individual semicircular canal nerve was stimulated selectively with a fine insulated electrode which was inserted through a hole made on the corresponding osseous canal, under a dissecting microscope. When an individual canal nerve was stimulated, the reflex movements of both eyes were observed, photographed, and recorded kymographically. Extraocular muscles were also studied to find their morphological characteristics and to correlate them with the function of the muscles. 1. At the beginning of the stimulation, both eyes moved to a specific direction depending upon the canal stimulated, and such directional eye movements were sustained during the whole course of stimulation. Amplitude of the eye movement showed graded responses to the increasing frequency of the stimulus, reaching to the maximal response at 200-300 cps. 2. Stimulation of the unilateral horizontal canal nerve caused conjugate eye movements, which was also observed in cats and other species by other investigators. 3. Stimulation of the unilateral vertical canal nerve caused a pattern of non-conjugate eye movements, which are different from those observed in cats. Such different patterns of vestibular eye movements in two different species are ascribable to the functional difference of the inferior and superior oblique muscles.

• 생명과학회지
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• 제18권8호
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• pp.1059-1065
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• 2008

KIF21A는 kinesin superfamily에 속하는 분자 motor로서 미세소관을 따라서 분비소포를 운반한다. 최근의 연구결과 KIF21A 유전자 일부의 missense 돌연변이에 의하여 congenital fibrosis of the extraocular muscles (CFEOM) 1의 유발됨이 밝혀졌다. CFEOM1은 KIF21A의 돌연변이로 인하여 분화 발생과정에 occulo-motor신경과 neuromuscular junction 형성에 필요한 단백질을 이동시키지 못함으로써 유발된다. 본 연구에서는 효모 two-hybrid system을 사용하여 KIF21A의 WD-40 repeat domain과 결합하는 분자량이 작은 Purkinje cell protein-1 (Pcp-2), 또는 L7으로도 알려진 단백질을 분리하였다. Pcp-2는 효모 two-hybrid assay에서 KIF21A와 KIF21B의 WD-40 영역과는 결합하지만 다른 종류의 KIFs와는 결합하지 않았다. 또한 단백질간의 특이적 결합을 pull-down assay로 확인하였으며, 생쥐의 뇌 파쇄액에 Pcp-2 항체로 면역침강을 행하여 KIF21A를 확인한 결과 Pcp-2와 같이 침강하였다. 이러한 결과들은 KIF21A는 Pcp-2와 결합하며, 또한 Pcp-2는 KIF21A의 adaptor 단백질로서 세포 내 KIF21A의 수송에서 매개 단백질로 작용함을 시사한다.

• 한국안광학회지
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• 제15권1호
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• pp.117-122
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• 2010

목적: 정상인 청년 62명(남: 29, 여: 33)을 대상으로 단안운동과 양안운동 시에 외안근의 운동력을 조사하고자 실시하였다. 방법: 단안운동력 검사에서는 우 좌안의 내전과 외전 그리고 상전과 하전능력을 제 l안위에서의 각막윤부를 기점으로 한 둔동거리로 측정하였고 양안운동력 검사에서는 우 좌안의 상사근과 하사근의 운동능력을 각막 윤부간 거리차로 측정하였으며 데이터 값은 고해상도 디지털 카메라를 이용하여 사진데이터를 얻은 후 high resolution digital image process를 거쳐 처리하였다. 결과: 조사대상 남여의 단안운동기능은 우 좌안에서 각각 외전능력은 (남) 9.35 mm. 9.75 mm. (여) 9.02 mm. 9.52 mm 이고, 내전능력은 (남) 10.23 mm. 10.16 mm, (여) 10.17 mm, 10.07 mm이었으며 상전능력은 (남) 7.01 mm, 6.91 mm, (여) 6.98 mm, 6.64 mm이고 하전능력은 (남) 7.52 mm. 6.82 mm, (여) 7.52 mm, 6.67 mm이었다. 조사대상자의 양안운동기능은 우 좌안에서 각각 하사근은 54.8% 기능항진, 45.1% 기능저하/67.7% 기능항진, 32.2% 기능저하이고, 상사근의 경우는 64.5% 기능항진, 35.5% 기능저하/58.1% 기능항진, 41.9% 기능저하이었다. 결론: 수평운동능력이 수직운동능력보다 더 우세하였으며, 수평운동에서는 내전능력이 외전능력보다 약간 더 우세하였고 수직운동에서는 하전능력이 상전능력보다 약간 더 우세하였다. 우 좌안의 하사근 모두 기증항진의 경우가 더 높은 비율로 나타났다.

• Annals of Clinical Neurophysiology
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• 제4권1호
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• pp.60-62
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• 2002

Two separate cranial nerve variants of Guillain-Barre syndrome(GBS) have been reported. One is Miller-Fisher syndrome, the other is polyneuritis cranialis. Involvement of the extraocular muscles in variants of GBS is well recognized, but complete external and internal opthalmoplegia is rare. Optic neuritis remains the only consistent, albeit very uncommon, evidence of inflammation of central nervous system myelin in GBS. This propose that GBS is part of a spectrum of central and peripheral inflammation. This case is an unusual clinical variant who had ptosis, opthalmoplegia, areflexia, ataxia, optic neurritis, marked oropharyngeal, and neck and shoulder weakness. This combined regional from is able to misdiagnose initially as botulism or diphtheria and less so, myasthenia. So if we were consider variant from of GBS, it is possible for make a correct diagnosis more easily and treatment without delay.