• Toxicological Research
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• v.29 no.1
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• pp.1-6
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• 2013

The process of drug discovery and development requires substantial resources and time. The drug industry has tried to reduce costs by conducting appropriate animal studies together with molecular biological and genetic analyses. Basic science research has been limited to in vitro studies of cellular processes and ex vivo tissue examination using suitable animal models of disease. However, in the past two decades new technologies have been developed that permit the imaging of live animals using radiotracer emission, X-rays, magnetic resonance signals, fluorescence, and bioluminescence. The main objective of this review is to provide an overview of small animal molecular imaging, with a focus on nuclear imaging (single photon emission computed tomography and positron emission tomography). These technologies permit visualization of toxicodynamics as well as toxicity to specific organs by directly monitoring drug accumulation and assessing physiological and/or molecular alterations. Nuclear imaging technology has great potential for improving the efficiency of the drug development process.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.5
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• pp.1037-1045
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• 2007

An efficient management system for parking lots and traffic monitoring in a metropolitan city is a very important issue, which is tightly closed to qualify of life. While a residential permit parking program has been contributing to resolve the lack of parking places, there has been no autonomous authentication system due to no apparent entrance gate and smallness of each parking zone. In this paper, we propose and implement an authentication system for residential permit parking lot using wireless sensor networks, which is cost-effective and even no need for additional managing person. Through the experimental evaluation, we analyzed relationship between the life time of sensor nodes and the various values of sleep periods to minimize power consumption of the nodes, and also showed that the difference of luminance sensed by each sensor node is at least 45 or bigger between when the parking place is occupied or not, resultingly it can be used to decide whether a parking place is occupied or not by simply detecting the change of luminance sensed.

• Journal of the Korean Society of Safety
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• v.8 no.4
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• pp.139-148
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• 1993

Thermosyphons are simple devices that can passively transport thermal energy over relatively long distance with little temperature degradation. These attributes permit the use of low grade thermal energy for thermal control of structures including the snow melting and deicing to the pavement surface. The thermosyphon system requires no costly energy input and Is completely maintenance free. This paper presents the experimental results of the snow melting system in which thermosyphon was utilized to transfer the geothermal energy to the pavement to obviate slipping traffic accidents due to freezing of pavement in winter.

• Fire Science and Engineering
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• v.10 no.2
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• pp.13-19
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• 1996

An estimation methodology, based on statistics and numerical method, has been developed for estimating the upper explosive limits(UEL) of paraffinic and olefinic hydrocarbon compounds. With proposed method, the UEL has been calculated for 24 paraffinic and 10 olefinic hydrocarbon compounds. The estimated the UEL agree with the experimental values within a few percent. A comparisond with four other methods avaiable in the literature are also presented. It is hoped eventually that this method will permit estimation of the UEL with improved accuracy and broader application for other compounds.

• Journal of Advanced Marine Engineering and Technology
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• v.13 no.1
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• pp.57-68
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• 1989

This paper treats the analytical and experimental studies on the improvement of commutating circuit for the speed control of DC motor. A simple circuit composed of R, L and C elements is proposed here for switching off power SCR carrying the load current. The real important in this chopper circuit is to determine the reasonable values of commutating circuit constants. In this paper, the reasonable values of the commutating circuit constants are basically determined on a view point of commutating performances in the given circuit model and must satisfy the following conditions. The first, the peak commutating current should be larger than the anticipated maximum load current. The second, the circuit turn-off time (tc) must be longer than the SCR turn-off time (tq). The third, the resistor should be enough large to permit the current to be neglected in the analysis of the commutation circuit, as well as be enough small to permit to charge the capacity voltage (Ec) to the half the value of source voltage (E) before the next communication cycle is initiated. The last, the period of chopping signal must be the least possible multiple of the damping vibration period of commutating circuit. The improved chopper circuit used in the experiment under unloaded condition was composed to meet the reasonable conditions mentioned above, and a successful commuting performance was achieved without failure. Several types of microprocessor having a different value of CPU speed individually have been applied to the experiment under the loaded conditions. Also it shows that the faster the speed of CPU is, the more stable the commutation turns out.

• Computers and Concrete
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• v.12 no.2
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• pp.109-129
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• 2013

This work presents an approach to model concrete shrinkage. The goal is to permit the concrete industry's experts to develop independent prediction models based on a reduced number of experimental data. The proposed approach combines fuzzy logic and genetic algorithm to optimize the fuzzy decision-making, thereby reducing data collection time. Such an approach was implemented for an experimental data set related to self-compacting concrete. The obtained prediction model was compared against published experimental data (not used in model development) and well-known shrinkage prediction models. The predicted results were verified by statistical analysis, which confirmed the reliability of the developed model. Although the range of application of the developed model is limited, the genetic-fuzzy approach introduced in this work proved suitable for adjusting the prediction model once additional training data are provided. This can be highly inviting for the concrete industry's experts, since they would be able to fine-tune their models depending on the boundary conditions of their production processes.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.06a
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• pp.888-893
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• 2000

This experimental study is the improvement of running stability for freight car. KNR (Korean National Railroad)'s conventional wagons, light bodies running on Barber style bogies with 5-1/$2{\times}10$ journals, would be considered fundamentally to be a most difficult car to control above 100km/h. From the results of experiment, to permit high speed operation safely, was realized with the resilient side bearing. Also, equipped with resilient side bearing, and elastowedge friction elements to eliminate bolster wedge pocket wear, KNR's wagons can be secure the running stability with lower maintenance requirements than current experience.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.30 no.3
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• pp.54-61
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• 2007

Machining processes produce high accurate metallic parts in metal working industries. Lubrication for machining enhances quality of machined surface and it prolongs the life of cutting tools. Since lubricant is poisonous to human body and environment, it causes occupational diseases for workers and air pollution in environment. Because of these problems generated, developed countries do not permit the excessive usage of lubricant in machining shops. This research focuses on the development of MQL machining technique that consumes minimal amount of lubricant, which reduces possible outbreak of occupational diseases and air pollution. This research sets experimental equipments for MQL machining. Experiments for this study are designed with major machining parameters in MQL. Through the analysis of experiments, this paper presents the optimal machining parameters.

• Korean Journal of Biological Psychiatry
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• v.6 no.2
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• pp.161-169
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• 1999

There are a number of approaches in developing experimental models for depression, but there is no such thing as a best model for depressive syndrome. Animal models are subject to the obvious limitations inherent in the assumption that human psychopathology can be represented accurately in lower animals. Recently, the concern increasingly is to develop a variety of experimental paradigms in animals to study selected aspects of human psychopathology, and animal models should be understood as basically experimental preparations that are developed to carry out these objects. Therefore, a battery of a variety of animal models should be applied to permit detailed pathophysiological studies and to develop new antidepressant treatments. Animal models of depression basically consider behavioral isomorphism with the human depression a plus, but not a req-uirement, and the model behavior should be defined operationally in order to be reproduced reliably by other researchers and be responsive to those agents possessing demonstrated clinical efficacy in human depression. In conclusion, animal models of depression have played a significant role in elucidating pathophysiology of depression and developing current treatments for depression, but there is no single comprehensive model for depression until now. Each of the proposed animal model has its advantages and limitations. In other words, certain paradigms are suitable for studying certain phenomena, whereas others are more suitable for studying other aspects. The best model for depression depends upon what the question is.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.833-836
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• 2008

In this study, we would like to study on the apply properties to salt water environment of pre-hydrated bentonite for complement problem that water leakage to permit salt water that existing bentonite does not initial swelling. Accordingly, execute viscosity properties, swelling properties, permeability and confirmed apply properties to salt water environment. Did not permit initial permeable in test result salt water environment, and permeable did not happen until 72 hours by maximum $3kgf/cm^2$ water pressure. Fresh water environment enough progress of gelation confirm that viscosity and swelling properties confirmation result and as delamination phenomenon of platy formation looked in salt water environment but this as bentonite hydrates crystallization layer swelling that is done consider. Synthetic study results, if compaction condition such as press layer is formed to bentonite upper, applied to the salt water environment of the underground structures of expectations.