• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10683-10690
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• 2015

The big gap between efficacy of population level prevention and expectations due to heterogeneity and complexity of cancer etiologic factors calls for selective yet personalized interventions based on effective risk assessment. This paper documents our research protocol aimed at refining and validating a two-stage and web-based cancer risk assessment tool, from a tentative one in use by an ongoing project, capable of identifying individuals at elevated risk for one or more types of the 80% leading cancers in rural China with adequate sensitivity and specificity and featuring low cost, easy application and cultural and technical sensitivity for farmers and village doctors. The protocol adopted a modified population-based case control design using 72, 000 non-patients as controls, 2, 200 cancer patients as cases, and another 600 patients as cases for external validation. Factors taken into account comprised 8 domains including diet and nutrition, risk behaviors, family history, precancerous diseases, related medical procedures, exposure to environment hazards, mood and feelings, physical activities and anthropologic and biologic factors. Modeling stresses explored various methodologies like empirical analysis, logistic regression, neuro-network analysis, decision theory and both internal and external validation using concordance statistics, predictive values, etc..

• 한국지하수토양환경학회지:지하수토양환경
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• 제9권1호
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• pp.28-38
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• 2004

본 연구는 지하수로부터 유래한 벤젠이 실내공기에 휘발되어 호흡을 통하여 인체에 유입될때 각 장기에 분포하고 제거되는 것을 묘사하는 동적약리학 모델의 불확실성 및 중요도 분석의 결과를 제공하였다. 오염된 실내공기의 호흡을 통해 체내에 유입된 벤젠이 각 장기에 분포하는 비율과 농도를 모의하기 위해 기존의 동적약리학 모델을 적용하였으며 간에서의 분해대사를 포함하여 구성하였다. 본 연구는 동적약리학 모델의 각 장기의 혈류량, 분배계수, 분해상수, 부피 등과 같은 인자들에 대한 지식 및 측정의 부족에서 오는 고정된 단일 값의 사용이 야기하는 불확실성 문제에 대해 초점을 맞추었다. 이를 해결하기 위해서 동적약리학 모델과 불확실성 분석을 동시에 수행되었으며 앞으로 휘발성 유기화합물과 관련한 위해도 평가에서의 이해를 높일 수 있다고 생각된다.

• 한국해안해양공학회지
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• 제10권4호
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• pp.151-164
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• 1998

서산 A·B지구 간척사업에 따른 방조제 축조에 따라 야기되는 천수만 내 조석현상 변화를 파악하기 위하여 수심적분 2차원 해수유동 수치모형실험을 실시하였다. 외해 개방경계조건을 확보하기 위하여 3개 지점에서 조석관측을 실시하였고 수치모형의 검증을 위하여 천수만 내 2개 지점에서 조류관측을 실시하였다. 수치모형 실험결과는 관측된 조류를 기준으로 할 때, 북부해역, 백사수도, 중부해역, 남부해역의 순으로 유속의 감소가 크게 나타났다. 방조제 건설 후 천수만 북부에서 조간대 노출이 발생하는 시각은 약 51분 정도 빨라졌으며, 노출시간은 23분 정도 길어진 것으로 나타났다. 고조 발생 시각은 1시간 정도 앞당겨졌으며, 고조 수위는 15 cm 정도 낮아졌다.

• Journal of electromagnetic engineering and science
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• 제13권2호
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• pp.113-119
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• 2013

We developed a transformed, symmetrical, mushroom-like surface without via holes in cells focused on a 2.4-GHz WLAN band. Each slot in the novel type structure plays a key role in modeling at the desired frequencies. The designed artificial magnetic conductor (AMC) has several advantages, including a small size, a wider bandwidth, a short reflecting distance to the antenna, and easy fabrication because there are no via holes. Overall dimensions of the AMC cell are 21 mm $(Width){\times}21mm$ $(Height){\times}2.6mm$ (Thickness), and the bandwidth is about three times wider (11.7%) compared to that of a conventional AMC (4.0%). For evaluating the performance of the proposed structure, a reflector, which periodically consists of the designed AMC cells, was developed. The antenna with the investigated AMC reflector not only works within a quarter of the wavelength because of the extremely high wave impedance generated by the AMC cells on the surface of the structure but also reduces the specific absorption rate (SAR). Electromagnetic field (EMF) exposure to a human phantom was analyzed by applying the designed reflector to the 2.4-GHz dipole antenna in a tablet PC. The calculated peak SAR averaged over 1 g was 0.125 W/kg when the input power was 1 W and the antenna was located at 20 cm from the human phantom. However, the SAR value was only 0.002 W/kg (i.e., 98.4% blocked) when the designed reflector was inserted in front of the antenna.

• Advances in environmental research
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• 제1권1호
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• pp.15-35
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• 2012

Mercury (Hg) is a global environmental pollutant that has been the cause of many public concerns. One particular concern about Hg in aquatic systems is its trophic transfer and biomagnification in food chains. For example, the Hg concentration increases with the increase of food chain level. Fish at the top of food chain can accumulate high concentrations of Hg (especially the toxic form, methylmercury, MeHg), which is then transferred to humans through seafood consumption. Various biological and physiochemical conditions can significantly affect the bioaccumulation of Hg-including both its inorganic (Hg(II)) and organic (MeHg) forms-in fish. There have been numerous measurements of Hg concentrations in marine and freshwater fish worldwide. Many of these studies have attempted to identify the processes leading to variations of Hg concentrations in fish species from different habitats. The development of a biokinetic model over the past decade has helped improve our understanding of the mechanisms underlying the bioaccumulation processes of Hg in aquatic animals. In this review, I will discuss how the biokinetic modeling approach can be used to reveal the interesting biodynamics of Hg in fish, such as the trophic transfer and exposure route of Hg(II) and MeHg, as well as growth enrichment (the increases in Hg concentration with fish size) and biomass dilution (the decreases in Hg concentration with increasing phytoplankton biomass). I will also discuss the relevance of studying the subcellular fates of Hg to predict the Hg bioaccessibility and detoxification in fish. Future challenges will be to understand the inter- and intra-species differences in Hg accumulation and the management/mitigation of Hg pollution in both marine and freshwater fish based on our knowledge of Hg biodynamics.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제39권
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• pp.32.1-32.5
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• 2017

Background: Osteochondroma is a benign tumor that tends to develop in mandibular condyle and coronoid process in the craniofacial region. If tumor mass has grown from condyle into the infratemporal space with zygomatic arch obstructing the access, there are risks associated with surgical exposure and local resection of these masses. Case presentation: This study reports on a case of osteochondroma on mandibular condylar head where we treated with surgical excision via preauricular approach with 3D analysis. After the local resection, there were no surgical and post-operative complications until 8-month follow-up period. Conclusions: In local excision of osteochondroma, our method is a minimally invasive method. It is a good example of osteochondroma treatment.

• Corrosion Science and Technology
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• 제6권5호
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• pp.261-268
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• 2007

Embedded sensors were used as an in-situcorrosion-sensing device for aircraft and vehicular structures protected by organic coatings. Results are presented changes associated with a standard Airforce aircraft coating and a standard Army vehicle coating were monitored by embedded sensors. These coatings consisted of a polyurethane topcoat and an epoxy primer, however are formulated to provide different characteristics. The ac-dc-ac testing method was used to accelerate the degradation of these coatings while being immersed in a NaCl medium. Electrochemical impedance spectroscopy and electrochemical noise measurement experiments were used to monitor the induced changes. A comparison of the results between coatings subjected to the ac-dc-ac exposure and coatings subjected to only constant immersion in the NaCl medium is presented. The results were used to demonstrate the effectiveness of the ac-dc-ac method at accelerating the degradation of an organic coating without observably changing the normal mechanism of degradation. The data highlights the different features of the coating systems and tracks them while the coating is being degraded. The aircraft coating was characterized by a high-resistant topcoat that can mask corrosion/primer degradation at the primer/substrate interface whereas the vehicle coating was characterized by a low-resistant topcoat with an effective corrosion inhibiting primer. Details of the ac-dc-ac degradation were evaluated by using an equivalent circuit to help interpret the electrochemical impedance data.

• Nuclear Engineering and Technology
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• 제20권2호
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• pp.120-131
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• 1988

지중매몰된 방사성핵종들이 지하수계를 통해 이동을 하는 Source를 수학적으로 표시하는 Source Term 모형이 필요하다. 물질전달식 또는 측정식에 근거한 여러 Source Term 모형을 비교 분석하였다. 일반적으로 용출 또는 용해에는 (1) 화학반응, (2) 확산 등에 의한 물질이동의 두 가지 작용이 관여한다. 화학반응은 고화체가 지하수에 노출된 후 초기의 짧은 기간 동안에만 용해율을 조절한다. 외부로의 물질전달율이 지하 처분장에서 방사성폐기물 고화체로부터의 장기간에 걸친 핵종유출율을 조절하는 역할을 한다. 물질전단 이론을 적용 할 때는, 필요로 하는 물질이동 현상을 기술할 수 있는 식을 선택해야 한다. 적절히 사용했을 경우, 물질전달 이론에 입각한 Source Term 모형은 핵종유출율의 신뢰할 만한 예측을 위한 귀중한 도구이다.

• Coupled systems mechanics
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• 제4권2호
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• pp.173-189
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• 2015

In reality, masonry infill modifies the seismic response of reinforced concrete (r.c.) frame structures by increasing the overall rigidity of structure which results in: increasing of total seismic load value, decreasing of deformations and period of vibration, therefore masonry infill frame structures have larger capacity of absorbing and dissipating seismic energy. The aim of the paper is to explore and assess actual influence of masonry infill on seismic response of r.c. frame structures, to determine whether it's justified to disregard masonry infill influence and to determine appropriate way to consider infill influence by design. This was done by modeling different structures, bare frame structures as well as masonry infill frame structures, while varying masonry infill to r.c. frame stiffness ratio and seismic intensity. Further resistance envelope for those models were created and compared. Different structures analysis have shown that the seismic action on infilled r.c. frame structure is almost always twice as much as seismic action on the same structure with bare r.c. frames, regardless of the seismic intensity. Comparing different models resistance envelopes has shown that, in case of lower stiffness r.c. frame structure, masonry infill (both lower and higher stiffness) increased its lateral load capacity, in average, two times, but in case of higher stiffness r.c. frame structures, influence of masonry infill on lateral load capacity is insignificant. After all, it is to conclude that the optimal structure type depends on its exposure to seismic action and its masonry infill to r.c. frame stiffness ratio.

• 한국항행학회논문지
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• 제23권4호
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• pp.265-272
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• 2019

본 논문에서는 우리나라에서 가장 교통이 혼잡한 수도권에서의 출퇴근 시나리오를 선정하고, 미국연방항공국에서 개발한 AEDT (aviation environmental design tool) 소트프웨어를 사용하여 PAV (personal air vehicle) 운용 시 발생하는 소음분석을 수행하였다. 미항공우주국에서 선보인 ODM (on-demand mobility) 개념에서 PAV를 운용하기 위한 안전성 다음으로 소음이 중요한 고려요소이다. PAV의 정확한 NPD (noise power distance) 데이터가 공개되어 있지 않는 문제를 해결하고자 eVTOL (electric vertical take off and landing) PAV와 같은 저소음 PAV를 민간용 헬리콥터로 모델링하여 소음 분석을 수행하고, 해당지역의 주거 적합성을 예측하였다. 전기추진과 같은 소음 감소 기술의 적용은 소음 노출 레벨을큰 폭으로 감소시켰고, 수도권내에서 소음문제 없이 PAV를 이용한 출퇴근이 실현 가능하다는 결론에 도달하였다.