• 한국산업보건학회지
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• 제24권2호
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• pp.201-207
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• 2014

Objectives: Flow rate stability is very important for obtaining reliable measurements. However there is no easily used method for checking whether the flow rate set at the initial stage is sustained during sampling. The purpose of this study was to develop a method to evaluate the flow rate performance of gas sampling pumps with adsorbents commonly used to sample gases. Materials and methods: We tested the back pressure of gas sampling pumps commonly used in Korea with adsorbents such as charcoal and silica tubes and attempted to discover the combination conditions of adsorbents in accordance with back pressure required by ISO standard 13137. Results: We found the combination of sampling adsorbents to be applicable to the pressure drop required by the ISO standard for evaluating flow rate stability under increasing pressure drop and long term (eight-hour) performance. Conclusions: This evaluation method of using a sampling media matrix for checking flow rate stability as proposed by this study could be a highly useful tool for determining the reliability of the performance pumps before sampling.

• Clinical and Experimental Pediatrics
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• 제56권6호
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• pp.242-246
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• 2013

Purpose: The cardiopulmonary exercise test (CPET) is an important clinical tool for evaluating exercise capacity and is frequently used to evaluate chronic conditions including congenital heart disease. However, data on the normal CPET values for Korean children and adolescents are lacking. The aim of this study was to provide reference data for CPET variables in children and adolescents. Methods: From August 2006 to April 2009, 76 healthy children and adolescents underwent the CPET performed using the modified Bruce protocol. Here, we performed a medical record review to obtain data regarding patient' demographics, medical history, and clinical status. Results: The peak oxygen uptake ($VO_{2Peak}$) and metabolic equivalent ($MET_{Max}$) were higher in boys than girls. The respiratory minute volume $(V_E)/CO_2$ production ($VCO_2$) slope did not significantly differ between boys and girls. The cardiopulmonary exercise test data did not significantly differ between the boys and girls in younger age group (age, 10 to 14 years). However, in older age group (age, 15 to 19 years), the boys had higher $VO_{2Peak}$ and $MET_{Max}$ values and lower $V_E/VCO_2$ values than the girls. Conclusion: This study provides reference data for CPET variables in case of children and adolescents and will make it easier to use the CPET for clinical decision-making.

• 한국농공학회논문집
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• 제55권5호
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• pp.37-48
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• 2013

The objective of this study is to assess the impact of potential climate change on the hydrological components, especially on the streamflow, evapotranspiration and snowmelt, by using the Soil Water Assessment Tool (SWAT) for 17 Hanriver middle watersheds of South Korea. For future assessment, the SWAT model was calibrated in multiple sites using 4 years (2006-2009) and validated by using 2 years (2010-2011) daily observed data. For the model validation, the Nash-Sutcliffe model efficiency (NSE) for streamflow were 0.30-0.75. By applying the future scenarios predicted five future time periods Baseline (1992-2011), 2040s (2021-2040), 2060s (2041-2060), 2080s (2061-2080) and 2100s (2081-2100) to SWAT model, the 17 middle watersheds hydrological components of evapotranspiration, streamflow and snowmelt were evaluated. For the future precipitation and temperature of RCP 4.5 scenario increased 41.7 mm (2100s), $+3^{\circ}C$ conditions, the future streamflow showed +32.5 % (2040s), +24.8 % (2060s), +50.5 % (2080s) and +55.0 % (2100s). For the precipitation and temperature of RCP 8.5 scenario increased 63.9 mm (2100s), $+5.8^{\circ}C$ conditions, the future streamflow showed +35.5 % (2040s), +68.9 % (2060s), +58.0 % (2080s) and +63.6 % (2100s). To determine the impact on snowmelt for Hanriver middle watersheds, snowmelt parameters of SWAT model were determined through evaluating observed streamflow data during snowmelt periods (November-April). The results showed that average SMR (snowmelt / runoff) of 17 Hanriver middle watersheds was 62.0 % (Baseline). The annual average SMR were 42.0 % (2040s), 39.8 % (2060s), 29.4 % (2080s) and 27.9 % (2100s) by applying RCP 4.5 scenario. Also, the annual average SMR by applying RCP 8.5 scenario were 40.1 % (2040s), 29.4 % (2060s), 18.3 % (2080s) and 12.7 % (2100s).

• 정보과학회 컴퓨팅의 실제 논문지
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• 제23권8호
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• pp.459-465
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• 2017

매니코어 기술에 힘입어 컴퓨터 하드웨어의 성능이 향상되고 있지만 그에 비례한 소프트웨어 성능 증가는 다소 미미한 실정이다. 함수형 언어는 병렬 프로그램의 성능을 향상시키는 대안 중 하나이다. 이러한 언어는 부수효과가 없는 순수한 수식을 통해 내재된 병렬성을 지원하기 때문이다. 함수형 언어인 Haskell은 모나드를 기반으로 하는 다양하고 쉬운 병렬 구조를 제공하기 때문에 병렬 프로그래밍에서 널리 사용된다. 하지만 Haskell로 작성된 병렬 프로그램의 성능 확장성은 코어 수가 증가함에 따라 변동이 큰 경향이 있다. 이는 프로그램 실행에 있어 가비지 컬렉션이 공간과 시간에 모두 영향을 미치는데 Haskell은 이러한 가비지 컬렉션을 사용하는 가상머신 위에서 실행되기 때문이라고 추정된다. 따라서 본 논문에서는 GC-Tune이라는 메모리 튜닝 도구를 사용하여 이 추정이 맞는지 검증하고 Haskell 병렬 프로그램의 성능 확장성을 높이는 방법을 모색한다. 병렬 Haskell 표절 검사 프로그램을 대상으로 실험한 결과 성능 확장성이 향상되었다. 특히 메모리 튜닝을 하지 않은 프로그램에 비해 속도 향상의 변동 범위가 39% 감소하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.107-115
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• 2017

Over the last decade, physiologically based pharmacokinetics (PBPK) application has been extended significantly not only to predicting preclinical/human PK but also to evaluating the drug-drug interaction (DDI) liability at the drug discovery or development stage. Herein, we describe a case study to illustrate the use of PBPK approach in predicting human PK as well as DDI using in silico, in vivo and in vitro derived parameters. This case was composed of five steps such as: simulation, verification, understanding of parameter sensitivity, optimization of the parameter and final evaluation. Caffeine and ciprofloxacin were used as tool compounds to demonstrate the "fit for purpose" application of PBPK modeling and simulation for this study. Compared to caffeine, the PBPK modeling for ciprofloxacin was challenging due to several factors including solubility, permeability, clearance and tissue distribution etc. Therefore, intensive parameter sensitivity analysis (PSA) was conducted to optimize the PBPK model for ciprofloxacin. Overall, the increase in $C_{max}$ of caffeine by ciprofloxacin was not significant. However, the increase in AUC was observed and was proportional to the administered dose of ciprofloxacin. The predicted DDI and PK results were comparable to observed clinical data published in the literatures. This approach would be helpful in identifying potential key factors that could lead to significant impact on PBPK modeling and simulation for challenging compounds.

• 한국콘텐츠학회논문지
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• 제7권7호
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• pp.114-123
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• 2007

전산화단층촬영(CT)은 영상의학에서 매우 유용한 검사의 진단법으로 적절한 정도관리에 의한 영상의 평가가 필요하다. CT의 정도관리 항목에서 영상의 질을 결정하는 중요한 요소를 위해 AAPM CT 팬텀으로 영상검사를 수행하였다. 정도관리 평가항목은 "특수의료장비의 설치 및 운영에 관한 규칙"에서 정한 기준으로 물의 CT 감약계수, 노이즈, 균일도, 공간분해능, 대조도 분해능, 절편 두께, 인공물 존재 유무를 평가하였다. 획득한 영상은 규칙의 합격기준에 충족하였다. CT 영상의 질을 최적으로 유지하기 위해서는 지속적으로 팬텀 및 임상검사를 통해 영상의 질을 평가하기 위해 정도관리를 시행하여야 한다.

• 한국멀티미디어학회논문지
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• 제21권6호
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• pp.723-735
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• 2018

Indicators to quantitatively assess the physical conditions can help optimize the effectiveness of rehabilitation therapy for stroke patients. The body composition variations in the paretic and non-paretic regions of stroke patients with cerebral infarction (7 males, 31 females) were analyzed using multi-frequency bioelectrical impedance. Specifically, resistance (R), lean mass (LM), fat mass (FM), extracellular water (ECW), intracellular water (ICW), R/LM relation, basal metabolic rate (BMR)/LM relation were utilized to evaluate the paretic and non-paretic regions of subjects with cerebral infarction. These values showed significant differences in gender and paretic/non-paretic regions. R and FM were high but LM and ICW were lower in female and paralysis. ECW was lower in females than males, but there was no considerable difference between paralysis and non-paralysis in both males and females. In addition, there was an inverse distribution between R and LM in paretic and non-paretic regions, with males on the upper left and females on the lower right. Furthermore, the relationship between BMR and LM showed excellent linearity (slope: 22.17 kcal/day/kg) irrespective of gender, paralysis, and non-paralysis. An easy, non-invasive and quantitative assessment using bioelectrical impedance would provide an useful tool for evaluating patients with cerebral infarction receiving rehabilitation therapy.

• Journal of Korean Neurosurgical Society
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• 제42권1호
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• pp.35-41
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• 2007

Objective : Determining the location of paraclinoid aneurysms for microsurgery is important for selecting treatment options, especially when deciding on the release of the dural ring in direct clipping. We examined the reliability of using the optic strut as an anatomical landmark for evaluating the location of paraclinoid aneurysms. Methods : Cadaveric dissection was performed to establish the relationship of the optic strut to the dural ring. Results from these anatomic studies were compared with the three-demensional computed tomographic angiographic [3D-CTA] findings of nine patients with ten paraclinoid aneurysms between May 2004 and October 2005. These, 3D-CTA results were then compared with intraoperative findings. Results : The inferior boundary of the optic strut accurately localized the point at the proximal dural ring in cadaveric study. The optic strut and its relationship to the aneurysms was well observed on the multiplanar reformats of 3D-CTA. During microsurgery, nine of ten aneurysms were verified to arise from distal to the upper surface of the optic strut. Two aneurysms that had arisen between the inferior and superior boundary of the optic strut were observed to lie within the carotid cave. One aneurysm which had arisen at the inferior boundary of the optic strut and directed inferiorly was observed to lie within the cavernous sinus just after the release of the proximal ring. Conclusion : The optic strut, as identified with multiplanar reformats of 3D-CTA, provided a reliable anatomic landmark for the proximal rings and an important information about the location of aneurysms around the anterior clinoid process (ACP). Therefore, 3D-CTA and the optic strut could become an invaluable tool and a landmark in the assessment of the location of paraclinoid aneurysms for microsurgery.

• Nutritional Sciences
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• 제7권2호
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• pp.92-97
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• 2004

Despite the universal recommendation to eat a variety of foods, we still do not know whether and to what extent the variety affects dietary quality. This study was performed to evaluate the dietary variety scores as tools for assessing the dietary quality of Korean young adults. The 1-day dietary intake data were collected from 144 male and 214 female college students (>18 years) using the 24-hour recall method Relative nutrient intake compared to Korean Recommended Dietary Allowance (KRDA) as the nutrient adequacy ratio (NAR), were computed Also, the mean adequacy ratio (MAR) was calculated. Dietary variety score (DVS) was determined by counting the number of food items consumed daily, and the dietary diversity score (DDS) by counting the number of food groups consumed daily. Results showed that DVS, DDS and MAR were significantly correlated to each other. The MAR score significantly increased as DDS increased in both men and women. When different DVS (20$\leqDVS\leq$ 30) was evaluated for its sensitivity, specificity, measured prevalence, true prevalence, and positive and negative predictive values towards MAR, DVS 21 was revealed to be optimal dietary variety score as a cutoff point to differentiate Korean young adults with or without an adequate and balanced diet. Nutrient intakes of subjects who had DVS<21 were significantly lower than those of subjects with DVS$\qeq$ 21. These results indicate that the dietary variety score appeared to be an effective tool for evaluating the adequacy of diet in Korean young adults.

• 대한수의학회지
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• 제42권4호
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• pp.485-493
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• 2002

The purpose of this study was to develope a computer program to help with gross diagnosis of protein-energy balance and feeding management practice and with the prediction about the risk possibility of productive disease such as reproductive and metabolic disorders by evaluating fat, protein, and milk urea nitrogen (MUN) from individual cow milk in dairy herd Somatic cell counts also represent the condition of udder health. The principal flow charts of this program was to check on herd management, sampling the composite milk, analysis the milk composition, conversion of data from milking equipment to program, input and analysis of data in program, and report. This program is compatible with window 95/98 system. The major analytical elements of this program were presented as; the profile of herd lactation curve analysis of the test-day milk production level, the distribution of somatic cell count, the fat to protein ratio to evaluate body energy balance, and the interpretation of dietary protein-energy balance by milk protein and MUN contents for individual cows. This program using milk fat, protein, MUN, and somatic cell counts will serve as a monitoring tool for the protein-energy balance and the feeding management practice, and for distribution of mastitis in individual cows. It will also be used to manage the nutritional and reproductive disorders and mastitis at the farm level.