• 한국환경보건학회지
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• 제48권2호
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• pp.75-85
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• 2022

Background: Various types of semi-volatile organic compounds (SVOCs) exist in the public's living environment. They occur in different forms in terms of their physical and chemical properties and partition coefficients. As a consequence, indoor exposure to SVOCs occurs via various routes, including inhalation of air and airborne particles, skin contact, and dust intake. Objectives: To propose a method for assessing human exposure to the SVOCs occurring in the air of an indoor environment, the concentrations of SVOCs in house dust and organic films measured in a real residential environment were estimated in terms of gas-phase concentration using the partition coefficient. Assessment of inhalation exposure to SVOCs was performed using this method. Methods: Phthalates were collected from samples of house dust and organic films from 110 households in a real residential environment. To perform an exposures assessment of the phthalates present in organic films, gas-phase concentration was calculated using the partition coefficient. The airborne gas-phase concentrations of phthalates from the house dust and organic films were estimated and exposure assessment was performed based on the assumption of inhalation exposure from air. Results: As a result of the exposure assessment for gas-phase phthalates from house dust and organic films, preschool children showed the highest level of inhalation of phthalates, followed by school children, adults, and adolescents. Conclusions: This study includes the limitation of not considering different SVOCs exposure pathways in the health impact assessment, including those of phthalates in the indoor living environment. However, this study has the significance of performing exposure assessment based on exposure to SVOCs present in indoor air that originated from organic films in the indoor residential environment. Therefore, the results of this study should be useful as basic data for exposure and health risk assessments of SVOCs associated with organic films in the indoor environment.

• 한국환경보건학회지
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• 제43권3호
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• pp.223-232
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• 2017

Objectives: In response to increased interest in the safety of children's products, a risk management system is being prepared through exposure assessment of hazardous chemicals. To estimate exposure levels, risk assessors are using deterministic and probabilistic approaches to statistical methodology and a commercialized Monte Carlo simulation based on tools (MCTool) to efficiently support calculation of the probability density functions. This study was conducted to analyze and discuss the usage patterns and problems associated with the results of these two approaches and MCTools used in the case of probabilistic approaches by reviewing research reports related to exposure assessment for children's products. Methods: We collected six research reports on exposure and risk assessment of children's products and summarized the deterministic results and corresponding underlying distributions for exposure dose and concentration results estimated through deterministic and probabilistic approaches. We focused on mechanisms and differences in the MCTools used for decision making with probabilistic distributions to validate the simulation adequacy in detail. Results: The estimation results of exposure dose and concentration from the deterministic approaches were 0.19-3.98 times higher than the results from the probabilistic approach. For the probabilistic approach, the use of lognormal, Student's T, and Weibull distributions had the highest frequency as underlying distributions of the input parameters. However, we could not examine the reasons for the selection of each distribution because of the absence of test-statistics. In addition, there were some cases estimating the discrete probability distribution model as the underlying distribution for continuous variables, such as weight. To find the cause of abnormal simulations, we applied two MCTools used for all reports and described the improper usage routes of MCTools. Conclusions: For transparent and realistic exposure assessment, it is necessary to 1) establish standardized guidelines for the proper use of the two statistical approaches, including notes by MCTool and 2) consider the development of a new software tool with proper configurations and features specialized for risk assessment. Such guidelines and software will make exposure assessment more user-friendly, consistent, and rapid in the future.

• 한국안전학회지
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• 제24권6호
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• pp.72-78
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• 2009

차량수리작업장에 일반적으로 사용하고 있는 HDI의 노출은 직업성 천식을 발생시키는 주요 원인이 된다. 비록 피부나 눈의 오염이 흡수경로로 고려되고 있음에도 불구하고 이들의 폭로에 관한 작업장의 노출허용 기준이 규정되어 있지 않으므로 많은 실험 자료들이 제공되어져야 한다. 따라서 이 연구는 피부, 눈 그리고 호흡보호구와 눈보호구의 표면에 대한 HDI의 오염정도를 확인하였으며, 손잡이, 작업대 그리고 분사건과 같이 다양한 오염표면이 있다는 것도 명확히 하였다. 상대적으로 짧은 시간의 분사임에도 불구하고 목, 이마, 손등, 팔과 손목 등에서 채취한 시료의 많은 부분(47~80%)이 HDI오염에 양성이었다. 분사실 내부에서의 오염정도는 좋지 못한 작업여건이나 보호경과 같은 부적절한 개인보호구 때문에 분사실 외부의 오염정도보다 일반적으로 높다. 경험이 있는 페인트 공보다 초보자들의 폭로수준이 높은 것은 안전이나 보건의식의 결여 때문인 것으로 사료되고, 보호구내부의 오염 정도는 호흡기관, 피부 및 눈의 잠재적인 노출을 야기할 것이다. 작업자 14명중에서 4명의 눈물시료로부터 HDI양성반응을 보였으며, 이것은 부적절한 눈 보호구에 의한 것으로 나타났다. 호흡기의 과민반응을 포함한 건강징후에 관여되는 피부와 눈의 노출 잠재성을 고려해볼 때 실질적 자료는 작업자들의 근무여건개선, 적절한 보호구의 선택과 사용 그리고 관리의 중요성을 잘 보여 주고 있다.

• Toxicological Research
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• 제33권1호
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• pp.7-14
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• 2017

Didecyldimethylammonium chloride (DDAC) is used in many types of biocidal products including tableware, carpets, humidifiers, and swimming pools, etc. In spite of increased chances of DDAC exposure through inhalation, studies on the inhalation toxicity of DDAC are not common even though the toxicity of DDAC might be significantly higher if it were to be administered through routes other than the respiratory system. DDAC aerosols were exposed to Sprague-Dawley rats in whole body exposure chambers for a duration of 13 weeks. The Mass Median Aerodynamic Diameters of the DDAC aerosol were $0.63{\mu}m$, $0.81{\mu}m$, and $1.65{\mu}m$, and the geometric standard deviations were 1.62, 1.65, and 1.65 in the low ($0.11{\pm}0.06mg/m^3$), the middle ($0.36{\pm}0.20mg/m^3$) and the high ($1.41{\pm}0.71mg/m^3$) exposure groups, respectively. Body weight was confirmed to be clearly influenced by exposure to DDAC and mean body weight was approximately 35% lower in the high ($1.41{\pm}0.71mg/m^3$) male group and 15% lower in the high ($1.41{\pm}0.71mg/m^3$) female group compared to that of the control group. In the bronchoalveolar lavage fluid assay, the levels of albumin and lactate dehydrogenase had no effect on DDAC exposure. The lung weight increased for the middle ($0.36{\pm}0.20mg/m^3$) and the high ($1.41{\pm}0.71mg/m^3$) concentrations of the DDAC exposure group, and inflammatory cell infiltration and interstitial pneumonia were partially observed in the lungs of the middle ($0.36{\pm}0.20mg/m^3$) and the high ($1.41{\pm}0.71mg/m^3$) exposure groups. However, severe histopathological symptoms, including proteinosis and/or fibrosis, were not found. Based on the results of the changes in the body weight and lung weight, it is considered that the NOAEL (no-observed adverse effect) level for the 13-week exposure duration is $0.11mg/m^3$.

• 한국지하수토양환경학회지:지하수토양환경
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• 제12권1호
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• pp.53-63
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• 2007

우리나라는 최근에 토양위해성평가 지침을 마련하였으며, 앞으로 토양위해성모델 개발에 대한 필요성이 대두되고 있다. 선진국에서는 자국 내 부지특성과 노출경로를 고려한 토양위해성평가 모델을 토양정책 전반에 활용하고 있다. 본 연구에서는 선진국에서 위해성평가에 이용되는 대표적인 오염토양 위해성평가 모델을 비교분석하였다. 연구대상이 된 모델은 미국, 영국, 네덜란드에서 사용하고 있는 CalTOX, CLEA, CSOIL로서, 노출경로, 토지이용도 그리고 노출량 산정식을 중심으로 비교분석하였다. 모델 검토시 우선적으로 비교 분석된 항목은 노출시나리오, 노출경로, 입력변수의 공통사항이며, 이러한 분석결과를 토대로 선진국의 토양위해성 모델들이 공통적으로 포함하고 있는 노출경로를 추출하여, 국내에 적용 가능한 토양 위해성평가 모델개발의 기초자료로 제안하였다. 인체노출량 산정식에서는 일반적으로 미국식 방법이 국내 상황에서 사용이 용이한 것으로 판단되며, 비산먼지나 휘발물질 흡입의 경우는 네덜란드식이 기본값이 제공되어 있으므로 사용하기가 편리할 것으로 판단된다.

• Journal of Radiation Protection and Research
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• 제29권2호
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• pp.141-150
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• 2004

특정 비행노선에서 우주선에 의한 누적선량을 계산하는 프로그램인 CARI-6를 이용하여 비행고도 우주선 방사선장의 선량률 변화 특성을 분석하고, 국적항공사에서 운행하는 전 국제선 노선에 대한 노선별 우주선 피폭선량을 산출하였다. 산출한 노선별 선량을 항공승무원의 비행스케쥴과 국민의 항공여행 통계에 적용하여 우리나라 항공승무원과 일반 여행객의 우주선에 의한 연간 피폭선량과 집단유효선량을 평가하였다. 평가 결과, 항공승무원의 피폭이 일반인의 선량한도인 연간 1 mSv를 초과하여 평균 2.62mSv로 다른 직업상 피폭을 받는 직군의 선량과 대등한 것으로 평가되었다. 따라서 항공승무원 적군의 우주선 피폭을 일종의 직업상 피폭으로 간주함이 타당함을 확인하였다. 나아가 국민의 해외여행으로 인한 집단선량은 2001년 기준으로 1,100만 명의 출입국자가 총 136man-Sv를 피폭한 것으로 나타났다. ICRP 92에서 양성자와 중성자의 방사선가중치를 변경한 결과를 반영하여 비행고도에서의 우주선 방사선장 정보가 수정될 경우 위의 평가 결과는 보완되어야 한다.

• 한국식품위생안전성학회지
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• 제38권6호
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• pp.409-419
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• 2023

Okadaic acid (OA) 군 독소는 설사성 패류중독(diarrhetic shellfish poison, DSP)을 유발하는 해양생물독소이다. 설사성패독은 오카다익산(OA)과 그 유사체인 디노피시스톡신(DTX)으로 구성되어 있으며, 주로 와편모조류에서 생성되어 이매패류의 체내에 축적되어 독화된다. 이에 EFSA, WHO에서는 안전관리를 위하여 수산물 내 OA군 독소 함량 기준을 설정하였다. 최근 우리나라 연안에서도 원인조류인 Dinophysis sp.의 출현이 보고된 바 있으며, 국내 수산물 생산과 소비에도 영향을 미치고 있다. 또한 국제적인 움직임에 발맞추어 국내에서도 2022년 설사성 패독 기준 관리 대상 물질에 DTX2를 추가하여 관리하고 있다. 본 연구는 OA군 독소의 이화학적 특성, 분석법, 인체 노출 사례와 국내외 관리 현황 등의 자료를 검토하여 OA군 독소의 체계적인 모니터링과 안전관리의 기반을 마련하고자 수행되었다.

• Archives of Pharmacal Research
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• 제14권2호
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• pp.188-192
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• 1991

Single non-lethal doses of chloroform $(CHCL_3)$ dichlorobromomethane $(CHCL_2Br)$, dibromochloromethane $(CHCIBr_2)$, or bromoform $(CHBr_3)$ were administered to male rats. Routes of exposure including single intraperitional (ip) and subcutaneous (sc) injection were used in order to permit comparison of severity of THM effects and renal toxicity was assessed at varied times following treatment. On an equimolar basis, sc administration of $CHBr_3$ (either 12 or 3 mmoles/kg) is more effective at increasing KW/BW than ip $CHCI_3$ treatment. Plasma urea nitrogen (BUN) following ip THM injections are markedly increased with all four THM at 24 hours post treatment. BUN response to $CHCL_2Br$ and $CHCIBr_3$-effected BUN levels have essentially returned to those of vehicle control. THM sc treatment results in a BUN response similar to that seen following ip treatment, with only the time course being different. With the exception of $CHCL_3$, sc and ip-treatments appear to be equally effective in evoking absolute BUN elevations. These results suggest that THM administration induce renal toxicity dependent upon the route or exposure.

• 한국조경학회지
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• 제33권6호
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• pp.127-139
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• 2006

Mt. Yokmang landscape design awarded first in [North container terminal site furtherance construction in Busan new port], design competition sponsoring in the Korea Container Terminal Authority in 2005. Design guideline was to propose the symbol of new port and to establish landscape plan in consideration of view and geological location. Because landscape plan required establishment of restoration plan for cutting slope, Mt. Yokmang became the major object. The purpose of planning are as follows. The first purpose is to minimize existent natural environment damage, and the second, to connect with ambit and create new image. The third is to provide place of rest and interchange for local resident. Reflecting stratum structure and landscape characteristics, cutting slope consisted of [utilization slope], [presentation slope], [landscape slope], and [ecological slope]. Vegetation design applied ecological restoration method through restoration of stratum, and eve environment-friendly afforestation, planned program that can connect area with existing ecosystem. In process that decides form of the cutting slope, analyze view structure and visual exposure in various access routes, sensitivity etc. was accomplished. Also, symbolic tower(Ocean Polaris) that presents in architecture and landscaping features, night landscape planning could gain synergy effect by keeping consistence with landscape and ecological planning. Passing through final design and construction process, I expect that the Mt. Yokmang will be a new landmark in Busan new port.

• Fisheries and Aquatic Sciences
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• 제27권2호
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• pp.66-75
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• 2024

Heavy metals are naturally found in the ecosystem, and their presence in the freshwater river is increasing through anthropogenic activities which pose a threat to living beings. In this study, heavy metal concentrations (Zn, Mn, Cu, Cd, Cu, Cr, Pb, and Ni) in different organs (muscle, skin, and gill) of fish from the Padma River were evaluated to quantify, and compare the contamination levels and related human health risks. The results revealed that the heavy metal concentrations in the water, surface sediments, and fish taken from the Padma River were far below the WHO/USEPA's permitted limits. The estimated daily intake (EDI) value in muscle was less than the tolerable daily intake (TDI). The target hazard quotient (THQ) and hazard indexes (HI) were less than 1, showing that consumers face no non-carcinogenic risk (CR). CR values of Cu, Cd, Cr, Pb, and Ni ranged from 4.00 × 10^-8 to 6.35 × 10^-6, less than 10^-4, and total carcinogenic risk (CRt) values ranged from 9.85 × 10^-6 to 1.10 × 10^-5, indicating some pose a CR from consumption of those fish from the Padma River. To establish a more accurate risk assessment, numerous exposure routes, including inhalation and cutaneous exposure, should be explored.