• Journal of the Society of Naval Architects of Korea
• /
• v.51 no.5
• /
• pp.396-408
• /
• 2014

In this study, uncertainty analysis based on ITTC(International Towing Tank Conference) Recommended Procedures is carried out in the towing-tank experiment for motion responses and added resistance. The experiment was conducted for KVLCC2 model in head sea condition. The heave, pitch and added resistance were measured in different wave conditions, and the measurement was repeated up to maximum 15 times in each wave condition in order to observe the uncertainty of measured data. The uncertainty analysis was carried out by adopting the ISO-GUM(International Organization for Standardization, Guide to the Expression of Uncertainty in Measurements) method recommended by ITTC. This paper describes the details about the analysis method, uncertainty and the measured uncertainty for each source. The uncertainty analysis results are summarized as a tabular form. To validate the accuracy of the present measurement, the experimental results are compared with the results of numerical computation and other experiment. From the present uncertainty analysis, the main sources of uncertainty are identified, which can be very useful to improve the accuracy for added resistance experiment.

• Animal cells and systems
• /
• v.12 no.4
• /
• pp.219-230
• /
• 2008

We are reporting the expression patterns and possible biological functions of a novel Kinesin-like protein, Surhe, in the zebrafish. Homology studies of derived amino acid sequences suggest that Surhe has an amino-terminal kinesin motor domain that is similar to that of the emerging MKLP-1 subfamily [Kim and Endow, 2000] and two coiledcoil domains in a central region. Cellular localization studies in mammalian cells revealed that Surhe protein is located in cytoplasm, suggesting that Surhe may be involved in the intracellular transport. During the developmental process, surhe transcripts are highly expressed in early embryonic stages. Overexpression of the dominant negative form of Surhe significantly down-regulates the dorsalization markers, such as goosecoid, bozozok, and chordin. Taken together, we postulate that Surhe may be involved in dorsalization process as a motor molecule.

• Molecules and Cells
• /
• v.25 no.3
• /
• pp.347-351
• /
• 2008

Several lines of evidence indicate that the oxidative modification of protein and the subsequent accumulation of the modified proteins have been found in cells during aging, oxidative stress, and in various pathological states including premature diseases, muscular dystrophy, rheumatoid arthritis, and atherosclerosis. The important agents that give rise to the modification of a protein may be represented by reactive aldehydic intermediates, such as ketoaldehydes, 2-alkenals and 4-hydroxy-2-alkenals. These reactive aldehydes are considered important mediators of cell damage due to their ability to covalently modify biomolecules, which can disrupt important cellular functions and can cause mutations. Furthermore, the adduction of aldehydes to apolipoprotein B in low-density lipoproteins (LDL) has been strongly implicated in the mechanism by which LDL is converted to an atherogenic form that is taken up by macrophages, leading to the formation of foam cells. During the search for an endogenous inducer of cyclooxygenase-2 (COX-2), an inducible isoform responsible for high levels of prostaglandin production during inflammation and immune responses, 4-hydroxy-2-noennal (HNE), one of the most representative lipid peroxidation product, has been identified as the potential inducer of COX-2. In addition, the following study on the molecular mechanism of the COX-2 induction by HNE has unequivocally established that a serum component, which is eventually identified to be denatured LDL, is essential for COX-2 induction. Here I review current understanding of the mechanisms by which HNE in cooperation with the serum component activates gene expression of COX-2.

• Molecules and Cells
• /
• v.25 no.3
• /
• pp.438-445
• /
• 2008

Leaf senescence is a highly regulated genetic process that constitutes the last stage of plant development and provides adaptive fitness by relocating metabolites from senescing leaves to reproducing seeds. Characterization of various senescence mutants, mostly in Arabidopsis, and genome-wide analyses of gene expression, have identified a wide array of regulatory components, including transcription factors and enzymes as well as signaling molecules mediating growth hormones and environmental stress responses. In this work we demonstrate that a membrane-associated NAC transcription factor, NTL9, mediates osmotic stress signaling in leaf senescence. The NTL9 gene is induced by osmotic stress. Furthermore, activation of the dormant, membrane-associated NTL9 is elevated under the same conditions. A series of senescence-associated genes (SAGs) were upregulated in transgenic plants overexpressing an activated form of NTL9, and some of them were slightly but reproducibly downregulated in a T-DNA insertional NTL9 knockout mutant. These observations indicate that NTL9 mediates osmotic stress responses that affect leaf senescence, providing a genetic link between intrinsic genetic programs and external signals in the control of leaf senescence.

• Journal of Korea Society of Digital Industry and Information Management
• /
• v.7 no.3
• /
• pp.123-136
• /
• 2011

Arts gains a new relation as the new academic area that deals with living organisms and through this technology, it affects everything, such as the body, entity, consciousness and unconsciousness to bring an overall change. Based on this premise, arts require a different interpretation from the previous product-focused interpretation or the analysis focusing on the aesthetics. As the result of arts using the scientific methods, I examined the changes of the arts semantics and how it evolved with what kind of contents and characteristics. The net art with the internet base also form a close relationship with the social and cultural codes. In categorizing the social issues and the topical discussions with semantic factors that evolve from the digital biological perspective, it can be divided into four types of complex interaction, positive feedback negative feedback, and amplification of unsettledness. Based on the characteristics of the multimedia and the interactive reaction, the technique and the imagery amplify the message through a spatial and timely meeting in a mutual repletion. In other words, the emotional communication is used to attempt the messages from the products and the expression in various methods.

• Korean Journal of Human Ecology
• /
• v.7 no.2
• /
• pp.49-61
• /
• 1998

The purpose of this study was to understand the new generation's culture and to analyze if the characteristics of their lifestyle is significant for the study of new generation's fashion. The new generation's characteristics of lifestyle can be described as a strong pride of their own self and the life which expresses that pride. To analyze this characteristics connecting it with fashion, it is as follows: -It is the egocentric sensitivity culture. In their fashion, there appears a tendency that sense and individuality are counted much rather than fashion. -Diverse fashion information is gained through the mass media and communication. The sense for fashion is liable to change according to the circumstances and, simulated world is made. -The sense of denial is not shown much to the western lifestyle and way of thinking owning to the international open culture. Their consciousness and favorite of fashion are beyond the border. The new generation showed the unprecedent way of expression, denying the established form, and this is defined as Borderless fashion. The Borderless fashion leads a whole trend of new generation's fashion in the late part of ninties. Two typical trends appear as Genderless look for the individualic group and Romanticism look laying stress on womanliness.

• Journal of Pharmaceutical Investigation
• /
• v.36 no.5
• /
• pp.293-297
• /
• 2006

Curcumin is a phytochemical compound with anticancer activity. Although curcumin has substantial pharmacological effect against various cancers, the low solubility of curcumin has hindered its development. For an organic solvent-free injectable formulation, we encapsulated curcumin in various liposomes. Due to its lipophilic property, curcumin was placed in the membrane region of liposomes. Curcumin was stably encapsulated in all formulations tested in this study. The cellular uptake of curcumin delivered in liposomal formulations or free form was measured in K562 human leukemia cell lines using a flow cytometry and MTT viability assay, respectively. Although all the liposomes could solubilize curcumin, the cellular levels and the anticancer effects of liposomal curcumin varied with the composition of liposomes. Moreover, liposomal curcumin down-regulated the expression of Notch-1, the molecule involved in the carcinogenesis, to the similar extent to free curcumin dissolved in dimethyl sulfoxide. These results warrant the development of liposomal curcumin as an injectable formulation for leukemia treatment.

• Bulletin of the Society of Naval Architects of Korea
• /
• v.25 no.2
• /
• pp.19-30
• /
• 1988

Sectional added masses of an elastic beam vibrating vertically on the free surface in higher harmonic modes are evaluated. Hydrodynamic interactions between neighboring sections, which strip theory ignores, are considered for modal wave lengths of the order of magnitude of cross-sectional dimensions of the body. An approximate solution of modified Helmholtz equation which becomes a singular perturbation problem at small wave lengths is secured to get an analytic expression for added masses attending higher harmonic modes. As a bound of the present theory, the modified Helmholtz equation is solved for the long flat plate vibrating at high frequency on the water surface without any limitations on modal frequency. Finally, extensive series of numerical calculations are carried out for ship-like forms. It is found that when modal wave length is comparable to or shorter than a typical cross-sectional dimension of a body, sectional interaction effects are large which result in considerable reductions in added masses. For a fuller section, the ratio of added mass reduction is greater. In the limit of vanishing sectional area, the added masses approach to that of flat plate of equal beam. It is shown that the added mass distribution for a Legendre modal from can be determined form the present theory and that the results agree with the extensive three-dimensional determination of Vorus and Hilarides.

• Journal of architectural history
• /
• v.20 no.1
• /
• pp.41-60
• /
• 2011

As Overturned-bowl Stupa of India, the origin of Stupa, is accepted by neighboring countries, pure form and local characteristics combined to bring change in unique style for each country. Such change is established as new style through combination with contemporary tradition in China. In this thesis, pattern of Stupa shown in Longmen Grottoes' Relief-Stupa relieves. Since study on how Indian Stupa was introduced into China has been partially undertaken, this study focuses on the pattern of Stupas from that perspective. 40 Stupas were explored during field work with naked eyes, among about 50 stupas reported on the research data by Longmen Grottoes Institute. Relief-Stupa relieves of Longmen Grottoes are as important as Yungang Grottoes. While Yungang Grottoes were built during a period when Gandhara style and Occidental expression were adopted and integrated with Chinese culture and Buddhism, building of Longmen Grottoes can be called a starting point of 'Chinese' style of Buddhist culture and Stupa, fully integrated with Chinese culture.

• The Research Journal of the Costume Culture
• /
• v.20 no.2
• /
• pp.129-143
• /
• 2012

This study focuses on the application of collage techniques to contemporary fashion and intends to show that collage techniques have a significant influence on contemporary fashion, leading to a more creative design aesthetic through the combination of fashion and art. The author carried out an empirical analysis focusing on domestic and global fashion collections from 2000S/S to 2010F/W, fashion publications, and internet data, along with a literature review. As a result, the papier-colle approach, as represented by cubism, showed a creative surface effect through the texture of the paper itself by applying real paper and other materials directly to the clothing items. Second, Dadaist ready-made expressed a distortion of the material and freedom of expression by creating a collage with ready-made fashion items and daily necessities. Third, a photomontage expressed unique images by printing various images of photos that contrasted in perspective. In addition to this, beauty in dissonance and a new sense of space by a collage of disparate material. Fourth, decalcomanie was expressed by printing methods, giving a stable image of the symmetry of the perfect landscape as well as the unintended effect of coincidence in abstract images and particular textures. Fifth, assemblage as the representative collage technique of pop art introduced the overall object itself or modified form by combining it with fashion to express three-dimensional aggregate structures.