• Toxicological Research
• /
• v.17
• /
• pp.41-45
• /
• 2001

The methods used for risk assessment from exposure to chemicals are well established. in most cases where toxicity other than carcinogenesis is being considered, the standard method relies on establishing the No Observed Adverse Effect Level (NOAEL) in the most sensitive animal toxicity study and using an appropriate safety factor (SF) to determine the exposure which would be associated with an acceptable risk. For carcinogens a different approach is used because it has been argued there is no threshold of effect. Thus mathematical equations are used to extrapolate from the high doses used in ani-mal experiments. These methods have been strongly criticised in recent years on several grounds. The most cogent criticisms are a) the equations are not based on a thorough understanding of the mechanisms of carcinogenesis and b) the outcome of a risk assessment based on such models varies more as a consequence of changes to the assumptions and equation used than it does from the data derived from carcinogenicity experiments. Other criticisms include the absence of any measure of the variance on the risk assessment and the selection of default values that are very conservative. Recent advances in the application of risk assessment emphasise that measures of both the exposure and the hazard should be considered as a distribution of values. The outcome of such a risk assessment provides an estimate of the distribution of the risks.

• Asian Journal for Public Opinion Research
• /
• v.8 no.3
• /
• pp.297-323
• /
• 2020

The relationship between compliance with behaviors recommended to prevent the spread of COVID-19 and media exposure, negative emotions, and risk perception was examined using regression analyses of data from KAMOS, a nationally representative survey of South Korean adults. The strongest predictor of preventive behaviors in general was negative emotions, which had the largest βh (.22) among the independent variables considered. The eight negative emotions, identified using factor analysis of a series of 11 emotions, were anger, annoyance, fear, sadness, anxiety, insomnia, helplessness, and stress. Negative emotions themselves were influenced most strongly by the respondent's anxiety over social safety (βe=.286), followed by prediction of COVID-10 spread (β=.121, p<.001) and perceived risk of COVID-19 infection (β=.70, p=.023). Females (β=-.134) and those who felt less healthy (βo=-.097) experienced more negative emotions. Media exposure and increased media exposure both have significant relationships with negative emotions and both a direct and indirect impact on the adoption of preventive measures. Women, older people, and healthier people perceived greater risks and engaged in more preventive behaviors than their counterparts.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.7 no.2
• /
• pp.171-180
• /
• 1997

The objectives of this study were both 10 discuss the sampling method for airborne metalworking fluids(MWF)' mist and 10 suggest measures to minimize worker's exposure to carcinogen contained in metalworking fluids. In order to measure airborne MWF mist, it seems to be appropriate to use NIOSH Method #0500(filler weight) rather than NIOSH Method # 5026(analysis by FTIR). Because MWF mist on PVC filter evaporated and migrated during sampling, worker's exposure to MWF could be underestimated. So, when evaluating worker's exposure to MWF mist, other environmental conditions also must be considered. Enclosure and local exhaust ventilation system seems to he the most effective measure and must be constructed with process facility. In order to control worker exposure to carcinogens contained in MWF, distillation type and condition for crude oil, PAH concentration in MWF, and viscosity index of MWF must legally be described.

• Imaging Science in Dentistry
• /
• v.36 no.2
• /
• pp.69-72
• /
• 2006

Purpose : We evaluated the fractal dimension changes on bovine rib radiographs according to the decalcification degree and the exposure time in the bovine rib. Materials and Methods : Twenty 5 mm thick cross-sectional blocks from bovine rib bone were progressively decalcified in 30 mL 0.1 N hydrochloric acid for 5, 30, and 90 minutes. They were radiographed at three exposure time settings (0.22, 0.36, 0.43 mAs) before and after each decalcification stage. We selected $100{\times}100$ pixel-sized regions of interests (ROIs) on trabecular bone and calculated fractal dimensions by box-counting method. Results : Repeated measures ANOVA showed that fractal dimensions gradually decreased after acid-induced demineralization and with more exposure (P<0.001). Conclusion : The fact that fractal dimensions decrease after decalcification might support the hypothesis that patients with osteoporosis have decreased radiographic fractal dimension in trabecular bone in comparison to normal subjects.

• Food Science and Industry
• /
• v.52 no.1
• /
• pp.52-59
• /
• 2019

The present article covers a brief introduction on how repeated exposure design can be utilized for developing new food products. A generic consumer taste test which measures consumer acceptance in one trial may have limitation in predicting long-term acceptability of a product. The article describes the changes in food preference and choice during the course of life from infants to elderly. Then, several possible theories that proposes to delineate the underlying mechanisms for acquiring the liking for food is introduced. The article also discusses general experimental design, case studies which adopted repeated exposure design, the limitations and rapid test methods to predict long-term acceptance.

• Safety and Health at Work
• /
• v.14 no.1
• /
• pp.1-9
• /
• 2023

Background: Firefighting involves exposure of firefighters to risks related to this activity, serious injuries, and occupational diseases are recorded. There are other consequences such as thermal and emotional stress. This systematic review is proposed in order to analyze the risks and consequences faced by these workers and thus provide elements to improve safety management systems in institutions. Method: A descriptive observational study of systematic literature review on the risks and consequences of exposure to firefighters' activity was proposed, and the information was analyzed and described based on the available data and according to the variables determined. Results: The studies showed data on mechanical, physical, chemical, psychosocial risks, workers' perception and resilience, and epidemiological data. Information related to firefighters' activity on falls and slips, exposure to noise, and high concentrations of carbon monoxide is detailed. In addition, the relationship between burnout, cognitive, and physical fatigue as adverse effects on health and performance is mentioned. Conclusions: Among the preventive measures, the use of personal protective equipment is suggested, incorporation in prevention programs of information on exposure to risk factors, as well as the implementation of models that can predict the perception of workers, additionally, the generation of management systems with safety climate models for fire departments.

• Korea Journal of Hospital Management
• /
• v.21 no.1
• /
• pp.51-61
• /
• 2016

This study attempted to investigate how mass media marketing of a hospital influences patient volume. Additionally, the association of patient volume with exposure time and the type of mass media was examined. Data from a university hospital in Bundang (from January 2014 to November 2014) were used. Degree of physicians' mass media marketing was measured by the number of media exposure. Linear mixed model for repeated measures data was run to identify the associations between the number of media exposure and patient volume. First, the number of hospital physician's mass media exposure and new patients and the first visit patients were positively associated. Second, broadcasting media which has relatively significant in patient volume is TV programs such as cultural programs and news. Third, hospital physicians with higher ranks who were exposed to press media receive more patient appointment. Also, nonsurgical hospital physicians who were exposed to press media receive more patients. Fourth, medical treatment activities for hospital staff who hold the rank of Professor in case of making an appearance at press media have relatively increased. Hospital physician's media exposure, particularly TV programs, was significantly related to patient volume for outpatients.

• Journal of Environmental Health Sciences
• /
• v.44 no.4
• /
• pp.370-379
• /
• 2018

Objectives: Bisphenol A (BPA) has been extensively used in a variety of consumer products, resulting in widespread non-occupational human exposure. It is often detected in the human body. Studies have reported many health effects associated with endocrine and metabolic disruptions, including obesity, diabetes, hypertension, and cardiovascular diseases. This study was performed to explain the relationship between BPA exposure and obesity in the Korean adult population. Methods: The second stage of the Korean National Environmental Health Survey (KoNHES) was conducted from 2012 to 2014 with 6,478 persons participating. Using the results of the survey, we analyzed the exposure levels for BPA and the influence on obesity of BPA. Results: In model 1, the volume-based measure concentration of BPA, total, female and the 30s to 60s age group were positively related with BMI. In model 2, creatinine adjusted as a covariate and positive associations for BPA with BMI were observed in the female group and was marginally significantly associated in low body weight group. In model 3, creatinine adjusted (g/g-creatinine), BPA exposure, and BMI were positively related with sex, in females, and there was a marginally significant association with the low body weight group in the BMI categories. BMI was significantly associated with BPA in the female group in all three models. Conclusion: This study added further evidence that exposure to EDCs, include bisphenol A, is related with obesity among the general population. Given the environmental health concerns over BPA, it is necessary to develop comprehensive measures to reduce BPA exposure.

• The Korean Journal of Pain
• /
• v.33 no.1
• /
• pp.73-80
• /
• 2020

Background: The aim of this study was to evaluate radiation exposure to the eye and thyroid in pain physicians during the fluoroscopy-guided cervical epidural block (CEB). Methods: Two pain physicians (a fellow and a professor) who regularly performed C-arm fluoroscopy-guided CEBs were included. Seven dosimeters were used to measure radiation exposure, five of which were placed on the physician (forehead, inside and outside of the thyroid protector, and inside and outside of the lead apron) and two were used as controls. Patient age, sex, height, and weight were noted, as were radiation exposure time, absorbed radiation dose, and distance from the X-ray field center to the physician. Results: One hundred CEB procedures using C-arm fluoroscopy were performed on comparable patients. Only the distance from the X-ray field center to the physician was significantly different between the two physicians (fellow: 37.5 ± 2.1 cm, professor: 41.2 ± 3.6 cm, P = 0.03). The use of lead-based protection effectively decreased the absorbed radiation dose by up to 35%. Conclusions: Although there was no difference in radiation exposure between the professor and the fellow, there was a difference in the distance from the X-ray field during the CEBs. Further, radiation exposure can be minimized if proper protection (thyroid protector, leaded apron, and eyewear) is used, even if the distance between the X-ray beam and the pain physician is small. Damage from frequent, low-dose radiation exposure is not yet fully understood. Therefore, safety measures, including lead-based protection, should always be enforced.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.10 no.1
• /
• pp.45-57
• /
• 2000

Results of environmental monitoring for 35 steel industry welders exposed to manganese and chromium fume were evaluated. Efficiency of respiratory protectors, welding face shields and local exhaust ventilation were also evaluated to establish more efficient preventive measures that can protect welders from occupational disease as related to welding fume. The results are as follows; 1. Total fume from $CO_2$ arc welding with mild steel occurred 1.5 to 2.2 times more than that from shielded metal arc welding. Chromium and nickel fume from welding with stainless steel occurred 27 to 59 times and 18 to 30 times, respectively, than those with mild steel. 2. Proportions of water-soluble chromium(VI) and insoluble chromium(VI) Compare to total chromium occurring from $CO_2$ arc welding with stainless steel were 10.5% and 8.7%, respectively, while those with mild steel were 57.1 to 63.2% and 31.6 to 38.1%, respectively. 3. The efficiencies of 4 types of respiratory protectors to reduce welding fume exposure were evaluated as 54.4 to 64.4%. 4. The reducing effect of head type welding face shield was 67.6%, and that of hand type welding face shield was 58.5%. The highest reducing effect was shown in air supply welding face shield as 99.2%, although it is not convenient to wear. 5. When welding face shield and respiratory protectors were worn together, the reducing efficiency increased to 79.0 to 87.5%. 6. When local exhaust ventilation was installed in workplace, the reducing efficiencies varied from 31.5 to 73.1% according to the types of welding.