• International Journal of Stem Cells
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• v.17 no.2
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• pp.130-140
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• 2024

Cardiac organoids have emerged as invaluable tools for assessing the impact of diverse substances on heart function. This report introduces guidelines for general requirements for manufacturing cardiac organoids and conducting cardiac organoid-based assays, encompassing protocols, analytical methodologies, and ethical considerations. In the quest to employ recently developed three-dimensional cardiac organoid models as substitutes for animal testing, it becomes imperative to establish robust criteria for evaluating organoid quality and conducting toxicity assessments. This guideline addresses this need, catering to regulatory requirements, and describes common standards for organoid quality and toxicity assessment methodologies, commensurate with current technological capabilities. While acknowledging the dynamic nature of technological progress and the potential for future comparative studies, this guideline serves as a foundational framework. It offers a comprehensive approach to standardized cardiac organoid testing, ensuring scientific rigor, reproducibility, and ethical integrity in investigations of cardiotoxicity, particularly through the utilization of human pluripotent stem cell-derived cardiac organoids.

• Communications for Statistical Applications and Methods
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• v.5 no.2
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• pp.459-475
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• 1998

In many clinical trials, we are interested in comparing the failure time distribution of different treatment groups. Because of ethical and economic reasons, clinical trials need to be monitored for early dramatic benefits or potential harmful effects. Prior knowledge, evolving knowledge, statistical considerations, medical judgment and ethical principles are all involved in the decision to terminate a trial early, and thus the monitoring is usually carried out by an independent scientific committee. This paper reviews the recently proposed group sequential testing procedures for clinical trials with survival data. Design considerations of such clinical trials are also discussed. This paper compares the characteristics of each of these methods and provides the biostatisticians with the guidelines for choosing the appropriate group sequential methods in a given situation.

• Journal of dental hygiene science
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• v.5 no.4
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• pp.155-163
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• 2005

The purpose of this exploratory study was to assess work performance of dental hygienists and identify factors influencing their work performance. A questionnaire was administered to 87 dental hygienists working dental clinics based in Ulsan during the period from June 2005 through July 2005. A total of 77 questionnaires were collected and used for analysis. SPSS 11.5 program was employed for statistical analysis. All data were expressed in terms of numbers, percentage and mean score. The results of the study are summarized as follows: 1. There was a significantly positive correlation between age and the level of work performance in the Scientific competency group and Esthetical competency group. 2. Unmarried dental hygienists demonstrated better work performance than married dental hygienists in Scientific, Esthetical and Personal competency groups, showing a statistically significant difference. 3. By education level, those with junior college degree had better work performance than those who are attending or graduated from college in the four groups. By workplace, those who were working at non-general hospitals demonstrated a higher level of performance in the three groups except the Ethical group, but the difference was not statistically significant. 4. A significantly positive relationship was observed between monthly pay and work performance in the Scientific, Personal and Esthetical competency groups. 5. A positive relationship was observed between work experience and performance in the Scientific competency group. But there was no difference between work experience and performance in the other three groups. 6. By working environment, those who were working with assistant nurses showed a higher level of performance than those working without assistant nurses in the Scientific competency group, and the difference was statistically significant.

• Journal of Korean Academy of Nursing
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• v.34 no.8
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• pp.1434-1442
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• 2004

Purpose. Professional nursing ethics is a living, dynamic set of standards for nurses' professional moral behavior. Furthermore, in daily clinical nursing training, nursing students are constantly confronted with decision-making that is moral in nature. The aim of this study was to identify the perceived ethical attitudes in the clinical training process of senior nursing students using Q-methodology to offer basic strategies for nursing ethics education and thereby improve patients' care. Methods. Q-methodology provides a scientific method for identifying perception structures that exist within certain individuals or groups. Thirty-seven participants in a university rated 38 selected Q-statements on a scale of 1-9. The collected data were analyzed using pc-QUNAL software. Results. Principal component analysis identified 3 types of ethical attitudes in nursing students in Korea. The categories were labeled Sacred-life, Science-realistic and Humane-life. Sacred-life individuals think that a life belongs to an absolute power (God), not a man, and a human life is a high and noble thing. Science-realistic individuals disagreed that allowing an induced abortion or embryo (human) duplication is unethical behavior that provokes a trend, which takes the value of a life lightly; most of them took a utilitarian position with respect to ethical decisions. Humane-life individuals exhibit a tendency toward human-centered thought with respect to ethical attitudes. Conclusion. This study will be of interest to educators of students of nursing and hospital nursing administrators. Also, the findings may provide the basis for the development of more appropriate strategies to improve nursing ethics education programs.

• Korean Journal of Biological Psychiatry
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• v.19 no.4
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• pp.153-158
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• 2012

Understanding of a clinical trial is essential in developing clinical guideline and adopting evidence based practice. In designing and executing clinical trials, following ethical requirements should be considered : social value, scientific validity, fair subject selection, informed consent, favorable risk-benefit ratio, institutional review board, and respect for human subjects. According to the stage of drug development, purpose of trials, accumulated scientific data, clinical trials for drug development are classified as phase 1, 2, 3, and 4. Phases of clinical trials can be overlapped and the judgment of entering into the next phase should be considered highly strategically. In reading, evaluating and interpreting clinical trial reports, various skills and challenges exist. Patient sample composition, trial duration, selection of endpoints, responders and non-responders, placebo effect, patient recruitment, and extrapolation to the real world are the examples of those challenges. Treatment success will come from the well balanced approach of evidence based decision making and consideration of specific single case.

• Development and Reproduction
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• v.17 no.4
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• pp.477-482
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• 2013

Science in the 21st century does not consider participants' welfare, safety and human rights in clinical studies, but modern science puts economic profits in its priority. This leads to a growing concern about social responsibility and professionalism ethics of companies, sponsors and scientists. Specifically, there is no way to control conflicts of participants' welfare with economic profits, leading to simply relying on individual ethics, social responsibilities and audit. This paper helps relevant agencies and people involved understand conflict of interest. Also this study presents the guidelines as well as independence, autonomy, ethical imagination and phronesis required for scientists.

• Imaging Science in Dentistry
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• v.53 no.2
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• pp.175-176
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• 2023

• Journal of Information Science Theory and Practice
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• v.9 no.3
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• pp.31-41
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• 2021

The growing number of threats to society through the uncontrolled distribution of information is forcing library communities in many countries to reconsider their views on free access to collections. Based on the content of numerous documents of international importance, it can be concluded that in any democratic country access to information is one of the most important human rights, along with the right to life, liberty, and security of person. However, the state has the right to restrict citizens' access to information within the framework of existing legislation. Constantly, restrictions on access to information are established in order to protect the ethical foundations of the constitutional order, morality, health, rights, and legitimate interests of others, to ensure the country's defense and state security. It goes without saying that each country has the right to independently decide where the boundaries lie between permitted and prohibited information, including printed information, contained in library collections. This article describes three levels of access restriction: foreign, state, and regional. The authors have analyzed the legal and regulatory documents that govern libraries, as well as the reasons and methods of limitation. A comparative analysis of the restriction of access to information in the countries of Europe and Asia is presented.

• Journal of Korean Academy of Nursing
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• v.22 no.3
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• pp.389-406
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• 1992

This study was designed to identify nursing students' attitudes toward life through a Q-methodology. A Q-sample was formed through a review of the literature and interviews(n＝160)l The final Q-sample consisted of 37 statements out of an initial 100 statements after consultation with an expert panel and pilot testing. The P-sample consisted of 14 university nursing students and 27 junior college nursing students, which was selected by convenience sampling method. Data were analyzed by the Q-analysis method. The correlation between type 2 and type 3 was relatively high (r＝0.539) ; that between type 1 and type 3 was lowest (r＝0.014). The first type of attitude was the “rational utilitarian” type. Students in this type valued life relative to the quality of life. They agreed with euthanasia and artificial abortion if the quality of life was threatened. The criteria for their judgement were scientific knowledge and rationality. The second type of attitude was the “Christian deontologic” type. These students appreciated the sanctity of life according to Christian dogma. They disagreed with euthanasia and artficial abortion. And they disagreed strongly that life should be created by scientific development, because only God creates life. The third type of attitude was the “unconditional deontologic” type. These students agreed with the sanctity of life, not from Christian belief but from belief in the sanctity of life. The final type of attitude was the “prima facie(conditional) deonologic” type. These students appreciated the value of life and humanity. They expressed concern for others' life and suffering. They do not want to afflict others with their own miseries. This group showed a dual value system toward themselves and others. So they experience conflict between their concern for their on and others' conditions. These nursing students' values may have been influenced by their clinical experience in hospitals and other nursing fields. Through this study, we may realize the importance of education in nursing ethics for discussion of ethical conflicts and to support ethical nursing practice.

• Journal of The Korean Association For Science Education
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• v.25 no.3
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• pp.336-345
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• 2005

This study examined the efforts of both national and international science museums and centers to educate the public on recent developments in science, technology, social issues, and ethical issues by analyzing STS-related content exhibits. The results indicated that all science centers informed the public about recent science technology and relevant social and ethical issues by a variety of channels. However, science museums in Korea merely introduced new science and technology at the rudimentary level and used attractions to gather people's attention, which contributed in eliciting distorted thoughts on science and new technology. Science centers in Korea are in need of an upgrade. By analyzing science museums in foreign countries, a unique education on STS themes or scientific issues in Korea can be developed.