• 한국응용과학기술학회지
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• 제27권4호
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• pp.391-398
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• 2010

Soybean lecithin liposomes composed phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol and phosphatidic acid were prepared by using the previously developed supercritical reverse phase evaporation method. The effect of phospholipid composition on the formation of liposomes and physicochemical properties were examined by means of trapping efficiency measurements, transmission electron microscopy, dynamic light scattering and zeta potential measurements. The trapping efficiency of liposomes for D-(+)-glucose made of CNA-Ⅰ which contains approximately 95% phosphatidyl choline is higher than that of CNA-II and CNA-O which contain approximately 32% phosphatidyl choline. However there is no any difference between the trapping efficiency of liposomes for D-(+)-glucose made of CNA-II which has saturated hydrocarbons tails and that of liposomes made of CNA-O which has unsaturated hydrocarbon chains. The electron micrographs of liposomes made of CNA-II and CNA-O show small spherical liposomes with diameter of $0.1\sim0.25{\mu}m$, while that of CNA-I shows large unilamellar liposomes with diameter of $0.2\sim1.2{\mu}m$. These results clearly show that phospholipid structure of phosphatidylcholine allows an efficient preparation of large unilamellar liposomes and a high trapping efficiency for water soluble substances. Liposomes made of CNA-II and CNA-O remained well-dispersed for at least 14 days, while liposome suspension made of CNA-I separated in two phase at 14 days due to aggregation and fusion of liposomes. The dispersibility of liposomes made of CNA-I is lower than that of CNA-II and CNA-O due to the smallar zeta potential of CNA-I.

• Journal of Pharmaceutical Investigation
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• 제31권4호
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• pp.257-263
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• 2001

The microspheres have been developed as a new drug delivery system. Although many particulate drug carriers, such as liposome, niosome and emulsion, have been introduced, injectable and biodegradable microspheres appears to be a particularly ideal delivery system because the local anesthesia is not necessary for the insertion of large implants and for the removal of the device after the drug release is finished. Biodegradable microspheres with nicotine and triamcinolone acetonide are prepared and evaluated. As biodegradible polymers, PLA (M.W. 15,000, PLA-0015), PLGA (M.W. 17,000, RG 502) and PLGA (M.W. 8,600, RG 502H) are used. This study attempted to prepare and evaluate the nicotine and triamcinolone acetonide-incorporated microspheres, which were prepared by two methods, solvent-evaporation and spray-drying methods. The microspheres, as a disperse system for injections, were evaluated by particle size, size distribution, entrapment efficiency, and in vitro drug release patterns. The differences of preparation method, partition coefficient, types of polymer, and preparation conditions of microspheres influence the particle size, entrapment efficiency, and in vitro drug release patterns.

• 한국산학기술학회논문지
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• 제17권1호
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• pp.88-98
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• 2016

여름철이 무더운 대한민국에서는 냉방에 많은 전력을 소비한다. 이 경우 간접증발냉각을 동시에 적용하면 전기 사용을 줄일 수 있다. 본 연구에서는 물 퍼짐성을 개선한 플라스틱/종이 재질의 간접 및 재생증발소자에 대해 일련의 실험을 수행하였다. ${\epsilon}-NTU$ 방식의 열 및 물질전달 해석 모델과 비교한 결과 모델의 예측치는 간접 및 재생증발소자의 간접증발효율, 냉각열량, 압력손실을 적절히 예측하였다. 모델 해석 결과 간접 및 재생증발소자 모두 건채널 입구온도와 상대습도가 증가하면 간접증발효율이 증가하였다. 또한 재생증발소자의 간접증발효율이 간접증발소자의 값보다 크게 나타났다.

• Macromolecular Research
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• 제16권8호
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• pp.717-724
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• 2008

In this study, we prepared all-trans retinoic acid (ATRA)-encapsulated, surfactant-free, PLGA nanoparticles. The nanoparticles were formed by nanoprecipitation process, after which the solvent was removed by solvent evaporation or dialysis method. When a nanoparticle was prepared by the nanoprecipitation - solvent evaporation method, the nanoparticles were bigger than the nanoparticles of the nanoprecipitation - dialysis method, despite the higher although loading efficiency. Nanoparticles from the nanoprecipitation - dialysis method were smaller than 200 nm in diameter, while the loading efficiency was not significantly changed. Especially, nanoparticles prepared from DMAc, 1,4-dioxane, and DMF had a diameter of less than 100 nm. In the transmission electron microscopy (TEM) observations, all of the nanoparticles showed spherical shapes. The loading efficiency of ATRA was higher than 90% (w/w) at all formulations with exception of THF. The drug content was increased with increasing drug-feeding amount while the loading efficiency was decreased. In the drug release study, an initial burst was observed for $2{\sim}6$ days according to the variations of the formulation, after which the drug was continuously released over one month. Nanoparticles from the nanoprecipitation - dialysis method showed faster drug release than those from the nanoprecipitation - solvent evaporation method. The decreased drug release kinetics was observed at lower drug contents. In the tumor cell cytotoxicity test, ATRA-encapsulated, surfactant-free, PLGA nanoparticles exhibited similar cytotoxicity with that of ATRA itself.

• 설비공학논문집
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• 제23권10호
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• pp.662-669
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• 2011

A numerical study was performed for thermodynamic efficiencies of a basic ORC (Organic Rankine Cycle), ORC with a FLH (Feed Liquid Heater), and ORC with a regenerator. The efficiencies of the basic ORC were higher in the order of R113, R123, R245ca, and R245fa for its working fluids. It was confirmed that an optimal FLH pressure existed to maximize efficiency of the ORC with a FLH. A correlation was developed to predict the optimal FLH pressure as a function of evaporation and condensation pressure and its average absolute deviation was 0.505%. The efficiency enhancement of the basic ORC with a FLH was higher than that with a regenerator. It was presented that the basic ORC efficiency could be improved more than 10% by a FLH with $30^{\circ}C$ condensation and over $110^{\circ}C$ evaporation temperatures.

• 대한기계학회논문집
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• 제10권1호
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• pp.150-156
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• 1986

본 논문에서는 열전달을 포함한 사이클 해석의 좀 더 실제적인 경우로서, 주어진 연소가스로부터 랜킨사이클을 사용하여 동력을 추출할 때 최대의 출력을 추출하기 위한 사이클의 운전조건을 고찰하고, 대표적인 랜킨 사이클에 대하여 여러가지 운전조건에 따른 출력등을 계산하여, 그 결과를 고찰하였다.

• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3208-3212
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• 2012

Controlled drug delivery systems employing microparticles offer lots of advantages over conventional drug dosage formulations. Microencapsulation technique have been conducted with biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) and poly(lactic acid) (PLA) for its adjustable biodegradability and biocompatibility. In this study, we evaluated two techniques, oil-in-water (o/w) emulsion solvent evaporation and spray drying, for preparation of polymeric microparticles encapsulating a newly synthesized drug, SS-AG20, for the long-term drug delivery of this low-molecular-weight drug with a very short half-life. Drug-loaded microparticles prepared by the solvent evaporation method showed a smoother morphology; however, relatively poor encapsulation efficiency and drastic initial burst were discovered as drawbacks. Spray-dried drug-loaded microparticles had an imperfect surface with pores and distorted portions so that its initial burst was critical (70.05-87.16%) when the preparation was carried out with a 5% polymeric solution. By increasing the concentration of the polymer, the morphology was refined and undesirable initial burst was circumvented (burst was reduced to 35.93-74.85%) while retaining high encapsulation efficiency. Moreover, by encapsulating the drug with various biodegradable polymers using the spray drying method, gradual and sustained drug release, for up to 2 weeks, was achieved.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2008년도 춘계학술대회 논문집
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• pp.438-440
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• 2008

Effects of Ga contents of CIGS absorber layer on the performance of thin films solar cells were investigated. As Ga content increased, the grain size of CIGS films decreased presumably because Ga diffusion during 2nd stage of co-evaporation process is more difficult than In diffusion. Performances of corresponding solar cell show systematic dependence on Ga content in which open circuit voltage increases and short circuit current and fill factor decrease as Ga contents increases. At a optimal condition of Ga/(In+Ga)=0.27, the solar cell shows a conversion efficiency of 15.6% with $V_{OC}$ of 0.625 V, $J_{SC}$ of 35.03 mA/$cm^2$ and FF of 71.3%.

• Journal of Mechanical Science and Technology
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• 제16권2호
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• pp.270-278
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• 2002

In order to reduce the exhaust emissions of a spark ignition engine, it is important not only to improve the catalyst conversion efficiency, but also to directly reduce the engine-out exhaust emissions during a cold starting of the engine and warm up periods. The purpose of this study is to evaluate feasibility of a glow plug for an early fuel evaporator. In order to promote atomization, gasoline is injected on the glow plug with room temperature(20$\^{C}$) and high temperature(250$\^{C}$). To analyze the spray behavior characteristics, a PMAS is used to measure the SMD and the dropsize distribution of an impinging spray and a free spray. Results show that the evaporation rate of the impinging spray on the high temperature surface of the glow plug was higher than that of the free spray on the room temperature surface.

• 한국태양에너지학회 논문집
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• 제22권2호
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• pp.11-17
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• 2002

This paper is concerned with the development of a new method for making, separating ice and storage floated ice by installing an evaporation plate at under-water within a storage tank. In a conventional harvest-type ice storage system, a tank saves ice by separating an ice from an installed evaporation plate, which is located above an ice storage tank as an ice storage system. Developed new harvest-type method shows good heat transfer efficiency than a convectional method. It is because the evaporation panel is directly contacted with water in a storage tank. Also, at a conventional system a circulating pump, a circulating water distributor and a piping are installed, however these components are not necessary in a new method. In this study ice storage systems are experimentally investigated to study the charge and discharge of thermal energy. The results show the applicable possibility and performance enhancement of a new type.