• 한국약용작물학회지
• /
• 제27권2호
• /
• pp.136-142
• /
• 2019

Background: Agrimonia pilosa Ledeb has been used as a traditional medicine for the treatment of hematuresis and uterine bleeding in Korea. It has been reported to have anti-obesity, anti-diabetes and anti-inflammaotry effect by regulating the inflammatory signaling pathway. However, the preventive effect of Agrimonia pilosa Ledeb on gastritis has not been elucidated. Thus, in the present study, we evaluated the effects of the water extract of Agrimonia pilosa Ledeb (APW) using HCl/EtOH-induced gastritis rat models. Method and Results: Gastritis was induced in rats by HCl/EtOH administration. The rats in each group were orally administered with two doses of APW (100 and 500 mg/kg). Omeprazole was used as a positive control drug. An enzyme-linked immunosorbent assay (ELISA) was used to measure the prostaglandin $E_2$ ($PGE_2$) levels in stomach. The treatment with 500 mg/kg APW reduced the gastric ulcer area. The APW treatment prevented a decreased in $PGE_2$ concentration induced by HCl/EtOH in rats. In the micronucleus test, the ratio of micronucleated polychromatic erythrocytes to polychromatic erythrocytes showed no significant change in the APW-treated group compared with the control group. Conclusions: These results indicate that APW could be used to prevent the gastritis caused by the HCl/EtOH-induced damage to stomach lining. In addition, the APW treatment showed no significant change in results of the micronucleus test. However, further experiments are required to determine how APW influenced the secretion of mucus and gastric acid using the chromosome aberration test and bacterial reverse mutation assay.

• 한국산학기술학회논문지
• /
• 제13권11호
• /
• pp.5317-5325
• /
• 2012

본 연구는 대사증후군 및 대사증후군 진단기준 인자의 유병률을 파악하고, 인구사회학적 및 건강관련행위 요인과의 관련성을 검토하며, 진단기준 인자의 군집화를 통해 대사증후군 위험의 분포를 분석하고자 하였다. 조사는 한 대학병원 건강검진센터에서 종합건강검진을 받았던 30세 이상의 지역주민 1,388명을 대상으로 허리둘레, 중성지방, 고밀도지단백콜레스테롤, 수축기혈압, 확장기혈압, 및 공복 시 혈당 등 대사증후군 진단기준 인자를 측정하였다. 분석은 이들 대사증후군 위험인자에 대한 유병률을 파악하고 위험인자의 군집화를 통해 대사증후군 위험의 분포를 파악하였으며, 관련요인에 따른 대사증후군의 위험비를 구하였다. 연구결과 조사대상자의 대사증후군의 유병율은 21.7%로 나타났으며, 대사증후군 위험인자별 유병률은 HDL-C, 혈압, TG, 허리둘레, FBS의 순으로 나타났다. 또한 관련변수에 따른 위험비에서 BMI, 흡연습관, 식품섭취 및 당뇨에 대한 가족력 등이 대사증후군의 위험비를 높이는데 관련된 것으로 나타났다. 따라서 대사증후군의 위험 관리를 위해서는 모든 생활습관 요인에 대한 평가와 중재가 필요함을 시사하고 있다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권17호
• /
• pp.7021-7027
• /
• 2014

Background: The problem of cancer, especially lung cancer, is very acute in Bangladesh. The present study was conducted to evaluate the risk of lung cancer among Bangladeshi people based on hereditary, socio-economic and demographic factors. Materials and Methods: This study was carried out in 208 people (patients-104, controls-104) from January 2012 to September 2013 using a structured questionnaire containing details of lung cancer risk factors including smoking, secondhand smoke, tobacco leaf intake, age, gender, family history, chronic lung diseases, radiotherapy in the chest area, diet, obesity, physical activity, alcohol consumption, occupation, education, and income. Descriptive statistics and testing of hypotheses were used for the analysis using SPSS software (version 20). Results: According to this study, lung cancer was more prevalent in males than females. Smoking was the highest risk factor (OR=9.707; RR=3.924; sensitivity=0.8872 and P<0.0001) followed by previous lung disease (asthma, tuberculosis etc.) (OR=7.095; RR=1.508; sensitivity=0.316 and P<0.0001)) for male patients. Highly cooked food (OR=2.485; RR=1.126; sensitivity=0.418 and P=0.004)) and also genetic inheritance (OR=1.93; RR=1.335; sensitivity=0.163 and P=0.138) demonstrated significant correlation with lung cancer as risk factors after these two and alcohol consumption was not prevalent. On the other hand, for female patients, tobacco leaf intake represented the highest risk (OR=2.00; RR=1.429; sensitivity= 0.667 and P=0.5603) while genetic inheritance and highly cooked food also correlate with lung cancer but not so significantly. Socioeconomic status and education level also play important roles in causing lung cancer. Some 78.5% male and 83.3% of female cancer patients were rural residents, while 58.2% lived at the margin or below the poverty line. Most male (39.8%) and female (50.0%) patients had completed only primary level education, and 27.6% male and 33.3% female patients were illiterate. Smoking was found to be more prevalent among the less educated persons. Conclusions: The results obtained in this study indicate the importance of creating awareness about lung cancer risk factors among Bangladeshi people and making appropriate access to health services for the illiterate, poor, rural people.

• 한국산학기술학회논문지
• /
• 제17권6호
• /
• pp.278-290
• /
• 2016

본 연구의 목적은 근로자들의 BMI 변화에 따른 혈청총콜레스테롤의 변화 및 고콜레스테롤혈증 발생비율과의 관련성을 파악하고자 시도하였다. 연구는 2002년부터 20012년까지 11년간 각 연도별로 1회 이상 정기건강검진을 받았던 30~69세 근로자 28,249명(남자 25,548명, 여자 2,701명)을 대상으로 검진기간을 전기(2002-2005), 중기(2006-2009) 및 후기(2010-2012)로 구분하여 각 기간별 BMI 구분에 따른 혈청지질의 평균치를 분석하였다. 또한, 기준년도(2002)로부터 10년간의 BMI의 변화량 구분별로 혈청총콜레스테롤의 평균변화량을 산출하였으며, 혈청총콜레스테롤 정상자에서의 BMI 구분별 10년간의 고콜레스테롤혈증 발생의 년차별 비율을 분석하였다. 연구결과, 서로 다른 3시기(전기; 2002~2005, 중기; 2006~2009 및 후기; 2010~2012)에서의 평균혈청총콜레스테롤은 BMI가 낮은 군($18.5kg/m^2$미만군)에서 중간군($18.5-25.0kg/m^2$군), 높은 군($25.0kg/m^2$ 이상군)으로 갈수록 유의하게 증가하였으며, 고콜레스테롤혈증 발생비율도 BMI가 낮은 군에서 높은 군으로 갈수록 유의하게 증가하였다. 위와 같이 10년간의 BMI 변화량에 대한 혈청총콜레스테롤의 평균변화량의 경년적 추이를 볼 때, BMI의 증가는 혈청총콜레스테롤의 증가에 유의한 영향을 미치는 것으로 밝혀졌다. 따라서 혈청지질치의 위험 관리를 위해서는 비만관리에 대한 평가와 중재가 필요함을 시사하고 있다.

• Clinical and Experimental Pediatrics
• /
• 제61권5호
• /
• pp.135-149
• /
• 2018

Growth charts are curves or tables that facilitate the visualization of anthropometric parameters, and are widely used as an important indicator when evaluating the growth status of children and adolescents. The latest version of the Korean National Growth Charts released in 2007 has raised concerns regarding the inclusion of data from both breastfed and formula-fed infants, higher body mass index (BMI) values in boys, and smaller 3rd percentile values in height-for-age charts. Thus, new growth charts have been developed to improve the previous version. The 2006 World Health Organization Child Growth Standards, regarded as the standard for breastfed infants and children, were introduced for children aged 0-35 months. For children and adolescents aged 3-18 years, these new growth charts include height-for-age, weight-for-age, BMI-for-age, weight-for-height, and head circumference-for-age charts, and were developed using data obtained in 1997 and 2005. Data sets and exclusion criteria were applied differently for the development of the different growth charts. BMI-for-age charts were adjusted to decrease the 95th percentile values of BMI. Criteria for obesity were simplified and defined as a BMI of ${\geq}95th$ percentile for age and sex. The 3rd percentile values for height-for-age charts were also increased. Additional percentile lines (1st and 99th) and growth charts with standard deviation lines were introduced. 2017 Korean National Growth Charts are recommended for the evaluation of body size and growth of Korean children and adolescents for use in clinics and the public health sector in Korea.

• Child Health Nursing Research
• /
• 제10권2호
• /
• pp.165-172
• /
• 2004

The main purpose of this study is to examine the concepts appeared on research and provide future research directions in field of child health nursing. 205 studies of the total 318 studies had been analyzed first for the concepts of the client domain and this time 113 studies were analyzed for the practice, the client-nurse and the environmental domain in nursing. The practice domain includes mentalistitic, enactment, knowledge utilization, role related phenomenon, the client-nurse domain includes touch, communication, interaction phenomenon, and the environmental domain includes physical, social, symbolic environment. All were originally published between 1990 and 2000 in Korea. An analysis of concepts for this study was used the metaparadigm framework for nursing proposed by H. S. Kim(2000). 1. 103 studies belonged to the practice domain. Among them, 56(54％) studies used concepts related to enactment phenomenon like education(21.4％), giving information(7.1％), breast feeding(5.4％), caring(5.4％), airway suction(5.4％), nonnutritive sucking(5.4％). 44(43％) studies used concepts related to knowledge utilization like program development and evaluation of smoking, mother-infant interaction, home health nursing, obesity management. And only 3(3％) studies used role related concepts like quality of nursing, direction of health education, contents of child health nursing education. 2. Only 2(0.006％) studies belonged to the client-nurse domain. One concept is empathy in communication phenomenon and the other concept is role conflict in interaction phenomenon. 3. 8(0.02％) studies belonged to the environmental domain. Among them, 3 studies related to physical environment like space, noise and 5 studies related to social environment like social support, home environment. But the concept of symbolic environment was not used. The findings of this study provide the evidence that research related to the client-nurse domain and the environmental domain should be conducted actively to improve the practice of child health nursing. So that the research in field of child health nursing should be dealt with the concepts of four domains to develop knowledge systematically.

• 한국의류산업학회지
• /
• 제13권4호
• /
• pp.600-613
• /
• 2011

The purpose of this study is to provide Torso pattern for Korean middle-aged women using 3D human body scan data. 155 women in their 40's or 50's were measured by Martin's anthropometry. Merging the data of 914 middle aged women provided by Korean agency for technology and standards, total of 1,069 subjects' data were analyzed. For data analysis, ANOVA, factor analysis and cluster analysis were done using SPSS PC+. And representative subject of each cluster was selected and they participated in 3D scanning and Torso pattern suggested for middle-aged women Torso pattern which investing the amount of ease according to each group for diffuse front interscye 30%, armscye circumference 30%, back interscye 40% using 3D human body scan data. The results of this study are as follows. Firstly, as a result of the factor analysis, the first factor was 'obesity index of body', The second factor was 'verticality size of body', The third factor was 'verticality length of upper bodice', The fourth factor was 'drop value to represent silhouette', and the fifth factor was 'physique of upper bodice'. And, middle-aged women type were classified 3 types according to the cluster analysis. Type 1(Y-type) was the long upper Torso with wide shoulder. Type 2(H-type) was flat-body type with comparatively thin upper bodice and thin lower bodice. And type 3(A-type) was the obese type with comparatively thin upper bodice and fat lower bodice. Secondly, using CAD program, point filtering was performed and approximated surface model was made. It used that generated surface smoothing corrected for abnormally extruded points and scattered points based on the curvature information. And 3D surfaces were flatted onto the plane by the internal tools of CAD program. Difference ratios of outline length and area between 3D curves and 2D plane were 0.42% and 0.54%, respectively. Third, wearing test by the sensory evaluation showed that distinct difference almost every category. The movement functionality test shows that, in all the tests which reveal significant differences, especially, 'comparison pattern A' experienced inconvenience to neck width and neck depth.

• 대한한방체열의학회지
• /
• 제2권1호
• /
• pp.17-23
• /
• 2003

Purpose The cold hypersensitivity is a subjective symptom and it is very difficult to evaluate the severity. It is possible to detect cold hypersensitivity by measuring the skin temperature on DITI, but there is limitation only using DITI to find the objective grade of the symptom. To set a new objective standard for the diagnosis of cold hypersensitivity, we examined the relationship between the Visual Analogue Scale (VAS) score for the cold hypersensitivity and the change of skin temperature on hands by cold stress test Method 23 patients with symptom of cold hypersensitivity were participated as subjects who visited the women medical center of Kangnam Kyunghee Korean Hospital, Kyung Hee Univ. from May 1, 2002 to August 31, 2002. There were all carefully examined to rule out other disease such as obesity, skin diseases, spinal nerve lesions and external wounds. Thermographic observations for this study were made using DITI. We performed cold stress test three times to compare with the results from thermographic observations by DITI: first, after 15 minutes-resting, second, right after 1 minutes soak in $20^{\circ}C$ water, the third for last, 10 minutes after the soak. VAS score was chosen to determine the severity of cold hypersensitivity. Result 1 male and 22 female patients were participated ranging in age from 22.17 to 45.21. There was a significant negative correlation between the recovery rate of finger skin temperature after cold stress test and the VAS score. And there was a significant positive correlation between the difference of finger skin temperature and the back and palm of hands after cold stress test and the VAS score. Conclusion In cold hypersensitivity patients, the cold stress test combined with DITI could be a accurate method for the objective evaluation of cold hypersensitivity, especially good at deciding the severity by numeric values. Using a more strict criterion, as diagnosing of cold hypersensitivity, and longer follow-up may improve the validity of the results attained in clinical trials.

• 한국식품저장유통학회지
• /
• 제24권3호
• /
• pp.483-489
• /
• 2017

본 연구에서는 저온 플라즈마를 활용하여 phloridzin을 20, 40 및 60분 동안 처리하여 얻어진 결과물에 대하여 DPPH 라디칼 소거, ${\alpha}$-glucosidase 및 pancreatic lipase 저해활성을 평가하였다. 그 결과, DPPH 라디칼 소거활성은 플라즈마로 처리하지 않은 phloridzin의 $IC_{50}$ 값이 $500{\mu}g/mL$ 이상이었으며, 이와 비교하여 플라즈마 60분 처리 반응물의 경우 $IC_{50}$ 값이 $100.5{\pm}2.9{\mu}g/mL$ 나타내어 항산화 활성이 상승한 것을 확인하였다. 또한 ${\alpha}$-glucosidase 저해활성은 60 분 동안 플라즈마 처리한 phloridzin의 $IC_{50}$ 값이 $43.5{\pm}2.2{\mu}g/mL$의 가장 우수한 저해활성을 나타내었으며 이 활성은 양성대조군인 acarbose의 $IC_{50}$ 값인 $541.3{\pm}1.9{\mu}g/mL$ 보다 10배 이상 강한 활성이었다. Pancreatic lipase 저해활성은 60분 플라즈마를 처리한 phloridzin의 $IC_{50}$ 값이 $29.8{\pm}2.0{\mu}g/mL$로 가장 우수한 활성을 나타내었다. 향후 이들 반응을 통하여 생성된 화합물의 대량생산을 통한 물질 분리 및 구조 동정을 통하여 DPPH 라디칼 소거활성, ${\alpha}$-glucosidase 및 pancreatic lipase 저해활성 메커니즘 검증을 수행할 필요성이 있다고 사료된다.

• 한국식품영양학회지
• /
• 제29권2호
• /
• pp.267-274
• /
• 2016

Increasing sugar intake of population has become a nutritional issue in Korea. Sweet taste perception may be related to behaviors such as eating sweet food including high sugars and total sugar intake. This study aimed to evaluate objective and subjective sweet taste perception and the association among objective sweet taste perception, dietary behaviors related to eating sweet snack food including high sugar, and total sugar intake from the snacks. Participants were 261 healthy female college students (mean age: $21.0{\pm}1.6years$), who were divided into three subgroups based on oral sweet taste evaluation using a sweet taste assessment tool provided by Ministry of Food and Drug Safety: sweet-seeker group (n=139), medium sweet-seeker group (n=54), and unsweet-seeker group (n=68). There was no significant difference in weight and body mass index (BMI) among the three groups; however, the sweet-seeker group had significantly higher sweet taste preference than that of the other groups. Though more people in the sweet-seeker group thought they tended to eat sweet foods than the medium sweet-seeker and unsweet-seeker groups, over half of the sweet-seekers did not think they tended to eat sweet foods. The sweet-seeker group was more likely to eat sweet snacks such as breads, chocolate products, sugar-sweetened milk, and so on than the unsweet-seeker group. Total sugar intake from the selected sweet snacks was 44.4 g for the sweet-seeker group, 34.4 g for the medium sweet-seeker group, and 28.0 g for the unsweet-seeker group with a significant difference. These results indicated the absence of relationship between objective sweet taste perception and the obesity index; however, significant associations were detected among objective sweet taste perception, eating sweet snacks and total sugar intake from the snacks. We also found high disagreement between objective and subjective sweet taste perception of the subjects. The present study provided the novel insight that measuring objective sweet taste perception may be useful for assessing the risk of high sugar consumption and undesirable dietary behaviors.