• Proceedings of the Korean Nuclear Society Conference
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• 2004.10a
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• pp.493-494
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• 2004

• Journal of Biomedical Engineering Research
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• v.3 no.1
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• pp.51-54
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• 1982

As the computerized methods and equipments in nuclear medicine imaging increases, quantitative information is needed on the single photon emission computed tomographic images as well as on the conventional nuclear medicine images. In this paper, the authors investigated the effect of several clinician - friendly reconstrution filters on the resultant transverse slices of backprojected profiles of radioisotope distribution from the quantitative point of view, and reduced the filter Parameters such as cutoff frequency and order of filter which are necessary to minimize the quantification error using computer -generated phantoms.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.347-349
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• 2014

Model verification and validation (V&V) is a current research topic to build computational models with high predictive capability by addressing the general concepts, processes and statistical techniques. The hypothesis test for validity check is one of the model validation techniques and gives a guideline to evaluate the validity of a computational model when limited experimental data only exist due to restricted test resources (e.g., time and budget). The hypothesis test for validity check mainly employ Type I error, the risk of rejecting the valid computational model, for the validity evaluation since quantification of Type II error is not feasible for model validation. However, Type II error, the risk of accepting invalid computational model, should be importantly considered for an engineered products having high risk on predicted results. This paper proposes a technique named as the response-adaptive experimental design to reduce Type II error by adaptively designing experimental conditions for the validation experiment. A tire tread block problem and a numerical example are employed to show the effectiveness of the response-adaptive experimental design for the validity evaluation.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10b
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• pp.372-377
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• 1993

In this paper, we investigate a set-membership identification approach to the quantification of an upper bound of model uncertainty in frequency domain, which is required in the H$_{\infty}$ robust control system design. First we formulate this problem as a set-membership identification of a nominal model error in the presence f unknown noise input with unknown bound, while the ordinary set-membership approaches assume that an upper bound of the uncertain input is known. For this purpose, the proposed algorithm includes the estimation of the bound of the uncertain input. thus the proposed method can obtain the hard bound of the model error in frequency domain as well as a parametric lower-order nominal model. Finally numerical simulation results are shown to confirm the validity of the presented algorithm..

• Journal of the Korean Society of Safety
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• v.13 no.1
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• pp.112-118
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• 1998

Human errors performed during the operations have a dominant portion of the accidents. But the systematic human error evaluation methodology universally accepted is not developed yet. One of the difficulties in performing human reliability analysis is to evaluate the performance shaping factors which represent the characteristics and the circumstances in the discriminate manner. For assessing a specific human action more exactly, it is necessary to consider all of the PSFs at the same time which make an effect on the human action. In this paper, dynamic influence diagrams are introduced to model simultaneously their effects on the specific human action. And the human actions and their subsequent PSFs are categorized and classified as the complementary works. A new human error evaluation methodology using influence diagrams is developed. This methodology involves the categorization of PSFs and the PSFs quantification. The applied analysis results for the example task are shown for representative purposes. It is shown that this approach is very flexible in that it can be applied to any kind of actions.

• Transactions of the Korean Society of Automotive Engineers
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• v.13 no.5
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• pp.96-103
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• 2005

One of the major problems limiting the accuracy of piezoelectric transducers fur cylinder pressure measurements in an internal combustion (IC) engine is the thermal shock. Thermal shock is generated from the temperature variation during the cycle. This temperature variation results in contraction and expansion of the diaphragm and consequently changes the force acting on the quartz in the pressure transducer An empirical equation for compensation of the thermal shock error was derived from consideration of the diaphragm thermal deformation and actual pressure data. The result indicate that the thermal shock equation provides reliable correction based on known surface temperature swing.

• YAKHAK HOEJI
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• v.48 no.1
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• pp.60-64
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• 2004

Near-infrared (NIR) spectroscopy was used to determine rapidly and nondestructively the content of ambroxol in intact ambroxol tablets containing 30 mg (12.5％ m/m nominal concentration) by collecting NIR spectra in range 1100-1750 nm. The laboratory-made samples had 10.3∼15.9％ m/m nominal ambroxol concentration. The measurements were made by reflection using a fiber-optic probe and calibration was carried out by partial least square regression (PLSR) with autoscaling. Model validation was performed by randomly splitting the data set into calibration and validation data set (7 samples as a calibration data set and 5 samples as a validation data set). The developed NIR method gave results comparable to the known values of tablets in a laboratorial manufacturing Process, standard error of calibration (SEC) and standard error of prediction (SEP) being 0.49％ and 0.49％ m/m respectively. The method showed good accuracy and repeatability NIR spectroscopic determination in intact tablets allowed the potential use of real time monitoring for a running production process.

• Korean Chemical Engineering Research
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• v.57 no.3
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• pp.438-443
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• 2019

A new measurement method is suggested to quantify the phosphate poisoning of cathodic Pt catalyst for HT-PEMFC. To do that, hydrogen peroxide was used as an indicator to reduce the error which has been occurred in conventional electrochemical measurement such as CV or ORR RDE with high concentration of phosphate ions. As a result, the current density induced from the reaction of hydrogen peroxide decomposition increased proportionally to the concentration of phosphate ion while the conventional methods show has a significant error with high concentration of phosphate ion. Thus, it is confirmed that the suggested way is superior to the conventional measurement method for the quantification of phosphate ion poisoning in an atmosphere similar to the actual operation condition of HT-PEMFC.

• Journal of Korean Society for Atmospheric Environment
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• v.27 no.2
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• pp.133-141
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• 2011

In this study, different calibration approaches for reduced sulfur compounds (RSCs) were investigated by using thermal desorption coupled with gas chromatography (GC) and pulsed flame photometric detection (PFPD). To evaluate the effects of calibration procedures, gaseous standards of 4 RSCs ($H_2S$, $CH_3SH$, DMS, and DMDS) prepared at 10 ppm level were analyzed at 7 loading injection volumes (40, 60, 80, 100, 160, 240, and 320 ${\mu}L$). The results were then compared with calibration curves made with the Z (zero offset) and N (non-zero offset) method. The concentrations of unknown samples were then quantified by using R (ratio) method in which the slope values are compared between standards and samples. Secondly, in A (average) method, results obtained from a multi-point analysis of unknown samples were also averaged to extract representative values for each sample. Results of both experiments showed that analytical error of low molecular weight components (such as $H_2S$ and $CH_3SH$) was greatly expanded with the Z method. In conclusion, the combined application of N-A method was the more realistic approach to reduce biases in the quantification of RSCs.

• Toxicological Research
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• v.29 no.3
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• pp.203-209
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• 2013

A simple and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of ${\varepsilon}$-acetamidocaproic acid (AACA), the primary metabolite of zinc acexamate (ZAC), in rat plasma by using normetanephrine as an internal standard. Sample preparation involved protein precipitation using methanol. Separation was achieved on a Gemini-NX $C_{18}$ column ($150mm{\times}2.0mm$, i.d., 3 ${\mu}m$ particle size) using a mixture of 0.1% formic acid-water : acetonitrile (80 : 20, v/v) as the mobile phase at a flow rate of 200 ${\mu}l/min$. Quantification was performed on a triple quadrupole mass spectrometer employing electrospray ionization and operating in multiple reaction monitoring (MRM) and positive ion mode. The total chromatographic run time was 4.0 min, and the calibration curves of AACA were linear over the concentration range of 20~5000 ng/ml in rat plasma. The coefficient of variation and relative error at four QC levels were ranged from 1.0% to 5.8% and from -8.4% to 6.6%, respectively. The present method was successfully applied for estimating the pharmacokinetic parameters of AACA following intravenous or oral administration of ZAC to rats.