• 대한임상독성학회지
• /
• 제13권2호
• /
• pp.78-86
• /
• 2015

Purpose: The purpose of this study is to understand what kinds of chemical substances have been used annually and to investigate incidents that occurred due to chemical hazard release and to analyze statistically clinically chemical injury patients who visited one regional emergency medical center in Gumi city with documented references review. Methods: Annual chemical waste emission quantity (Kg/Year) (Cwep) was reproduced using national web site data governed by the Ministry of Environment and 5 years (from 1 .Jan. 2010 to 31. Dec. 2014) of medical records of chemical injury patients who visited our emergency department were reviewed retrospectively. By applying exclusion criteria, 446 patients of 460 patients were selected. Results: Dichloromethane, Toluene, Trichloroethylene, and Xylene were always included within Top 5 of Cweq. Six cases of chemical incidents were reported and in 3 of 6 cases involving Hydrogen fluoride were included during the study period. Male gender and twenties were the most prevalent group. Injury evoking chemicals were Hydrogen fluoride, unknown, complex chemicals (over 2 substances) in sequence. The most frequent site of wounds and injuries was the respiratory tract. Gas among status, intoxication among diagnosis, and discharge among disposition was most numerous in each group. Conclusion: There have been no uniform clinical protocols for chemical wounds and injuries due to various kinds of chemicophysical properties and ignorance of antidotes. Therefore conduct of a multicenter cohort study and experiments for ruling out chemicals according to chemicophysical priority as well as development of antidotes and clinical protocols for chemical injury patients is needed.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권15호
• /
• pp.6581-6589
• /
• 2015

Background: Previously, stingless bee (Trigona spp.) products from East Kalimantan, Indonesia, were successfully screened for in vitro antiproliferative activity against human cancer derived cell lines. It was established that propolis from T. incisa presented the highest in vitro cytotoxicity against the SW620 colon cancer cell line (6% cell survival in $20{\mu}g/mL$). Materials and Methods: Propolis from T. incisa was extracted with methanol and further partitioned with n-hexane, ethyl acetate and methanol. The in vitro cytotoxicity of the extracts was assessed by the MTT assay against human colon (SW620), liver (Hep-G2), gastric (KATO-III), lung (Chago) and breast (BT474) cancer derived cell lines. The active fractions were further enriched by silica gel quick column, absorption and size exclusion chromatography. The purity of each fraction was checked by thin layer chromatography. Cytotoxicity in BT-474 cells induced by cardanol compared to doxorubicin were evaluated by MTT assay, induction of cell cycle arrest and cell death by flow cytometric analysis of propidium iodide and annexin-V stained cells. Results: A cardol isomer was found to be the major compound in one active fraction (F45) of T. incisa propolis, with a cytotoxicity against the SW620 ($IC_{50}$ of $4.51{\pm}0.76{\mu}g/mL$), KATO-III (IC50 of $6.06{\pm}0.39{\mu}g/mL$), Hep-G2 ($IC_{50}$ of $0.71{\pm}0.22{\mu}g/mL$), Chago I ($IC_{50}$ of $0.81{\pm}0.18{\mu}g/mL$) and BT474 (IC50 of $4.28{\pm}0.14{\mu}g/mL$) cell lines. Early apoptosis (programmed cell death) of SW620 cells was induced by the cardol containing F45 fraction at the $IC_{50}$ and $IC_{80}$ concentrations, respectively, within 2-6 h of incubation. In addition, the F45 fraction induced cell cycle arrest at the G1 subphase. Conclusions: Indonesian stingless bee (T. incisa) propolis had moderately potent in vitro anticancer activity on human cancer derived cell lines. Cardol or 5-pentadecyl resorcinol was identified as a major active compound and induced apoptosis in SW620 cells in an early period (${\leq}6h$) and cell cycle arrest at the G1 subphase. Thus, cardol is a potential candidate for cancer chemotherapy.

• 한국보건간호학회지
• /
• 제16권2호
• /
• pp.239-253
• /
• 2002

Health care for women regularly focuses on the reproductive system to the exclusion of other health needs. The lack of research focusing on women's common health issues is a major problem to the enhanced optimal level of women's health. Health care providers have to recognize biological and social differences between men and women. This study was conducted to identify the baseline data and their correlation of health perception, health behavior, and health status of adult women for developing nursing intervention. The study was a descriptive correlational design. A convenient sampling method was used for collecting data from 103 adult women, over 18 years of age, during the period from Sep 1 to Nov 30, 2001. The study's subjects were interviewed using a structured questionnaire. The instruments for this study were the health perception scale modified by Lee(1985) based on the tool developed by Ware(1977) and Jenkins (1966), and the health behavior scale by Ko, Kumja(1987). Health status was measured by the short form Cornell Medical Index(CMI) modified by Nam, Hochang(1965). The data were analyzed SPSS PC+, by frequency, mean, t-test, ANOVA, and Pearson correlation coefficients. Also, the Duncan test was utilized for a post hoc test of ANOVA. The results of this study are as follows: 1. The mean score for health perception was 3.02(S.D=0.39) on a 5 point scale. 2. The mean score for health behavior was 3.08(S.D=0.43) on a 5 point scale. 3. The mean score for health status was 18.54 on 58 items. The mean score for physical symptoms of a subscale of health status was 11.30 on 36 items and the mean score for psychological symptoms was 7.37 on 22 items. 4. The relationship of sociodemographic variables to health perception. health behavior, and health status of women.: 1) There were significant differences in the scores of health perception by disease experience(t=-3.37, p=0.00). 2) There were significant differences in the scores of health behavior by age(F=10.52, p=0.00), height(F=4.73, p=0.01), marital status(t=-5.56, p=0.00), educational background(t=2.90, p=0.00), and drinking or non-drinking(t=2.17, p=0.03). 3) There were significant differences in the scores of health status by educational background(t=2.28, p=0.02) and disease experience(t=2.61, p=0.01). 5. Health perception showed significant positive correlation with health behavior(r=0.39, p=0.00). Health perception showed significant negative correlation with health status(r=-0.44, p=0.00), that is, the more women perceived health, the less she complained about unhealthy symptoms. Health behavior had no significant correlation with health status but showed a positive correlation with psychological symptoms of a subscale of health status(r=-0.19, p=0.05). Many of the leading causes of disease are preventable through changes in health perception and behavior. The need to increase individual awareness of relationships among health perception, health behavior, and health status and to enhance knowledge regarding the long-term effects of positive health behaviors, is an important nursing strategy for women's health promotion.

• 기본간호학회지
• /
• 제7권2호
• /
• pp.208-221
• /
• 2000

The objective of this research was to compare the flushing effects using 1:1,000 diluted heparin or 0.9% normal saline in relation to needle gauge and frequency of IV medications. The comparative categories were clotting, duration of patency, and incidence of phlebitis. The design of research was a Nonequivalent Control group, Post test, Nonsynchrorized Design. The independent variable was 0.9% normal saline flushing the IV locks and the dependent variables were clotting, duration of patency, and incidence of phlebitis. Subjects were medical-surgical inpatients over 15 years old and with peripherally placed IVs who were hospitalized in a university medical center. Exclusion criteria included foreigners and those who were rejected for this research. The final sample for data analysis included 295 IV sites in 194 patients; 154 were in the saline group and 141 were in the heparin group. Subjects were assigned to have IV locks is flushed with 0.9% normal saline in the experimental group and to have IV lock flushed with 1:1,000 diluted heparin(100 units) in the control group. In order to increase reliability, the nurses who were assigned to the units involved in the study received an explanation on the standard method for locking an IV, recording method for observational data and criteria for the detection of phlebitis. Data were collected for a period of 2 weeks, from March 16, 2000 to March 29, 2000. Total duration of IV was defined the time of IV insertion to the time of discontinuation. Phlebitis was defined as the presence of the following : pain, swelling. erythema at the insertion site. Chi-square was used to determine the association between the degree of clotting, duration of patency, and incidence of phlebitis for the diluted heparin or the normal saline and needle gauge and frequency of IV medications. The results are summarized as follows : (a) There was difference in the degree of clotting between two groups($X^2=5.882$, p=.015). (b) There was no difference in the degree of duration of patency between two groups($X^2=2.439$, p=.295). (c) There was no difference in the incidence of phlebitis between two groups($X^2=0.190$, p=.663). (d) There was difference in the degree of clotting($X^2=6.209$, p=.013) and in the degree of duration of patency($X^2=6.978$, p=.031) according the needle guage between the two groups. (e) There was difference in the incidence of phlebitis($X^2=5.008$, p=.025) according to the frequencies of IV injection between two groups.

• Asian-Australasian Journal of Animal Sciences
• /
• 제15권6호
• /
• pp.905-911
• /
• 2002

A study was carried out to assess the therapeutic effect of ascorbic acid in mastitis of dairy cows. The herd with a population of 250-275 lactating cows was screened for clinical and subclinical mastitis for a period of 5 months. Based on inclusion and exclusion criteria, eighteen animals each with clinical and subclinical mastitis in one quarter only were selected as study population. Twelve cows (group A) with normal udder and health were also selected as a healthy control. Clinical mastitis cows were grouped as B (n=12) and C (n=6). Cows of group B were treated with ascorbic acid at 25 mg/kg, subcutaneously for 5 consecutive days and intramammary infusion (Ampicillin sodium 75 mg and Cloxacillin sodium 200 mg/infusion) based on antibiotic sensitivity test, till complete recovery. Group C cows received only intramammary infusion till the complete recovery. Eighteen subclinical mastitis cows were divided in group D (n=12) and E (n=6). Cows of group D were treated with ascorbic acid at 25 mg/kg subcutaneously for 5 consecutive days while group E did not receive any treatment. California mastitis test (CMT), somatic cell count (SCC), physical changes of udder and milk were used to diagnose and classify the mastitis. Evaluation of the therapy was based on CMT score and physical changes of udder and milk. Sample size calculation was also performed but was not followed for control groups due to scarcity of cases. Adequate blinding was done when and where required to avoid the biases. Confounding variables like herd, age of the cow, stage of the lactation, season and geographical region were duly considered and adequate blocking was followed. Ascorbic acid was administered in clinical and subclinical cases even after cure considering its immunostimulatory and healing inducing effects. The recovery rate was faster in cases of clinical mastitis treated with ascorbic acid along with an intramammary infusion (group B) than the quarters of group C cows. Quarter wise the average duration/number (3.16${\pm}$0.11 days) of antimicrobial intramammary infusion was significantly (p<0.01) less in group B than that of average duration/number (5.33${\pm}$0.20 days) of group C. Subclinical mastitis cows treated with ascorbic acid showed 83.33% recovery while 16.77% did not respond to treatment till last day of study. Cows of group E (untreated) did not recovered from the mastitis. Subjective parameters viz. swelling, pain reflex of udder and physical changes in milk from quarter of ascorbic acid treated cows (group B) disappeared earlier than that of group C cows. It is concluded from this study that the ascorbic acid might be useful as an adjunct in case of clinical mastitis to get quick recovery with less number of intramammary infusions. High recovery rate in subclinical mastitis quarters of group D cows is appreciable and opens a new avenue to conduct further trials in a larger population in various field conditions. However, the pharmacology of ascorbic acid with particular reference to health of mammary gland needs to be investigated.

• 산업노동연구
• /
• 제24권2호
• /
• pp.247-291
• /
• 2018

본 연구는 대다수가 원-하청 구조 하의 간접고용 되어 있는 청소노동자의 고용구조와 노동형태, 그리고 사회보장제도 경험에 대한 질적 사례연구를 실시하였다. 이를 위해, 하청 여성 청소노동자의 노동시장에서의 불안정성을 구체적으로 살펴보고 이러한 특징이 어떻게 사회안전망에서의 배제와 연결되어 있는지 분석하였다. 분석결과, 하청업체에 고용되어 있는 중고령 여성 청소노동자들은 높은 고용 불안정성과 장시간의 높은 강도의 노동을 하고 있으면서도, 중고령 여성이기 때문에 사회보장제도에 충분히 포괄되거나 보호받지 못하고 있었다. 이러한 청소 노동자들에 대한 한국의 사회안전망은 다음과 같은 허구성을 가진 것으로 드러났다. 첫째, 여성 청소노동자들은 청소노동 종사 이전에는 비공식적 노동시장에서 일하는 등 국민연금에 최소한의 금액만 납부하였거나 최소 가입기간을 채우지 못한 경우가 많았다. 따라서 기초연금 및 국민연금을 포함한 공적 연금제도에 의한 노후소득보장 수준이 매우 열악하였다. 둘째, 한국 퇴직급여 제도가 퇴직연금체계로 전환되는 흐름 속에서, 원-하청업체 간의 계약 해지에 따라 업체변경이 빈번한 하청 청소노동자들은 안정적인 기금 형성이 어려워 퇴직연금체제가 노후소득보장제도로서 실효성을 갖는 데 한계가 있었다. 셋째, 고용보험의 경우 현행 실업급여제도는 가입자격 관련 연령기준으로 인해 수급자격이 박탈되는 경우가 많았으며, 직업훈련과 구직활동 서비스 또한 대개 활용하지 않는 것으로 나타났다. 넷째, 중고령의 청소노동자들은 반복적인 육체노동에 따른 근골격계 질환에 많이 노출되어 있는 것으로 나타났는데, 그럼에도 불구하고 노화와 산재간 판정의 어려움, 그리고 원-하청의 고용구조로 인해 산재보험의 혜택을 받는 경우는 드물었다. 결론적으로, 하청 청소노동시장에서 중고령 여성 청소노동자의 일에 대한 불안정성은 상당히 높은데도 불구하고, 한국의 사회보장제도는 이들이 노동자로써 뿐만 아니라 최소한의 인간다운 삶을 유지하게 하는 데 많은 한계를 보이고 있다고 분석되었다.

• Journal of Nutrition and Health
• /
• 제54권5호
• /
• pp.459-473
• /
• 2021

마늘건조분말을 준건강인이 섭취하였을 때 혈압 개선 효과가 있는지를 평가하기 위하여 메타 분석 기법으로 평가를 수행하였다. 2020년 7월까지 총 3,203건의 자료를 검색하여, 미리 계획한 선정 기준 및 제외 기준에 따라 선별한 결과 총 9건의 연구가 분석에 포함되었다. 편향 위험이 중등도 이상인 2건을 제외하고 총 7건의 연구를 포함하여 분석 결과, 마늘건조분말의 섭취는 수축기혈압 및 이완기혈압을 각각 -6.0 mmHg, -2.7 mmHg 수준으로 대조군 대비 유의하게 개선시키는 것으로 분석되었다.

• Korean Journal of Acupuncture
• /
• 제39권2호
• /
• pp.23-33
• /
• 2022

Objectives : The purpose of this study is to establish a Korean medical perspective on the human body through understanding of the meridians according to the distribution of the three yin and three yang (삼음삼양) and the opening, closing and pivot (관합추) as defined in ≪Huangdi's Internal Classic≫. Methods : A total of 8 medical databases including KISS, Earticle, DBpia, RISS, OASIS, KMbase, and ScienceON were used to search studies published through July 2021, and literature was included without limitations on the publication period. The search terms were "(meridian OR acupoint OR meridian sinew) AND position" OR "Gwan-Hap-Chu" OR "Gae-Hap-Chu" OR "three yin and three yang". Two researchers independently made choices among the searched literature based on the preplanned selection/exclusion criteria. The search terms were"(meridian OR acupoint OR meridian sinew) AND position" OR "Gwan-Hap-Chu" OR "Gae-Hap-Chu" OR "three yin and three yang". Results : Of the 36 obtained from the survey, 19 (53%) followed the definitions of "internal diameter" for "three yin and three yang" and "the opening, closing and pivot," but 6 (about 16%) took a neutral position and 10 (22%) avoided mentioning. Therefore, it was judged that research was needed to end the debate on the distribution of 'three yin and three yang' and 'the opening, closing and pivot'. In order to apply the definition of ≪Huangdi's Internal Classic≫ on 'distribution of the three-yin and three-yang' and 'the opening, closing and pivot' to the upper limb and lower limb as well as the torso of the human body, this author proposed a human body model with both upper limb and lower limb attached, inspired by the posture of the fetus in the developmental stage. Conclusions : In this study, using a new human body model, it was revealed that the distribution of the three yin and three yang and the opening, closing and pivot' as defined in the ≪Huangdi's Internal Classic≫ can be applied not only to the torso of the human body, but also to the upper limb and lower limb. Based on the understanding of meridians, the selection of meridians in the clinical acupuncture should be made accurately, and continuous interest and research on this are expected.

• 대중서사연구
• /
• 제26권2호
• /
• pp.157-190
• /
• 2020

주변부적 관점에서 그리고 젠더적 관점에서 1996년 8월 '연세대 사건'는 어떻게 기억되는가. 이 질문을 두고 본고에서는 한국문학에 나타난 1996년에서 2016년에 이르는 시기 동안의 혁명의 기록과 기록이 누락한 기억들을 검토하였다. 1996년의 학생운동에 대한 낯선 회상이 이루어지는 소설들, 윤이형의 「큰 늑대 파랑」(『큰 늑대 파랑』, 2011), 최은영의 「몫」(2018), 황정은의 『디디의 우산』(2019)을 중심으로 정치적으로 비가시화되었거나 젠더적으로 배제되었던 존재들이 경험하고 기억하는 혁명에 대한 이야기를 복원해보고자 하였다. 주변부적 위상에 대한 인식과 '기억될 수 없는' 혁명에 대한 호명의 상관성은, 더 나은 사회에 대한 상상과 체제 재편의 열망을 나누는 혁명의 한복판을 '함께' 통과할 때에도, 혁명이 모두에게 동일한 의미가 아니라는 것을, 혁명의 순간에도 여전히 배제와 위계의 논리가 작동하고 있었음을 역설하였다. 이러한 검토를 통해 1996년 '연세대 사건'의 역사적 복원과 계보화 작업이 단지 학생운동에 대한 재고에서 나아가 1990년대 한국사회에 대한 젠더적 관점의 재평가를 요청한다는 사실을 확인하였다.

• 예술인문사회 융합 멀티미디어 논문지
• /
• 제6권3호
• /
• pp.403-411
• /
• 2016

본 연구에서는 재한 중국동포의 한국에서의 민족 정체성의 변화과정에 대해서 알아보고자 하였다. 이를 위해 한국에 거주하는 중국동포 12명에 대한 심층인터뷰를 통해 그들이 한국에 거주하면서 민족 정체성이 어떻게 변화되었는지를 고찰하고자 하였다. 연구결과 재한 중국동포들의 민족 정체성은 그들의 문화적응과정과 밀접한 연관이 있었으며 3단계의 변화과정을 보여주었다. 첫째, 한국에 입국한 초창기의 중국동포들은 고국에 대한 기대와 설렘에서 한국생활을 시작한다. 둘째, 중국동포들은 주류사회와의 부딪침 속에서 민족정체성의 위기를 맞이하여 중국 조선족으로 회귀한다. 셋째, 지금 재한 중국동포의 민족정체성은 재조정기로 일부는 한국인, 일부는 중국조선족, 일부는 한국인도 중국인도 아닌 제3의 정체성을 지니고 있는 것으로 확인되었다. 따라서 본 연구결과를 통해 재한 중국동포들의 한국문화 적응과정 중의 민족정체성의 변화를 살펴볼 수 있었다. 그들의 건강한 민족정체성은 한국사회의 사회통합에도 큰 영향을 미친다. 이를 위해서는 한국 주류사회와 중국동포들이 함께 노력해야 할 필요성을 알 수 있었다.