• 천문학논총
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• 제27권4호
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• pp.237-242
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• 2012

We have performed a systematic study of interstellar dust grains in various environments of galaxies. AKARI has revealed the detailed properties of dust grains not only in star-forming regions but also in regions not relevant to star formation, some of which are found not to follow our old empirical knowledge. Because of its unique capabilities, AKARI has provided new knowledge on the processing of large grains and polycyclic aromatic hydrocarbons (PAHs). For example, we detect PAHs from elliptical galaxies, which show unusual spectral features and spatial distributions, demonstrating importance of material processing in the interstellar space. We find that copious amounts of large grains and PAHs are flowing out of starburst galaxies by galactic superwinds, which are being shattered and destroyed in galactic haloes. We discover evidence for graphitization of carbonaceous grains near the center of our Galaxy, providing a clue to understanding the activity of the Galactic center. We review the results obtained from our AKARI program, focusing on the processing of carbonaceous grains in various environments of galaxies.

• 대한한의학회지
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• 제41권1호
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• pp.21-44
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• 2020

Objectives: This study was aimed to develop a pharmacovigilance practice training course for future doctors of Korean medicine, the graduate students of a college of Korean medicine, and to verify the educational effect of the curriculum. Methods: Fifty-six students were given a training course designed as follows: 1) pre-class homework (basic theory self-study, online course, causality assessment, and adverse event reporting simulation); 2) in-class: homework submission and case discussion; 3) after-class: homework revision and resubmission. An online survey to assess the change of the level of basic knowledge and attitudes toward pharmacovigilance, the willingness to report adverse events, and self-efficacy for the causality assessment and adverse event reporting was conducted before and after education. Results: The survey participation rate was 96.5% in pre-education and 64.3% in the post-education survey. After education, knowledge level was improved (mean score from 4.3±2.11 to 6.7±1.96 points, modal value from 3 to 8 points) and positive changes were observed in almost all questions on attitudes. In the post-education survey, more students felt that they could do causality assessment (from 13% to 80.5%), could report adverse events to the agency in charge (from 7.4% to 96.2%), and expressed their strong willingness to report adverse events in the future (from 77.8% to 88.9%) than in the pre-education survey. Conclusions: More schools of Korean medicine need to adopt pharmacovigilance training courses in their curriculum to foster future doctors of Korean medicine with pharmacovigilance capabilities. Such efforts will be the basis for achieving an evidence-based, safe use of herbal medicine.

• 디지털융복합연구
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• 제12권6호
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• pp.35-42
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• 2014

우리나라에서 해상에서 발생하는 살인, 강도, 마약밀매, 불법조업 등 해양범죄에 관한 일반적 수사관할권은 해양경찰에게 있다. 해양범죄는 육지에서 발생하는 일반범죄에 비해 희소성, 피해의 대형화, 증거물의 오염가능성을 띄고 있기 때문에 이러한 범죄를 다루는 수사관들이 평소 담당사건에 대한 고도의 전문성을 보유하고 있어야 한다. 그런데 현재 해양경찰은 범죄수사전문가가 부족하고, 경찰수사연수원 등 일반경찰의 교육기관에 수사교육을 위탁하는 등 자체적인 수사교육 역량이 부족한 실정이다. 이에 해양범죄에 관한 정보와 자료를 축적하고 수사전문가를 양성한 후, 해양범죄에 관한 전문교육기관을 설치하여 해양범죄 특유의 교육과정을 통해 해양범죄 수사역량을 강화할 것을 제안한다.

• 정보화정책
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• 제18권4호
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• pp.103-137
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• 2011

1990년대 이후 인터넷 등 정보화기기의 급속한 발전 및 보급으로 디지털 디바이드(Digital Divide : 정보격차)는 정보화 사회의 주요 정치, 경제, 사회적 이슈로 떠올랐다. 또 정보격차 문제를 규명하고 이를 해결하기 위한 많은 정책적 노력과 학문적 연구들이 진행되어 왔다. 이에 본 연구는 지난 2000년부터 2011년까지 약 10년간 진행된 정보격차와 관련된 다양한 연구들을 체계적으로 정리하고자 했다. 이를 위해 Engineering Village 2(EV2) 데이터베이스를 활용, 정보격차와 관련된 기존 연구들에 대한 자료를 수집했으며 연구자가 설정한 기준에 따라 이를 분석하고 분석결과를 정리했다. 20여년 간의 관심과 지속적인 노력에도 불구하고 정보격차는 여전히 현재진행형인 이슈로 기존의 연구경향을 분석 정리한 본 연구는 향후 정보격차에 대한 후속연구에도 도움이 될 수 있을 것으로 기대된다.

• 기술혁신연구
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• 제18권1호
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• pp.153-175
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• 2010

기업은 경쟁우위를 확보하고 지속적인 성장을 이끌기 위해 기술개발을 위한 R&D 투자 및 혁신활동에 집중해야 한다. 그러나, 기업의 이러한 활동은 언제나 성공하는 것이 아니며, 기술개발의 위험도가 높고 이익의 전용가능성이 낮거나 기업내부의 역량이나 자원이 부족할 경우, 기업의 혁신활동은 저해되기 쉽다. 이러한 상황에서 외부파트너와의 연구협력은 이러한 문제들을 해결할 수 있는 좋은 전략이라고 할 수 있다. 본 연구에서는 한국의 제조업체를 대상으로 각 기업이 기술혁신을 위해 연구협력을 선택할 때 어떤 요인들이 연구 협력결정에 영향을 미치는지를 분석하였다. 이를 위해서 과학기술정책연구원(STEPI)에서 수행한 기술혁신조사 데이터를 활용하였으며, 분석결과 기업의 규모가 클수록, 과거의 연구 협력경험이 많을수록, 하이테크 기업에 속한 기업일수록 연구협력을 통해 제품혁신을 수행하는 것으로 나타났으며, 혁신실패의 위험성, 자금조달의 어려움, 조직내부의 역량부족, 외부환경요인 등과 같은 혁신활동저해요소들은 제품혁신활동 수행시 외부와의 연구협력에 영향을 미치지 못하는 것으로 나타났다.

• 화약ㆍ발파
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• 제15권3호
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• pp.14-19
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• 1997

Koreans have emphasized education as the primary means to reconstruct our country means to reconstruct our country after two catastrophic events-the Japanese occupation and the Korean War(1950-1953). A Strong belief- in education coupled with sheer deter-mination spurred the period of industrial and eeonomic development that started in the early 1970-'s. The "can-do" attitude of the general public was matched and aided by small S & T communities. Scientists and engineers provided the neeessary expertise to manufacture goods and process the many raw materials imported from overseas. After nearly three decades of reconst-ructing our completely devastated country, Korea has become a modern, cosmo-politan, fast-paced and dynamic country. In order to further increaser our manufac- turing capabilities and double the per-capita income by the beginning of the 21st century, we must improve productivitiy and encourage creatitivity in all sectors of our country. The S & T community's efforts in research and development. education, and interna-tional cooperation will be invaluable in determining our direction and reaching these goals. The general public is eager to peacefully unite our foreign powers since 1945. Toward that end. members of the S & T community are willing to coope-rate with our north Korean counterparts in all areas of S & T with the exception of defense related endeavors. Establi-shing scientific ties with north Korea will result in mutual economic benefit and greater regional stability in East Asia. In particular. scientists and manu-facturers in each province are eager to initiate cordial and professional relation-ships with north Korea in the hopes of securing these benefits. The Korean Federation of Science and Technology Societies(KOFST) has played an important role both in developing S & T policies, and in gostering the frowty of S & T societies. A non-governmental umbrella organization composed of over 251 professional societies, KOFST facili-tates the transfer of research outcomes and technology from research institutions to the various industries. KOFST also seeks to increase cooperation between the countries of the Pacific Rim. As evidence of that, we have pursued joint research and industrial ventures with China. Established projects include those on environmental conditions in the Yellow Sea, and improvement of aircraft manufacturing, telecommunica-tion equipment, and agricultural produ-cts. Increased cooperation between the Pacific Rim countries, particularly in S & T, would foster social and economic development for the region as a whole.

• 융합보안논문지
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• 제10권4호
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• pp.31-37
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• 2010

IT에서 보안은 위험 및 위협으로부터 시스템을 보호하고, 피해를 방지하며 Risk를 최소화해야한다. 이와 같은 맥락으로 정보보안 제품의 정보가 처리, 저장, 전달되는 과정에서 정보와 시스템의 보안기준, 즉 기본적인 기밀성, 가용성, 무결성과 부차적인 명확성, 증명가능성, 감지, 경보 및 방어능력 등이 충분히 보장될 수 있도록 하여야 한다. 웹 서비스에서 보안은 가장 중요한 요소이며, 웹 특성상 서비스를 위해 80번 포트 같은 통로를 열어놔야 하는 구조로서, 웹 어플리케이션, 웹 소스 및 서버, 네트워크 모든 요소가 근본적인 취약점을 안고 있다. 이에 따라 이런 요소를 통해 웹 프로그램의 설정오류나 개발 오류 및 웹 애플리케이션 자체의 취약점을 이용한 홈페이지 와 웹 서버 해킹을 방지하며, 효율성을 높이는 웹서비스 보안 BMT 수행 방법론을 제시하고자 한다.

• Journal of Microbiology and Biotechnology
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• 제20권5호
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• pp.935-941
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• 2010

The emergence of antibiotic-resistant bacterial strains is one of the most critical problems of modern medicine. Bacteriophages have been suggested as an alternative therapeutic agent for such bacterial infections. In the present study, we examined the therapeutic potential of phage Kpn5 in the treatment of Klebsiella pneumoniae B5055-induced burn wound infection in a mouse model. An experimental model of contact burn wound infection was established in mice employing K. pneumoniae B5055 to assess the efficacy of phage Kpn5 in vivo. Survival and stability of phage Kpn5 were evaluated in mice and the maximum phage count in various organs was obtained at 6 h and persisted until 36 h. The Kpn5 phage was found to be effective in the treatment of Klebsiella-induced burn wound infection in mice when phage was administered immediately after bacterial challange. Even when treatment was delayed up to 18 h post infection, when all animals were moribund, approximately 26.66% of the mice could be rescued by a single injection of this phage preparation. The ability of this phage to protect bacteremic mice was demonstrated to be due to the functional capabilities of the phage and not due to a nonspecific immune effect. The levels of pro-inflammatory cytokines (IL-$1{\beta}$ and TNF-${\alpha}$) and anti-inflammatory cytokines (IL-10) were significantly lower in sera and lungs of phage-treated mice than phage untreated control mice. The results of the present study bring out the potential of bacteriophage therapy as an alternate preventive approach to treat K. pneumoniae B5055-induced burn wound infections. This approach not only helps in the clearance of bacteria from the host but also protects against the ensuing inflammatory damage due to the exaggerated response seen in any infectious process.

• 생명과학회지
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• 제23권12호
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• pp.1553-1556
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• 2013

본 연구는 재래감귤종의 하나인 진귤 과피 추출물이 산화적 스트레스에 의한 MMP-1의 발현 조절에 미치는 효과를 확인하기 위해 수행되었다. $H_2O_2$를 피부세포에 처리하여 산화적 스트레스를 유도한 결과 노화 유발에 중요한 역할을 하는 것으로 알려진 MMP-1의 발현량이 증가하였고 진귤과피 추출물의 처리는 산화적 스트레스에 의해 증가된 MMP-1의 활성을 현저히 감소시켰다. 이러한 활성 조절이 ERK signaling을 통해 조절되는지 확인한 결과 산화적 스트레스에 의해 증가된 ERK의 인산화는 진귤과피 추출물의 처리로 억제되었고 MEK 억제재인 U0216을 처리하였을 경우 MMP-1의 활성도 또한 저해시키는 것을 확인하였다. 이상의 결과로 보아 $H_2O_2$에 의해 유도된 산화적 스트레스는 MMP-1의 발현을 촉진시켰고 진귤과피 추출물은 ERK 신호전달 경로를 통해 MMP-1의 발현을 조절하는 것으로 보여진다.

• 한국안전학회지
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• 제28권1호
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• pp.158-163
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• 2013

While job stress evaluations are reported in the recent surveys upon the nuclear power plants(NPPs), any significant advance in the types of questionnaires is not currently found. There are limitations to their usefulness as analytic tools for the management of safety resources in NPPs. Data mining(DM) has emerged as one of the key features for data computing and analysis to conduct a survey analysis. There are still limitations to its capability such as dimensionality associated with many survey questions and quality of information. Even though some survey methods may have significant advantages, often these methods do not provide enough evidence of causal relationships and the statistical inferences among a large number of input factors and responses. In order to address these limitations on the data computing and analysis capabilities, we propose an advanced procedure of survey analysis incorporating the DM method into a statistical analysis. The DM method can reduce dimensionality of risk factors, but DM method may not discuss the robustness of solutions, either by considering data preprocesses for outliers and missing values, or by considering uncontrollable noise factors. We propose three steps to address these limitations. The first step shows data mining with response surface method(RSM), to deal with specific situations by creating a new method called response surface data mining(RSDM). The second step follows the RSDM with detailed statistical relationships between the risk factors and the response of interest, and shows the demonstration the proposed RSDM can effectively find significant physical, psycho-social, and environmental risk factors by reducing the dimensionality with the process providing detailed statistical inferences. The final step suggest a robust stress management system which effectively manage job stress of the workers in NPPs as a part of a safety resource management using the surrogate variable concept.