• Toxicological Research
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• 제7권1호
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• pp.93-112
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• 1991

This study was carried out to investigate the various factors on induction of experimental hepatocarcinogenesis in Sprauge-Dawley rats. The experimental animals were divided into three Experiment. Experiment I, II and III were began rats with initial age of 6, 16 and 55 weeks, respectively. All Experiment were injected intrapertioneal with diethylnitrosamine (DENA` 200 mg/kg) as an intiator and group 3, 4 of Experiment I, II and III were fed on diet containing 0.02% 2-acetylaminofluorene (2-AFF) as a promoter for 6 weeks. Three weeks after two-thirds partial hepatectomy was performed in group 2, 4 of Experiment I & II and group 3 of Experiment III.

• 한국식품위생안전성학회지
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• 제31권6호
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• pp.399-405
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• 2016

고지방-고콜레스테롤 식이와 색소 2호 알곡 및 속대 추출물의 첨가량을 달리한 식이를 2주간 급여한 결과, 색소 2호 알곡 및 속대 추출물 첨가로 인한 식이섭취량 감소효과는 없었으며 체중 증가율은 대조군(C)대비 모든 처리군에서 유의적으로 감소하였고, 식이효율에서는 처리군(T3)을 제외하고 모든 처리군에서 유의적으로 감소하였다. 장기중량은 실험군 간의 체중 당 신장 무게는 유의적인 차이는 없었으며 체중 당 간 무게는 대조군(C)이 정상군(N)에 비하여 유의적으로 증가하였고, 처리군(T2)가 대조군(C)대비 유의적으로 낮았다. 혈청 중 중성지방 함량은 전체 실험군에서 유의적 차이는 없었으며, 총콜레스테롤 함량은 처리군(T2)이 대조군(C)대비 유의적으로 낮았고, HDL-콜레스테롤 함량은 처리군(T2)이 대조군(C)대비 유의적으로 높았다. 고지방-고콜레스테롤 식이로 인하여 대조군(C)의 간 조직 내 MDA 함량이 정상군(N)에 비하여 유의적으로 증가하였으며 처리군 T3와 T4가 대조군(C) 대비 간 조직 내 MDA 함량이 유의적으로 감소하는 경향을 보였다. 고지방-고콜레스테롤 식이로 인하여 대조군(C)의 catalase 활성은 정상군(N)에 비하여 유의적으로 감소하였으며 모든 색소 2호 알곡 및 속대 추출물 처리군(T1~T4)의 catalase 활성은 정상군(N)과 비슷한 수준으로 유의하게 증가하였다.

• 한국콘텐츠학회논문지
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• 제19권5호
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• pp.455-463
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• 2019

본 연구는 최종대상자는 56명을 대상으로 실험군 29명, 대조군26명을 배정한 후, 실험군에게 구강안면프로그램을 교육하여 저작기능을 향상 시킴으로써 집단 간 구강위생 및 실천 효과를 확인하고자 하였다. 수집한 자료는 프로그램 효과분석은 프로그램 전-후 차이를 알아보기 위해 Wilcoxon signed rank -test를 실시하였다. 실험군의 평균 사후 $9.57{\pm}1.44$점 이었고, 대조군은 사후 평균은 $8.68{\pm}1.46$점으로 실험군의 OHBI가 대조군에 비해 유의하게 높은 것(p<0.05)으로 나타났다. 실험군의 QHI 점수는 평균 사후 $1.00{\pm}.14$점 이었고, 대조군은 사후 평균은 $1.03{\pm}.23$점으로 실험군의 QHI 대조군에 비해 유의하게 낮은 것으로 나타났으나 이는 통계적으로 유의하지는 않았다. 실험군의 프로그램 만족도는 평균점수는 $4.13{\pm}.17$점 이었고 대조군은 $3.94{\pm}.22$점으로 통계적으로 유의한 것으로 조사되었다. 이상과 같은 결과를 바탕으로 구강안면프로그램을 이용한 구강보건교육의 효과는 집단 간 치면세균막 지수, 구강건강행동지수의 차이가 있는 것으로 나타났다. 구강안면운동프로그램을 저작기능의 향상과 구강위생을 위한 도구로 활용할 가치가 있다고 사료된다.

• 대한물리치료과학회지
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• 제9권3호
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• pp.107-119
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• 2002

Astrocyte, which shares the greatest part of the brain (about 25%), is a land of glial cell that composes the central nervous system along with microglia, ependymal cell and oligodendroglia. It has 7-9nm of fibers in its cytoplasma, which are composed of glial fibrillary acidic protein (GFAP) and vimentin. As for the functions of the astrocyte, it has, so far, been supposed that the astrocyte will play a cytoskeletal role in maintaining the structure of the cerebrum, play a role as a blood-brain barrier so that it can induce migration of the neuron in its development and substances in the blood cannot go into the nervous tissue, and a role of immunology and phagocytosis. However, it was revealed today that it will be a role in preventing expansion of injury by attaching itself to the connective tissue such as the vessel and the pia mater when the nervous tissue or the arachnoid is injured. Microcurrent stimulation can control current, on the basis of A unit. That is, with such devices using it, it is possible to sense, from the outside, the injured current(wound current) of the lesion and to change it into the normal current, thereby promoting the restoration of the cells. In order to examine the effects of microcurrent stimulation on the injured astrocytes in the rabbits, this study was conducted with 24 New Zealand White Rabbit as its subjects, which were divided into 8 animals of the experiment group and 16 animals of the control group. After the animals in the experiment group were fixed to the stereotaxic apparatus, their hair was removed and their premotor area(association area) perforated by the micro-drill for skull-perforation with the depth of 8mm from the scalp. In one week after the injury, 4 animals in the control group and 8 animals in the experiment group were sacrificed and examined with immunohistochemical method. And in three weeks, the remaining 4 animals in the control group and 8 animals in the experiment group were also sacrificed and examined with the same way. The conclusion has been drawn as follows : In the control group sacrificed in one week after the injury, the astrocytes somewhat increased, compared with the normal animals, and in the group sacrificed in three weeks after the injury, they increased more (p < 0.05). The experiment group A in one week showed a little increase, but there was no significant differences, but the experiment group in three weeks showed more increase, compared with the experiment group in one week (p < 0.05). The experiment group B in one week showed more increase than the control group or the experiment group A, and the experiment group in three weeks showed more increase than the experiment group in one week (p < 0.05). Among the astrocytes, fibrous astrocytes were mostly observed, increasing as they are close to the lesion, and decreasing as they are remote from it. The findings show that microcurrent can cause the astrocytes to proliferate and that it will be more effective to stimulate the cervical part somewhat remote from the lesion rather than to directly stimulate the part of the lesion. Thus, microcurrent stimulation can be one of the methods that can activate the reaction of astrocytes, which is one of the mechanism for treating cerebral injury with hemorrhage. Therefore, this study will be used as basic research data for promoting restoration of functions in the patient with injury in the central nervous system.

• 대한물리의학회지
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• 제8권4호
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• pp.559-566
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• 2013

PURPOSE: The present study examines how feedback respiratory exercise affects gait performance of stroke patients. METHODS: Forty stroke patients were randomly divided into an experiment group and a control group. For the former group, patients went through a half-hour of training therapy and a half-hour of feedback respiratory device exercise. For the latter group, patients went through 30 minutes of training therapy and a half-hour of motomed exercise. All participants had five training sessions each week for four weeks. For measurement, a GAITRite system was used to examine spatial parameters, and functional ambulation performance before and after the training. RESULT: In terms of spatial parameters, double support ratio, stance phase increased significantly in the experiment group after the walking exercise(p<.05). FAP rose more significantly in the experiment group than in the control group(p<.05). In comparison of two exercise groups, double support ratio, Stance phase, gait velocity, FAP was significant difference(p<.05). CONCLUSION: The experiment results showed that feedback respiratory exercise is effective in enhancing gait performance.

• 한국간호교육학회지
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• 제5권2호
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• pp.300-314
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• 1999

This study is an attempt to evaluate the effect of the medication and symptoms self-care education on the psychiatric patients' quality of life. This exploratory study was designed to a quasi-experiment of pretest-postest with a non equivalent control group. Subjects of 40 patients who were discharged from a mental hospital in Pusan were selected to be experiment and control group, with each group consisting of 20. The research period was from March, 6 to May, 29, 1999 and the pre-post test was given before and after implementing MSSE to the both experiment and control group. The results finding were summarized as follows ; 1. subjects who attended self-care education scored significantly higher than control group in quality of life.(Z=-2.06, P=0.034) 2. Those who were in the experiment group reported more significant higher scores than control group in item of quality of life, living situation(A=-2.62 P=0.012), relations with spouse (Z=-2.31 P=0.038) and children (Z=3.37, P=0.008), fear (Z=-1 95, P=0.049) and anger(Z=-2.07 P=0.041), work functioning (Z=-2.34, P=0.021), environmental adjustment. (Z=-2.05, P=0.039)

• The Journal of Korean Physical Therapy
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• 제15권4호
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• pp.90-102
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• 2003

Purpose: The purpose of this study is to search effect that GCM joint treatment gets to range of motion of cervical, lumbar, trunk and anke. And cervical gets in ankle joint. Methods: Estimated body deformity using GCM body type assesment chart then measured range of motion of each region. After control group did as act freely after do experiment pre measurement control group did post measurement. After control group did as act freely after do experiment premeasurement, control group did postmeasurement. Each region was measured by measurer who each subject person differs. Experimental group did GCM joint treatment and all measurements each region by measurer who each subject person differs three times measure postmeasurement after premeasurement. When measure with each measurement, measured after leave and walk time interval for 10 minutes. Result: For the analysis of the result of experiment, the results is change amount comparison increased to keep in mind except cervical flexion and both ankle joint's dorsiflexion after experiment of experimental group. In experimental group, cervical, lumber and ankle joint of range of motion was significantly increased(p<.05).

• 대한물리치료과학회지
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• 제10권2호
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• pp.112-122
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• 2003

The purpose of this study is to search effect that GCM joint treatment gets to right and left range of motion of neck, lumbar, trunk and anke joint. Estimated body deformity using GCM body type assesment chart then measured range of motion of each region. After control group did as act freely after do experiment premeasurement control group did postmeasurement. Each region was measured by measurer who each subject person differs. Experimental group did GCM joint treatment and all measurements each region by measurer who each subject person differs three times measured. When measure with each measurement, measured after leave and walk time interval for 10 minutes. For the analysis of the resulr of experiment the results is change amount comparison increased to keep in mind except ankle joint's dorsiflexion before experiment of experimental group and control group(P<.05). Before an experiment and after an experiment of experimental group, differed to keep in mind in right and left comparison of neck rotation, dorsiflexion, plantaflexin of ankle joint in change amount comparison(P<.05). Neck lateral flexion appears and displayed significantly level right and left difference than rotation after experiment of experimental group(P<.05). Because dorsiflexion, plantefleaion of ankle joint became similar right and left significantly difference did not appear(P<.05).

• 동의생리병리학회지
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• 제19권3호
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• pp.736-742
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• 2005

This study was carried out to investigate the inhibiting and repairing effects of Bojung-ikki-tang Gamibang(BI-G) on the bone marrow injuries in rats. Bone marrow injury was induced by a single intraperitoneal injection of cyclophosphamide(CP)(150mg/kg). In experiment I, designed for inhibiting effect, extract of BI-G(80mg) was administrated from pre-5 days to post-5 days of CP injection. In experiment II, designed for repairing effect, extract of BI-G(80mg) was administrated after 5 days to 12 days of CP injection. Hematological and histopathological examinations were performed at 5 days after CP injection in experiment I, and at 12 days after CP injection in experiment II. In experiment I, the results were as follows ; RBC(${\times}10^6/{\mu}l$) of BI-G treated group$(8.39{\pm}0.84)$ was increased significantly compared with control group$(7.52{\pm}7.67)$. Hemoglobin(g/dl) of BI-G treated group$(13.76{\pm}1.20)$ was increased significantly compared with control group$(12.24{\pm}1.11)$. WBC(${\times}10^3/{\mu}l$) of BI-G treated group$(1.75{\pm}0.41)$ was increased significantly compared with control group$(0.55{\pm}0.17)$. Necrotic changes of myeloid cells of BI-G treated group were less severe than those of control group. Histopathologically, distention of sinus and edematous changes of bone marrow of BI-G treated group were alleviated compared with those of control group. In experiment II, the results were as follows ; WBC(${\times}10^3/{\mu}l$) of BI-G treated group(4.27 0.94) was increased significantly compared with control group$(3.02{\pm}0.79)$. Hemoglobin(g/dl) of BI-G treated group$(12.61{\pm}0.85)$ was increased significantly compared with control group$(11.49{\pm}0.74)$. Platelets(${\times}10^3/{\mu}l$) of BI-G treated group$(1885{\pm}133)$ was increased significantly compared with control group$(1616{\pm}251)$. These results indicated that Bojung-ikki-tang Gamibang has the inhibiting and repairing effects on the cyclophosphamide-induced bone marrow injuries in rats.

• Journal of Acupuncture Research
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• 제23권2호
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• pp.159-164
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• 2006

Objectives : This study was conducted for objective verification of effects of spiral taping therapy for the patients with motor disturbance. Methods : To verify whether spiral taping therapy is effective for treating motor disturbance from cervical sprain, 28 patients were randomly allocated into the control and experiment groups. Then 23 subjects who fulfilled the experiment requirements were measured for lateral rotation angle using the goniometer. Changes in rotation were observed and compared. Control group received acupuncture and herbal acupuncture treatment, whileas the experiment group received spiral taping therapy in addition. Results : Differences in age and the degree of motor disturbance were disregarded in comparison of the groups prior to rendering treatments. For the control group, significant changes were observed after the second treatment until the termination of treatment. For the experiment group, significant changes were observed after the first treatment until the termination of treatment. Difference between the groups was insignificant but experiment group with spiral taping therapy showed better results. Conclusion : Spiral taping therapy can be an effective complementary treatment method for treating neck motor disturbance. Further studies in the subject should be conducted to yield more concrete verification.