• Journal of Acupuncture Research
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• v.34 no.2
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• pp.1-18
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• 2017

Objectives : The purpose of this study was to evaluate the effects of water extracts of Eucommiae cortex (EC), Psoraleae semen (PS), and their combination on receptor activator of nuclear factor-kappa-B ligand (RANKL)-induced osteoclast differentiation. Methods : We assayed the protein expression levels of nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), c-Fos, mitogen-activated protein kinases (MAPKs), and ${\beta}-actin$ in cell lysates using western blotting. Similarly, mRNA expression levels of NFATc1, c-Fos, tartrateresistant acid phosphate (TRAP), and glyceraldehyde-3-phosphate dehydrogenase, spermatogeni (GAPDHS) from bone marrow macrophages (BMMs) were analyzed using reverse transcription-polymerase chain reaction (RT-PCR). Furthermore, we determined the anti-osteoporotic effects of the water extracts of EC, PS, and their combination in a lipopolysaccharide (LPS)-induced bone-loss mouse model. Results : The in vitro data revealed showed that the combination of EC and PS extract showed a more remarkable inhibition of osteoclast differentiation than each herb did alone. The combination downregulated the induction of c-Fos, NFATc1, and TRAP by suppressing the phosphorylation of p38 and c-Jun N-terminal kinases (JNKs) and inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells ($NF-{\kappa}B$). Lastly, the in vivo data showed that PS reduced the LPS-induced bone erosion. Conclusion : The result of this study suggests that EC and PS could be potential therapeutic agents for bone loss diseases such as osteoporosis.

• Journal of Wetlands Research
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• v.22 no.3
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• pp.187-193
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• 2020

The increase in the area of impervious water due to the recent abnormal weather conditions and rapid urbanization led to a decrease in the amount of low current, resulting in an increase in the amount of surface runoff. Increased surface runoff is causing erosion, destruction of underwater ecosystems, human and property damage in urban areas due to flooding of urban river. The damage has been increasing in Korea recently due to localized heavy rains, typhoons and floods. As a countermeasure, the Busan Metropolitan Government will proceed with the creation of the Eco-Delta City waterfront zone in Busan with the aim of creating a future-oriented waterfront city from 2012 to 2023. Therefore, the current urban river conditions and precipitation data were collected by utilizing SWMM developed by the Environment Protection Agency, and the target basin was selected to simulate flood damage. Measures to reduce flood damage in various cases were proposed using simulated data. It is a method to establish a disaster prevention plan for each case by establishing scenario for measures to reduce flood damage. Considering structural and non-structural measures by performing an analysis of the drainage door with a 30-year frequency of 80 minutes duration, the expansion effect of the drainage pump station is considered to be greater than that of the expansion of the drainage door, and 8 scenarios and corresponding alternatives were planned in combination with the pre-excluding method, which is a non-structural disaster prevention measure. As a result of the evaluation of each alternative, it was determined that 100㎥/s of the pump station expansion and the pre-excluding EL.(-)1.5m were the best alternatives.

• The Journal of Korean Physical Therapy
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• v.21 no.2
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• pp.117-124
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• 2009

Purpose: This study examined the effects of swimming exercise and Achyranthes Radix extracts on the inflammatory and behavioral responses in type II collagen-induced arthritic rats for 28 days. Methods: Sprague-Dawley rats were allocated randomly to one of the following four groups: only type II collageninduced (group Ⅰ), application of swimming exercise after type II collagen-induced (group II), application of Achyranthes Radix ointment after type II collagen-induced (group III), application of swimming exercise and Achyranthes Radix ointment after type II collagen-induced (group IV). Arthritis was established in SD rats by an intradermal injection of Chick type II collagen plus incomplete Freund's adjuvant at the base of the tail of the animals. The swimming exercise program consisted of a 25 min swimming session/day with a load corresponding to 5.5% of the weight bearing, three days/week for four weeks. The Achyranthes Radix ointment (0.1g) was applied twice a day for five days. The changes in behavior, H & E stain, and cyclooxygenase-2 (COX-2) level in the knee joint were assessed. Results: The gross and histological examination, after RA induction showed reddening, edema and erythema. The H & E stain revealed the destruction of articular cartilage, bony erosion and the infiltration of inflammatory cells after RA induction. The mechanical allodynia test results were significantly higher in group I than in groups II, III and IV (p<0.01). The immunohistochemistrical response of COX-2 in the knee joint showed that groups II, III, IV had a lower response effect than group I. Conclusion: Swimming exercise training and Achyranthes Radix ointment decreased the inflammatory responses and enhanced the behavioral responses in the arthritic rats.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.22 no.1
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• pp.58-66
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• 2010

In this paper, we have constructed high-resolution topographical map of macro-tidal Malipo beach through integration of terrestrial LiDAR measurement and MBES survey data at inter-tidal zone. To acquire the enough information of inter-tidal zone, we have done terrestrial LiDAR measurement mounted on the roof of vehicle with DGPS through go-stop-scan method at the ebb tide and MBES depth surveying with tide gauge and eye staff measurement for tide correction and MSL calculation at the high tide all together. To integrate two kinds of data, we have unified the vertical coordination standard to Incheon MSL. The mean error of overlapped inter-tidal zone is about 2~6 cm. To verify the accuracy of terrestrial LiDAR, RTK-DGPS measurement have done simultaneously and the difference of Z value RMSE is about 4~7 cm. The resolution of Malipo topographical map is 50 cm and it has constructed to DEM (Digital Elevation Model) based on GIS. Now it has used as an input topography information for the storm-surge inundation prediction models. Also it will be possible to use monitoring of beach process through the long-term periodic measurement and GIS-based 3D spatial analysis calculating the erosion and deposition considering with the artificial beach transition and coastal environmental parameters.

• Journal of the korean academy of Pediatric Dentistry
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• v.41 no.3
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• pp.233-240
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• 2014

An in vitro study on cariogenic potential of four over-the-counter nutritional supplements for children was performed. The experimental groups were four over-the-counter nutritional supplements. The positive control group was 10% sucrose solution (S), and the negative control group was artificial saliva (T). The pH of each group, the buffering capacities, acid production, the microhardness changes of the bovine teeth specimens were measured. The pH of all experimental groups were lower than critical pH 5.5 where enamel demineralization starts. The buffering capacity of the Hama Vitamin Pharm (Hamsoa Pharm Co., Korea) was highest, and the Smart Chewable Vitamin A (JW Pharm Co., Korea) had the lowest buffering capacity. The reduction rates of the pH of the experimental groups were significantly higher than that of the negative control group (p < 0.05). The microhardness of enamel of all experimental groups and the positive control group significantly decreased. In contrast, the microhardness of enamel of the negative control group significantly increased after experiment (p < 0.05). The reduction rate of the microhardness of enamel of the Hama Vitamin Pharm (Hamsoa Pharm Co., Korea) was significantly higher and Hikid Plus (Sanga Pharm Co., Korea) was significantly lower than the other experimental groups.

• Journal of the Korean Geographical Society
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• v.42 no.2 s.119
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• pp.165-176
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• 2007

Absolute age of the deposition of 1.3 km-thick Bunthang sequence within the Skardu intermontane basin of the Central Karakoram was determined using radioactive decay of cosmogonic $^{10}Be$ and $^{26}Al$ burial dating. The Bunthang sequence deposited around 2.65 Ma, which is the oldest glaciation in the region. The timing of deposition of the Bunthang sequence is consistent with the previous suggestion that the basin filling took place between Brunhess and Matuyama chrons. Four major sedimentary facies interfinger within the Bunthang sequence: glacial diamict, lacustrine, fluvial and lacustrine facies upward. This sedimentary distinctiveness and the lack of evidence on the faults for alternative pull-apart basin model around the Bunthang sequence, suggest that the depressional basin was formed by deep subglacial erosion during the exrtensive Bunthang Glacial Stage and subsequently the sediments underlain by basal diamict, was quickly deposited by preglacial and paraglacial processes. Temporary ponding of the Indus River due to tectonic uplift in the downstream or blockage by mass movements might make the basin filing more possible. The hypothesis that the single ice sheet developed on the Tibetan Plateau during the global last glacial cycle should be refuted by the existence of the older extensive Bunthang glacier Furthermore, the extensive glaciation during the early Quaternary (and thus progressive decrease in extent with time) suggests that there may have been significant uplift of the Pamir to the west and Himalaya to the south, which would have reduced the penetration of westerlies and Indian summer monsoon and hence moisture supply to the region.

• Restorative Dentistry and Endodontics
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• v.25 no.1
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• pp.91-108
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• 2000

Most of cervical abrasion and erosion lesions show gingival margin where the cavosurface angle is on cementum or dentin. Composite resin restoration of cervical lesion shrink toward enamel margin due to polymerization contraction. This shrinkage has clinical problem such as microleakage and secondary caries. Several methods to diminish contraction stress of composite resin restoration, such as modifying cavity form and building up restorations in several increments have been attempted. The purpose of this study was to compare polymerization contraction stress of composite resin in Class V cavity subjected to cavity forms and placement methods. In this study, finite element model of 5 types of Class V cavity was developed on computer tomogram of maxillary central incisor. The types are : 1) Box cavity 2) Box cavity with incisal bevel 3) V shape cavity 4) V shape cavity with incisal bevel 5) Saucer shape cavity. The placement methods are 1) Incisal first oblique incremental curing 2) Bulk curing. An FEM based program for light activated polymerization is not available. For simulation of curing dynamics, time dependent transient thermal conduction analysis was conducted on each cavity and each placement method. For simulation of polymerization shrinkage, thermal stress analysis was performed with each cavity and each placement method. The time-temperature dependent volume shrinkage rate, elastic modulus, and Poisson's ratio were determined in thermal conduction data. The results were as follows : 1. With all five Class V cavifies, the highest Von Mises stress at the composite-tooth interface occurred at gingival margin. 2. With box cavity, V shape cavity and saucer cavity, Von Mises stress at gingival margin of V shape cavity was lower than the others. And that of box cavity was lower than that of saucer cavity. 3. Preparing bevel at incisal cavosurface margin decreased the rate of stress development in early polymerization stage. 4. Preparing bevel at incisal cavosurface margin of V shape cavity increased the Von Mises stress at gingival margin, but decreased at incisal margin. 5. At incisal margin, stress development by bulk curing method was rapid at early stage. Stress development by first increment of incremental curing method was also rapid but lower than that by bulk curing method, however after second increment curing final stress was the same for two placement methods. 6. At gingival margin, stress development by incremental curing method was suddenly rapid at early stage of second increment curing, but final stress was the same for two placement methods.

• Korean Journal of Soil Science and Fertilizer
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• v.38 no.2
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• pp.66-71
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• 2005

Soil loss into stream and river by runoff shall be considered for non-point source pollution management as national land conservation. The purpose of this study was to develop the mathematical equation to predict soil loss from inclined uplands of maize cultivation due to the runoff by rainfall which mainly converges on July and August. Soil loss was concentrated on May because of low canopy over an entire field in 2002 and on June and July because of heavy rainfall in 2003. By regression analysis the relation between runoff and soil loss can be represented by a linear equation of y =1.5291x - 3.4933, where y is runoff ($Mg\;ha^{-1}$) and x is soil loss ($kg\;ha^{-1}$). The determination coefficient of this equation was 0.839 (P<0.001). Therefore, the mathematical equation derived from the practical experiment at the inclined upland can be applicable to predict soil loss accompanied by runoff due to periodic rainfall converging on short periods within a couple of months.

• Ocean and Polar Research
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• v.43 no.4
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• pp.205-217
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• 2021

A shallow channel between Jeju and Udo Islands, which is located in the northeastern Jeju Island, is influenced by storm- or typhoon-induced currents and surface waves as well as strong tidal currents. This study examines the typhoon-induced current and wave patterns in the channel, using Acoustic Doppler Current Meter (ADCP) measurements and an ocean-wave coupled modeling experiment. Three typhoons were chosen - Chaba (2016), Soulik (2018), and Lingling (2019) - to investigate the responses of currents and waves in their pathways. During the pre-typhoon periods, dominant northward flow and wave propagation were observed in the channel due to the southeasterly winds before the three typhoons. After the passage of Chaba, which passed over the eastern side of Jeju Island, the northward flow and wave propagation were totally reversed to the opposite direction, which was attributed to the strong northerly winds on the left side of the typhoon. In contrast, in the cases of Soulik and Lingling, which passed over the western side of Jeju Island, strong southerly winds on the right side of the typhoons continuously intensified the northward current and wave propagation in the channel. The model-simulated current and wave fields reasonably coincided with observational data, showing southward/northward flow and wave propagation in response to the right/left side of the typhoon pathways. Typhoon-induced downwind flows, and surface waves could enhance up to 2m/s and 3m due to the strong winds that lasted for more than 12 hours. This suggests that the flow and wave patterns in the Udo channel are highly sensitive to the pathway of typhoons and accompanying winds; thus, this may be a crucial factor with regard to the movement of seabed sediments and subsequent coastal erosion.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.1
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• pp.409-418
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• 2019

Debris flows occur in mountainous areas due to heavy rains resulting from climate change and result in disasters in the downstream area. The purpose of this study is to estimate the impact force of a debris flow when a check dam according is installed in various locations in the channel of a highly mountainous area. A Finite Differential Element Method (FDM) model was used to simulate the erosion and deposition based on the equation for the mass conservation and momentum conservation while considering the continuity of the fluid. The peak impact force from the debris flow occurred at 0 to 5 sec and 15 to 20 sec. When the supplied water discharge was increased, greater peak impact force was generated at 16 to 19 sec. This means that when increasing the water supply, the velocity of the debris flow became faster, which results in increased energy of the consolidation between the particles of the water and the sediment made. If a number of check dams were to be set up, it would be necessary to investigate the impact force at each location of the check dam. The results of this study could provide useful information in predicting the impact force of the debris flow and in installing the check dams in appropriate locations.