• Herbal Formula Science
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• v.10 no.2
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• pp.159-188
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• 2002

The purpose of this study was to reseach the effect of Daehwanggamchoeumja(大黃甘草飮子) and its component groups on diabetes, free radicals, and antioxidants system in Alloxan-induced diabetic rats. The experimental group was divided into three groups: Daehwanggamchoeumja(DG), and its components groups, Gamdutang (Gamcho&Daedu; DG-I) and Daehwanggamchotang(DG-2). The results were obtained as follows: 1. In the study of effect on diabetic metabolic dysfunction(Glucose, Triglyceride, Total Cholesterol, HDL Cholesterol, Total Protein, Albumin, Creatine, BUN), only DG has a significant effect. 2. In the study on free radical scavenging effect in vitro(the suppressing effect on peroxidation of linoleic acid on concentration, the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system, inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2Fe^{2-}$system, and the effect on Nitrate reductase activity), DG and DG-2 have more effect than DG-l relatively. 3. In the study on antioxidants system in vivo(The level of serum LPO, The level of hepatic LPO, Catalase, GSH, GST), only DG has a significant effect. These results suggest that Daehwanggamchoeumja(大黃甘草飮子) has an effect on diabetes, peroxidative damage by free radical, so it seems to be useful to prevent and treat diabetes. The mechanisms of these are supposed to be involved in antioxidant and three drugs' cooperative synergy effect.

• Herbal Formula Science
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• v.10 no.2
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• pp.73-83
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• 2002

The single dose toxicity of Jengjengamiyjintang, a herbal drug for duodenal ulcer was evaluated in male and female Sprague-Dawley (SD) rats. Jengjengamiyjintang was once administered to both sexes of rats at the dose levels of 2000, 1000, 500, 250 and 125mg／kg for oral route according to KFDA guidelines for single dose toxicity test (1999-61). In addition, vehicle control group was added in order to compare clinical signs, body weight changes and abnormal necropsy findings. After single administration, clinical signs were observed every twice a day for 14 days and body weights were measured 5 times including initial measurement on day 0. When observation period was over, the animals were sacrificed and macroscopic examination of major organs was conducted. Neither significant clinical signs nor death after administration was observed during the observation periods except for soft feces or diarrhea that were restricted to Day 1 of 2000 and 1000mg/kg-dosing groups. Although some accidental findings such as gross and histopathological changes of lung that were demonstrated in some animals of all experimental groups including vehicle control group, no abnormal necropsy findings and changes of body weight were observed at terminal necropsy in both sexes. From these results, it is considered that $LD_{50}$ of Jengjengamiyjintang is over 2000mg／kg in oral administration in both sexes of rats and approximated lethal dose was considered over 2000mg/kg.

• The Journal of the Korea Contents Association
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• v.15 no.2
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• pp.499-506
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• 2015

The friction velocity is a quantity with the dimensions of velocity defined by the friction stress and density of a wall surface at near wall of flow condition. Also, the friction velocity is the hydraulic parameter describing shear force at the bottom flow. Moreover, it is a very important factor in designing open channel and essential to determine the mixing coefficient in the main flow direction. The estimation of the friction velocity are such as methods using channel slope, linear law of the mean velocity at viscous sub-layer and direct measurement of wall shear stress, etc. In the present study, we propose a friction velocity equation that has been optimized by combining the concept of entropy, which is used in stochastic method, and to verify the proposed equation, the experimental data measured by Song was used. The R squared for friction velocities between proposed equation and friction velocity formula analyzed 0.999 to 1.000 in a very good agreement with each equation.

• Journal of the Korea institute for structural maintenance and inspection
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• v.11 no.1
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• pp.68-76
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• 2007

In the present study, tests for U-type steel box girder are performed to observe the effects of W-type and X-type of top lateral bracings on the bending behavior of the U-type steel box girder system. Another objective of the present study is to investigate the adequacy of the currently available design formula. For the structural tests, the test specimen with two third scale of the system constructed in the field was used. In this test, several different spacings are used for the top lateral bracings. The stresses measured from the bending tests are compared with those by the formula proposed by Helwig. An adequate type and the required number of panel for diagonal bracing was obtained.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.8 no.1
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• pp.1-12
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• 1996

In lots of application to heat exchanger systems, closed two-phase thermosyphons are tilted from a horizontal. If the tilt angle, especially, is less than 30$^{\circ}$, the operational performances of thermosyphon are highly dependent on tilt angle. The present study was conducted to better understand such operational behaviors as mech-anni는 of phase change, and flow patterns inside a tilted thermosyphon. For experiment, an ethanol thermosyphon with a 35% of fill charge rate was designed and manufactured, using a copper tube with a diameter 19mm and a length 1500mm. Through a series of test, the tilt angle was kept constant at each of 4 different values in the range 10~25deg. and the heat supply to the evaporator was stepwisely increased up to 30㎾/$m^2$. When a steady state was established to the thermosyphon for each step of thermal loads, the wall temperature distribution and vapor temperature at the condenser were measured. The wall temperature distributions demonstrated a formation of dry patch in the top end zone of the evaporator, with a values of temperature 20~4$0^{\circ}C$ higher than the wetted surface for a moderate heat flux q≒20㎾/$m^2$. Inspite of the presence of hot dry patch, however, the mean values of boiling heat transfer coefficient at the evaporator wall were still in a good agreement with those predicted by Rohsenow's formula, which was based on nucleate boiling. For the condenser, the wall temperatures were practically uniform, and the measured values of condensation heat transfer coefficient were 1.7 times higher than the predicted values obtained from Nusselt's film condensation theory on tilted plate. Using those two expressions, a correlation was formulated as a function of heat flux and tilt angle, to determine the total thermal resistance of a tilted thermosyphon. The correlation formula showed a good agreement with the experimental data within 20%.

• The Journal of the Convergence on Culture Technology
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• v.6 no.4
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• pp.655-661
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• 2020

In this study, the correlation between concrete core compressive strength and rebound hardness of urban railway underground structures was analyzed. The equations for the range of rebound hardness were derived and compared with the measured concrete core strengths for each range of rebound hardness to confirm the adequacy of the estimated compressive strength. As the result, the linear regression analysis results of the average compressive strength by the Gaussian probability density function (representative compressive strength estimation formula) and the estimation formula by the rebound hardness range were founded to match well within 3% of the experimental concrete core compressive strength test results. Therefore, the stochastic statistical analysis using the rebound hardness measurement results suggested in this study could be help to secure the confidence level of the correlation between the rebound hardness and the concrete compressive strength which are relatively large deviation according to the estimation equations.

• Journal of the Society of Disaster Information
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• v.13 no.3
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• pp.313-321
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• 2017

In order to investigate the basic performance of the high strength anchor for asphalt road subjected to tensile load, the static pullout test was carried out and the pullout strength of the asphalt anchor was analyzed. In the pullout test, the depth of anchor, depth of pavement, diameter of anchor, type of anchor, experimental temperature, epoxy type and amount of anchor were used as test variables. As a result, the steel strength of asphalt anchor was 1.08 times higher than that of conventional concrete anchor, therefore it is considered appropriate to use the steel strength formula of concrete anchor for asphalt anchor. Compared with the proposed formula, the pullout load obtained from the test of the asphalt anchor was within ${\pm}10%$. The ratio of the projected area of the asphalt anchor is similar as that of the concrete anchor.

• Weed & Turfgrass Science
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• v.5 no.4
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• pp.225-229
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• 2016

This study was conducted to investigate the herbicidal efficacy of up granule formula of benzobicyclon mixtures, benzobicyclon + azimsulfuron + oxaziclomefone up granule (BAO UG) and benzobicyclon + bensulfuron-methyl + fentrazamide up granule (BBF UG) to control annual and perennial weed species in a rice paddy field. Four annual weed species including Echinochloa crus-galli L. and three perennial weeds were dominated in the experimental field. Application of BAO UG and BBF UG was highly effective to control both annual and perennial weed species. No phytotoxic effect was observed in the rice based on the plant height, the number of tillers, and culm and panicle length. Finally, rice yield in the BAO UG and BBF UG treatment was as much as that in the hand weeding. This study indicates that self-dispersible floating formula of benzobicyclon mixtures can be applied to control both annual and perennial weed species in rice paddy fields and contribute to save labor costs.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.2
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• pp.101-111
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• 2021

Two different types of shear-friction tests were classified by external loadings and referred to as a push-off and a pull-off test. In a pull-off test, a tension force is applied in the transverse direction of the test specimen to produce a shear stress at the shear plane. This paper presents a method to evaluate shear transfer strengths of uncracked pull-off specimens. The method is based on the compression field theory and different constitutive laws are applied in some ways to gain accurate shear strengths considering softening effects of concrete struts based on Modified Compression Field Theory (MCFT) and Softened Truss Model (STM). The validity of the proposed method is examined by applying to some selected test specimens in literatures and results are compared with the predicted values. A general agreement is observed between predicted and measured values at ultimate loading stages in initially uncracked pull-off test specimens. A shear strength evaluation formula considering the effective compressive strength of a concrete strut was proposed, and the applicability of the proposed formula was verified by comparing with the experimental results in the literature.

• Herbal Formula Science
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• v.27 no.2
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• pp.137-149
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• 2019

Objective : This study is conducted in order to investigate the effect of Banggibongnyeongtang(BBT) on Lipopolysaccharide (LPS)-induced depression. Method : LPS $5{\mu}g$ was injected to lateral ventricle. Experimental groups were administered BBT intraperitoneally. Depressive behavior was confirmed by weight change, sucrose preference, open field test(OFT), and forced swimming test(FST). The plasma concentration of $IL-1{\beta}$ and $TNF-{\alpha}$, Corticotropin-Releasing Factor(CRF), Adrenocorticotropin Hormone(ACTH) and Corticosterone(CORT) were measured by ELISA. Result : BBT did not change the body weight significantly than LPS group, but on sucrose preference, BBT increased significantly in LPS+BBT400 group compared to LPS group (P<0.05). In the OFT, BBT increased spending time in the central zone and decreased grooming number. LPS+BBT400 group increased central zone-spending time, and decreased grooming number than LPS group significantly (P<0.05). In the FST, LPS+BBT400 group decreased immobility time than LPS group significantly (P<0.05). BBT decreased $IL-1{\beta}$ concentration does-dependently, but only with significant decrease in LPS+BBT400 group than LPS group in plasma (P<0.05). But BBT did not decrease $TNF-{\alpha}$ concentration significantly in plasma. BBT decreased plasma CRF, ACTH, and CORT. And CRH and CORT of LPS+BBT400 group were shown significant decrease comparing with LPS group (P<0.05). Conclusion : It is postulated that the anti-depressant effect of BBT can be validated through inhibition of HPA axis abnormal activity by the anti-inflammatory effect.