• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3067-3074
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• 2013

Background: Faced with highly prevalent and recalcitrant cancer-related fatigue (CRF), together with the absence of any official guidelines on management, numerous groups have been striving to seek and test alternative therapies including acupuncture and moxibustion. However, different patients have various feedbacks, and the many clinical trials have given rise to varied conclusions. In terms of the therapeutic effect of acupuncture and moxibustion, there exist vast inconsistencies. Objective: The aim of the study was to evaluate the auxiliary effectiveness of acupuncture and moxibustion in the treatment of CRF, and to provide more reliable evidence to guide clinical practice. Methods: Randomized controlled trials (RCTs) published before December 2012 were all aggregated, focusing on evaluation of acupuncture or moxibustion for CRF. The quality of the included studies was assessed basing on Cochrane handbook 5.1.0, and the available data were analyzed with RevMan software (version 5.2.0). Descriptive techniques were performed when no available data could be used. Results: A total of 7 studies involving 804 participants were eligible. With real acupuncture versus sham acupuncture, subjects receiving true acupuncture benefited more in the reduction of fatigue. With real acupuncture versus acupressure or sham acupressure, fatigue level appeared 36% improved in the acupuncture group, but 19% in the acupressure group and only 0.6% with sham acupressure. When real acupuncture plus enhanced routine care was compared with enhanced routine care, the combination group improved mean scores for general fatigue, together with physical and mental fatigue. With real acupuncture versus sham acupuncture or wait list controls, the real acupuncture group displayed significant advantages over the wait list controls at 2 weeks for fatigue improvement and better well-being effects at 6 weeks. When moxibustion plus routine care was compared with routine care alone, the meta-analyses demonstrated the combination had a relatively significant benefit in improving severe fatigue and QLQ-C30. Conclusion: Up to the search date, there exist few high quality RCTs to evaluate the effect of acupuncture and moxibustion, especially moxibustion in English. Yet acupuncture and moxibustion still appeared to be efficacious auxiliary therapeutic methods for CRF, in spite of several inherent defects of the included studies. Much more high-quality studies are urgently needed.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10905-10909
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• 2015

Purpose: The aim of this study was to evaluate the diagnostic value of FNA-Tg for detecting lymph node metastases in patients with a history of differentiated thyroid cancer (DTC). Materials and Methods: A total of 58 patients with DTC diagnosis and evidence of single or multiple suspicious cervical lymph nodes were assessed. All underwent total or near-total thyroidectomy with (35 cases) or without (23 cases) radioiodine (RAI) ablation, followed by thyroid stimulating hormone (TSH) suppression therapy. A total of 68 lymph nodes were examined by ultrasound-guided fine needle aspiration (US-FNA) for both cytological examination and FNA-Tg measurement. Serum Tg and anti-thyroglobulin antibody (TgAb) levels were also measured. Diagnostic performance including sensitivity, specificity, accuracy, positive (PPV) and negative predictive value (NPV) of FNAC and FNA-Tg were calculated and compared. The Spearman's rank correlation coefficient was used to estimate the relationship between FNA-Tg and serum TgAb. Results: The FNA-Tg levels were significantly higher with DTC metastatic lymph nodes (median 927.7 ng/mL, interquartile range 602.9 ng/mL) than non-metastatic lymph nodes (median 0.1 ng/mL, interquartile range 0.4 ng/mL) (p<0.01). Considering 1.0 ng/mL as a threshold value for FNA-Tg, the sensitivity, specificity, accuracy, PPV and NPV of FNA-Tg were 95.7%, 95.5%, 95.6%, 97.8% and 91.3%, respectively. The sensitivity and accuracy of the combination of FNAC and FNA-Tg were significantly higher than that of FNAC alone (p<0.05). The diagnostic performance of FNA-Tg was not significantly different between cases with or without RAI ablation, and the serum TgAb levels did not interfere with FNA-Tg measurements. Conclusions: Measurement of FNA-Tg is useful. The combination of FNAC and FNA-Tg is more sensitive and accurate for detecting lymph node metastases in patients with a history of DTC than FNAC alone. Serum TgAbs appear to be irrelevant for measurement of FNA-Tg.

• 통상정보연구
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• 제7권4호
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• pp.387-407
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• 2005

This paper is to study globalization motives and strategies of Japanese and Korean industries by analyzing the causes and patterns of foreign direct investment (FDI) of the firms of the two countries during the 1980s and 1990s. First we develop a FDI function from the profit maximizing model of firms. Then we use regression analysis to determine internally driving-out factors and externally-inducing factors. Japanese FDI strategy has gone through three different stages; from natural resource-seeking investment in the 1950s and 1960s to market-expansion investment in the 1970s and 1980s and to a combination of cost-reducing (low-cost labor-seeking) investment and market-penetrating investment in the 1990s. On the other hand, Korean FDI behavior has gone through four different stages; from the learning stage with small investments in the 1970s, to natural resource-seeking investment in the early and mid 1980s, to the growth stage in the late 1980s and the early 1990s, to the maturity stage of the mid and late 1990s. The last two stages were characterized by a combination of cost-reducing investment and market-seeking investment. As a late comer, Korea began its FDI two decades later than Japan, but caught up the patterns of Japanese FDI by the mid 1990s and is in a competing position with Japan. Our findings show that both Japanese FDI and Korean FDI in Asia and other developing countries tendto be in labor-intensive sectors where their firms are losing their comparative advantages at home. The main motive for FDI into these regions is low-cost resource seeking. On the other hand, both Japanese FDI and Korean FDI in the U.S. and Europe tend to be knowledge-intensive sectors where Japanese and Korean firms attempt to internalize transaction and information costs by globalizing its production. The main motive for FDI into these regions is market-seeking. Firms in both countries have increased their investments in Mexico and Western and Eastern Europe in order to penetrate large economic blocs such as the EU and NAFTA area. Korean firms are more aggressive in expanding into new and untested markets than are their counterpart in Japan. Evidence of this can be seen in the scarcity of Japanese FDI and abundance of Korean FDI in Eastern Europe and China.

• 대한수의학회지
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• 제44권3호
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• pp.433-439
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• 2004

This study was carried out to investigate the efficacy of rifampin with or without streptomycin in male Sprague-Dawley (SD) rats experimentally inoculated with Brucella abortus. Thirty rats were intraperitoneally inoculated with $1.0{\times}10^9$colony-forming units of B. abortus. They were divided into 3 groups by treatment with antibiotic. 10 rats in Group A were orally administrated with rifampin, 10 rats in Group B with rifampin orally and with streptomycin intramuscularly over 12 weeks starting at 1 week post infection (PI). A placebo recipient in Group C was inoculated with sterile saline without antibiotics. All animals were monitored by tube agglutination test (TAT) and AMOS-PCR to evaluate the efficiency of the antibiotics to B. abortus infection. The antibody titers in Groups A, B and C were 1:400, 1:400 and 1:800 as measured by TAT at the first week PI, respectively. The antibody titer in Group A decreased to 1:100 by the 13th week PI. That in the control group was observed as high antibody titer until 13th weeks PI, but the antibody response in Group B was low(1:50) from the 5th week to the 13th week PI. AMOS-PCR there was evidence of relapse of B. abortus in group A in liver and spleen specimens at the 13th week PI. B. abortus DNA was detected in Group C in liver and spleen specimens from the 1st week to 13th week PI by AMOS-PCR. However AMOS-PCR could not detect any organism in Group B from the 3rd week PI until the end of the study. This study demonstrated that administration of a combination of rifampin and streptomycin was more efficacious than administration of rifampin alone. A significant reduction in antibody titer was observed when a combination of 15 mg/kg/day of rifampin per os and 15 mg/kg/day streptomycin intramuscularly was used in comparison with the antibody of control group.

• Nutrition Research and Practice
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• 제16권sup1호
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• pp.113-125
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• 2022

In the current years, it has now become necessary to establish standards for micronutrient intake based on scientific evidence. This review discusses issues related to the development of the 2020 Dietary Reference Intakes for Koreans (KDRI) for magnesium (Mg), zinc (Zn), and copper (Cu), and future research directions. Following issues were encountered when establishing the KDRI for these minerals. First, characteristics of Korean subjects need to be applied to estimate nutrient requirements. When calculating the estimated average requirement (EAR), the KDRI used the results of balance studies for Mg absorption and factorial analysis for Zn, which is defined as the minimum amount to offset endogenous losses for Zn and Mg. For Cu, a combination of indicators, such as depletion/repletion studies, were applied, wherein all reference values were based on data obtained from other countries. Second, there was a limitation in that it was difficult to determine whether reference values of Mg, Zn, and Cu intakes in the 2020 KDRI were achievable. This might be due to the lack of representative previous studies on intakes of these nutrients, and an insufficient database for Mg, Zn, and Cu contents in foods. This lack of database for mineral content in food poses a problem when evaluating the appropriateness of intake. Third, data was insufficient to assess the adequacy of Mg, Zn, and Cu intakes from supplements when calculating reference values, considering the rise in both demand and intake of mineral supplements. Mg is more likely to be consumed as a multi-nutrient supplement in combination with other minerals than as a single supplement. Moreover, Zn-Cu interactions in the body need to be considered when determining the reference intake values of Zn and Cu. It is recommended to discuss these issues present in the 2020 KDRI development for Mg, Zn, and Cu intakes in a systematic way, and to find relevant solutions.

• 대한한의학방제학회지
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• 제31권4호
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• pp.361-371
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• 2023

Objectives : Gastric cancer is a malignant tumor of the digestive tract that not only has a high mortality rate, but also affects quality of life. In Traditional Korean Medicine, acupuncture and herbal medicines can increase the survival rate for Gastric cancer and improve the quality of life. Traditional Korean Medicine treatment played an important role when used alone or in combination with chemotherapy. However, there is still insufficient evidence to support the efficacy and safety of Traditional Korean Medicine in patients undergoing chemotherapy after surgery. Therefore, the purpose of this study is to systematically evaluate the effect of oriental medicine treatment on patients as a complementary therapy for Gastric cancer. Methods : 2 researchers will search using EMBASE, Pubmed, CNKI, Cochrane Library, CiNii, KMBASE, KISS, OASIS, RISS, ScienceON. The search period of the database is from inception until June 2022. This study will include a randomized controlled trial of GC for acupuncture and herbal treatment. Primary outcomes include anti-cancer effects. Secondary outcomes evaluate survival rates and improvements in quality of life. The data uses Review Manager Software 5.4. Results : This study will provide a systematic evaluation by synthesizing the anti-cancer effect, survival rate and quality of life of Gastric cancer when Traditional Korean Medicine is combined with chemotherapy. Conclusion : The conclusion of this study will provide a basis for determining whether Traditional Korean Medicine treatment for Gastric cancer treatment is an effective and safe treatment method in clinical practice.

• 한국잠사곤충학회지
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• 제21권2호
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• pp.11-19
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• 1979

본연구는 백반이 sericin 정착하는 작용을 구명하기 위해서 시행된 것이며 이미 유혁기술에서 사용하여 오던 실예를 생사에 적용해보려는 것이었다. 타인의 보고는 Cr-명반이나 tannin, formalin 또는 vinyl acetate로 sericin 정착한 사실이 있기는 하나 이들은 섬유의 흡습성을 도외시한 것이어서 본보는 섬유의 흡습성을 보존하면서 sericin 정착을 하는 방식을 취하기로 했다. 한편 sericin 정착기구를 상세히 알기위해 섬유의 침간 mechanism과 정착 mechanism도 고찰하여 보았다. 본실험에서 얻어진 결과는 다음과 같다. 1. 백반을 sericin 정착에 이용할 때는 타인의 보고에서와 같이 고온처리는 금물이며 고온처리는 섬유를 경화시켰다. 2. 백반을 저온처리하는 대신 3 시간 이상 처리함이 바람직하였고 이때 백반만으로도 sericin 정착과 더불어 방수효과를 보였다. 3. 1% 백반농도이면 sericin 정착이 가능하였다. 4. sericin 정착만 고려할때는 0.5% NaOH 10분간 처리후 1% 백반용액 3시간처리방식이 가장 좋았다. 5. 그러나 sericin 정착과 흡습성을 고려할때는 상기 방식의 역방법이 가장 좋았다. 6. sericin 정착검정은 습윤시료의 건조곡선도시로 더욱 선명하게 다루었다. 7. 연감률은 백반 -NaOH 처리의 경우 4.3%였는데 이러한 정도이면 실용 선습에 능히 sericin 유실을 막을 것으로 본다. 8. 흡습성도 백반-NaOH 처리방식에서 미처리손과 동일한 흡습성을 유지했다. 9. 처리직후와 처리 3개월후의 강력경도에 변화가 없었다. 10. 결론적으로 본처리는 무연무색처리로서 유색처리(탄닌, Cr-명반)방법과 취기처리(formalin, vinyl acetate 처리)보다 개선된 방식이었다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제27권6호
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• pp.678-689
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• 2000

논 본문은 문서의 주요 내용을 나타내는 문장을 추출함으로써 요약문을 작성하는 자동 요약 기법에 대해 기술하고 있다. 개발한 시스템은 문서 집합으로부터 추출한 어휘적, 통계적 정보를 고려하여 요약 문장을 작성하는 모델이다. 시스템은 크게 두 부분, 학습과정과 요약과정으로 구성이 된다. 학습 과정은 수동으로 작성한 요약문장으로부터 다양한 통계적인 정보를 추출하는 단계이며, 요약 과정은 학습 과정에서 추출한 정보를 이용하여 각 문장이 요약문장에 포함될 가능성을 계산하는 과정이다. 본 연구는 크게 세 가지 의의를 갖는다. 첫째, 개발된 시스템은 각 문장을 텍스트 구성 요소의 하나로 분류하는 텍스트 구성 요소 판별 모델을 사용한다. 이 과정을 통해 요약 문장에 포함될 가능성이 없는 문장을 미리 제거하는 효과를 얻게 된다. 둘째, 개발한 시스템이 영어 기반의 시스템을 발전시킨 것이지만, 각각의 자질을 독립적으로 요약에 적용시켰으며, Dempster-Shafer 규칙을 사용해서 다양한 자질의 확률 값을 혼합함으로써 문장이 요약문에 포함될 최종 확률을 계산하게 된다. 셋째, 기존의 시스템에서 사용하지 않은 새로운 자질 (feature)을 사용하였으며, 실험을 통하여 각각의 자질이 요약 시스템의 성능에 미치는 효과를 알아보았다.

• Clinical and Experimental Pediatrics
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• 제53권7호
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• pp.745-752
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• 2010

Purpose: There is currently little evidence to support intravenous immune globulin (IVIG) therapy for pediatric myocarditis. The purpose of our retrospective study was to assess the effects of IVIG therapy in patients with presumed myocarditis on survival and recovery of ventricular function and to determine the factors associated with its poor outcome. Methods: We reviewed all consecutive cases of patients with myocarditis with left ventricular dysfunction verified by echocardiogram who had visited 3 university hospitals between January 2000 and September 2009. These patients were divided into 2 groups. Group 1 consisted of 23 patients (69.6%) who received IVIG alone or IVIG in combination with steroids, and group 2 consisted of 10 patients (30.3%) who received neither IVIG nor other immunosuppressive agents. Clinical manifestations, laboratory results, echocardiographic findings, and outcomes were compared between these 2 groups. Results: One year after the initial presentation, the difference in the probability of survival did not show statistical significance in IVIGtreated patients ($P$=0.607). Of the echocardiographic parameters on admission, a shortening fraction of less than 15% was associated with unremitting cardiac failure. Furthermore, anemic patients were more likely to have elevated N-terminal fragment levels of the B-type natriuretic peptide (NT-proBNP) in the progressed group ($P$=0.036). Conclusion: There was no difference between the IVIG-treated patients and the control patients in the degree of recovery of left ventricular function and survival. Prospective, randomized, clinical studies are needed to elucidate the effects of IVIG treatment during the acute stage of myocarditis on ultimate outcomes.

• 천문학회보
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• 제40권1호
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• pp.85.2-86
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• 2015

The YORP effect is non-gravitational force that changes the spin-status of asteroid. So far this effect has been directly detected only from the Near-Earth asteroids (Taylor et al. 2007; Lowry et al. 2007, 2014; Breiter et al. 2011; Durech et al. 2008, 2012). Pravec at el. 2008 found the evidences for changing spin rate of small asteroids (3 - 15 km) by the YORP effect in the Main-Belt and Mars-crossing asteroids. The Mars-crossing asteroids (1.3 < q < 1.66 AU) are objects that cross orbit of the Mars. The Mars-crossing asteroids are regarded as one of the main sources for the Near-Earth asteroids. We expect that rotation of Mars-crossing asteroids would be influenced by the YORP effect. We try to search observational evidence of the YORP effect for the Mars-crossing asteroid. Our target 2078 Nanking is a population of the Mars-crossing asteroid. First light-curve of 2078 Nanking was obtained from Mohamed et al. 1994, and Warner et al. 2015 recently published new observational data. We observed this asteroid on 26th Nov. 2014 and 17th Jan. 2015 using SOAO (Sobaeksan Optical Astronomy Observatory) 0.61 m telescope with 4K CCD. Using light-curve inversion method (Kaasalainen & Torppa 2001; Kaasalainen et al. 2001), we try to determine the pole orientation and shape model of this asteroid based on the combination of our light-curve and literature photometric data. Knowing spin parameters, such as rotational period and spin axis, are essential for studying the YORP effect. In this presentation, we provide some preliminary results of our recent study: light-curve and processing of shape modeling of 2078 Nanking. We plan to find observational clue for the YORP effect on the Mars-crossing asteroids.