• 디지털융복합연구
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• 제12권11호
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• pp.395-405
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• 2014

본 연구는 중학교 청소년의 신체활동이 정신건강에 미치는 영향을 파악함으로써 중학교 청소년의 정신건강 증진에 도움이 될 수 있는 보다 구체적 방안을 모색하고자 하였다. '2013년 제9차 청소년건강행태온라인조사' 원시자료를 이용하여 중학생 36,530명을 분석하였다. 복합표본자료 분석방법에 의해 분석하였다. 행복감 인지 정도는 학교 체육시간에 주 3회 이상 직접 운동하는 경우에 비해 2회 이하인 경우 행복감은 낮았으며 스트레스 인지 정도와 자살시도 가능성은 높았다. 참여하고 있는 팀 스포츠 수가 1개 팀 이하인 경우 행복감이 낮았으며 스트레스 인지 정도는 높았다. 4개 팀 이상 참여하는 학생에 비해 '1개 팀', '2개 팀' 참여가 자살가능성이 낮았다. 중학교 청소년들의 행복감 향상과 스트레스 완화에 도움이 될 수 있도록 2개팀 정도의 정규적 팀 스포츠 활동 참여와 교내 체육시간에 직접 운동을 주 3회 이상 수행함이 필요하며, 저학년인 경우 극단적 행동을 조절할 수 있도록 정서적 지지를 위한 교육프로그램이 함께 병행됨이 필요하다 여겨진다.

• 약학회지
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• 제44권1호
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• pp.22-28
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• 2000

The extracts of Euphoria longan, Ziryphus jujuba, Thuja orientalis, Polygala tenuifolia, Acorus gramineus, Cyperus rotundus, Poria cocos, Uncaria rhynchophylla, and Albizzia julibrissin, which have been used as sedative drugs in Korean folk medicine, were evaluated for their effects on neurotransmission and antioxidative system in vitro. Among the tested drugs, Acorus gramineus showed most inhibitory activities on monoamine oxidase, xanthine oxidase, aldehyde oxidase, and lipid peroxidation and Uncaria rhynchophylla also inhibited most effectively GABA transaminase and DPPH radical.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제30권1호
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• pp.114-116
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• 2008

Mania in psychiatry describes not only the state of temporary elation of the mood but also of the general mental function such as contents of a thought, thinking process, motivation, enthusiasm, interest, behavior, slumber and physical activities. The time of period when the above changes of mood, mental and behavioral disorder appear is called a manic episode. Postoperative mania is very rare and it has been reported only 5 times in english literature. It's an extremely rare case which has not yet been reported in Oral and Maxillofacial surgery. Patients normally deny the symptoms and it is easy to miss the diagnosis since the patient tends to seem content and happy. Patients show the following initial symptoms of mania - postoperative insomnia, atypical gregariousness, euphoria and unstability. Patients who are not disaffected with insomnia can also be included.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 제4회 추계심포지움
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• pp.171-172
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• 1996

Cocaine is a powerful reinforcer that has become a popular drug of abuse in man. CNS effects that are related to the abuse of cocaine include feeling of well-being and euphoria. Brain dopamine systems are thought to mediate reinforcement and it is often assumed that cocaine's inhibition of dopamine uptake is the mechanism underlying its reinforcing effects. With increase in cocaine use among general population in recent years, adverse effects of the drug have occurred in all social strata and age groups. Therefore, it has been recognized that the epidemic of cocaine abuse is a growing major concerning public health. One of the most troubling aspects of cocaine abuse is its use by pregnant women. Drug abuse during pregnancy puts two lives at risk. Cocaine produces toxic effects on the fetus at concerntrations that are apparently nontoxic to the mother. Not only does cocaine cross the placenta via diffusion and via rapid penetration to mucous membranes, due to its high lipid solubility, but cocaine can also be found in breast milk, the effects of the cocaine can persist long after the child is born. Although it is known that prenatal cocaine exposure is associated with developmental risk to the fetus ana newborn, few studies have been conducted to assess the mechanisms whereby either short-term or long-term administration of cocaine can exert its harmful effects on the mother or the child. Therefore, it was our great interest to investigate the pharmacological and neurobehavioral changes in offspring that are prenatally exposed to cocaine.

• 생명과학회지
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• 제10권4호
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• pp.374-379
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• 2000

This study was attempted to evaluate an agonistic activity to benzodiazepine receptor of several medicinal pants, which have been used as sedatives in oriental medicine. The activities of the methanol extracts of composite preparation of oriental drugs were compared with those of the simple drugs, furthermore, the active fraction was found out from the simple preparation. Inhibitory effects of composite preparations, Cyperus rotundus/Acorus gramineus, Thuja orientalis/Euphoria longan, Thuja orientalis/Albizzia julibrissin, on the binding of ${[^3H]}$Ro15-1788, a selective benszodiazepine receptor antagonist to benzodiazepine receptor of rat cortices, were observed to be lower than those of corresponding simple preparations. These unexpected results suggest that some components of the composite druge may rather act as an obstacle, not to show the sinergistic effect. The methanol extracts of Cyperus rotundus having the highest activity were fractionated using polar and nonpolar solvents to give ethylacetate and hexane fractions, respectively. The ethylacetate fraction containing relatively polar components exhibited much higher activity than the hexane fraction, which consiste of nonpolar agonist, binding to benzodiazepine receptor. However, in the presence of GABA, this fraction inhibited ${[^3H]}$flunitrazepan binding, and these positive GABA shift supported the strong possibility of agonistic activity to benzodiazepine receptro. As a result, it may be concluded that the substance or substances with neurochemical properties as a benzodiazepine receptor agonist may contribute to the sedative property of Cyperus rotundus.

• 지역사회간호학회지
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• 제12권1호
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• pp.261-268
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• 2001

Recently, social concerns about addiction problems not only to substances like alcohol and drug but also to gambling or internet have been increasing. Addiction is caused by a combined influence of biological, psychological. and social factors. However, addiction may also occur due to weak will-power or poor education on addiction. Even though addicted behavior provides temporal mood change such as euphoria, satisfaction. or relaxation. it leads to serious physical and mental disorder of the addicted person and its family members, which possibly results in fatal consequences. Nurses are in an environment to meet and take care of those who are addicted or vulnerable to addiction in order to help the clients to recover or to prevent people from addiction. Despite the importance of nurses role in addiction problems, there is a lack of consistency of addiction is often interchangeably used with other similar concepts in the society. In this study, a concept analysis of addiction was performed to more clearly and comprehensively understand addiction and to develop effective nursing intervention methods for addicted clients. The analysis is conducted according to a series of processes described by Walker and Avant. The defining attributes of addiction identified in this study are as follows: 1) existence of object 2) control loss 3) withdrawal symptoms 4) continued use despite adverse consequences.

• 통합자연과학논문집
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• 제16권3호
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• pp.75-80
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• 2023

Bipolar disorder is a mental illness characterized by extreme mood and behavioral swings, such as highs of euphoria and lows of depression. It is a socially significant disorder in which people with the disorder experience intense mood swings and, for those with severe bipolar disorder, it is even difficult leading a normal life. High stress levels in people with mental illness can lead to neuroendocrine disruption, and it is strongly linked to aging. When the neuroendocrine system becomes vulnerable to these mental illnesses and stress, it is likely to accelerate aging. And it's the epigenetic clock that can measure the extent of this accelerated aging. The Epi clock, a pan tissue clock, measures aging through DNA methylation, and the degree of methylation is modified and changed by environmental conditions in the body. Therefore we wanted to check the changes in the epigenetic age of the patients with bipolar disorder. While we found no significant differences in epigenetic age, we did confirm the possibility that people with bipolar disorder have different methylation than normal people. We also found that the EPIC array data fit better on the Epi clock than on the Horvath clock with age-accelerated data from normal people.

• 디지털융복합연구
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• 제15권8호
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• pp.247-256
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• 2017

본 연구는 성인용 한국사회의 사회 심리적 불안 실태조사 자료를 이용하여 에코세대의 사회인식 및 건강상태가 사회적지지에 미치는 융복합적 영향을 파악하기 위하여 실시되었다. 성인용 한국사회의 사회 심리적 불안 실태조사 자료는 2015년 8월 8일부터 9월 22일까지 실시되었고, 분석대상자는 1,653명이었다. 수집된 자료는 SPSS WIN Version 23.0을 이용하여 기술통계, Independent t-test, ANOVA, 위계적 중회귀분석을 실시하였다. 연구결과, 에코세대의 사회적지지 평균점수는 19.60점이었다. 에코세대 사회적지지 영향요인은 이웃관계 원만함, 계층인식, 행복감 유무, 사회의 평등성 여부, 사회의 안정성 유무, 자존감 정도, 의사소통 정도 및 스트레스 정도로 나타났다. 에코세대의 사회적지지를 향상시키기 위하여 에코세대의 사회인식 및 건강상태의 특성을 반영한 지역사회네트워크프로그램을 개발하고 지역사회 연계 체계를 구축하며 지속적인 상담과 교육이 필요하다.

• 동의생리병리학회지
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• 제25권3호
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• pp.406-416
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• 2011

In this study, we have verified the memory and cognitive enhancing effect of Longanae Arillus, the fruit of Euphoria longana Lamarck, which has been used as a tonic and for the treatment of amnesia, insomnia, and palpitations in oriental medicine. To investigate the effect of Longanae Arillus water extract(LAE) on the memory and cognitive dysfunction, scopolamine (1 mg/kg, i.p.) was injected in C57BL/6 mice and several behavior tests including Y-maze, Morris water-maze, passive avoidance and fear conditioning tests were conducted. Administration of LAE (100 or 200 mg/kg/day, p.o.) effectively improved scopolamine-induced memory impairment and dysfunction. To further determine the possible molecule mechanism of LAE, we have examined the activity and/or mRNA expression of diverse proteins involved in the acetylcholine metabolism. LAE particularly increased the amount of acetylcholine in the cortex which was mediated by suppression of acetylcholine esterase (AchE) activity. In addition, LAE elevated the mRNA expression of muscarinic acetylcholine receptors (mAchRs) without affecting the mRNA levels of choline acetyltransferase (ChAT) and acetylcholine esterase (AchE). In another experiment, LAE effectively inhibited mRNA expression of pro-inflammatory cytokines such as tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-$1{\beta}$ (IL1-${\beta}$), which seemed to be mediated by inhibition of upstream transcription factor NF-${\kappa}B$ and extracellular-regulated kinase 1/2 (ERK1/2). These results demonstrate that Longanae Arillus can increase acetylcholine amount the cortex via regulation of AchE activity as well as mAchRs expression and decrease pro-inflammatory responses via inhibition of NF-${\kappa}B$ signaling pathway, thereby having therapeutic potential to improve memory and cognitive deficit in amnesia.

• 한국콘텐츠학회논문지
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• 제20권1호
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• pp.684-691
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• 2020

본 연구는 성인여성의 우울정도를 파악하고, 우울에 영향을 미치는 요인을 파악하여 우울완화를 위한 건강 증진 프로그램의 기초자료를 제공하기 위해 시도되었다. 일 해양도시 성인여성 249명을 대상으로 구조화된 설문지를 이용하여 자료를 수집하였으며 기술통계, Pearson correlation coefficient 및 다중회귀분석으로 분석하였다. 연구 결과 일 해양도시 성인여성의 우울정도는 76.3%(190명)이었다. 우울을 나타낸 대상자는 사회적 지지와 자아존중감, 주관적 행복감은 음의 상관관계로 나타났으며, 우울과 스트레스는 양의 상관관계로 나타났다. 우울에 미치는 영향을 파악하기 위해 다중회귀분석을 실시한 결과 스트레스가 주요 영향요인으로 유의하게 나타났으며, 이 모델은 21.1%의 설명력을 나타내었다. 그러므로 연구 결과 성인여성의 우울에 유의한 영향요인으로는 스트레스가 나타났으므로 성인여성의 우울을 감소하기 위해서는 스트레스를 감소할 수 있는 건강증진 프로그램의 개발과 적용이 필요하다.