• Toxicological Research
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• v.18 no.1
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• pp.87-98
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• 2002

This study was conducted to evaluate the safety of a recombinant human Factor VIII(GC-$\gamma$ AHF) manufactured by Korea Green Cross Company with different technology according to the Regulation of Korean Food and Drug Administration (l 998. 12. 3). In acute toxicity test, both genders of Sprague-Dawley rats and Beagle dogs were administered intravenously with GC-$\gamma$ AHF of three doses (3,125, 625 and 125 IU/kg), and single dose of 3,125 IU/kg, respectively. No dead animal and abnormal autopsy findings were found in Control and GC-$\gamma$ AHF treated group. Therefore, the 50% lethal dose ($LD_{50}$) of GC-$\gamma$ AHF was conidered to be higher than 3,125 IU/kg in rats and dogs. In the four weeks repeated intravenous toxicity study, GC-$\gamma$ AHF was administrated intravenosly to both genders of rats and dogs with 3 doses (500, 150, 50 IU/kg). There were neither dead animals nor significant changes of body weights during the experimental Period. In addition, no significant GC-$\gamma$ AHF related changes were found in clinical sign, urinalysis and other finding. Statistically changes were observed in hematological, biochemical and organ weight parameters of treated groups: however these changes were not dose dependent. No histopathological lesion were observed in both control and treated animals. Above data suggest that no observed adverse effect level of test materials in rats and dogs might be over 500 IU/kg/day in this study. In ocular irritation test, any injury on iris, conjunctiva and cornea in rabbits were not observed. The acute ocular irritation index (A.O.I.), mean ocular irritation index (M.O.I.) and Day-7 individual ocular irritation Index (I.O.I.) of GC-$\gamma$ AHF were 0. In the primary skin Irritation test, the primary irritation index (P.I.I.) oj GC-$\gamma$ AHF were 0. Therefore, the GC-$\gamma$ AHF is considered not to have the primary skin and eye toxicity in rabbits. In active systemic anaphylaxis (ASA) test, GC-$\gamma$ AHF and GC-$\gamma$ AHF emulsified with Freund's complete adjuvant (FCA) did not induce any symptom of anaphylactic shock in guinea pigs. In passive cutaneous anaphylxis (PCA) test, after sensitization with antisera of GC-$\gamma$ AHF sensitized mice, blue spots were observed on the hypodermis of back of rats, but diameter of each spot was smaller than 5 mm in each test groups except the positive control group. Based on the results of this study, GC-$\gamma$ AHF is not conidered to have any antigenic potential. In conclusion, at levels of up to 500 IU/kg, GC-$\gamma$ AHF did not produce treatment-related toxicity under the conditions of these acute-, four week repeated-toxicity, primary skin and eye toxicity, and antigenicity test.

• Journal of Information Technology and Architecture
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• v.11 no.4
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• pp.409-426
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• 2014

Korea has won 3 times in a row in the evaluation of e-government services in 2014. And the last year, the government-EA has been awarded the UN Public Service Award. Because of the development and execution of personalized integrated services based on the government-EA, Korea has won the two award from the UN. EA has been selected and proceeded as one of the 31 e-Government projects in early period, in 2005 the law which public sector must adopt the EA for efficient informatization had been enacted. Many public agencies in which actively utilized to derive such as internal and external performance through the EA. On the other hand, in the last 10 years, some public agencies have still been as recognized level of management in the EA. In this study, the main purpose is that to find out what is a major factor for successful use and result of EA, what is the EA success Model and how to examine it. To do that, this study will study the related prior research such as EA services, information systems success factors, performance measures, and develop the success model for EA and then examine the model. This study will contribute great implications in practical and theoretical in EA success model because this is the nation's first research that SERVQUAL model and the IS Success Model(DeLone & McLean 2003) has been combined and examined.

• Cartoon and Animation Studies
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• s.31
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• pp.209-226
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• 2013

With rapidly changing multimedia environment, various artistic changes and digitalized up-to-date social infra, urban environment construction based on culture contents has been activated. The large image in front of urban building that is expressed as media-façade, increasing rapidly in a recent period, is not a new thing at all. In addition, IT technology molten in city space is testing the possibility of new media through the meeting with architecture. However, unlike its infra enlargement, the definition about media-façade is not clear so the system was constructed in a level of night lightscape or outdoor image advertisement. The purpose of this guideline is the regulation from the negative aspect rather than the possibility of various visual, artistic media expressions. Therefore, it could not show essential concept of media-façade. Moreover, most of companies or building owners focus on short-term profit and marketing effect rather than prepare various contents so they can not use constructed infra properly. After all, in many cases, they discolor the meaning of media-façade. This paper is a pilot study to grasp the current definition of media-façade to construct right guideline of media-façade. On the basis of this study, it will prepare academic definition of media-façade and construct the guideline for design evaluation.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.6 no.4
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• pp.245-255
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• 2008

Korea Hydro and Nuclear Power Company(KHNP) conducted site investigations for a low and intermediate-level nuclear waste repository in the Gyeong Ju site. The site characterization work constitutes a description of the site, its regional setting and the current state of the geosphere and biosphere. The main objectives of hydogeological investigation aimed to understand the hydrogeological setting and conditions of the site, and to provide the input parameters for safety evaluation. The hydogeological characterization of the site was performed from the results of surface based investigations, i.e geological mapping and analysis, drilling works and hydraulic testing, and geophysical survey and interpretation. The hydro-structural model based on the hydrogeological characterization consists of one-Hydraulic Soil Domain, three-Hydraulic Rock Domains and five-Hydraulic Conductor Domains. The hydrogeological framework and the hydraulic values provided for each hydraulic unit over a relevant scale were used as the baseline for the conceptualization and interpretation of flow modeling. The current hydrogeological characteristics based on the surface based investigation include some uncertainties resulted from the basic assumption of investigation methods and field data. Therefore, the reassessment of hydrostructure model and hydraulic properties based on the field data obtained during the construction is necessitated for a final hydrogeological characterization.

• Journal of the Korean Society of Marine Environment & Safety
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• v.18 no.2
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• pp.145-152
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• 2012

As the problems of global warming are brought up recently, many skillful solutions for developing new renewable energy are suggested. One of the most remarkable things is ocean energy. Korea has abundant ocean energy resources owing to geographical characteristics surrounded by sea on three sides, thus the technology of commercialization about tidal current power, wave power is demanded. Especially, Tidal energy conversion system is a means of maintaining environment naturally. Tidal current generation is a form to produce electricity by installing rotors, generators to convert a horizontal flow generated by tidal current into rotating movement. According to rotor direction, a tidal current turbine is largely distinguished between horizontal and vertical axis shape. Power capacity depends on the section size crossing a rotor and tidal current speed. We therefore investigated three dimensional flow analysis and performance evaluation using commercial ANSYS-CFX code for an 100 kW class horizontal axis turbine for low water level. Then We also studied three dimensional flow characteristics of a rotating rotor and blade surface streamlines around a rotor. As a result, We found that torque increased with TSR, the maximum torque occurred at TSR 3.77 and torque decreased even though TSR increased. Moreover we could get power coefficient 0.38 at designed flow velocity.

• Quality Improvement in Health Care
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• v.26 no.1
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• pp.23-34
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• 2020

Purpose: This qualitative study was conducted to examine the current status and problems concerning the collection of present on admission (POA) indicators and determine how to use these indicators for evaluating the quality of care and degree of patient safety. Methods: A total of 11 health information managers were divided into two groups according to the size of their hospitals. Two focus group discussions (FGDs) were conducted, one for each group, which followed a pre-developed semi-structured guideline. The verbatim transcriptions of the FGDs were analyzed. Results: The majority of participants were concerned about entering POA flags honestly because they did not know how future POA indicators would be used. In particular, for some participants, POA N was a burden that could imply a signal of mismanagement within the medical institution. In addition, the lack of awareness and indifference of physicians regarding POA indicators were some of the difficulties for POA flag entry. Although medical institutions are making efforts to improve the accuracy of POA flagging, many participants mentioned the need to develop real case-oriented POA entry guidelines to improve the accuracy of POA flagging. Conclusion: To increase the validity of POA indicators, it is necessary to increase the level of awareness of POA indicators in physicians and other medical professionals. Furthermore, efforts related to POA indicators by individual medical institutions need to be reflected in the process evaluation.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.16 no.4
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• pp.473-478
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• 2018

Radioactive aerosol generated in cutting and melting work during the NPP decommissioning process can cause internal exposure to body through workers' breath. Thus, it is necessary to assess worker internal exposure due to the radioactive aerosol during decommissioning. The actually measured value of the working environment is needed for accurate assessment of internal exposure, but if it is difficult to actually measure that value, the internal exposure dose can be estimated through recommended values such as the fraction of amount of intake and the size of particles suggested by the International Committee on Radiological Protection (ICRP). As for the selection of particle size, this study applied a value of $5{\mu}m$, which is the size of particles considering the worker recommended by the ICRP. As for the amount of generation, the amount of intake was estimated using data on the mass of aerosol generated in a melting facility at a site in Kozloduy, Bulgaria. In addition, using these data, this study calculated the level of radioactivity in the worker's body and stool and conducted an assessment of internal exposure using the BiDAS computer code. The internal exposure dose of Type M was 0.0341 mSv, that of Type S was 0.0909 mSv. The two types of absorption showed levels that were 0.17% and 0.45% of the domestic annual dose limit, respectively.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.17 no.3
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• pp.321-328
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• 2019

The detection performances of the NaI(Tl), $LaBr_3$(Ce) and $CeBr_3$ scintillation detectors, which can be used to rapidly evaluate the major artificial radionuclides deposited on the soil surface in a nuclear accident or radiological emergency, were compared. Detection performance was assessed by calculating the minimum detectable activity (MDA). The detection efficiency of each detector for artificial radionuclides was semi-empirically determined using mathematical modelling and point-like sources having certified radioactivity. The background gamma-ray energy spectrum for MDA evaluation was obtained from relatively wide and flat grassland, and the MDA values of each detector for the major artificial radionuclides that could be released in nuclear accidents were calculated. As a result, the relative MDA values of each detector regarding surface deposition distribution at normal environmental radiation level were evaluated as high in the order of the NaI(Tl), $LaBr_3$(Ce), and $CeBr_3$ detectors. These results were compared based on each detector's intrinsic and measurement environment background, detection efficiency, and energy resolution for the gamma-ray energy region of the radionuclide of interest.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.5
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• pp.127-136
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• 2023

Gyeonggi Province has established a bus information system to provide real-time bus arrival information, aiming to make bus usage convenient for its residents. While the Gyeonggi bus information system is becoming more advanced through the application of IT technology, there are still information-vulnerable groups finding it difficult to use. In particular, the elderly have a low level of digital information literacy and habe difficulty using it. In this regard, this study aims to address the information usage disparity among the elderly in public transportation by utilizing expert in-depth survey methodology known as the Delphi technique. The study classified the policy initiatives that Gyeonggi Province should undertake into three categories: user education and expanded promotion, technological development and dissemination, and providing convenient usage environment. Through two rounds of surveys, the study assessed the priority of ten specific sub-tasks within these categories. Additionally, it gathered opinions on the effectiveness and feasibility of each item. The results yielded prioritization and evaluation of effectiveness and feasibility for nine sub-tasks. Based on these outcomes, the study proposed future projects that Gyeonggi Province should implement to address the information disparity among the elderly, offering a comprehensive approach to bridge the gap.

• Journal of Radiation Industry
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• v.17 no.4
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• pp.345-357
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• 2023

Nuclear forensics has been understood as a mendatory component in the international society for nuclear material control and non-proliferation verification. Radiochronometry of nuclear activities for nuclear forensics are decay series characteristics of nuclear materials and the Bateman equation to estimate when nuclear materials were purified and produced. Radiochronometry values have uncertainty of measurement due to the uncertainty factors in the estimation process. These uncertainties should be calculated using appropriate evaluation methods that are representative of the accuracy and reliability. The IAEA, US, and EU have been researched on radiochronometry and uncertainty of measurement, although the uncertainty calculation method using the Bateman equation is limited by the underestimation of the decay constant and the impossibility of estimating the age of more than one generation, so it is necessary to conduct uncertainty calculation research using computer simulation such as Monte Carlo method. This highlights the need for research using computational simulations, such as the Monte Carlo method, to overcome these limitations. In this study, we have analyzed mathematical models and the LHS (Latin Hypercube Sampling) methods to enhance the reliability of radiochronometry which is to develop an uncertainty algorithm for nuclear material radiochronometry using Bateman Equation. We analyzed the LHS method, which can obtain effective statistical results with a small number of samples, and applied it to algorithms that are Monte Carlo methods for uncertainty calculation by computer simulation. This was implemented through the MATLAB computational software. The uncertainty calculation model using mathematical models demonstrated characteristics based on the relationship between sensitivity coefficients and radiative equilibrium. Computational simulation random sampling showed characteristics dependent on random sampling methods, sampling iteration counts, and the probability distribution of uncertainty factors. For validation, we compared models from various international organizations, mathematical models, and the Monte Carlo method. The developed algorithm was found to perform calculations at an equivalent level of accuracy compared to overseas institutions and mathematical model-based methods. To enhance usability, future research and comparisons·validations need to incorporate more complex decay chains and non-homogeneous conditions. The results of this study can serve as foundational technology in the nuclear forensics field, providing tools for the identification of signature nuclides and aiding in the research, development, comparison, and validation of related technologies.