• Korean Journal of Digital Imaging in Medicine
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• v.15 no.2
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• pp.63-68
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• 2013

Purpose : The relaxation times of tissue in MRI depend on strength of magnetic field, morphology of nuclear, viscosity, size of molecules and temperature. This study intended to analyze quantitatively that materials' temperatures have effects on T1 and T2 relaxation times without changing of other conditions. Materials and Methods : The equipment was used MAGNETOM SKYRA of 3.0T(SIEMENS, Erlagen, Germany), 32 channel spine coil and Gd-DTPA water concentration phantom. To find out T1 relaxation time, Inversion Recovery Spin Echo sequences were used at 50, 400, 1100, 2500 ms of TI. To find out T2 relaxation time, Multi Echo Spin Echo sequences were used at 30, 60, 90, 120, 150, 180, 210, 240, 270 ms of TE. This experiment was scanned with 5 steps from 25 to $45^{\circ}C$. next, using MRmap(Messroghli, BMC Medical Imaging, 2012) T1 and T2 relaxation times were mapped. on the Piview STAR v5.0(Infinitt, Seoul, Korea) 5 steps were measured as the same ROI, and then mean values were calculated. Correlation between the temperatures and relaxation times were analyzed by SPSS(version 17.0, Chicago, IL, USA). Results : According to increase of temperatures, T1 relaxation times were $214.39{\pm}0.25$, $236.02{\pm}0.87$, $267.47{\pm}0.48$, $299.44{\pm}0.64$, $330.19{\pm}1.72$ ms. T2 relaxation times were $180.17{\pm}0.27$, $197.17{\pm}0.44$, $217.92{\pm}0.39$, $239.89{\pm}0.53$, $257.40{\pm}1.77$ ms. With the correlation analysis, the correlation coefficients of T1 and T2 relaxation times were statistically significant at 0.998 and 0.999 (p< 0.05). Conclusion : T1 and T2 relaxation times are increased as temperature of tissue goes up. In conclusion, we suggest to recognize errors of relaxation time caused local temperature's differences, and consider external factors as well in the quantitative analysis of relaxation time or clinical tests.

• Korean Journal of Ichthyology
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• v.27 no.1
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• pp.26-32
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• 2015

The histological structure of the heart in Pseudorasbora parva was investigated by light microscope. The heart consisted of four consecutive chambers, the sinus venosus, atrium, ventricle and bulbus arteriosus. The wall of the sinus venosus was divided into endocardium, myocardium and epicardium, and the walls of the atrium and ventricle were divided into endocardium, subendocardium, myocardium, subepicardium and epicardium, and the wall of the bulbus arteriosus was divided into endocardium, subendocardium (ridge tissue), middle layer, subepicardium and epicardium. The valves were observed in the sinoatrial, artrioventricular and bulboventricular junctions. The sinus venosus wall was mostly made up of collagen. The rings of tissue were observed at the sinoatrial junction. The atrium was composed of a spongy trabeculate myocardium surrounded by an external rim of thin myocardium, and collagens were distributed in the subepicardium and trabeculae. The ventricle was a spongy myocardium with vessels in subepicardium. In the subepicardium and trabeculae of the ventricle, collagens were distributed. In the bulbus arteriosus, the diameter and length of the ridges were differed. The endocardial cells were convex and the non-clustered subendocardial cells showed irregular shapes. The cells of the middle layer were arranged into incomplete layers that showed different orientations. The subepicardium was formed by cells of different morphology. Collagens and elastins were demonstrated in the subendocardium, middle layer and subepicardium of the bulbus arteriosus. The epicardium was a single layer composed of flattened cells.

• Journal of Acupuncture Research
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• v.26 no.5
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• pp.65-75
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• 2009

Objectives : Pyrite is one of the important prescriptions that has been used in oriental medicine for healing of fracture. It is reasonable, therefore, to postulate that native copper affects the process of bone metabolism and bone formation. The purpose of this study is to discover the effect of Pyrite on the healing of tibia fracture. Methods : 1. In vitro test : MG-63 cell in human body and the Pyritum in the ratio of 0.5mg/ml, 1.0mg/ml, 1.5mg/ml, 2.0mg/ml were incubated for 24 hours. After 24 hours, RNA was extracted via trizol reagent (Sigma, USA). In order to understand the activation of osteoblast, the level of OPN mRNA, osteopontin, was measured. 2. In vivo tesgroups normal group, control group and experimental group. Left tibia bones of mice in CON and JT groups were fractured by bone cutters. Pyrite was orally administered to the experimental group. After 14 days, each group's tibia specimen was constructed to observe changes in activation of proinflmmatory cytokines in relation to MIF and IL-6. Also, proliferation of osteoblast and osteopontin were measured via changes in levels of OPN and OPN mRNA. Results : In jn-Titro test, the level of OPN mRNA, osteopontin production was remarkably increased in Pyritum-treated MG-63 cells. In in-vitro test, fractured area in external tibia morphology was increased more in the JT group than that of the CON group. Osteogenesis, endochodrial ossification, and osteoid in fractured area were also increased more in the JT group than that of the CON group. Increase in OPN mRNA, osteopontin level and osteoblast's proliferation were observed. Activation of MIF and IL-6 was confirmed from the fracture region. Conclusions : From the result, development of a new stimulator in healing fracture via pyrite is expected.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.49-54
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• 2014

Background: Hydrogels are a class of polymers that can absorb water or biological fluids and swell to several times their dry volume, dependent on changes in the external environment. In recent years, hydrogels and hydrogel nanocomposites have found a variety of biomedical applications, including drug delivery and cancer treatment. The incorporation of nanoparticulates into a hydrogel matrix can result in unique material characteristics such as enhanced mechanical properties, swelling response, and capability of remote controlled actuation. Materials and Methods: In this work, synthesis of hydrogel nanocomposites containing magnetic nanoparticles are studied. At first, magnetic nanoparticles ($Fe_3O_4$) with an average size 10 nm were prepared. At second approach, thermo and pH-sensitive poly (N-isopropylacrylamide -co-methacrylic acid-co-vinyl pyrrolidone) (NIPAAm-MAA-VP) were prepared. Swelling behavior of co-polymer was studied in buffer solutions with different pH values (pH=5.8, pH=7.4) at $37^{\circ}C$. Magnetic iron oxide nanoparticles ($Fe_3O_4$) and doxorubicin were incorporated into copolymer and drug loading was studied. The release of drug, carried out at different pH and temperatures. Finally, chemical composition, magnetic properties and morphology of doxorubicin-loaded magnetic hydrogel nanocomposites were analyzed by FT- IR, vibrating sample magnetometry (VSM), scanning electron microscopy (SEM). Results: The results indicated that drug loading efficiency was increased by increasing the drug ratio to polymer. Doxorubicin was released more at $40^{\circ}C$ and in acidic pH compared to that $37^{\circ}C$ and basic pH. Conclusions: This study suggested that the poly (NIPAAm-MAA-VP) magnetic hydrogel nanocomposite could be an effective carrier for targeting drug delivery systems of anti-cancer drugs due to its temperature sensitive properties.

• Journal of Sasang Constitutional Medicine
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• v.19 no.3
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• pp.30-50
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• 2007

1. Objectives Facial features are the important personal characteristics. As a study of all the standardization research about the morphology of face and head, this study was carried out to find the differences according to sex, age. 2. Methods We have collected 1140 cases of patients of the Sasang constitutional Department of Kyung-Hee Medical Center and Kangnam Kyung-Hee Oriental Hospital. we took pictures their frontal view, lateral view of face and measured height, breaths and projected length of face with Face Features Measurement Program(FFMP) and analyzed shape differences of face according to sex, age. 3. Results We got the morphologic characteristics of face according to sex, age. And we will upgrade the Sasangin Classification System by this Morphologic study of Head and Face. 4. Conclusions 1) The morphologic characteristics of face according to sex (1) A man's head is longer and wider than a woman's in most measurement. (2) A woman's eye is bigger in height than man's. (3) A woman's face is looked full-filled than man's. (4) A man's polion is higher than pupil but a woman's polion is lower than pupil. 2) The morphologic characteristics of face according to age (1) Young age's forehead is longer and higher than old age's. (2) Young age's eyebrow is wider than old age's (3) Young age's eye is bigger in height than old age's (4) Old age's nose is longer, wider and lower than young age's (5) Old age's ear is longer than young age's (6) Old age's bigonial breath is wider than young age's (7) Old age's low face is extinguished than you age's

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.31 no.6
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• pp.493-500
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• 2019

In this study, sensitivity analysis of sediment transport scaling factors in Delft3D-Morphology was performed to examine the effect those parameters on simulation results of cross-shore profile changes. For numerical experiments, one-year wave time series data which were observed in 2018 on the Maengbang coast in Gangwon prefecture were applied as external force. Bathymetric data observed in January and October of the same year were used as initial bathymetric data and annual bathymetric change data, respectively. The simulation performance of the model was evaluated based on the Brier Skill Score index for each part by dividing an arbitrary cross section within the calculation domain into the onshore and offshore parts. As a result, it was found thet the f_BED variable has a slight effect on the simulation results. The f_BEDW and f_SUSW variables show good simulation performance in onshore part when the value less than 0.5 is applied and vice versa. Among the experimental conditions, the optimal combinations of variables are f_BED = 1.0, f_BEDW = 1.0, f_SUSW = 0.1 for the onshore region and f_BED = 1.0, f_BEDW = 1.0, f_SUSW = 0.5 for the offshore region. However, since these combinations were derived based on the observation data on Maengbang beach in 2018, users should be careful when applying those results to other areas.

• Korean Journal of Ecology and Environment
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• v.33 no.4 s.92
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• pp.342-349
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• 2000

This paper demonstrates the influence of intensity of the monsoon on morpho-hydrological fluctuations in Taechung Reservoir during 1993${\sim}$1994. During the study, hydrological variables including rainfall, inflow, and discharge volume showed distinct contrast between 1993 and 1994. Interannaul differences in rainfall occurred during the monsoon in July${\sim}$August monsoon and influenced inflow, discharge, and water residence time (WRT). Total inflow in 1993 was four times greater than that of 1994, and summer inflow in 1993 was 8 times greater than summer 1994. Annual Mean WRT was 93.2 d in 1993 vs. 158.6 d in 1994 and the largest differences occurred between monsoons of 1993 and 1994. Morphometric variables reflected the interannual contrasts of hydrology, so that in 1993 surface area, total volume, shoreline development, and mean depth increased consistently from premonsoon to postmonsoon and over this same period in 1994 they decreased. This outcome indicates that the area of shallow littoral zones in 1993 was greater than in 1994. Also, the drainage area to surface area (D/L) at 80 m MSL was 60.7 which was much greater than values in Soyang and Andong reservoirs and natural lakes world-wide. The morpho-hydrodynamic conditions seemed to influence in-reservoir nutrient concentration which is one of the most important factors regulating the eutrophication processes. I believe, under the maximum hydrodynamic fluctuations in Korean waterbodies during the monsoon, applications of mass balance models to man-made lakes for assessments of external loading should be considered because the models can be used under the seasonally stable inflow and water residence time.

• The Journal of the Korean dental association
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• v.53 no.9
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• pp.644-655
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• 2015

Purpose: This study was conducted to evaluate the effect of the fixture abutment connection type and diameter on the screw joint stability in external butt joint for 2nd surgery and internal cone connected type implant system for 1st and 2nd surgery using ultimate fracture strength. Materials and Methods: USII system, SSII system and GSII system of Osstem Implant were used. Each system used the fixture with two different diameters and cement-retained abutments, and tungsten carbide / carbon coated abutment screws were used. Disc shaped stainless steel metal tube was attached using resin-based temporary cement. The experimental group was divided into seven subgroups, including the platform switching shaped specimen that uses a regular abutment in the fixture with a wide diameter in USII system. A static load was increased to the metal tube at 5mm deviated point from the implant central axis until it reached the compression bending strength at a rate of 1mm/min. Then the deformations and patterns of fracture in threaded connection were compared. Results and Conclusion: 1. In the comparison between the Regular diameter, compression bending strength of SSII system was higher than USII system and GSII system. There was no significant difference between USII system and GSII system. 2. In the comparison between wide diameter, compression bending strength was increased in the order of GSII system, USII system, and SSII system. 3. In comparison between the implant diameter, compression bending strength of the wide diameter was greater than the regular diameter in any system(P<0.05). 4. There was no significant difference between the platform switching (III group) and the regular diameter (I group) in USII system. 5. In USII system, fracture of abutment screw and deformation of both fixture and abutment were observed in I, II and III subgroups. 6. Failure pattern of SSII system, which was the fracture of abutment screw and deformation of the abutment and fixture, was observed in both IV and V subgroups. Fracture of some fixtures was observed in subgroup V. 7. Failure pattern of GSII system, which was the fracture of the abutment screw and deformation of the fixture and the abutment, was observed in both VI and VII subgroups. Apart from other subgroups, subgroup VII demonstrated no bending neither the fracture at the top of the fixture. The compressive deformation of internal slope in the fixture was the only thing observed in subgroup VII.

• Journal of Aquaculture
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• v.10 no.3
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• pp.363-371
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• 1997

Backcross hybridization between female cyprinid loach(Misgurnus anguillicaudatus) any male mud loach (M. mizolepis)$\times$cyjprinid loach hybrid were made, and its effect on early survival, cytogenetic traits, and gonad development were examined. Mean fertilization rate and hatching success of backcross hybrids were similar to those found in the maternal species, the cyprinid loach. However, the backcross hybrids revealed significantly improved early survival up to yolk sac absorption (86.0%) compared to cyprinid loach (0%) under low culture temperature ($15^{\circ}C$). the erythrocytic size and DNA content of backcross hybrids were nearly intermediate to those of the parents. Karyological analysis of backcross hybrids displayed two kinds of modal chromosome number of 2n=48 or 2n=49. Growth of backcross hybrids over 6 months after hatching was proven to be intermediate between their parental species. Although backcross hybrids had intermediate values between those of thier parents in most morphometric traits, overall external morphology of backcross hybrids was morer simlar to cyprinid loach than mud loach$\times$cyprinid loach hybrid. Histological examination of gonads at 2 and 4 months of age revealed that no female was obseved in backcross hybrid groups, suggesting the possibility of production of monosex male population.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.22 no.5
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• pp.306-316
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• 1989

We examined the state of Korean pomfret(Pampus echinogaster) in Korean waters and considered the management strategy of the stock based on the theory yield Per recruit. It is not facile to discriminate Korean pomfret distributed in Korean waters from silver pomfret (p. argenteus) due to the similarities in their external morphologies. For this rea- son, Korean pomfret has been treated in silver pomfret in fisheries statistics of Korea. In this study, we asserted Korean pomfret from pomfrets caught commercially by the morphology, from which we recognized that Korean pomfret took $60\~70\%$ in catch(in weight) and that the smaller the body length, the higher the proportion of Korean pomfret. Parameters estimated for Korean pomfret were as follows: natural mortality(M) = 0.6, fishing mortality(F) =0.924(mean value for $1986\~1988$), age at recruit to fishery($t_r$) =0.19 yrs, age at first capture($t_c$) : 0.49 yrs, and the rate of recruit of age-0 fish to fishery(Q) = 0.29. The results obtained from the theory of yield per recruit indicated that the present state of stock was below the optimum level of exploitation and that the control of fishing intensity rarely had an effect on the increasing of yield. Accordingly, we conclude that proper management can be made by increasing the current age of 0.49 yrs at first capture to 1.5 yrs.