• Journal of Gynecologic Oncology
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• 제29권6호
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• pp.96.1-96.12
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• 2018

The 3-weekly regimen of carboplatin and paclitaxel is the backbone of first line adjuvant chemotherapy for advanced ovarian cancer. The landmark Japanese Gynaecologic Oncology Group (JGOG) 3016 study demonstrated significant improvements in progression-free survival and overall survival with dose dense weekly administration of paclitaxel in combination with 3-weekly carboplatin. However, efforts to replicate these benefits have failed in subsequent phase III trials. Weekly paclitaxel is purported to have enhanced antitumor activity, with stronger anti-angiogenic effects, and yet is better tolerated. In this review, we explore the rationale for dose dense weekly paclitaxel, and compare the relevant trials as well as quality of life considerations. Possible reasons for the difference in outcomes between the JGOG 3016 and other studies are reviewed, with a focus on how the addition of bevacizumab, the variations between histological and molecular subtypes of epithelial ovarian cancers, and ethnic pharmacogenetic differences may potentially affect the efficacy of dose dense paclitaxel.

• 농촌계획
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• 제30권3호
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• pp.37-53
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• 2024

The purpose of this study is to analyze the effectiveness of an agriculture and rural development ODA project in southern Nepal's Terai region to improve food security, and to suggest appropriate project approaches to improve food security. The subject of the analysis is the KOICA-funded 'Inclusive Rural Development project', and a framework for analyzing food security was established based on the FAO's four pillars of food security, and indicators were proposed to measure the food security of project farmers. The data for this study were obtained from a survey of project beneficiary farmers and their control group, and the effects of the project on food security were measured using a a t-test analysis, difference-in-difference analysis, propensity score matching-linear regression combined model (PSM-OLS) and a propensity score matching-difference-in-difference combined model(PSM-DID). The results showed that, in general, the ODA project treatment group had significant improvements in each of the four pillars of food security (food availability, access, utilization, and stability). In addition, cooperative membership had a positive impact on food security improvements, and there were also differences in outcomes among different ethnic groups in the Terai region. The implications of this study are that the Korean government's ODA policy should set aside the food security sector and incorporate food security indicators to contribute to the improvement of food security in ODA partner countries, and that agricultural and rural development ODA projects should include food security indicators as performance indicators in their pre-planning to contribute to securing food security for vulnerable groups as food insecurity is higher among vulnerable groups.

• Toxicological Research
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• 제32권3호
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• pp.195-205
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• 2016

This study was performed to select single nucleotide polymorphisms (SNPs) related to the body burden of heavy metals in Koreans, to provide Korean allele frequencies of selected SNPs, and to assess the difference in allele frequencies with other ethnicities. The candidate-gene approach method and genome-wide association screening were used to select SNPs related to the body burden of heavy metals. Genotyping analysis of the final 192 SNPs selected was performed on 1,483 subjects using the VeraCode Goldengate assay. Allele frequencies differences and genetic differentiations between the Korean population and Chinese (CHB), Japanese (JPT), Caucasian (CEU), and African (YIR) populations were tested by Fisher's exact test and fixation index ($F_{ST}$), respectively. The Korean population was genetically similar to the CHB and JPT populations ($F_{ST}$ < 0.05, for all SNPs in both populations). However, a significant difference in the allele frequencies between the Korean and CEU and YIR populations were observed in 99 SNPs (60.7%) and 120 SNPs (73.6%), respectively. Ten (6.1%) and 26 (16.0%) SNPs had genetic differentiation ($F_{ST}$ > 0.05) among the Korean-CEU and Korean-YIR comparisons, respectively. The SNP with the largest $F_{ST}$ value between the Korean and African populations was cystathionine-${\beta}$-synthase rs234709 ($F_{ST}$: KOR-YIR, 0.309; KOR-CEU, 0.064). Our study suggests that interethnic differences exist in SNPs associated with heavy metals of Koreans, and it should be considered in future studies that address ethnic differences in heavy-metal concentrations in the body and genetic susceptibility to the body burden of heavy metals.

• 한국인구학
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• 제31권3호
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• pp.131-157
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• 2008

이 연구는 현재 우리사회에 거주하는 외국인 아내들의 우울수준을 살펴보고, 이들의 출산과 경제활동이 우울에 미치는 효과를 분석하였다. 이 연구에서는 외국인 아내들의 출신국적에 따라 출산, 경제활동이 우울증에 미치는 효과가 다를 것으로 보고, 그 차이를 분석하는데 초점을 맞추었다. 일본, 중국, 베트남 아내 524명에 대한 설문 조사 자료를 분석한 결과, 아내들의 출신 국적별로 우울수준에 차이가 있었다. 베트남 아내는 일본, 중국 아내들보다 더 우울한 것으로 나타났다. 이는 베트남 아내들이 적응에 있어서 일본이나 중국 아내들보다도 취약한 상황임을 말해준다. 또한 출산과 경제활동의 효과도 출신국별로 차이가 있었다. 베트남 아내에게는 출산이 우울감을 떨어뜨리는데 중요한 요인인 것으로 나타났다. 반면에 중국이나 일본 아내들에게는 출산보다는 경제활동이 우울을 낮추는데 더 중요한 요인으로 나타났다. 사회적 자원, 문화정체성을 비롯한 다른 요인들이 모두 포함된 결과에서도 우울에 영향을 미치는 인구학적, 사회적, 문화적 요인의 구성이 차이가 있었다. 이러한 결과는 외국인 아내들의 적응방식이 출신국별로 상이하며, 이러한 차이점들을 반영하는 정책적 고려가 필요함을 시사한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1459-1463
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• 2014

Background: Urological cancers represent a major public problem associated with high mortality and morbidity. The pattern of these cancers varies markedly according to era, region and ethnic groups, but increasing incidence trends overall makes focused epidemiological studies important. The aim of the present study was to assess the incidence of most prevalent urological cancers in Iran from 2003 to 2009. Materials and Methods: The data for this study were obtained from the population-based Cancer Registry Center of the Iran Ministry of Health and Medical Education. Differences of mean age and age distributions of each cancer were compared between 2003 and 2009 in men and women. Results: Bladder cancer was the most common urologic cancer in both genders. The rate difference of age standardized ratio (ASR) of bladder and renal cell carcinoma in women were 1.54 and 2.01 percent per 100,000 population from 2003 to the 2009, respectively. In men, the rate difference of age standardized ratio of prostate, testis, kidney and bladder cancer was also 2.23, 1.2, 1.8 and 1.5 percent per 100,000 population from 2003 to 2009, respectively. The mean ages of patients in all cancers in both genders did not differ significantly through time (p value>0.05) but the distribution of ages of patients with bladder and prostate cancer changed significantly from 2003 to 2009 (p value<0.001). Conclusions: The results of present study suggest the general pattern and incidence of urological cancers in Iran are changing, the observed increase pointing to a need for urological cancer screening programs.

• 한국의류학회지
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• 제33권4호
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• pp.554-562
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• 2009

As a result of comparison analysis on body types of Korean women in their forties and Korean women residing in Japan, the following results had been found. 1. In terms of factors composing the body type, while women residing in Korea did not show large differences in obesity and horizontal size factors, women living in Japan showed higher contribution of obesity factor compared to horizontal size factor. That is, obesity factor was substantially more important among factors composing the body type for women residing in Japan. 2. Cluster analysis was done to understand the characteristics of body types and comparatively analyze them. Women residing in Korea were classified into tall and normal body, normal height with obese body, and short and chubby body. Women residing in Japan showed different characteristics with tall and obese body, tall and normal body with long lower part, and short and thin body. As a result of this study, identical ethnic group was found to take on different body types resulting from sociocultural differences and difference in eating habits if their place of residence differs for a long time.

• 한국의상디자인학회지
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• 제13권2호
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• pp.1-11
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• 2011

As a result of comparison analysis on body types of Korean women in their twenties and Korean women residing in Japan, the following results had been found. 1. The comparison of 49 items in physical measurements between the Korean women in their 20's and Korean women residing in Japan resulted in the differences in 33 items. 2. The comparison of the factor analysis results for physical measurements did not reveal big differences. 3. The comparison of the physical shapes according to the grouping resulted in three types each for both groups, with different features for individual types. Women residing in Korea were classified into tall and normal body, normal height with obese body, and short and thin body. Women residing in Japan showed different characteristics with tall and obese body, short and thin body and normal height with obese body. As a result of this study, identical ethnic group was found to take on different body types resulting from sociocultural differences and difference in eating habits if their place of residence differs for a long time.

• 복식
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• 제64권4호
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• pp.131-149
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• 2014

Tibetans are one of the ethnic Chinese minorities, and this research examined the characteristics and features of their traditional costumes by investigating their historical, geographical and cultural background. This research also examined the cultural elements according to their characteristics based on Tibet's nature, religion, arts culture such as the Jang-po, Chin-sam, Kam-kjun and belts, which are used to fix the costumes. Based on such studies the traditional Tibetan costumes were set as a motif and were expressed appropriately into a contemporary style. By studying the composition of its costumes and its costume culture, the characteristics of the Tibetan costumes could be classified into four features. First, the 'variability of form' expresses a new type depending on how it is worn. Second, the 'color contrast' shows a strong visual contrast. Third, the 'difference of materials' combines different materials into one. Fourth, the 'symbolic meaning' grants meaning to the wearer. As a result of this study, by using the characteristics of the Tibetan nature culture, religion culture and art culture as a basis, two suits of clothes for each characteristics and six suits of clothes were produced as a fashion design product.

• 대한한의학회지
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• 제24권4호
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• pp.113-119
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• 2003

The association between apolipoprotein E (apo E) gene polymorphism and ischemic cerebrovascular disease (ICVD) has been controversial. These controversies may be due to inaccurate classification of patients and ethnic differences. We investigated the association between apo E genotypes and ICVD patients by case-control study in a Korean population. The association between apo E polymorphism and ICVD was examined in 121 patients with ICVD and 132 controls without ICVD. The E3/E4 phenotype was more frequent in control subjects (23.8％) than in patients (13.0％) (p<0.05). The E2/E3 phenotype was more frequent in patients (14.8％) than in control subjects (10.8％), but the difference was not statistically significant (p>0.05). These results suggest that the E4 allele may be a protective factor against early vascular morbidity, and the E2 allele may be a risk factor for cerebrovascular morbidity.

• 복식
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• 제64권6호
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• pp.161-175
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• 2014

This paper investigates the differences between characteristics of street fashions due to regional and cultural differences in southern and northern region of China. Beijing and Shenzhen were chosen as representative cities for the two areas. Empirical research and literature study were performed for this study. Empirical studies were performed by using a total of 708 images of dresses, which were collected through direct imaging. Through discussion with experts, the collected data were classified into five categories; Modern trendy, Romantic, Easy casual, Ethnic, and Classical/Traditional. The data was analyzed by using cross tabulation and frequency analysis. Content analysis for each category was also conducted. As a consequence of this study, a significant difference between Beijing and Shenzhen were observed. As a city, which puts emphasis on practicality and modernity, Beijing showed a higher frequency of modern and trendy style than the other city. On the other hand, Shenzhen showed a higher frequency of romantic style and was distinguished as a city of femininity and decorative preference of fashion style. This study intends to contribute to the academic community of Chinese fashion and to help Korean clothing companies to be launched in Chinese market in the future.