• Journal of Microbiology and Biotechnology
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• 제1권3호
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• pp.163-168
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• 1991

A new angiogenesis inhibitor, FR-118487 was obtained by chemical modification of FR-111142 which was isolated from the fermentation products of Scolecobasidium arenarium F-2015. The antiangiogenic activity of FR-118487 was compared with that of the parent compound, FR-111142. In the endothelial cell proliferation test in vitro and the angiogenesis in the chick embryo chorioal-lantoic membrane assay, FR-118487 had about 5∼10 times stronger antiangiogenic activities than FR-111142. In addition, FR-118487 inhibited the angiogenesis in the rabbit corneal assay and suppressed the solid tumor growth in mice. These findings showed that FR-118487 would be a unique antiangiogenic agent with promising antitumor activity.

• 지식경영연구
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• 제10권1호
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• pp.53-70
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• 2009

This study empirically explored what promotes exploration, through a case analysis of a Korean SME (small and medium sized enterprise), based on the research framework which focuses on the identification and the selection of exploratory NPD (new product development) alternatives, and the accumulation of novel capabilities in new technology domains. The learning process of the exploratory NPD project described is as follows. The identification barrier of exploratory NPD project is relatively low. Constructive crisis is germane to selecting exploratory NPD alternatives and to enduring the long payback period. New separated R&D unit is likely to implement the exploratory NPD project. The length of the gestation period of the exploratory NPD project is related with the level of the conflict between old members and new members. This study identified several antecedents of the exploratory NPD project. Prior success promotes the identification process of the exploratory NPD projects. Constructive crisis is related with CEO's personal characteristics such as future oriented and proactive personality. The proactive involvement and persuasion of CEO are germane to reducing the conflict between old and new members and to the success of the exploratory NPD project. Based on the results, this study discusses several implications and future research directions.

• 한국IT서비스학회지
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• 제15권1호
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• pp.19-37
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• 2016

Advance of the Internet environment is applied not only to information search but also to the area of consumption behavior. Current research analyzes online use behavior and online information search of consumers in terms of users' perception. With the result of the research, it is noticed that promotion focus brings broader variation of information use behavior, and utilitarian value has a beneficial impact on the online exploratory information search. In addition, it is revealed that the more exploratory the information search is, the wider the range of online shopping information search is. Finally, people who have utilitarian shopping value showed more exploratory behavior in online search, especially for the search of informational products, than those who have hedonic shopping value. Present research is believed to improve practical influence of consumers' personality on online use behavior when customers purchase search products online. As a result, it would contribute to consumer research and marketing held online.

• 대한수학교육학회지:수학교육학연구
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• 제12권1호
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• pp.1-16
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• 2002

The 7th Curriculum emphasizes that in mathematics classes, mathematical concepts be understood and mathematical problems be solved through student's own exploratory activities including the use of data, manipulatives, andtechnological devices. Following the main idea of the Seventh Mathematics Curriculum, this paper dealt with instructional methods applied suitably and effectively in mathematics classes, and focused on the 'exploratory learning in groups' method in mathematics education. For this purpose, this paper reviewed and summarized theories related to general pedagogy and of mathematics education. Based on the results, it investigated appropriate instructional methods in mathematics education. In particular, this paper focused on studying the exploratory learning method while investigating its properties and understand- ing the relationship between the 'exploratory learning in groups' method and the discussion-centered method. Finally, in order to show the usefulness of the exploratory learning method, this paper developed an example of a teaching module using the exploratory learning method in addition to discussion and lecture-centered methods by the use of manipulatives. The main goal of the module was to make students understand the principle of multiplication of integers.

• 지식경영연구
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• 제12권4호
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• pp.91-119
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• 2011

Compared to the industrial society, the knowledge-based economy of the 21st century has placed importance on intellectual capital as a sustainable competitive advantage of an organization. The ownership, creation, and interaction of intellectual capital is emerging as the main challenges of the management and, moreover, it might extend to the issue of intellectual capital management. This research found that the exploitation and sharing of knowledge was more efficient in a networked organization through a case study for A research institute, which attempted intellectual capital management domestically for the first time. The contribution of this exploratory research is to suggest new perspectives on the ownership of intangible asset, the evaluation of knowledge-based product, and the competitive advantage and complementarity of an organization in the knowledge-based economy. The limitation is that this research is just exploratory due to the inaccessibility of data. If the intellectual capital management would be more common, the diverse researches should be empirically carried out.

• 품질경영학회지
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• 제49권1호
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• pp.81-95
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• 2021

Purpose: The purpose of this study was to analysis pattern of nonconforming farmers who is one of the factors of unconformity in residual pesticides. Methods: Pattern analysis of nonconforming farmers were analyzed through convergence of safety data and farmer's DB data. Exploratory data analysis and association rule analysis were used for extracting factors related to unconformity. Results: The results of this study are as follows; regarding the exploratory data analysis, it was found that factors of farmers influencing unconformity in residual pesticides by total 9 factors; sampling time, gender, age, cultivation region, farming career, agricultural start form, type of agriculture, cultivation area, classification of agricultural products. Regarding the association rule analysis, non-conformity association rules were found over the past three years. There was a difference in the pattern of nonconforming farmers depending on the cultivation period. Conclusion: Exploratory data analysis and association rule analysis will be useful tools to establish more efficient and economical safety management plan for agricultural products.

• 한국경영과학회지
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• 제36권4호
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• pp.125-141
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• 2011

There have been some research papers on financial services marketing, but there are only few exploratory studies that analyze characteristics of financial consumers in Korea. This study examines, based on FGI and web survey results, which factors consumers consider more important when choosing their financial services. I found that 'product profitability' is the most important factor when consumers choose their financial services, followed by 'relational benefits', 'convenience', 'product diversity', 'company stability', 'branch satisfaction', and 'social responsibility' in order of importance. The study also showed that there are differences in perception of these important factors depending on the types of consumers such as gender, age, size of financial assets, degree of risk-taking, and main financial company they are using. This study hopefully provide implications to marketing managers in financial services that they could decide which factors they have to focus on more when planning marketing strategies. Another objective of this study is to provide useful insights to the future researchers in financial services marketing.

• 지식경영연구
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• 제16권1호
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• pp.171-191
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• 2015

This paper investigates how internal knowledge dependency and its interaction with external knowledge adoption affect innovation performance in Korean companies. We categorize innovation performance into exploratory innovation and exploitative innovation. Especially, we examine business group effects as group headquarters and sister subsidiaries holistically form the boundary of the firm. Our empirical results first suggest that the degree of internal knowledge dependency is positively associated with exploitative innovation, but negatively with exploratory innovation. Second, internal knowledge dependency is more negatively related to exploratory innovation in independent firms than in business group affiliates. Third, independent firms' adoption of external knowledge tends to strengthen the positive relationship between internal knowledge dependency and exploitative innovation. Finally, exploitative external knowledge search appears to strengthen the negative relationship between internal knowledge dependency and exploratory innovation in both types of firms.

• Nuclear Medicine and Molecular Imaging
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• 제41권6호
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• pp.525-529
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• 2007

Regulation for the radiopharmaceuticals should be reasonably different from that of other drugs. Radiopharmaceuticals are always used by compounding based on the doctor's order, have short half life and very low administration dose. Its pharmacological effect is not from its chemical effect but from radiation. The background for exploratory IND (Investigational New Drug) explained by the FDA was to reduce the time and resources expended on candidate products that are unlikely to suceed, new tools are needed to distinguish earlier in the process those candidates that hold promise from those that do not. In this review, basic concept for exploratory IND and RDRC guideline is summarized and various suggestions for improving and expediting procedure for new radiopharmaceutical development would be described.

• 아태비즈니스연구
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• 제11권3호
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• pp.107-122
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• 2020

Purpose - This paper investigates the relations among exploratory and exploitative supply chain management practices, competitive advantage, and firm performance. Design/methodology/approach - This study takes a hypothesis-generating study to capture the tradeoffs between exploration and exploitation and develops some hypotheses which involve the relations among SCM practices, competitive advantage, and short-term and long-term performance. Findings - Exploitative SCM practices have more positive effects on short-term performance rather than long-term performance, whereas exploratory SCM activities affect long-term performance. Further competitive strategy, environmental dynamism, and organizational slack moderates the relationship between SCM and performance. Exploitative SCM is more desirable when a firm uses low cost strategy, lacks slack resources, and faces stable environment, while exploratory SCM is more effective when a firm employs differentiation strategy, has slack resources, and confront dynamic environment. Research implications or Originality - In order to understand the performance effects of a variety of SCM practices, we should distinguish between exploitative and exploratory SCM activities. Further the relationship between SCM and performance may differ depending upon some contingent variables such as external environment, competitive strategy and organizational slack.