• 제목/요약/키워드: Escape design

검색결과 234건 처리시간 0.027초

Bioinspired Polymers that Control Intracellular Drug Delivery

  • Allan S. Hoffman;Patrick S. Stayton;Oliver-Press;Niren-Murthy;Chantal A. Lackey;Charles-Cheung;Fiona-Black;Jean Campbell;Nelson Fausto;Themis R. Kyriakides;Paul-Bornstein
    • Biotechnology and Bioprocess Engineering:BBE
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    • 제6권4호
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    • pp.205-212
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    • 2001
  • One of the important characteristics of biological systems os their ability to change im-portant properties in response to small environmental signals. The molecular mechanisms that biological molecules utilize to sense and respond provide interesting models for the development of "smart" polymeric biomaterials with biomimetic properties. An important example of this is the protein coat of viruses, which contains peptide units that facilitate the trafficking of the virus into the cell via endocytosis, then out of the endosome into the cytoplasm, and from there into the nucleus, We have designed a family of synthetic polymers whose compositions have been de-signed to mimic specific peptides on viral coats that facilitate endosomal escape. Our biomimetic polymers are responsive to the lowered pH whinin endosomes, leading to distruption of the en-dosomal membrane and release of important biomolecular druges such as DNA, RNA, peptides and proteins to the cytoplasm before they are trafficked to lysosomes and degraded by lysosomal en-zymes. In this article, we review our work on the design, synthesis and action of such smart, pH-sensitive polymers.

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Fitness cost and competitive ability of transgenic herbicide-tolerant rice expressing a protoporphyrinogen oxidase gene

  • Chun, Young Jin;Kim, Dae In;Park, Kee Woong;Jeong, Soon-Chun;Park, Sangkyu;Back, Kyoungwhan;Kim, Chang-Gi
    • Journal of Ecology and Environment
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    • 제36권1호
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    • pp.39-47
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    • 2013
  • The expression of transgenic traits in genetically modified crops is sometimes associated with decreases in crop performance or fitness. These decreases in performance or fitness of transgenic plants in unfavourable conditions may provide valuable information about the ecological consequences of transgene escape. In a glasshouse trial, we tested the cost associated with resistance to herbicides by comparing the growth, yield, and competitive ability of transgenic rice with its parental non-transgenic line. This new line was developed for constitutive overexpression of protoporphyrinogen oxidase (PPO) to increase resistance to herbicides. We evaluated nine agronomic traits of transgenic and non-transgenic rice grown in a replacement series design over four densities. Competitive ability was also assessed between transgenic and non-transgenic plants by analyzing their relative yields based on biomass and seed weight data. Our results indicated that non-transgenic plants showed greater performance than did the transgenic plants when those genotypes were grown in mixtures. The non-transgenic rice plants exhibited superior competitive ability at certain combinations of planting densities and genotype proportions. These results suggest that PPO-herbicide resistance incurs some costs in plant performance and competitive ability.

페이스북광고의 커뮤니케이션 요소에 관한 연구 (Case Study for the Communication Elements of Facebook Advertising)

  • 김종민
    • 한국콘텐츠학회논문지
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    • 제18권9호
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    • pp.231-239
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    • 2018
  • 본 연구는 사용자를 통한 실험 및 심층면접을 통해 최근 많은 광고물량이 몰리고 있는 페이스북 광고운영에 도움이 되는 요소가 무엇이 있는지 모바일매체를 중심으로 찾아보는 탐색적 논문이다. 연구 방법은 모바일광고, 그리고 모바일광고 내 매체현황, 콘텐츠성향, 광고회피현상을 고찰한 후, 남녀 대학생 50명을 대상으로 실험자 자신의 페이스북을 30초간 체험하게 하여 사용과정에서의 물리적 행위를 관찰하고, 실험 후 토론을 기반으로 심층 분석하였다. 실험의 결과는 광고의 긍정적 요인와 부정적 요인으로 나누어 논할 수 있었다. 페이스북을 이용하는 동안 광고를 좋게 보이게 해주는 긍정적 요인으로 네이티브 광고디자인 효과, 지인 효과, 검색 효과의 영향을 받고 있음을 확인할 수 있었으며, 페이스북 사용자로 하여금 광고회피를 쉽게 해주는 광고의 부정적 요인으로 초당 평균 1.5-3회의 빠른 스크롤 행위로 광고스킵이 가능함을 발견할 수 있었다. 그러나, 부정적 행위에 해당하는 빠른 스크롤 행위는 앞서 언급한 긍정적 요소들과 더불어 페이스북은 모바일 상에서 다른 매체 대비 광고로 인한 스트레스가 높지 않다는 의견이 나왔다.

도시근교형 자연휴양림 이용 행태와 만족도 분석 - 서울 근교를 중심으로 - (Visitor Behavior and Satisfaction in Suburban Recreational Forests - Focused on the suburbs of Seoul -)

  • 서주환;최현상;전형석
    • 한국조경학회지
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    • 제30권6호
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    • pp.57-65
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    • 2003
  • This study researches attributes , behaviors , satisfaction factors and degrees of curiosity of visitors to recreational forests in the suburbs of a large city. It aims to present suggestions for urban forest development and management policy by offering basic data which help to plan, design and manage recreational forests to increase the quality of these environments. The results are as follows First, in attribute, the visiting rate of males is higher than that of females, and the main users are in their thirties and forties. Sixty percent of visitors graduated from university and their rate of employment is evenly distributed. 95 percent of visitors are residents of the metropolitan area. In terms of behavior, major visitors are family units visiting during summer seasons and for overnight stays. 75% are re-visitors. 85% of visitors came to escape the city with families and friends, keep in good health and experience nature. Second, to extract the factors affecting visitor satisfaction in recreational forests, the natural environment, facilities, and management/use systems were identified as independent variables, while subordinate satisfactions were dependent variables. so regression analysis was used. Thus, the variables affecting the natural environment are quality of water, stream use, biodiversity, fresh air and landscape factors. The variables affecting facilities are puking, convenience, play facilities, sanitary arrangement and camping. Most important among the variables affecting management/use systems are educational facilities and access condition. On the basis of generalizing the study in the existing individual site, we must verify the visiting characteristics in recreational forests in the suburbs of a large city. Since development of recreational forests is understood as a sequence considering a site and a given condition, and since management and improvement must unfold according to these characteristics, a strategy is needed to reveal visitors' opinions about the site. Depending on the facilities and service, satisfaction of recreational forests is generally influenced by social and economic qualities. Also, this study can look into the effect according to use pattern motive and season. As suburban recreational forests have many overnight-users and younger men, programs suitable for these groups are needed. On the basis of variables affecting satisfaction according to natural environment, facilities, and use system, policies which can manage the natural environment and introduce educational programs are needed.

Development of Potential Function Based Path Planning Algorithm for Mobile Robot

  • Lee, Sang-Il;Kim, Myun-Hee;Oh, Kwang-Seuk;Lee, Sang-Ryong
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2005년도 ICCAS
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    • pp.2325-2330
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    • 2005
  • A potential field method for solving the problem of path planning based on global and local information for a mobile robot moving among a set of stationary obstacles is described. The concept of various method used path planning is used design a planning strategy. A real human living area is constructed by many moving and imminence obstacles. Home service mobile robot must avoid many obstacles instantly. A path that safe and attraction towards the goal is chosen. The potential function depends on distance from the goal and heuristic function relies on surrounding environments. Three additional combined methods are proposed to apply to human living area, calibration robots position by measured surrounding environment and adapted home service robots. In this work, we proposed the application of various path planning theory to real area, human living. First, we consider potential field method. Potential field method is attractive method, but that method has great problem called local minimum. So we proposed intermediate point in real area. Intermediate point was set in doorframe and between walls there is connect other room or other area. Intermediate point is very efficiency in computing path. That point is able to smaller area, area divided by intermediate point line. The important idea is intermediate point is permanent point until destruction house or apartment house. Second step is move robot with sensing on front of mobile robot. With sensing, mobile robot recognize obstacle and judge moving obstacle. If mobile robot is reach the intermediate point, robot sensing the surround of point. Mobile robot has data about intermediate point, so mobile robot is able to calibration robots position and direction. Third, we gave uncertainty to robot and obstacles. Because, mobile robot was motion and sensing ability is not enough to control. Robot and obstacle have uncertainty. So, mobile robot planed safe path planning to collision free. Finally, escape local minimum, that has possibility occur robot do not work. Local minimum problem solved by virtual obstacle method. Next is some supposition in real living area.

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포스트모던 페미니즘과 '몸' 양식의 탈고정적 표현에 관한 연구 (The Research on Post-modern Feminism and the Expression of the Post-Fixation of Body Pettern)

  • 이신영;김혜영
    • 복식
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    • 제53권1호
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    • pp.49-66
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    • 2003
  • In the relationship between post-modern feminism and the body. the body of women, which has been taken as 'other' by dominant arguments, has escaped from the fixed idea at post-modern times and the post-modern feminists tried to escape from the taste of the times about body image that was prevalent in the former times.'The taste of the times' here means the fixed physical form of ideal women's body by the educational custom, and it includes the educational prescription which establishes the docile body of women. This kind of educational custom aims at the perfect and permanent restriction on size, shape, desire, attitude and movement as well as on the overall demeanor and each part of the body. And the custom produces 'dependent and trained'. that is, inferiorized women's body. Hence, this paper points out that the feminity as a fixed Physical form should be overcome in order to move forward, and as one part of the effort, it attempts to analyze the designs which deformed and distorted women's body in 1990s. This research indicates that the work, which tries to deviate the fantasized and casted women's mystery, has been closely connected with the expression of 'non-separate bodies' and 'irregular body shapes' in 1990s, which aims at escaping from the fixation of women's body Image. Therefore, it is concluded that the target design trend of this research, which expressed the deformation and perversion of the body, provides the anti-these against the ideal body image of women and the these of feminity. which have been reproduced in various methods and patterns throughout the public and the culture on the whole by expressing the refusal and deviation of the existing women's body image through the post-fixation of the body pattern.

승강로 가압 제연설비의 설계개선에 관한 연구 (A Study on Design Improvement for Smoke-Control System Using the Pressurization of the Elevator Shaft)

  • 김일영;김경진;홍지환;권창희;유철권
    • 한국화재소방학회논문지
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    • 제33권3호
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    • pp.74-83
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    • 2019
  • 승강로 가압방식은 미국에서 1972년에 시작된 방식으로 화재 시 피난 계단을 이용하기 곤란한 노약자등 피난 약자가 승강기를 이용하여 피난할 수 있도록 개발한 방식이며 수직덕트를 사용하지 않음으로서 공간 절약적인 측면에서 이점이 있다. 본 연구는 기존 국내 특허에 근거한 승강로 가압방식의 문제점을 도출하고 이에 대한 개선사항을 제안하였다. 풍량 계산 방법은 수직모델링을 제안하였다. 엘리베이터 출입문의 누설틈새는 실험데이터나 실측데이터를 통하여 재검토가 필요하다. 피난층을 구획하고 엘리베이터 기계실의 개구부를 화재신호에 자동폐쇄하고 릴리프 댐퍼를 설치하여 성능을 개선하였다. 개선된 방식은 자동차압댐퍼가 차압유지보다는 방연풍속을 공급하는 기능을 수행한다. 연구 결과의 신뢰성을 높이기 위해 Contam을 이용하여 검증하는 절차를 수행하였다.

국내 최장대 양방향 도로터널 설계사례-배후령터널 (Case Study of the Longest Roadway Tunnel in Korea, Baehuryeong Tunnel)

  • 이선복;제해찬
    • 터널과지하공간
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    • 제15권6호
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    • pp.432-440
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    • 2005
  • 배후령 터널은 강원도 춘천과 화천을 연결하는 길이 5,057 m의 2차선 양방향 단선 터널로 장래 4차선으로 확장 될 계획이다. 본 터널은 55개월의 공기로 현재 시공 중이며 완공 후 국내 최장대 양방향 도로터널이 될 것이다. 양방향 단선터널은 복선터널에 비해 환기 및 화재 대처에 대한 단점을 가지고 있다. 이러한 이유로 배후령 터널에는 국내 최초로 연장 5,173 m, 직경 5 m의 서비스터널을 계획하였으며, 횡류식 환기방식을 적용하였다. 이 환기 시스템은 화재 시 제연효과로 대피자의 안전을 확보할 수 있다. 배후령 터널 구간은 편마암과 화강암을 기반암으로 하며, 터널 방향을 따라 큰 규모의 배후령 단층이 발달 되어있다. 이 단층의 영향 범위는 각종 조사 및 시험결과 약 70 m로 분석되어, 안전을 고려 터널 노선은 단층에서 100 m이상 이격하여 선정되었다.

바이어스 드레이핑 디자인 연구(硏究) (A Study of Bias Draping Design)

  • 김희균;조규화
    • 패션비즈니스
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    • 제4권4호
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    • pp.1-16
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    • 2000
  • The purpose of this study is to investigate the formative beauty, changes in fashion and aesthetical sense that can be seen in the bias drapings of Madeleine Vionnet and her influences on modern fashion since she used draping as a new fashion means to represent the new feminine images which modernism of the early 20th century and social changes from the two great World War's generated, and to provide proper data to encourage designers' creativity that is wanting in the circle of Korea fashion. Bias draping led women to respect worship their body from the heart with seductive modernism enriching the material's texture to the utmost through geometrical patterns of triangle, quartered plane and quardrants and simple cylindrical cuts and with an attribute adapting itself to the wearer's body. Bias draped wear consisted of light and transparent materials and overall surface decoration revealed women's movements and sought the extension of environmental movements and demonstrated its eroticism. On the other hand, biased daywear gained anonymity through cutting true to body line and psychological protective quality as of cape, and this went well with the independent femininity accepting difference as well as pursuing revolution from the inside. The great inflation and the 2nd World War gave birth to escape from reality like surrealistic artistic tendencies and Hollywood films and increased romanticism. Bias draping once underwent unpopularity except in expensive clothes due to knit wear boom and the utilization of new elastic materials, however, it began to receive lights again from pluralization waves and retro tendencies and to be introduced in many designers' collections. A young genius of England, John Galliano improved functions of Haute Couture through creation of new styles and fantastic shows to promote profits in the fashion markets. Bias draping fitted in human body line provides us comfort and aesthetic qualities through careful choice of material and elegance by delicate cutting.

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Health monitoring sensor placement optimization for Canton Tower using virus monkey algorithm

  • Yi, Ting-Hua;Li, Hong-Nan;Zhang, Xu-Dong
    • Smart Structures and Systems
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    • 제15권5호
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    • pp.1373-1392
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    • 2015
  • Placing sensors at appropriate locations is an important task in the design of an efficient structural health monitoring (SHM) system for a large-scale civil structure. In this paper, a hybrid optimization algorithm called virus monkey algorithm (VMA) based on the virus theory of evolution is proposed to seek the optimal placement of sensors. Firstly, the dual-structure coding method is adopted instead of binary coding method to code the solution. Then, the VMA is designed to incorporate two populations, a monkey population and a virus population, enabling the horizontal propagation between the monkey and virus individuals and the vertical inheritance of monkey's position information from the previous to following position. Correspondingly, the monkey population in this paper is divided into the superior and inferior monkey populations, and the virus population is divided into the serious and slight virus populations. The serious virus is used to infect the inferior monkey to make it escape from the local optima, while the slight virus is adopted to infect the superior monkey to let it find a better result in the nearby area. This kind of novel virus infection operator enables the coevolution of monkey and virus populations. Finally, the effectiveness of the proposed VMA is demonstrated by designing the sensor network of the Canton Tower, the tallest TV Tower in China. Results show that innovations in the VMA proposed in this paper can improve the convergence of algorithm compared with the original monkey algorithm (MA).