• Herbal Formula Science
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• v.8 no.1
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• pp.329-342
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• 2000

Citri Reticulatae Viride Pericarpium(CRVP) is being used to regulate the flow of Q(氣) However, the mechanism of it's pharmacological actions is not well understood. The purpose of this research was to investigate effects of CRVP contractil response of isolated on abdominal and femoral artery in rabbits and renal artery in pigs. 1. Abdominal artery was relaxed by CRVP in a dose-dependent manner. 2. Femoral artery was relaxed by CRVP in a dose-dependent manner 3. Pretreatment with methylene blue and indomethacin did not inhibited CRVP induced relax in abdominal artery and femoral artery. 4. Renal artery was relaxed by $H_{2}O$ fraction in a dose-dependent manner, 5. Pretreatment with regitine inhibited $H_{2}O$ fraction(CRVP) induced relax in renal artery in a dose-dependent manner. 6. Renal artery was not relaxed by hexane fraction(CRVP) in a dose-dependent manner. 7. Pretreatment with regitine$(10^{-7}M)$ was relaxed by methylene chloride(MC)(CRVP) and $H_{2}O$ fraction in a $0.5{\mu}g/m{\ell}$.

• Herbal Formula Science
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• v.15 no.2
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• pp.119-126
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• 2007

Objectives: This study presents observation of microorganism such as total aerobic bacteria, total fungus, E. coli, Pseudonomas aerugjnosa, Staphylococcus aureus, and Salmonella typhimurium in herbal decoction manufactured by Korean medical clinic. Methods: We examined to observe microorganism using the requirements for the experimental methods recommended by FDA. For the identification, we observed microscopic methods and carried out polymerase chain reaction (PCR) and DNA purification. The purified DNA samples were analyzed by DNA sequencer. As compared with NCBI database. the results were identified by sequences similarity. Results and conclusion: 26 (55%) of 46 decoctions observed positive for microbial test. 12 (46 %) of 26 positive decoctions exceed requirement of microbial limit test. These microbial colony identified genus of Bacillus using microscopic and DNA sequencing methods.

• Earthquakes and Structures
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• v.12 no.1
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• pp.23-34
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• 2017

Composite steel plate deep beam (CDB) is proposed as a lateral resisting member, which is constructed by steel plate and reinforced concrete (RC) panel, and it is connected with building frame through high-strength bolts. To investigate the seismic performance of the CDB, tests of two 1/3 scaled specimens with different length-to-height ratio were carried out under cyclic loads. The failure modes, load-carrying capacity, hysteretic behavior, ductility and energy dissipation were obtained and analyzed. In addition, the nonlinear finite element (FE) models of the specimens were established and verified by the test results. Besides, parametric analyses were performed to study the effect of length-to-height ratio, height-to-thickness ratio, material type and arrangement of RC panel. The experimental and numerical results showed that: the CDBs lost their load-carrying capacity because of the large out-of plane deformation and yield of the tension field formed on the steel plate. By increasing the length-to-height ratio of steel plate, the load-carrying capacity, elastic stiffness, ductility and energy dissipation capacity of the specimens were significantly enhanced. The ultimate loading capacity increased with increasing the length-to-height ratio of steel plate and yield strength of steel plate; and such capacity increased with decreasing of height-to-thickness ratio of steel plate and gap. Finally, a unified formula is proposed to calculate their ultimate loading capacity, and fitting formula on such indexes are provided for designation of the CDB.

• Journal of the Korean Society of Hazard Mitigation
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• v.1 no.2 s.2
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• pp.93-101
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• 2001

The objective of this study is to derive a shrinkage correction formula that considers temperature effect and to develop a methodology for the improved prediction of the long-term behavior of the FCM bridges by considering seasonal temperature variations in-situ. Thereby, current formulation were performed by using the actual experimental shrinkage data including seasonal temperature variation. The investigation of the long-term behavior of the FCM bridge was performed on the construction site in order to decide applicability of the shrinkage formula Numerical results by the general method indicates inaccurate values of total strain when considering real strain, whereas the applied method demonstrates a good agreement in the resultant strain. In consequently, the applied method will improve the prediction of the long-term deformation of the FCM Bridges.

• Journal of KIISE:Software and Applications
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• v.35 no.11
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• pp.661-670
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• 2008

In some applications of software engineering such as the verification of software model or embedded program, SAT solver is used. To practical use a SAT solver, a problem is encoded to a CNF formula, but because the formula has lower expressiveness than software models or source codes, optimal CNF encoding is required. In this paper, we propose optimal encoding techniques for the problem of "Selecting adjacent $k{\leq}n$ among n objects," Through experimental results we show the proposed constraint is efficient and correct to solve Japanese puzzle. As we know, this paper is the first study about CNF encoding for adjacency in BCC.

• Journal of Korean Society of Steel Construction
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• v.13 no.2
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• pp.201-210
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• 2001

A numerical analysis and experimental study were performed to investigate the behavior and strength of tube-gusset connection subjected to axial and lateral forces. To investigate the behavior of the connections, experiment was conducted by applying three directional loads. Local buckling and local plastic bending deformation of the connection were observed from the test. Analytical results were compared with test results for the limited cases. Primary interests here are the effect of eccentricity on the strength of the connection. To suggest a formula for the strength of tube-gusset connection, lateral forces were replaced with equivalent wall moment and eccenrtric vertical component force of lateral force. Ultimate strength formula for the each force was proposed. Finally, nondimensionalized ultimate strength interaction relationships between the wall moment of tube($M_w$), vertical axial force($P_v$), and eccentric vertical component of lateral force($P_e$) were formulated through parametric study.

• Structural Engineering and Mechanics
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• v.58 no.1
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• pp.1-19
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• 2016

Recently, the high-strength concrete is increasingly used in the construction of reinforced concrete structures due to its benefits, but this use is influenced negatively on the local ductility of structural elements. The objective of this study is the prediction of a new approach to evaluate the curvature ductility factor of high strength concrete beams according to Eurocode 2. After the presentation of the Constitutive laws of materials and the evaluation method of curvature ductility according to the Eurocode 2, we conduct a parametric study on the factors influencing the curvature ductility of inflected sections. The calibrating of the obtained results allows predicting a very simple approach for estimating the curvature ductility factor. The proposed formula allows to calculate the curvature ductility factor of high strength concrete beams directly according to the concrete strength $f_{ck}$, the yield strength of steel $f_{yk}$ and the ratio of tension and compression reinforcements ${\rho}$ and ${\rho}^{\prime}$ respectively, this proposed formula is validated by theoretical and experimental results of different researchers.

• Steel and Composite Structures
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• v.26 no.6
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• pp.693-703
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• 2018

To better understand the influence of hollow ratio on the hollow concrete-filled circular steel tubular (H-CFT) stub columns under axial compression and to propose the design formula of ultimate bearing capacity for H-CFT stub columns, 3D finite element analysis and laboratory experiments were completed to obtain the load-deformation curves and the failure modes of H-CFT stub columns. The changes of the confinement effect between core concrete and steel tube with different hollow ratios were discussed based on the finite element results. The result shows that the axial stress of concrete and hoop stress of steel tube in H-CFT stub columns are decreased with the increase of hollow ratio. AfteGr the yield of steel, the reduction rate of longitudinal stress and the increase rate of circumferential stress for the steel tube slowed down. The confinement effect from steel tube on concrete also weakened slowly with the increase of hollow ratio. Based on the limit equilibrium method, a simplified formula of ultimate bearing capacity for the axially loaded H-CFT stub columns was proposed. The predicted results showed satisfactory agreement with the experimental and numerical results.

• Herbal Formula Science
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• v.16 no.2
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• pp.47-69
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• 2008

Objectives : The purpose of this study is to inspect trends of the papers of osteoporosis in the field of herbal medicines and to establish the future direction for evaluation and development of natural medicines. Methods : We reviewed 80 oriental medicine papers in Korean journals published between 1994 and 2008. Results : There were 6 review, 2 clinical paper, 72 experimental papers and we confirmed that the drugs used in the experiments are almost yang-invigorating drugs which are good for kidney deficiency pattern Conclusions : We found out some of the herbal extracts are very efficacious for osteoporosis. More studies of oriental medicinal herbs are needed for developing anti-osteoporosis drugs with these basic data.

• Herbal Formula Science
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• v.16 no.2
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• pp.101-114
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• 2008

Objective : The purpose of this study was to investigate the anti-inflammatory effects of Hwagae-san extract(HGSE) on the peritoneal macrophage. Methods : To evaluate anti-inflammatory effects of HGSE, We measured cytokines(interleukin-6; IL-6, interleukin-12; IL-12, tumor necrosis factor-${\alpha}$; TNF-${\alpha}$) and nitric oxide(NO) production in lipopolysaccharide(LPS)-induced macrophages. Furthermore, We examined molecular mechanism using western blot and also LPS-induced endotoxin shock. Results : 1. HGSE did not have any cytotoxic effect in the peritoneal macrophages. 2. HGSE reduced LPS-induced IL-6, TNF-${\alpha}$, IL-12 and NO production in peritoneal macrophages. 3. HGSE inhibited the activation of extracelluar signal-regulated kinase(ERK), C-Jun NH2-terminal kinase(JNK) but not of p38, degradation of IkB-${\alpha}$ in the LPS-stimulated peritoneal macrophages. 4. HGSE inhibited the production of TNF-$\alpha$, IL-6 and IL-12 in serum after LPS injection. Conclusion : These results suggest that HGSE may inhibit the production of TNF-${\alpha}$, IL-6, and IL-12 through inhibition of ERK and JNK activation, and that HGSE may be beneficial for inflammatory diseases.