• Proceedings of the KOR-BRONCHOESO Conference
• /
• 1977.06a
• /
• pp.4.1-4
• /
• 1977

A variety of diagnostic means for evaluating the hearing ability of neonates and infants have been studied so far, and some physical responses of neonates and infants to loud sound is still of much value. The author studied some normal responses of 100 neonates (male 54, female 46) in our neonatal room from Jan, 1977 to April, 1977. We took 90dB pure tone at 3, 000Hz by Beltone Audiometer model l0D (ANSI 1969) for a stimulus. The results are as follows: 1. The range of the examinees' age is between 2 and 3.5 hours (average 2.4 hours), and auropalpebral response is in 39% (eyelid blinking 10%, eyelid widening 29%), Moro reflex in 35%, sucking response in 14%, cessation of movement in 6%, head turning response in 2%, and no response in 4%. 2. The duration of response is between 2 and 5 Seconds (average 3.3 seconds).

• Journal of the Korean Dietetic Association
• /
• v.23 no.1
• /
• pp.27-38
• /
• 2017

Maintaining adequate fluid balance is essential for all biological functions in the body. The purpose of this study was to evaluate vulnerability to dehydration by analyzing age, gender, body mass index (BMI), and blood lipid parameters in health checkup examinees who visited Sahmyook Seoul Hospital for comprehensive health checkups. In a binary logistic regression analysis stratified by age and body mass index the odd ratio for dehydration was as high as 3.317 (95% CI: 1.666~6.605) in the 50s age group, 4.224 (95% CI: 2.038~ 8.755) in the 60s age group, and 4.610 (95% CI: 1.943~10.940) in the above 70s age group compared to 20s reference age group. Aged females showed greater vulnerability to dehydration with significance levels of P<0.01 and P<0.001. Compared to a normal weight (BMI: 18.5~22.9) the odd ratio was higher in males with an under weight (BMI: less than 18.5) (5.130 [95% CI: 1.631~16.132]) and in females with an over weight (BMI: 23.0~24.9) (1.500 [95% CI: 1.065~2.114]). In conclusion, our results showed that vulnerability to dehydration increased with age and was higher in under weight males and over weight females than that in normal weight.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.14 no.9
• /
• pp.4335-4341
• /
• 2013

This study was performed to evaluate the prevalence and risk factors of colonic polyps which is an established premalignant lesion and to provide basic data for the management of colon cancer in asymptomatic adults. The subjects of this study were 995 persons who underwent screening colonoscopy between January to December 2010 in health promotion center of an University Hospital located in Busan, and structured questionnaire, medical questionnaire, medical records were reviewed retrospectively. The data were analyzed by SPSS 18.0 program. Colonic polyps were found in 63.2% of the subjects. The prevalence rate of colonic polyps was significantly higher in males and it increased with age. Age, sex and exercise were found to be related independently to colonic polyps. Early detection of colonic polyps by colonoscopy is important for adults over 40 years, and it is necessary to advise such subjects to correct a wrong life-style in order to primarily prevent the development of colonic polyps.

• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.31 no.4
• /
• pp.540-548
• /
• 2021

Introduction: Preplacement health examination (PHE) is performed when a worker starts a certain work task which is designated as having occupational risks by the Ministry of Employment and Labor (MOEL). All data related to health examination except PHE are reported to the MOEL by the law. This study has been performed to understand the status of PHE at certain workplaces. Methods: PHE data gathered in a university hospital were analyzed and they were followed with results of the special health examination (SHE) in 2019 and 2020. Those who were evaluated as unfit to work as it was, were interviewed directly or indirectly through an occupational health manager to follow up the management status of their recognized health problems. Results: The unfit to work (unFTW) rate of PHE was 2.8%, and was not different according to the size of workplace or having occupational health service. The major cause of unfit to work was the uncontrolled life-style diseases such as hypertension and diabetes. The rate of SHE followed by PHE was 31.1%. It was not different by the unFTW rates, however, they were different according to having a full time in-house occupational health manager. Thirty-one among 71 examinees who were evaluated as unFTW underwent SHE after controlling their health condition and were finally evaluated as fit to work. Nineteen among 31 started to take medicine and eight have been placed in the work without designated risks. Conclusion: PHE can be used for new workers, who may have unknown or uncontrolled life-style diseases, to be asked to manage life-style diseases as well as work-related risks such as shift work. In order to have a better tracking system for work-related risks, the information of PHE should be analyzed together with other data from health examination.

• Journal of Preventive Medicine and Public Health
• /
• v.51 no.6
• /
• pp.298-309
• /
• 2018

Objectives: The objective of this study was to assess the relationship between systolic and diastolic blood pressure (SBP, DBP) and the risk of death from specific causes other than cardiovascular diseases. Methods: We calculated the risk of specific death by SBP and DBP categories for 506 508 health examinees in 2002-2003 using hazard ratios (HRs) and 95% confidence intervals (CIs) in a Cox proportional hazards model. Results: Compared to normal levels (SBP <120 or DBP <90 mmHg), stage I systolic and diastolic hypertension (SBP 140-159, DBP 85-89 mmHg, respectively) were associated with an increased risk of death from diabetes mellitus, alcoholic liver disease, and renal failure (HR, 1.83; 95% CI, 1.51 to 2.22; HR, 1.24; 95% CI, 1.06 to 1.46; HR, 2.30; 95% CI, 1.64 to 3.21; HR, 1.67; 95% CI, 1.27 to 2.20; HR, 1.99; 95% CI, 1.41 to 2.81; HR, 1.31; 95% CI, 0.99 to 1.73, respectively), but a decreased risk of death from intestinal pneumonia (HR, 0.64; 95% CI, 0.42 to 0.98; HR, 0.59; 95% CI, 0.39 to 0.91). Only stage II systolic hypertension (SBP ${\geq}160mmHg$) was associated with an increased risk of death from pneumonia, liver cirrhosis, and intestinal ischemia (HR, 1.54; 95% CI, 1.19 to 1.98; HR, 1.46; 95% CI, 1.00 to 2.15; HR, 3.77; 95% CI, 1.24 to 11.40, respectively), and stage I and II diastolic hypertension (SBP 140-159 and ${\geq}160mmHg$) were associated with an increased risk of death from intestinal ischemia (HR, 3.07; 95% CI, 1.27 to 7.38; HR, 4.39; 95% CI, 1.62 to 11.88, respectively). Conclusions: An increase in blood pressure levels may alter the risk of death from certain causes other than cardiovascular diseases, a well-known outcome of hypertension, although the mechanism of these associations is not well documented.

• Journal of Industrial Convergence
• /
• v.19 no.1
• /
• pp.1-6
• /
• 2021

The purpose of this study is to find a way to increase the examination rate by presenting the current state of national health examination. To this end, demographic factors(Gender, age, income level, education level) and health factors(Smoking, alcohol, obesity, subjective health status) were selected, and whether the selected factors were different for each group, and the examinees according to the number of hospitals and income level were visualized. As a result, except for subjective health status in health factors, population factors, and number of hospitals were all related to the examination. In addition, among the age factors of the demographic factor, those in their twenties and those with a low income level and those who were underweight among the health factors of obesity had a high rate of non-testing. Therefore, it is considered necessary to promote, support, and educate those untested by these groups.

• Biomedical Science Letters
• /
• v.26 no.4
• /
• pp.368-375
• /
• 2020

Metabolic syndrome (MetS) is a disease that is accompanied by various metabolic related problems and refers to a disease in which various adult diseases occur along with obesity. These metabolic syndromes appear according to the individual's genetic background. APOA5-ZPR1-BUD13, a gene cluster belonging to chromosome 11q23.3, is well known for its risk of plasma triglycerides and coronary artery disease. Recently, the GWAS results for metabolic syndrome were published in Koreans. The results included the APOA5-ZPR1-BUD13, and the SNPs that first appeared in Koreans in the ZPR1 and BUD13 were also discovered. In this study, the reproducibility was investigated for the newly discovered ZPR1 (rs964184) and BUD13 (rs2075295, rs1558861) using The Health Examinees (HEXA) cohort and showed significance. In addition, BUD13 (rs117548857, rs10488698, rs149527022, rs10790162), ZPR1 (rs2075290, rs145796806, rs201247587), APOA5 (rs12791103, rs1263173, rs7396835, rs17520254) were additionally discovered and significant results were obtained. For the SNPs that showed significant results, the effect on protein expression and the effect of expression quantitative trait loci (eQTL) were also confirmed. This study is expected to contribute to the prevention and treatment of diseases with differences in onset based on individual genetic patterns as well as presenting the effect of genetic mutations in the APOA5-ZPR1-BUD13 on metabolic syndrome and blood lipid levels.

• Safety and Health at Work
• /
• v.14 no.3
• /
• pp.279-286
• /
• 2023

Background: This study aimed to evaluate the association between exposure to occupational hazards and the metabolic syndrome. A secondary objective was to analyze the additive and multiplicative effects of exposure to risk factors. Methods: This retrospective cohort was based on 31,615 health examinees at the Pusan National University Yangsan Hospital in Republic of Korea from 2012-2021. Demographic and behavior-related risk factors were treated as confounding factors, whereas three physical factors, 19 organic solvents and aerosols, and 13 metals and dust were considered occupational risk factors. Time-dependent Cox regression analysis was used to calculate hazard ratios. Results: The risk of metabolic syndrome was significantly higher in night shift workers (hazard ratio = 1.45: 95% confidence interval = 1.36-1.54) and workers who were exposed to noise (1.15:1.07-1.24). Exposure to some other risk factors was also significantly associated with a higher risk of metabolic syndrome. They were dimethylformamide, acetonitrile, trichloroethylene, xylene, styrene, toluene, dichloromethane, copper, antimony, lead, copper, iron, welding fume, and manganese. Among the 28 significant pairs, 19 exhibited both positive additive and multiplicative effects. Conclusions: Exposure to single or combined occupational risk factors may increase the risk of developing metabolic syndrome. Working conditions should be monitored and improved to reduce exposure to occupational hazards and prevent the development of the metabolic syndrome.

• KIPS Transactions on Software and Data Engineering
• /
• v.11 no.6
• /
• pp.267-272
• /
• 2022

Online exams are not limited by time and space. It has the advantage that it does not require a separate exam site for examinees, and there is no time and cost required to move to the exam site. However, the online exam has the disadvantage that various cheating is possible because the exam is conducted in an individual environment. In addition, there is a difficulty in detecting cheating due to the lack of exam supervision methods. In addition, since the exam process and result data exist only as digital data, it is inconvenient to check directly on the server where the exam result is stored in order to check whether the exam result is forged or not. If the data related to the exam is maliciously changed, the authenticity cannot be verified. In this study, we tried to increase the reliability of the online exam by developing a blockchain-based online exam cheating detection system that stores exam progress-related data in the blockchain to detect cheating. Through the experiment, it was confirmed that forgery and falsification are detected as a result of the exam.

• The Korean Journal of Nuclear Medicine Technology
• /
• v.27 no.2
• /
• pp.133-136
• /
• 2023

Purpose: Prolactin in the blood is separated into three types, and over 90% of prolactin presents as a double monomer (23 KDa). Rarely, it can exist in the size of big prolactin (150 KDa), which is called macroprolactin and is known as an autoantibody complex. When macroprolactin accounts for more than 60% of prolactin in the blood, it is called macroprolactinemia. The presence of such macroprolactin was first reported in a patient with hyperprolactinemia but without typical symptoms. Macroprolactinemia is emerging as an important cause of idiopathic hyperprolactinemia. The polyethylene glycol (PEG) precipitation method using the property of precipitating large-molecular-weight proteins is simple and recently has been widely used as a screening test. The results are in good agreement with the results of gel chromatography. The purpose of this study was to confirm the measurement method and reference value verification of monomeric prolactin in blood prolactin using the PEG precipitation method. Materials and Methods: For 40 examinees who visited the Gangnam Center of Seoul National University Hospital in 2021, the prolactin level was verified using radioimmunoassay (RIA). For macroprolactinemia PEG precipitation method, 25% PEG (molecular weight 6000kDa) solution and serum were mixed in equal amounts in a test tube, then left at room temperature for 20 minutes and centrifuged at 4℃ for 30 minutes (1500g). The prolactin level was measured in the supernatant. Results : After confirming that more than 90% of the 40 tested samples within the reference range <25 ng/mL, the same value as the reference value for prolactin was applied. Since the concentration of monomeric prolactin in serum from which macroprolactin has been removed from blood is diluted 1:1 with PEG, our laboratory is currently reporting the result by multiplying the result by a dilution factor of 2. Conclusion: Radioimmunoassay using PEG precipitation method using the property of precipitating large molecular weight proteins is simple and effective for quantitative measurement of monomeric prolactin in blood prolactin.