• Toxicological Research
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• 제18권3호
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• pp.215-226
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• 2002

Acute or repeated physical exercise affects a large number of physiological parameters including hemodynamics, respiration, pH, temperature, gastrointestinal function and biotransformation, which determine the pharmacokinetics of drugs and chemicals. The rate and the amount of a chemical reaching the active site are altered by physical exercise, which results in significant changes in pharmacolosical/toxicological activity of the chemical. This aspect of physical exercise has vast implication in therapeutics and in safety evaluation, particularly for chemicals that have a low margin of safety. However there appears to be a wide inter- and intraindividual variation in the effects of physical exercise depend-ing on the duration, intensity and type of exercise, and also on the properties of each chemical. It is suggested that more studies need to be done to determine which factor(s) plays a major role in the disposition of chemicals in human/animals performing physical exercise. Certain chemicals induce severe toxicity due to metabolic conversion to reactive intermediate metabolites. it is suggested that repeated exercise may enhance the free radical scavenging system by increasing the activity of antioxidant enzymes. This area of research remain to be explored to elucidate the interaction of exercise and chemical on the antioxidant system.

• 운동과학
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• 제26권3호
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• pp.204-211
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• 2017

PURPOSE: This study was to investigate the effects of resistance exercise on serum inflammatory markers and CatSper 1-4 expression in testis of OLETF rats. METHODS: Male OLETF rats were divided into two groups; control group (n=12), resistance exercise group (n=12). The exercise group performed a total of 8 weeks of moderate intensity resistance exercise on a 1.35 m vertical ladder with weights secured to their tails. RESULTS: The results of this study was following; The exercise group showed a significant decreased in the inflammatory ($IL-1{\beta}$, IL-6, $TNF-{\alpha}$) levels as compared to the control group. But CRP was no significant difference between control and exercise groups. Also, CatSper 1 and 2 were significantly increased in the exercise group compared to the control group, whereas CatSper 3, 4 were no significant difference between both groups. CONCLUSIONS: This study suggests that resistance exercise training can contribute to reduce pro-inflammatory responses in whole body and it affects male reproductive function by improve sperm quality and CatSper protein expression.

• 운동영양학회지
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• 제23권1호
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• pp.28-35
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• 2019

[Purpose] The purpose of this study was to investigate the effects of treadmill exercise on oxidative stress in the hippocampal tissue and mitochondrial dynamic-related proteins in rats fed a long-term high-fat diet (HFD). [Methods] Obesity was induced in experimental animals using high fat feed, and the experimental groups were divided into a normal diet-control (ND-CON; n=12), a high fat diet-control (HFD-CON; n=12) and a high fat diet-treadmill exercise (HFD-TE; n=12) group. The rats were subsequently subjected to treadmill exercise (progressively increasing load intensity) for 8 weeks (5 min at 8 m/min, then 5 min at 11 m/min, and finally 20 min at 14 m/min). We assessed weight, triglyceride (TG) concentration, total cholesterol (TC), area under the curve, homeostatic model assessment of insulin resistance, and AVF/body weight. Western blotting was used to examine expression of proteins related to oxidative stress and mitochondrial dynamics, and immunohistochemistry was performed to examine the immunoreactivity of gp91phox. [Results] Treadmill exercise effectively improved the oxidative stress in the hippocampal tissue, expression of mitochondrial dynamic-related proteins, and activation of NADPH oxidase (gp91phox) and induced weight, blood profile, and abdominal fat loss. [Conclusion] Twenty weeks of high fat diet induced obesity, which was shown to inhibit normal mitochondria fusion and fission functions in hippocampal tissues. However, treadmill exercise was shown to have positive effects on these pathophysiological phenomena. Therefore, treadmill exercise should be considered during prevention and treatment of obesity-induced metabolic diseases.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2005년도 제45회 학술심포지움 및 추계학술대회
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• pp.123-123
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• 2005

• 대한물리치료과학회지
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• 제2권3호
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• pp.587-598
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• 1995

The purpose of this study was to test the microcurrent electrical neuromuscular stimulation on muscle soreness, serum creatine kinase levels and force deficits evident following a high-intensity eccentric exercise bout. 10 volunteer male subjects were randomly assigned to a treatment group or to a control group. Exercise consisted of high-intensity eccentric contractions of the elbow flexors. Resistance was reduced as subjects fatigued, until they reached exhaustion. Muscle soreness rating was determined using a visual analog scale. Serum creatine kinase levels were analyzed using a blood sample. Force deficits were determined by measures of maximal voluntary isometric contraction at $90^{\circ}$ of elbow flexion on a Orthotron II dynamometer. Muscle soreness rating, serum creatine kinase levels and maximal voluntary isometric contraction were determined at the before exercise and again at 24 and 48 hours postexericse. Treatments were applied immediately following exercise. The control group subjects rested following their exercise bout. Statistical analysis showed significant increases in muscle soreness rating and significant decreases in maximal voluntary isometric contraction when the before exercise was compared with 24 and 48 hour measures(p<0.01). No significant effects were observed between groups in muscle soreness rating and maximal voluntary isometric contraction(p>0.05). Highly significants differences in serum creatine kinase levels were found using on Analysis of variance(ANOVA) repeated measures between groups for each time cycles(p<0.001). This modality may have benefits when used early stage in the muscle damage.

• 한국융합학회논문지
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• 제7권5호
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• pp.247-254
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• 2016

이 연구의 목적은 생활체육 참여정도가 지체장애인의 객체화된 신체의식에 어떠한 영향을 미치는지를 규명하는데 있다. 연구대상은 A시에 거주하면서 생활체육에 참여하고 있는 지체장애인들 221명을 대상으로 하였다. 자료처리는 SPSS 21.0 프로그램을 이용하여 빈도분석, 요인분석을 실시하였으며, 구체적인 요인에 대한 분석은 독립 t검증과 일원변량분석 및 중다회귀분석을 실시하였다. 모든 통계적 유의 수준은 .05로 설정하였다. 연구결론으로는 첫째, 지체장애인의 인구사회학적 특성에 따른 성별(남성), 연령별(40대, 50대), 장애등급별(4급)에 따른 객체화된 신체의식 수준에는 긍정적인 효과가 있는 것으로 나타났다. 둘째, 지체장애인의 생활체육 참여정도(운동기간, 운동시간, 운동강도)는 객체화된 신체의식의 신체 수치심에 긍정적인 효과가 있으며, 신체 감시성에서는 운동기간, 신체수치심에서는 운동강도, 통제신념에서는 운동시간이 각각 긍정적인 영향을 미치는 것으로 나타났다.

• 생명과학회지
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• 제19권6호
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• pp.825-831
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• 2009

본 연구에서는 저압.저산소환경의 노출을 시켜 30분간의 유산소성 자전거운동이 호흡기계 반응 및 면역기능의 응답에 미치는 영향을 검토하였다. 그 결과 몇 가지 지견을 도출해낼 수 있었다. 첫째로 75 $%HR_{max}$ 강도에서 30분간의 유산소성 운동 중에 저산소성 환기억제 또는 저하(hypoxic ventilatory depression or decline)라고 하는 현상은 평지뿐만이 아니라 3,000 m 고도에서도 나타나고 있고, 둘째 호흡기계의 반응은 축구선들이 특히 고소에서 적응과 감수성이 우수하다고 할 수 있으며, 셋째 면역기능의 항목인 단구(monocyte)는 운동습관의 유무 및 3,000 m의 고도에 따라 서로 다른 양상(상호작용)으로 변화를 하고 있다고 할 수 있다.

• 대한물리치료과학회지
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• 제10권1호
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• pp.149-157
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• 2003

The purpose of this study was to compare the effects of different exercise types including isokinetic, isometric, and istonic exercise of same exercise intensity on cardiopulmonary function and blood lactate level. The subjects of this study included 17 males college students. Each subjects after pretraining measurement performed isokinetic, isometric and isotonic exercise of 1 week interval using Cybex 6000 System. KBI-C and YSI 1500 were used to measure changes in cardiopulmonary function and blood lactate level respectively. First, comparing changes in RPP relative to exercise type, isokinetic group showed significant difference between before exercise ($7.08{\pm}1.12mg/kg/min$) and post exercise ($18.98{\pm}1.75mg/kg/min$). Isometric group showed that significant difference between before exercise($7.89{\pm}0.98mg/kg/min$) and post exercise($20.22{\pm}2.41mg/kg/min$). Isotonic group showed significant difference between before exercise ($8.14{\pm}0.11mg/kg/min$) and post exercise ($19.84{\pm}2.30\;mg/kg/min$). Second, comparing changes in blood lactate level relative to exercise type, isokineic group showed significant difference between before exercise ($2.99{\pm}0.65mmol$) and post exercise ($6.55{\pm}6.55mmol$). Isometric group showed significant difference between before exercise($1.71{\pm}5.48mmol$) and post exercise ($5.48{\pm}1.97mmol$). Isotonic group showed significant difference between before exercise($1.16{\pm}0.48mmol$) and post exercise($5.21{\pm}1.28mmol$). The results of this study indicate significant differences RPP in isometric exercise and significant differences blood lactate in isotonic exercise.

• 한국응용과학기술학회지
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• 제37권1호
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• pp.17-27
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• 2020

본 연구는 6주간의 고강도 복합 훈련 프로그램을 통해 카누 선수의 심폐기능(Cardiorespiratory Function), 체간 등속성 근력(Isokinetic Trunk Strength) 그리고 무산소성 파워(Anaerobic Power)에 미치는 영향을 확인하는데 있다. 이를 위해 고등학교 카누 선수 9명을 대상으로 고강도 복합 훈련 프로그램을 적용하였으며, 고강도 훈련 프로그램은 주 2회의 유산소 운동(화, 목), 주 3회의 무산소 운동(월, 수, 금) 그리고 주 5회의 유연성 운동을 실시하였다. 고강도 복합 훈련 프로그램의 핵심은 무산소성 훈련 프로그램으로 기존 1RM의 퍼센트(%)를 나누어 훈련하던 방식과는 달리 횟수에 대한 100%의 중량을 가지고 하는 훈련이며, 유산소성 운동과 짐볼운동은 보조적인 개념으로 실시하였다. 연구결과, 고강도 복합 훈련 프로그램에 따른 신체구성에서 신장과 근육량은 통계적으로 의한 차이가 있었으며, 체중, 체지방율, BMI는 통계적으로 유의한 차이는 없는 것으로 나타났다. 심폐기능의 경우, 최대산소섭취량과 총 운동시간은 통계적으로 유의한 차이가 있는 것으로 나타났다. 체간 등속성 근력의 경우, 각속도 30°/sec에서는 Flexors 운동시 Peak Torque 항목에서만 통계적으로 유의한 차이가 있는 것으로 나타났다. 각속도 120°/sec에서는 Extensors 운동시 Total Work 항목에서만 통계적으로 유의한 차이가 있는 것으로 나타났다. 무산소성 파워의 경우, Peak Power, Average Power, Peak Drop의 모든 항목에서 통계적으로 유의한 차이가 없는 것으로 나타났다. 이상의 결과를 종합해보면 심폐기능에서는 유의한 개선효과가 있었지만 체간 등속성 근력과 무산소성 파워 항목에서 증가하는 경향은 있었지만 통계적인 차이는 없는 것으로 나타났다. 결론적으로 선수 개개인의 근력과 파워가 개선되는 경향이 나타난 것을 고려하면 훈련기간을 6주 이상으로 구성하고 사례수가 보강된다면 체계적인 결과를 얻을 수 있을 것으로 생각된다. 본 연구에서 적용한 고강도 복합 훈련 프로그램은 카누 선수들의 경기력 향상 효과를 기대할 수 있는 훈련 프로그램으로 적용될 수 있을 것으로 판단된다.

• 대한간호학회지
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• 제36권1호
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• pp.94-102
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• 2006

Purpose: The purpose of this study was to confirm the effects of a moderate and fast walking exercise program on middle-aged women's fatigue, serum lipids and immunoglobulins. Method: A non-equivalent control group pretest-posttest design was used for this study. The experiment was conducted for 10 weeks from May 17th to July 25th, 2004 with 44 middle-aged women, consisting of 16 for the moderate walking group, 15 for the fast walking group and 13 for the control group. Result: Walking exercise at both a moderate and fast speed was effective in middle-aged women in reducing fatigue and serum lipids. It was also revealed that extended periods of exercise was more effective in decreasing fatigue while for reducing serum lipid, high intensity exercise was more effective. In this study, serum immunoglobulins were reduced after moderate and fast walking exercise but its cause was not fully understood so further research is needed. Conclusion: This study helps us recognize the importance of regular exercise and promotes motivation to exercise for a healthy life among middle-aged women.