• 혜화의학회지
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• 제8권2호
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• pp.211-243
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• 2000

This study was performed to investigate the cause, symptom, treatment, medicine of Wei symptom through the literature of oriental and western medicine. The results obtained were as follows: 1. Wei symptom is the symptom that reveals muscle relaxation without contraction and muscle relaxation occures in the lower limb or upper limb, in severe case, leads to death. 2. Since the pathology and etiology of Wei symptom was first described as "pe-yeol-yeop-cho"(肺熱葉焦) in Hung Ti Nei Ching(黃帝內經), for generations most doctors had have accepted it. but after Dan Ge(丹溪), it had been classified into seven causes, damp-heat(濕熱), phlegm-damp(濕痰), deficiency of qi(氣虛), deficiency of blood(血虛), deficiency of yin(陰處), stagnant blood(死血), stagnant food(食積). Chang Gyeng Ag(張景岳) added the cause of deficiency of source qi(元氣). 3. The concept of "To treat Yangming, most of all"(獨治陽明) was emphasized in the treatment of Wei symptom and contains nourishment of middle warmer energy(補益中氣), clearance of yangming-damp-heat(淸化陽明濕熱). 4. Since Nei-ching era(內經時代), Wei and Bi symptom(痺症) is differenciated according to the existence of pain. After Ming era(明代) appeared theory of co-existence of Wei symptom and pain or numbness but they were accepted as a sign of Wei symptom caused by the pathological factor phelgm(痰), damp(濕), stagnancy(瘀). 5. In the western medical point of view, Wei symptom is like paraplegia, or tetraplegia. and according to the causative disease, it is accompanied by dysesthesia, paresthsia, pain. thus it is more recommended to use hwal-hyel-hwa-ae(活血化瘀) method considering damp-heat(濕熱), qi deficiency of spleen and stornach(脾胃氣虛) as pathological basis than to simply differenciate Wei and Bi symptom according to the existence of pain. 6. The cause of Gullian-Barre syndrome(GBS) is consist of two factors, internal and external. Internal factors include asthenia of spleen and stomach, and of liver and kidney. External factors include summur-damp(暑濕), damp-heat(濕熱), cold-damp(寒濕) and on the basis of "classification and treatment according to the symptom of Zang-Fu"(臟腑辨證論治), the cause of GBS is classified into injury of body fluid by lung heat(肺熱傷津), infiltration of damp-heat(濕熱浸淫), asthenia of spleen and kidney(脾腎兩虛), asthenia of spleen and stomach(脾胃虛弱), asthenia of liver and kidney (肝腎兩虛). 7. The cause of GBS is divided by according to the disease developing stage: Early stage include dryness-heat(燥熱), damp(濕邪), phlegm(痰濁), stagnant blood(瘀血), and major treatment is reducing of excess(瀉實). Late stage include deficiency of essence(精虛), deficiency with excess(虛中挾實), and essencial deficiency of liver and kidney(肝腎精不足) is major point of treatment. 8. Following is the herbal medicine of GBS according to the stage. In case of summur-damp(暑濕), chung-seu-iki-tang(淸暑益氣湯) is used which helps cooling and drainage of summer-damp(淸利暑濕), reinforcement of qi and passage of collateral channels(補氣通絡). In case of damp-heat, used kun-bo-hwan(健步丸), In case of cool-damp(寒濕), used 'Mahwang-buja-sesin-tang with sam-chul-tang'(麻黃附子細辛湯合蓼朮湯). In case of asthenia of spleen and kidney, used 'Sam-lyeng-baik-chul san'(蔘笭白朮散), In case of asthenia of liver and kidney, used 'Hojam-hwan'(虎潛丸). 9. Following is the herbal medicine of GBS according to the "classification and treatment according to the symptom of Zang-Fu"(臟腑辨證論治). In the case of injury of body fluid by lung heat(肺熱傷津), 'Chung-jo-gu-pae-tang'(淸燥救肺湯) is used. In case of 'infiltration of damp-heat'(濕熱浸淫), us-ed 'Yi-myo-hwan'(二妙丸), In case of 'infiltration of cool-damp'(寒濕浸淫), us-ed 'Yui-lyung-tang', In case of asthenia of spleen, used 'Sam-lyung-bak-chul-san'. In case of yin-deficiency of liver and kidney(肝腎陰虛), used 'Ji-bak-ji-hwang-hwan'(知柏地黃丸), or 'Ho-jam-hwan'(虎潛丸). 10. Cervical spondylosis with myelopathy is occuered by compression or ischemia of spinal cord. 11. The cause of cervical spondylosis with myelopathy consist of 'flow disturbance of the channel points of tai-yang'(太陽經兪不利), 'stagnancy of cool-damp'(寒濕凝聚), 'congestion of phlegm-damp stagnant substances'(痰濕膠阻), 'impairment of liver and kidney'(肝腎虛損). 12. In treatment of cervical spondylosis with myelopathy, are used 'Ge-ji-ga-gal-geun-tang-gagam'(桂枝加葛根湯加減), 'So-hwal-lack-dan-hap-do-hong-eum-gagam(小活絡丹合桃紅飮加減), 'Sin-tong-chuck-ue-tang-gagam(身痛逐瘀湯加減), 'Do-dam-tang-hap-sa-mul-tang-gagam'(導痰湯合四物湯加減), 'Ik-sin-yang-hyel-guen-bo-tang'(益腎養血健步湯加減), 'Nok-gakyo-hwan-gagam'(鹿角膠丸加減). 13. The cause of muscle dystropy is related with 'the impairement of vital qi'(元氣損傷), and 'impairement of five Zang organ'(五臟敗傷). Symptoms and signs are classified into asthenia of spleen and stomach, deficiency with excess, 'deficiency of liver and kidney'(肝腎不足) infiltration of damp-heat, 'deficiency of qi and blood'(氣血兩虛), 'yang deficiency of spleen and kidney'(脾腎陽虛). 14. 'Bo-jung-ik-gi-tang'(補中益氣湯), 'Gum-gang-hwan'(金剛丸), 'Yi-gong-san-hap-sam-myo-hwan'(異功散合三妙丸), 'Ja-hyel-yang-gun-tang'(滋血養筋湯), 'Ho-jam-hwan'(虎潛丸) are used for muscle dystropy. 15. The causes of myasthenia gravis are classified into 'insufficiency of middle warmer energy'(中氣不足), 'deficiency of qi and yin of spleen and kidney'(脾腎兩處), 'asthenia of qi of spleen'(脾氣虛弱), 'deficiency of qi and blood'(氣血兩虛), 'yang deficiency of spleen and kidney'(脾腎陽虛). 16. 'Bo-jung-ik-gi-tang-gagam'(補中益氣湯加減), 'Sa-gun-ja-tang-hap-gi-guk-yang-hyel-tang'(四君子湯合杞菊地黃湯), 'Sa-gun-ja-tang-hap-u-gyi-eum-gagam'(四君子湯合右歸飮加減), 'Pal-jin-tang'(八珍湯), 'U-gyi-eum'(右歸飮) are used for myasthenia gravis.

• Journal of Nutrition and Health
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• 제53권2호
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• pp.141-154
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• 2020

본 연구에서는 국민건강영양조사 제 6기 1-3차년도 (2013년-2015년) 참여자 중 1-12세 미만인 어린이의 AD 여부와 에너지 및 영양소 적정섭취비율과의 관계를 분석하였다. AD군은 전체 연구대상자의 약 15.2%로, 남아 비율이 높았으며, non-AD군보다 평균나이가 약 0.7세 더 많았고, 나이를 세분화하여 비교했을 때, 나이가 들수록 AD 환아 수가 증가하였다. 신체 계측 결과, AD군이 non-AD군보다 신장과 체중 값이 더 컸지만, BMI는 군 간의 차이를 보이지 않았다. AD 여부와 식품군 및 영양소섭취 현황을 나이와 성별을 보정하여 비교한 결과, 두 군 간의 유의미한 차이가 있는 영양소는 없었다. 다만, 칼슘의 RNI 대비 섭취비율이 두 군 모두에게서 약 70% 수준으로 나타났는데, 이는 우리나라 어린이의 전반적인 칼슘 섭취량 부족에서 온 것으로 볼 수 있다. AD 여부에 따른 에너지와 영양소 섭취량의 차이는 나타나지 않았으나, KDRIs에 따른 적정섭취비율을 비교한 결과, AD군에서 지방과 비타민 C를 적정한 수준으로 섭취하는 비율이 더 높았고, 부족하거나 과잉으로 섭취하는 비율은 더 낮았다. AD 위험도와 에너지 및 영양소 적정섭취비율과의 관계를 분석하였을 때에는 지방은 과잉으로 섭취했을 경우, 비타민 C는 부족하거나 과잉으로 섭취했을 경우 AD 위험도가 감소하였다. 결론적으로, 어린이에게서 AD는 지방과 비타민 C의 영양소섭취비율과 관련이 있는 것으로 보이며, 이러한 결과는 AD 관리를 위한 식이 제한의 영향도 있을 것으로 예상한다. 이에 대해 좀 더 명확하게 인과관계를 규명하기 위한 추가 연구가 요구된다.

• Nutrition Research and Practice
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• 제9권4호
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• pp.404-410
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• 2015

BACKGROUND/OBJECTIVES: Although the association of body mass index (BMI) with metabolic syndrome (MetS) is well documented, there is little knowledge on the independent and joint associations of BMI and physical activity with MetS risk based on a continuous scoring system. This study was designed to explore the effect of physical activity on interactions between excess body weight and continuous metabolic syndrome (cMetS) in a nationwide survey of Iranian children and adolescents. SUBJECTS/METHODS: Data on 5,625 school students between 10 and 18 years of age were analyzed. BMI percentiles, screen time activity (STA), leisure time physical activity (LTPA) levels, and components of cMetS risk score were extracted. Standardized residuals (z-scores) were calculated for MetS components. Linear regression models were used to study the interactions between different combinations of cMetS, LTPA, and BMI percentiles. RESULTS: Overall, 984 (17.5%) subjects were underweight, whereas 501 (8.9%) and 451 (8%) participants were overweight and obese, respectively. All standardized values for cMetS components, except fasting blood glucose level, were directly correlated with BMI percentiles in all models (P-trend < 0.001); these associations were independent of STA and LTPA levels. Linear associations were also observed among LTPA and standardized residuals for blood pressure, high-density lipoprotein, and waist circumference (P-trend < 0.01). CONCLUSIONS: Our findings suggest that BMI percentiles are associated with cMetS risk score independent of LTPA and STA levels.

• 대한한의학원전학회지
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• 제23권5호
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• pp.11-22
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• 2010

Treatise on the Pathogenesis and Manifestations of All Diseases(諸病源候論)was written by Chao Yuanfang that was most active during the Sui Dynasty at A.D. 610. It classified clinical medicine by some departments of internal medicine, surgery, obstetrics and gynecology, pediatrics, and otorhinolaryngology and within each specific department, categorizes etiology and pathology according to characteristics of various diseases. It was the total disease classification book that based on the bibles of the Oriental medicine, (Huangdi''s) Internal Classic(黃帝內經), Classic of Difficult Issues(難經) and Treatise on Cold Damage and Miscellaneous Diseases(傷寒雜病論), A-B Classic of Acupuncture and Moxibustion(鍼灸甲乙經), Essential Prescriptions Worth a Thousand Gold for Emergencies(備急千金要方) and Medical Secrets of an Official(外臺秘要). It was arranged tussive causes, classes, diagnosis, prognosis and stretching for treatment by Volume 13, all symptoms of tussiculation. Dialectic part was divided into cough(咳嗽), cough with dyspnea(咳逆上氣), cough with pus and blood(咳嗽吐膿血), cough with duck crying sound(?嗽), sudden cough(暴氣咳嗽), cough with dyspnea(咳逆), cough with dyspnea and vomiting(咳逆上氣嘔吐). Disease situation part was divided into the new cough(新咳) and old cough(舊咳), deficiency syndrome(虛證) and excess syndrome(實證), visceral cough(藏府咳), etc. Out of these, cough with counterflow(咳嗽上氣), cough with dyspnea(咳逆上氣), cough with dyspnea and vomiting(咳逆上氣嘔吐), cough with shortness of breath(咳逆短氣) have a close connection with dyspnea(上氣), counterflow of qi(逆氣), dyspnea and vomiting(上氣嘔吐) and shortness of breath(短氣) in the Pathogenesis and Manifestations of All qi(氣病諸候) of vol 13. So two parts may be refer to each other. However, the content on the original book has been addition and subtraction on the original context along with many reprints. Therefore, this paper, with regard to the prints of former editions, tried to help in better comprehension of the original context through readings and Korean translation.

• 대한한의학원전학회지
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• 제22권3호
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• pp.31-51
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• 2009

The characteristics of Jin's ideas on clinic theory can be arranged as follows. 1. Jin emphasized warming and tonifying[溫補] in treatment and the part that shows this the best is the taking care of[調理] the Vital gate[命門], kidney, liver, and spleen. His ideas were based on his understanding of a human life's origin, and was influenced by Seolgi(薛己), Joheon-ga(趙獻可) and Janggaebin(張介賓)'s Vital gate and source Gi theory(元氣說) so scholastically, he has that in common with them but was later criticized by later doctors such as Oksamjon(玉三尊) as an 'literary doctor(文字醫)' who followed the ideas of "Uigwan(醫貫)". 2. The warming and tonifying school[溫補學派], who were influenced by Taoism, said in their theory of disease outbreak[發病學說] that since one must not hurt one's Yin essence and Yang fire [陰精陽火] there is more deficiency than excess, so that was why they used tonifying methods. Jin was also like them and this point of view is universal in internal medicine, gynecology, pediatric medicine and surgery and so on. 3. Jin, who saw the negative form of pulse diagnosis[診脈] emphasized following symptoms over pulse diagnosis using the spirit of ‘finding truth based on truth[實事求是]' in "Maekgyeolcheonmi(脈訣闡微)", but emphasized 'the combination of pulse and symptoms[脈證合參]'. He understood pulse diagnosis as a defining tool for symptoms, and in "Seoksilbirok(石室秘錄)" simplified pulse diagnosis into 10 methods : floating/sunken(浮沉), slow/fast(遲數), large/fine(大小), vacuous/replete(虛實) and slippery/rough(滑澀). 4. Jin used 'large formulas(大方)' a lot that usually featured a large dose, and in " Bonchosinpyeon(本草新編)" he thought of the seven formulas(七方) and ten preparations(十劑) as the standard when using medicine. He did away with old customs and presented a 'new(新)' and 'extra(奇)' point of view. He especially used a lot of Insam(人蔘) when tonifying Gi and Geumeunhwa(金銀花) when treating sores and ulcers. 5. In the area of surgery Jin gave priority to the early finding and treatment of disease with internal treatment[內治] and was against the overuse of acupuncture. However records of surgical measures in a special situation like lung abscesses(肺癰) and liver abscesses(肝癰), and anesthetic measures using 'Manghyeongju(忘形酒)' and 'Singoiyak(神膏異藥)' and opening the abdomen or skull, and organ transplants using a dog's tongue are important data. 6. Jin stated the diseases of Gi and blood broadly. Especially in the principles of treating blood, blood diseases had to be forwarded[順] and Gi regulation[理氣] was the number one priority and stated the following two treatments. First, in "Jeonggiinhyeolpyeon(精氣引血篇)" of volume 6 of "Oegyeongmieon(外經微言)", for the rules for treating blood he stated the pattern identification of finding Gi in blood and blood in Gi. Second, he emphasized Gi regulation(理氣) in blood diseases and stated that the Gi must be tonifyed after finding the source of the loss of blood.

• 대한한의학원전학회지
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• 제31권2호
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• pp.141-153
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• 2018

Objectives : Acupuncture therapy's reinforcement and reduction method is now widely used in the clinical practices. Meanwhile, there has been a voice of concern since the past that acupuncture has no reinforcement. This thought has not been given enough discussion, and the paper attempts to remedy this absence and verify the validity of the concern. Methods : The acupunctural reinforcement and reduction method found in the Huangdineijing is reviewed, and a number of medical books that discuss the idea of lack of reinforcement in acupuncture are studied. Results : Huangdineijing describes the acupunctural unique feature of reduction. The text explains that acupuncture work in a way that is different that medicine, and thus cannot be used for a disease based on deficiency. In addition, it warned the loss of the primordial qi when needling oneself. Reinforcement in the reinforcement and reduction technique as described in Huangdineijing mainly revolves around preventing the loss of the primordial qi. Conclusions : The purpose of the acupunctural reinforcement and reduction is to control the body's disproportional qi deficiency and excess, where some parts of the body has more qi than others. The reinforcement in "acupunctural reinforcement and reduction method" and the reinforcement in "acupuncture only has reduction and no reinforcement" within the thought of "acupuncture has no reinforcement" are different in that one deals with controlling the imbalance of qi in body, and the other deals with dispelling the deficiency by flowing the qi in the viewpoint of entering and out. This calls for a need to establish the proper acupunctural points, numbers, and times for each disease based on the theory of "acupuncture has no reinforcemen."

• Journal of Microbiology and Biotechnology
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• 제26권12호
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• pp.2159-2170
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• 2016

Many plant-pathogenic bacteria are dependent on quorum sensing (QS) to evoke disease. In this study, the population of QS and quorum quenching (QQ) bacteria was analyzed in a consecutive monoculture system of Pseudostellaria heterophylla. The isolated QS strains were identified as Serratia marcescens with SwrIR-type QS system and exhibited a significant increase over the years of monoculture. Only one QQ strain was isolated from newly planted soil sample and was identified as Bacillus thuringiensis, which secreted lactonase to degrade QS signal molecules. Inoculation of S. marcescens to P. heterophylla root could rapidly cause wilt disease, which was alleviated by B. thuringiensis. Furthermore, the expression of lactonase encoded by the aiiA gene in S. marcescens resulted in reduction of its pathogenicity, implying that the toxic effect of S. marcescens on the seedlings was QS-regulated. Meanwhile, excess lactonase in S. marcescens led to reduction in antibacterial substances, exoenzymes, and swarming motility, which might contribute to pathogensis on the seedlings. Root exudates and root tuber extracts of P. heterophylla significantly promoted the growth of S. marcescens, whereas a slight increase of B. thuringiensis was observed in both samples. These results demonstrated that QS-regulated behaviors in S. marcescens mediated by root exudates played an important role in replanting diseases of P. heterophylla.

• 동의생리병리학회지
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• 제22권1호
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• pp.60-81
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• 2008

This thesis is written about the causes, the processes and the treatments of edema. It consists of 31 chapters. Covering 11 chapters, there are prescriptions and constructions. When one of the organs fails to work metabolizing water, you can have edema. It is the result of the accumulation of excess fluid under the skin. Edema most commonly occurs in the head facial, the palpebral portion, the feet and legs or all the body. Sometimes it is accompanied with ascites. There are three classifications in the thesis. First, according to the cause and the symptom of disease, it is divided into 5 types. Type 1. The swelling caused by the disorder of the lungs from the troubling wind. Type 2. The swelling caused by the weak spleen. Type 3. The swelling caused by abnormal condition between the kidneys and the lungs. Type 4. The swelling in abdomen caused by the weak kidneys. Type 5. The swelling (Yellow sweat) caused by the heat inside body as water outside. Second, the swelling and the abnormal symptom of five viscera. Third, the swelling accompanied with menstruation in female and with chilliness. In short, the original textbook is showed that the treatment of edema focuses on the cause and the region of fluid accumulation. When the swelling is in the upper body or the cause of diseaseis outside, the useless humidity can be expelled through sweating. On the other hand, when the swelling is in the lower body or the cause of disease is inside, it is pushed out by urination. In this book, the author presents further treatments. And these treatments are often cited by doctors after ages. Even one of them suggested that the swelling be divided by cosmic dual forces. In spite of many researches, it is too complicate for us to understand the writer’s intend. For that reason, comparing with other medical books and referring to guides explained by doctors, I have studied the textbook to help understand.

• 대한지역사회영양학회지
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• 제15권6호
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• pp.717-726
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• 2010

This study was conducted to investigate health status and nutrient intakes among 5th grade elementary students at Korea Centers for Disease Control and Prevention 2010. This study was cross-sectional study on 1,384 children (687 boys, 697 girls) from nine elementary schools located in Seoul and Gyeonggi province. The average height, weight and BMI were 145 cm, 40.6 kg $19.2\;kg/m^2$ for boys and 145.4 cm, 38.2 kg, $18.0\;kg/m^2$ for girls. The prevalence of overweight and obesity were 11.3%, 5.2%, respectively. Serum AST, ALT, glucose, HDL-Cholesterol and RBC levels were significantly higher, while TG levels was significantly lower for boys than for girls. The average energy intake was 1772.4 kcal, which was 98.7% of Estimated Energy Requirement (EER). The boys consumed more energy intake (1800.4 kcal) than the girls (1744.7 kcal). Also, they took insufficient calcium and folate (69.1% and 83.3% of Recommended Intake (RI)) and excess sodium (297.6% of Adequate Intake (AI)) and 85.1% of the subjects had breakfast everyday. In general, the proportion of the children who consumed fruits and vegetables at least once or more a day was low. There was a higher proportion of children in boys who had ramyun and milk with sufficient physical activity than those in girls. As a result of this study, we can find risk factors on obesity and metabolic disorders, and the results can be used for an evidence of nutrition education program and the intervention program.

• 한국노년학
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• 제29권2호
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• pp.645-656
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• 2009

본 연구는 의료기관 가정간호사업 현황을 총체적으로 파악하여, 의료기관 가정간호사업 활성화와 노인장기요양보험제도 도입 이후 세 가지 유형의 가정방문 간호사업을 효율적으로 기능역할 정립하는데 필요한 기초자료를 생성하기 위함이다. 건강보험심사평가원의 2006년 의료기관 가정간호 급여청구자료를 2차 분석하고, 전국 75개 의료기관 가정간호사업소의 사업현황을 횡단적 조사 분석하였다. 2006년 전체 의료기관 가정간호 이용자 중 65세 이상 노인은 20,343명(전체 대상자의 64.0%), 급여 청구는 98,822건(전체 청구의 70.1%), 방문은 333,889건(전체 방문의 76.8%)이었다. 이용자의 진단명은 뇌졸중 23.6%, 뇌졸중을 제외한 심장 등 순환기질환이 17.7%로 전체 청구 중 41.3%가 뇌졸중을 비롯한 순환기질환에 의한 것이었다. 다음은 당뇨 등 내분비계질환 10.4%, 신생물 9.7% 순이었다. 2006년 일 년간 노인대상 의료기관 가정간호 총 진료비는 13,247,992,290원(전체의 70.5%), 가정간호비용은 6,544,430,760원(전체의 72.2%)이었다. 2006년 일 년간 의료기관 가정간호 서비스 이용 노인 일인당 평균 총 진료비는 646,262원, 가정간호비용은 319,476원, 총 방문건수는 15.3건이었다. 의료기관 가정간호사업은 보건소 방문보건사업과 중재 종류는 유사하나, 보건소 방문보건사업에서는 수행되지 않는 헤마토크릿(16.8%), 혈색소(15.6%), 적혈구 침강속도(5.6%), 경피적산소분압(0.1%) 등 임상검사와 흡입배농 및 배액(0.7%), 약물저류 관장(0.1%) 및 가스관장(0.01%)등 특수처치가 수행되었다. 건강보험 급여한도 월 8회를 초과하여 전액본인부담금으로 의료기관 가정간호를 이용한 노인은 질환별로 욕창 7.0%, 암 5.4%, 당뇨 2.5%, 고혈압 1.1%, 뇌졸중 0.9%였다. 따라서, 이러한 서비스 차이를 반영하여 세 가지 유형의 가정방문 간호사업간 기능역할을 설정하고, 서비스 이용을 활성화하기 위해서 보험급여를 확대할 필요가 있다.