• Title/Summary/Keyword: Experimental Simulation

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Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth

  • Yoo, Su Woong;Park, Hee-Jin;Oh, Gyungseok;Hwang, Soonjoo;Yun, Misun;Wang, Taejun;Seo, Young-Seok;Min, Jung-Joon;Kim, Ki Hean;Kim, Eung-Sam;Kim, Young L.;Chung, Euiheon
    • Current Optics and Photonics
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    • v.1 no.1
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    • pp.51-59
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    • 2017
  • In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractional ablative lasers are commonly used for cosmetic/aesthetic purposes (e.g., photorejuvenation, hair removal, and scar reduction), we propose a novel use of such laser treatments as a stromal treatment to delay tumorigenesis and suppress carcinogenesis. In this study, we found that non-ablative fractional laser (NAFL) irradiation may have a possible suppressive effect on early tumor growth in syngeneic mouse tumor models. We included two syngeneic mouse tumor models in irradiation groups and control groups. In the irradiation group, a thulium fiber based NAFL at 1927 nm was used to irradiate the skin area including the tumor injection region with 70 mJ/spot, while no laser irradiation was applied to the control group. Numerical simulation with the same experimental condition showed that thermal damage was confined only to the irradiation spots, sparing the adjacent tissue area. The irradiation groups of both tumor models showed smaller tumor volumes than the control group at an early tumor growth stage. We also detected elevated inflammatory cytokine levels a day after the NAFL irradiation. NAFL treatment of the stromal tissue could potentially be an alternative anticancer therapeutic modality for early tumorigenesis in a minimally invasive manner.

Estimation of Head Loss Coefficients at Surcharged Square Manhole Using Numerical Model (수치모형을 이용한 과부하 사각형 맨홀에서의 손실계수 산정)

  • Kim, Jung-Soo;Lim, Ga-Hui;Rim, Chang-Soo;Yoon, Sei-Eui
    • Journal of the Korean Society of Hazard Mitigation
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    • v.11 no.3
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    • pp.143-150
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    • 2011
  • Energy loss at manholes, often exceeding friction loss of pipes under surcharged flow, is considered as one of the major causes of inundation in urban area. Therefore, it is important to analyze the head losses at manholes, especially in case of surcharged flow. The stream characteristics were analyzed and head loss coefficients were estimated by using the computational fluid dynamics(CFD) model, FLUENT 6.3, at surcharged square manhole in this study. The CFD model was carefully assessed by comparing simulated results with the experimental ones. The study results indicate that there was good agreement between simulation model and experiment. The CFD model was proved to be capable of estimating the head loss coefficients at surcharged manholes. The head loss coefficients with variation of the ratio of manhole width(B) to inflow pipe diameter(d) and variation of the drop height at surcharged square manhole with a straight-path through were calculated using FLUENT 6.3. As the ratio of B/d increases, head loss coefficient increases. The depth and head loss coefficient at manhole were gradually increased when the drop height was more than 5cm. Therefore, the CFD model(Fluent 6.3) might be used as a tool to simulate the water depth, energy losses, and velocity distribution at surcharged square manhole.

Analysis of Microstructure and Thermal Conductivity of Concrete Thermal Energy Storage based on Amount of Graphite Mixture (그라파이트 혼입량에 따른 에너지 저장 콘크리트의 미세구조 및 열전도도 분석)

  • Kim, Se-Yun;Kim, Sung-Jo;Suh, Jeewoo;Han, Tong-Seok
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.34 no.5
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    • pp.293-300
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    • 2021
  • In this study, the microstructure and thermal conductivity correlation was investigated for concrete materials used in concrete thermal energy storage (CTES) among real-time energy storage devices. Graphite was used as admixture to increase the thermal conductivity performance of the CTES. Concrete specimens of 10% and 15% substitution of cement by mass with graphite, as well as ordinary portland cement (OPC) specimens were prepared, and the microstructural changes and effects on thermal conductivity were analyzed. Porosities of OPC and concrete with graphite were compared using micro-CT, and the microstructural characteristics were quantified using probability functions. Three-dimensional virtual specimens were constructed for thermal analysis, to confirm the effect of microstructural characteristics on thermal conductivity, and the results were compared with the measured conductivity obtained using the hot-disc method. To identify thermal conductivity of graphite for thermal analysis, solid phase conductivity was inversely determined based on simulation and experimental results, and the effect of graphite on thermal conductivity was analyzed.

Study on the neutron imaging detector with high spatial resolution at China spallation neutron source

  • Jiang, Xingfen;Xiu, Qinglei;Zhou, Jianrong;Yang, Jianqing;Tan, Jinhao;Yang, Wenqin;Zhang, Lianjun;Xia, Yuanguang;Zhou, Xiaojuan;Zhou, Jianjin;Zhu, Lin;Teng, Haiyun;Yang, Gui-an;Song, Yushou;Sun, Zhijia;Chen, Yuanbo
    • Nuclear Engineering and Technology
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    • v.53 no.6
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    • pp.1942-1946
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    • 2021
  • Gadolinium oxysulfide (GOS) is regarded as a novel scintillator for the realization of ultra-high spatial resolution in neutron imaging. Monte Carlo simulations of GOS scintillator show that the capability of its spatial resolution is towards the micron level. Through the time-of-flight method, the light output of a GOS scintillator was measured to be 217 photons per captured neutron, ~100 times lower than that of a ZnS/LiF:Ag scintillator. A detector prototype has been developed to evaluate the imaging solution with the GOS scintillator by neutron beam tests. The measured spatial resolution is ~36 ㎛ (28 line pairs/mm) at the modulation transfer function (MTF) of 10%, mainly limited by the low experimental collimation ratio of the beamline. The weak light output of the GOS scintillator requires an enormous increase in the neutron flux to reduce the exposure time for practical applications.

Experimental determination of design parameters for filtration trench using phosphorus removal granular materials (인 제거 입상소재를 적용한 여과수로 설계인자의 실험적 결정)

  • Jang, Yeoju;Lim, Hyunman;Jung, Jinhong;Ahn, Kwangho;Chang, Hyangyoun;Park, Nari;Kim, Weonjae
    • Journal of Korean Society of Water and Wastewater
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    • v.33 no.1
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    • pp.9-16
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    • 2019
  • The algal blooms in stagnant streams and lakes have caused many problems. Excessive algae leads to disturbance of ecosystem and overload of water treatment processes. Therefore, phosphorus(P), source of algal blooms, should be controlled. In this study, a filtration trench has been developed to convert dissolved phosphorus into hydroxyapatite(HAP) so that it could be crystallized on the surface of 'phosphorus removal granular material'; and residual particulate phosphorus could be removed by additional precipitation and filtration. The front and rear parts of filtration trench consisted of 'phosphorus removal granular material contact bed' and 'limestone filtration bed', respectively. As a result of the column test using phosphorus removal granular material and limestone serially, $PO_4-P$ was removed more than 90% when EBCT(empty bed contact time) of the contact bed was over 20 minutes; and T-P represented 60% of removal efficiency when total EBCT was over 1.5 hours. The results of column tests to figure out the sedimentation characteristics showed that more than 90% of particulate phosphorus could be removed within 24 hours. It was necessary to optimize the filtration part in order to increase removal efficiency of T-P additionally. Also, it was confirmed through the simulation of Visual MINTEQ that most of particulate phosphorus in the column tests is the form of HAP. Based on the results of the study, it could be suggested that the design parameters are over 0.5 hour of EBCT for phosphorus removal granular material contact bed and over 1.5 hours of EBCT for limestone filtration bed.

CFD Analysis on the Internal Reaction in the SNCR System (SNCR 시스템 내부의 물질 반응에 관한 전산해석적 연구)

  • Koo, Seongmo;Yoo, Kyung-Seun;Chang, Hyuksang
    • Clean Technology
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    • v.25 no.1
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    • pp.63-73
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    • 2019
  • Numerical analysis was done to evaluate the chemical reaction and the reduction rate inside of selective non-catalytic reduction to denitrification in combustion process. The $NO_X$ reduction in selective non-catalytic reduction is converted to not only nitrogen but also nitrous oxide. Simultaneous $NO_X$ reduction and nitrous oxide generation suppressing is required in selective non-catalytic reduction because nitrous oxide influences the global warming as a greenhouse gas. The current study was performed compare the computational analysis in the same temperature and amount of NaOH, and in comparison with the previous research experiments and confirmed the reliability of the computational fluid dynamics. Additionally, controlling the addition amount of NaOH to predict the $NO_X$ reduction efficiency and nitrous oxide production. Numerical analysis was done to check the mass fraction of each material in the measurement point at the end of selective non-catalytic reduction. Experimental Value and simulation value by numerical analysis showed an error of up to 18.9% was confirmed that a generally well predicted. and it was confirmed that the widened temperature range of more than 70% $NO_X$ removal rate is increased when the addition amount of NaOH. So, large and frequent changes of the reaction temperature waste incineration facilities are expected to be effective.

Experimental Study on Reducing Effect for Surface Temperature of Recycled Synthetic-Resin Permeable Block (재생 합성수지 투수블록의 표면온도 저감효과에 관한 실험적 연구)

  • Lee, Chul-Hee;Lee, Arum;Shin, Eun-Chul;Ryu, Byung-Hyun
    • Journal of the Korean Geosynthetics Society
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    • v.18 no.1
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    • pp.79-89
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    • 2019
  • The field measurement and laboratory experiment were conducted to investigate the effect of reducing the surface temperature of the functional aspect of the heat island phenomenon of the permeable block which is made the recycled synthetic resin rather than the existing concrete permeable block. Field measurement was taken for 3 days in consideration of dry condition and wet condition and laboratory experiment was divided into dry condition, rainfall simulating condition, and wetting condition. The variations of temperature and the evaporation rate of water moisture content after experiment were confirmed. As a result of field measurement, it is confirmed that the surface temperature decreases due to the difference in albedo of the pore block surface rather than the cooling effect due to the latent heat of vaporization. The evaporation of moisture in a dry state where drought persisted or a certain level of moisture was not maintained in the surface layer. As a result of laboratory experiment, resin permeable block gives higher surface temperature when it is dry condition than concrete permeable block, but the evaporation of water in the pore is kept constant by capillary force in rainfall simulation condition, and higher temperature reduction rate. As a result of measuring the evaporation rate after laboratory experiment, it is confirmed that the effect of reducing temperature is increased as the evaporation rate of water is higher. Based on these results, correlation formula for evaporation rate and temperature reduction rate is derived.

Applications of Surface Cover Materials for Reduction of Soil Erosion (토양유실 저감을 위한 지표피복재 적용)

  • Won, Chul-hee;Shin, Min-hwan;Choi, Yong-hun;Shin, Jae-young;Park, Woon-ji;Choi, Joong-dae
    • Journal of Korean Society on Water Environment
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    • v.27 no.6
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    • pp.848-854
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    • 2011
  • The objective of this research was to experimentally test the effect of rice straw mats on the reduction of runoff, sediment and discharge under a laboratory scale with different rainfall intensity and slopes. We used the small runoff plots of $1m{\times}1m{\times}0.65m$ ($L{\times}W{\times}H$) in size were filled with loamy sand. Experimental treatments were bare (control), rice straw mats + PAM(SP), rice straw mats + PAM + sawdust(SPS) and rice straw mats + PAM + rice husks(SPR); slope of 10% or 20%; and rainfall intensity of 30 or 60 mm/hr. Runoff volume and coefficient from covered plots were significantly lower than those from control plots. Under the 30 mm/hr and 10% simulations, average runoff coefficient of covered plots decreased more than 92%. Under 60 mm/hr and 20% simulations, the ratios were between 39.8~58.1%. Under the condition of 30 mm/hr rainfall and 10% slope, sediment discharge from covered plots was practically zero. And at 20% plots, sediment reduction ratio was more than 95%. Under the condition of 60 mm/hr rainfall, sediment reduction ratio of 10 and 20% plots ranged between 86.3~95.3% and between 79.8~86.5%, respectively. The differences in initial runoff time, runoff and sediment discharge among different cover materials were not significant. Rainfall intensity showed higher impact on initial runoff time, runoff, and sediment discharge than slope. It was also shown that even if runoff reduction by surface cover were low, sediment discharge reduction could be very significant and contribute to improve the water quality of streams in sloping agricultural regions. It was concluded that the use of straw mat and PAM on sloping agricultural fields could reduce soil erosion and muddy runoff significantly and help improve the water quality and aquatic ecosystem in receiving waters.

A Study on the Flow Assurance in Subsea Pipeline Considering System Availability of Topside in LNG-FPSO (LNG-FPSO에서 상부구조물의 시스템 가용도를 고려한 해저 배관의 유동안정성 연구)

  • Kim, Young-Min;Choi, Jun-Ho;Lee, Jeong-Hwan
    • Journal of the Korean Institute of Gas
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    • v.24 no.6
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    • pp.18-27
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    • 2020
  • This study presents flow assurance analysis in subsea pipeline considering system availability of topside in LNG-FPSO. A hydrate management strategy was established, which consisted of PVCap experiments, system availability analysis of LNG-FPSO topside, hydrate risk analysis in the pipeline, and calculation of PVCap injection concentration. The experimental data required for the determination of PVCap injection concentration were obtained by measuring the hydrate induction time of PVCap at the subcooling temperatures of 6.1, 9.2, and 12.1℃. The availability of LNG-FPSO topside system for 20 years was 89.3%, and the longest downtime of 50 hours occurred 2.9 times per year. The subsea pipeline model for multiphase flow simulation was created using field geometry data. As a result of risk analysis of hydrate plugging using subsea pipeline model, hydrate was formed at the end of flowline in 23.2 hours under the condition of 50 hours shutdown. The injection concentration of PVCap was determined based on the PVCap experiment results. The hydrate plugging in subsea pipeline of LNG-FPSO can be completely prevented by injecting PVCap 0.25 wt% 2.9 times per year.

Comparative Analysis of the Psychological State and Driving Safety for Driving within the Platoons of Trucks by Drivers Driving Performance (화물차 군집주행 간격에 따른 운전자의 운전수행능력별 심리상태 및 주행안전성 비교 연구)

  • Park, Hyun jin;Park, Jae beom;Lee, Ki young;Song, Chang jun
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.20 no.6
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    • pp.147-161
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    • 2021
  • The purpose of this study was to investigate the psychological state and driving safety of drivers driving around the truck platoon driving. Using the driving simulator, the experimental environment was constructed with the situation of changing lanes to the platoon and driving within the platoon. We tried to qualitatively and quantitatively analyze the driver's psychological state and driving safety through simulation driving experiments. As a result, in the case of the older driver group, there were many cases where they judged themselves to be driving safely, even though they were driving dangerously in the actual lane change to the platoon or driving within the platoon. In particular, this group showed that the narrower the distance between vehicles, the greater the misrecognition. The results of this study are expected to be useful in deriving the optimum interval when the interval between platooning of trucks needs to be temporarily extended.