• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2003년도 춘계종합학술대회
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• pp.574-577
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• 2003

본 논문에서는 캐릭터 애니메이션의 효율적인 동작 제어를 위하여 익스프레션을 이용한 애니메이션을 제작하였다. 익스프레션을 이용한 애니메이션은 움직임의 표현에 있어서, 자연스러운 애니메이션을 좀더 쉽고 유용하게 표현하기 위한 방법으로 캐릭터의 동작 제어점들을 분석하여 익스프레션에서 애니메이션을 제어할 수 있는 요소를 찾아 그 식에 사용하였으며, 이것을 토대로 캐릭터의 동작을 자동적으로 제어하는 애니메이션을 구현하였다. 익스프레션에 의한 애니메이션은 간편한 조작으로 자연스럽고 현실적인 움직임을 생성할 수 있다는 익스프레션의 효율성이 장점으로 나타났지만, 애니메이터에 의한 키 프레임 방식에 의한 애니메이션보다는 어색함을 보였다.

• 한국콘텐츠학회논문지
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• 제8권2호
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• pp.18-26
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• 2008

본 논문은 사용자로 하여금 표정공간으로부터 일련의 표정들을 선택하게 함으로써 3차원 아바타의 표정을 제어할 수 있는 표정공간의 단계적 가시화 기법을 기술한다. 본 기법에 의한 시스템은 무표정 상태를 포함하여 11개의 서로 다른 모션들로 구성된 2400여개의 표정 프레임으로 2차원 표정공간을 구성하였으며, 3차원 아바타의 표정 제어는 사용자가 표정공간을 항해함으로서 수행되어진다. 그러나 표정공간에서는 과격한 표정 변화에서부터 세밀한 표정 변화까지 다양한 표정 제어를 수행할 수 있어야하기 때문에 단계적 가시화 기법이 필요하다. 표정공간을 단계적으로 가시화하기 위해서는 퍼지 클러스터링을 이용한다. 초기 단계에서는 11개의 클러스터 센터를 가지도록 클러스터링하고, 단계가 증가될 때 마다 클러스터 센터의 수를 두 배씩 증가시켜 표정들을 클러스터링한다. 이때 클러스터 센터와 표정공간에 분포된 표정들의 위치는 서로 다른 경우가 많기 때문에, 클러스터 센터에서 가장 가까운 표정상태를 찾아 클러스터 센터로 간주한다. 본 논문은 본 시스템이 어떤 효과가 있는지를 알기 위해 사용자들로 하여금 본 시스템을 사용하여 3차원 아바타의 단계적 표정 제어를 수행하게 하였으며, 그 결과를 평가한다.

• 한국동물학회:학술대회논문집
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• 한국동물학회 1995년도 한국생물과학협회 학술발표대회
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• pp.82-82
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• 1995

Regulation of enzyme synthesis by transcriptional and translational control systems provides rather stable adaptation to change of amino acid level in the growth medium, while manipulation of enzyme activity through endproduct feedback inhibition represents rather short-term and reversible ways of adjusting metabolic fluctuation of amino acid level. Various control mechanisms interplay to regulate genes encoding enzymes for amino acid biosynthesis in the yeast, Sacchromyces cerevisiae. When amino acids are in short supply, genes under a cross-pathway regulatory mechanism Or general amino acid control (general control) increase their action, in which Gcn4p is the major positive regulator of gene expression. When cells are cultured in minimal medium, basal level expression is also regulated by supplementary control elements, where inorganic phosphate level is additionally involved. Most of amino acid biosynthetic genes are also regulated by the level of endproduct of the pathway. This pathway-specific regulatory mechanism is called specific amino acid control (specific controD, under which gene expression is reduced when endproduct is present in the medium. Derepression of a gene through general control can be usually overridden by repression through specific control, where the endproduct level of that particular pathway is high and not limiting. In this presentation, regulatory factors for basal level expression and general control of yeast amino acid biosynthesis will be discussed, m addition to pathway-specific repression patterns and interaction between CrOSS- and specific-control mechanisms. Preliminary results are also presented from the investigation of the cloned genes in the threonine biosynthetic pathway of the yeast. yeast.

• 대한약침학회지
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• 제6권2호
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• pp.77-90
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• 2003

The purpose of this study was to investigate the effect of Bee Venom on the lipopolysaccharide(LPS), sodium nitroprusside(SNP), hydrogen peroxide($H_2O_2$)-induced expressions of cyclooxygenase-2(COX-2), p38, jun N-terminal Kinase(JNK) and extra-signal response kinase(ERK) in RAW 264.7 cells, a murine macrophage cell line. Method : The expressions of COX-2, p38, JNK and ERK were determined by western blotting with corresponding antibodies. Results : 1. The 0.5, 1 and $5\;{\mu}g/ml$ of bee venom inhibited significantly LPS and SNP-induced expression of COX-2 compared with control, respectively. The 0.5, 1 and $5\;{\mu}g/ml$ of bee venom inhibited insignificantly $H_2O_2$-induced expression of COX-2 compared with control, respectively. 2. The 0.5, 1 and $5\;{\mu}g/ml$ of bee venom inhibited significantly LPS, SNP and $H_2O_2$-induced expression of p38 compared with control, respectively. 3. The 1 and $5\;{\mu}g/ml$ of bee venom inhibited significantly SNP-induced expression of JNK compared with control, respectively. All of bee venom inhibited insignificantly LPS and $H_2O_2$-induced expression of JNK compared with control, respectively. 4. The $5\;{\mu}g/ml$ of bee venom inhibited significantly SNP-induced expression of ERK, the $0.5\;{\mu}g/ml$ of bee venom increased significantly $H_2O_2$-induced expression of ERK compared with control. The 0.5, 1 and $5\;{\mu}g/ml$ of bee venom inhibited insignificantly LPS-induced expression of ERK compared with control, respectively.

• 동의생리병리학회지
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• 제25권4호
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• pp.674-682
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• 2011

The present study was undertaken to investigate the effect of acupuncture & moxibustion therapy on the hair follicle growth of skin 5 days and 10 days by macroscopic, microscopic and immunohistochemical methods. The results were as follows : Macroscopic hair follicle growth of plum-blossom needle treated group and strong moxibustion treated group was more increase than that of control group. Microscopic hair follicle growth of plum-blossom needle treated group and strong moxibustion treated group was hair growing cycle, anagen phase VI and that of control group and weak moxibustion treated group was hair growing cycle, anagen phase IV. Immunohistochemical observations on the expression of various growth factors, enzyme and receptor in hair follicle cycle after local treatment of acupuncture & moxibustion therapy are as follows: Expression of fibroblast growth factor was more intense in epidermis in plum-blossom needle treated group, epidermis and secondary hair germ cells in strong moxibustion treated group than control group. Expression of epidermal growth factor was more intense in epidermis in all experimental groups, and secondary hair germ cells in moxibustion treated group than control group. Expression of c-kit receptor was more intense in epidermis, secondary hair germ cells, outer root sheath in all experimental groups than control group. Expression of protein kinase C-${\alpha}$ was more intense in epidermis, secondary hair germ cells, outer root sheath in all experimental groups than control group. Expression of vascular endothelial growth factor was more intense in epidermis, bulge, secondary hair germ cells, outer root sheath in plum-blossom needle treated group and strong moxibustion treated group than control group. We concluded that acupuncture & moxibustion therapy related to the expression of various growth factors, enzymes and receptor on the hair growth cycle for hair growth.

• 정보처리학회논문지A
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• 제14A권2호
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• pp.85-90
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• 2007

본 논문은 애니메이터로 하여금 표정공간으로부터 임의의 표정상태 수 개를 선택하도록 하면, 최적의 표정전이경로를 자동적으로 설정하도록 해줌으로써, 얼굴 표정 애니메이션을 실시간적으로 생성하거나 표정 제어가 가능하도록 하기 위한 기법을 기술한다. 표정공간은 약 2500개의 얼굴 표정상태 간의 거리를 구하고, 다차원 스케일링 기법을 사용하여 2차원 평면에 분포시킴으로서 형성된다. 표정공간에서 최적의 표정전이경로를 설정하기 위해서는 임의의 얼굴 표정상태를 기준으로 사분면처럼 4개의 영역으로 나눈다. 그리고 각 영역별로 최단거리에 존재하는 열굴 표정상태를 결정하고, 그 중에서 가장 가까운 얼굴 표정상태를 선택하여 전이시키고, 전이가 끊어진 얼굴 표정상태에서는 두 번째, 세 번째 혹은 네 번째로 가까운 얼굴 표정상태를 선택하여 순서대로 전이시킴으로써 완전한 표정전이경로가 결정된다. 그리고 애니메이터가 표정공간에서 대표적인 수 개의 표정상태만을 선택해주면 시스템은 자동적으로 최적의 표정전이경로를 설정하여 준다. 본 논문은 애니메이터들로 하여금 본 시스템을 사용하여 얼굴 애니메이션을 생성하거나 표정 제어를 수행하도록 하였으며, 그 결과를 평가한다.

• 한국생활과학회지
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• 제21권1호
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• pp.1-14
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• 2012

This research examines the effects of parental attachment as a family-related variable, and depressive mood as an individual variable on anger expression style among Korean college students. Anger expression style was divided into three domains including anger-in, anger-out, and anger-control. The data were collected from 437 college student respondents using a self-administered questionnaire. The results demonstrated that male students displayed higher levels of anger-control compared to females, but no gender-related difference in the level of anger-in and anger-out. In addition, anger-control was positively associated with parental attachment. However, anger control in terms of anger-in and anger-out were negatively related to parental attachment and positively linked to depression. Additionally, parental attachment demonstrated a negative correlation with depressive mood. Multiple regression results indicated that after controlling for the effect of gender, anger-control expression style was influenced by parental attachment but not by depressive mood. In addition, anger-out and anger-in expression styles were influenced by depressive mood but not by parental attachment. Finally, implications for educators and clinicians working with college students and their family are discussed along with some suggestions for future research.

• Archives of Pharmacal Research
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• 제26권4호
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• pp.321-329
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• 2003

Rats were given nicotine (25 ppm) in their drinking water at the start of their mating period in order to study the expressions of glutamate transporter subtypes in cerebellar astrocytes following the chronic exposure of nicotine after mating. After the offspring were delivered, each group was divided into two subgroups. One group, the control group, was given distilled water only and the other group, the experimental group, was given distilled water containing nicotine. The cerebellar astrocytes were prepared from 7 day-old pups at each group. Ten days after the cells were cultured, the expression of the glutamate transporter subtypes (GLAST and GLT-1) was determined using immunochemistry and immunoblotting. During the continuous treatments, the developmental expression patterns of the GLAST and GLT-1 in the cerebellum were also determined from 2, 4 and 8 week-old rats. The expression levels of GLAST in cultured astrocytes of both the pre- or post-natally exposed groups were higher than those of the control group. However, these expression levels of the continuously exposed group were lower than those of the control group. Compared to those of the control group, the GLT-1 expression levels of all the nicotine-treated groups were higher, particularly in the continuously treated group.. According to the results from the immochemistry procedure, the cerebellar GLAST and GLT-1 expression levels of all nicotine-treated groups were lower than those of the control group at each age. However, the immunoblotting procedure showed that the cerebellar GLT-1 expression levels of all the nicotine-treated groups were higher than those of the control group, except for the rats that were continuously exposed for 8 weeks using immunoblotting. These results suggest that the expression of the glial GLAST and GLT-1 are altered differently depending on the initial exposure time and the partcicular period of nicotine exposure. In addition, nicotine exposure during gestation has persistent effects on glial cells.

• 제어로봇시스템학회논문지
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• 제20권5호
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• pp.520-525
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• 2014

Generally, feature area detection methods are widely used for face expression recognition by detecting the feature areas of human eyes, eyebrows and mouth. In this paper, we proposed a face expression recognition method using the histograms of the face, eyes and mouth for many applications including robot technology. The experimental results show that the proposed method has a new type of face expression recognition capability compared to conventional methods.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2519-2525
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• 2016

There are several existing reports of microarray chip use for assessment of altered gene expression in different diseases. In fact, there have been over 1.5 million assays of this kind performed over the last twenty years, which have influenced clinical and translational research studies. The most commonly used DNA microarray platforms are Affymetrix GeneChip and Quality Control Software along with their GeneChip Probe Arrays. These chips are created using several quality controls to confirm the success of each assay, but their actual impact on gene expression profiles had not been previously analyzed until the appearance of several bioinformatics tools for this purpose. We here performed a data mining analysis, in this case specifically focused on ovarian cancer, as well as healthy ovarian tissue and ovarian cell lines, in order to confirm quality control results and associated variation in gene expression profiles. The microarray data used in our research were downloaded from ArrayExpress and Gene Expression Omnibus (GEO) and analyzed with Expression Console Software using RMA, MAS5 and Plier algorithms. The gene expression profiles were obtained using Partek Genomics Suite v6.6 and data were visualized using principal component analysis, heat map, and Venn diagrams. Microarray quality control analysis showed that roughly 40% of the microarray files were false negative, demonstrating over- and under-estimation of expressed genes. Additionally, we confirmed the results performing second analysis using independent samples. About 70% of the significant expressed genes were correlated in both analyses. These results demonstrate the importance of appropriate microarray processing to obtain a reliable gene expression profile.