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Uncertainty Analysis of a Pharmacokinetic Modeling for Inhalation Exposure of Benzene from the Use of Groundwater at Dwelling  

김상준 (한국과학기술원 생명화학공학과 환경복원공학연구실)
이현호 (LG 환경안전연구원)
박지연 (한국과학기술원 생명화학공학과 환경복원공학연구실)
이유진 (한국과학기술원 생명화학공학과 환경복원공학연구실)
유동한 (한국원자력연구소)
양지원 (한국과학기술원 생명화학공학과 환경복원공학연구실)
Publication Information
Journal of Soil and Groundwater Environment / v.9, no.1, 2004 , pp. 28-38 More about this Journal
Abstract
This study presents the result of uncertainty and sensitivity analysis of a pharmacokinetic model which describes the distribution and removal of benzene at each organ when an indivisual inhales indoor contaminated air with benzene originated from groundwater. The pharmacokinetic model simulates the distribution of benzene deposited in organs of human body through inhalation of contaminated indoor air as well as degradation-metabolism in liver. This study focused on the uncertainty problem induced from the use of the single values for blood flow, partition coefficient, degradation constant, volume, etc. of each organ which was due to a lack of knowledge about these parameters or their measurements. To solve this problem, uncertainty analysis on the pharmacokinetic model was conducted simultaneously which would help understanding the risk assessment associated with VOCs.
Keywords
Indoor air pollution; Benzene; Physiologically based pharmacokinetic model; Uncertainty analysis; Sensitivity analysis;
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