• 제목/요약/키워드: Epileptic seizure

검색결과 127건 처리시간 0.024초

Neuroprotective Effect of N-nitro-L-arginine Methylester Pretreatment on the Early Stage of Kainic Acid Induced Neuronal Degeneration in the Rat Brain

  • Koh, Jun-Seok;Kim, Gook-Ki;Lim, Young-Jin;Rhee, Bong-Arm;Kim, Tae-Sung
    • Journal of Korean Neurosurgical Society
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    • 제38권4호
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    • pp.287-292
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    • 2005
  • Objective : Kainic acid[KA] enhances the expression of nitric oxide synthase, increases nitric oxide[NO], and thus evokes epileptic convulsion, which results in neuronal damage in the rat brain. NO may stimulate cyclooxygenase type-2 [COX-2] activity, thus producing seizure and neuronal injury, but it has also been reported that KA-induced seizure and neurodegeneration are aggravated on decreasing the COX-2 level. This study was undertaken to investigate whether the suppression of NO using the NOS inhibitor, N-nitro-L-arginine methyl ester[L-NAME], suppresses or enhances the activity of COX-2. Methods : Silver impregnation and COX-2 immunohistochemical staining were used to localize related pathophysiological processes in the rat forebrain following KA-induced epileptic convulsion and L-NAME pretreatment. Post-injection survival of the rat was 1, 2, 3days and 2months, respectively. Results : After the systemic administration of KA in rats, neurodegeneration increased with time in the cornu ammonis [CA] 3, CA 1 and amygdala, as confirmed by silver impregnation. On pretreating L-NAME, KA-induced neuronal degeneration decreased. COX-2 enzyme activities increased after KA injection in the dentate gyrus, CA 3, CA 1, amygdala and pyriform cortex, as determined by COX-2 staining. L-NAME pretreatment prior to KA-injection, caused COX-2 activities to increase compared with KA- injection only group by 1day and 2days survival time point. Conclusion : These results suggest that L-NAME has a neuroprotective effect on KA-induced neuronal damage, especially during the early stage of neurodegeneration.

웨이블릿 변환과 힐버트 변환을 이용한 간질 파형 분류 (Classification of Epileptic Seizure Signals Using Wavelet Transform and Hilbert Transform)

  • 이상홍
    • 디지털융복합연구
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    • 제14권4호
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    • pp.277-283
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    • 2016
  • 본 논문에서는 가중 퍼지소속함수 기반 신경망(neural network with weighted fuzzy membership functions; NEWFM) 기반의 웨이블릿 변환(wavelet transform)과 힐버트 변환(Hilbert transform)에 의해 추출한 첨점(peak)을 사용하여 뇌파(EEG)로부터 정상 파형과 간질 파형을 분류하는 새로운 방안을 제안하였다. NEWFM의 입력을 추출하는데 다음과 같은 3개의 단계가 수행되었다. 첫 번째 단계에서는 뇌파로부터 잡음을 제거하기 위해서 웨이블릿 변환을 사용하였다. 두 번째 단계에서는 웨이블릿 계수로부터 첨점(peak)을 추출하기 위해서 힐버트 변환을 사용하였다. 또한 크기가 큰 첨점을 추출하기 위해서 첨점의 평균값보다 큰 첨점만을 선택하였다. 세 번째 단계에서는 통계적 방법을 이용하여 첨점으로부터 NEWFM의 입력으로 사용할 16개의 특징을 추출하였다. NEWFM은 이들 16개의 특징을 입력으로 사용하여 99.25%, 99.4%, 99%의 정확도, 특이도, 민감도를 각각 구하였다. 향후 연구에서는 특징선택을 이용하여 16개의 특징으로부터 좋은 특징을 선택하여 정확도를 향상시킬 계획이다.

전간 발작과 관련된 견관절 전방 불안정성 환자에서 시행한 관절경적 Bankart봉합술 - 2예 보고 - (Arthroscopic Bankart Repair for Post-seizure Anterior Instabilities of Shoulder - 2 Cases Report -)

  • 문영래;양훈
    • Clinics in Shoulder and Elbow
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    • 제12권1호
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    • pp.98-101
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    • 2009
  • 목적: 본 증례 보고는 드물게 보고되고 있는 간질 발작과 동반된 견관절 전방 불안정성에서 발견되는 골병변을 기술하고 고빈도의 재발 요인을 파악하고자 하였다. 대상 및 방법: 저자들은 전간 발작과 동반된 2례의 재발성 전방 탈구를 경험하였으며 본 증례 통하여 일반적인 재발성 견관절 탈구에 준하여 치료하면서 정기적으로 경과를 관찰하였다. 결과: 본 두 증례에서 수술의 경과는 전간 발작의 조절 여부에 따라 경과가 결정됨을 알 수 있었다. 즉 간질 조절이 잘된 환자에서는 안정성을 유지할 수 있었으나 발작이 조절되지 않은 전방 불안정성의 경우 결국 재발성 탈구가 유발되게 되었다. 결론: 전간 발작과 동반된 견관절 불안정성에서 재발 방지를 위해서는 경련 조절이 필수적인 인자임을 인지하게 되었다.

Roles of Valproic Acid in Improving Radiation Therapy for Glioblastoma: a Review of Literature Focusing on Clinical Evidence

  • Ochiai, Satoru;Nomoto, Yoshihito;Yamashita, Yasufumi;Watanabe, Yui;Toyomasu, Yutaka;Kawamura, Tomoko;Takada, Akinori;Ii, Noriko;Kobayashi, Shigeki;Sakuma, Hajime
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권2호
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    • pp.463-466
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    • 2016
  • Glioblastoma (GBM) is the most common and aggressive type of primary brain neoplasm. The current standard therapy for GBM consists of maximal surgical resection within safe limits, followed by radiation therapy (RT) and chemotherapy with temozolomide. Despite advances in treatment, the prognosis of GBM remains poor. Epileptic seizure is one of the most common symptoms in patients with GBM. Valproic acid (VPA), a histone deacetylase inhibitor, is often used as an anti-epileptic drug in patients with brain neoplasms due to its effectiveness and low toxicity profile. Several in vivo and in vitro studies have indicated that VPA has radiosensitizing effects for gliomas and radioprotective influence on normal brain tissue or hippocampal neurons. The results of several retrospective studies have also indicated potential benefit to improve survival of patients with GBM. Moreover, the promising treatment results of a phase 2 trial of concurrent radiation therapy, temozolomide, and VPA for patients with GBM have been recently reported. The use of VPA in patients with GBM has thus recently receiving more attention. In this article, we review the role of VPA in radiation therapy for GBM, focusing on the clinical evidence.

Evaluation of Immunological Safety of Topiramate, an Anti-epileptic Drug, in a Murine Model

  • Han, Sang-Bae;Kim, Jee-Youn;Kwon, Soon-Woo;Kang, Jong-Soon;Kim, Hwan-Mook;Song, Suk-Gil;Hong, Jin-Tae;Kim, Young-Soo;Kim, Won-Seop
    • Biomolecules & Therapeutics
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    • 제17권2호
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    • pp.168-174
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    • 2009
  • Epilepsy is one of the most common neurological disorders, and topiramate (TPM) is one of the most effective drugs that can render patients seizure-free. The focus of the present study was to evaluate the immunological safety of TPM in a mouse model. We examined the in vitro effect of TPM on immune functions of BV2 microglial cells, RAW 264.7 macrophages, B cells, T cells, and dendritic cells. We also examined the in vivo effect of TPM on mouse immune organs, such as lymph node, spleen, and thymus. When cells were directly treated with TPM at concentrations from 1 to $30{\mu}g/ml$, TPM did not affect nitrite production by BV2 cells and macrophages, proliferation of B cells and T cells, or maturation of dendritic cells. In addition, TPM did not change the weight and cellularity of lymph nodes, spleen, and thymus in vivo at doses from 3 to 100 mg/kg injected i.p. into mice once a day for 4 consecutive days. These data showed that TPM, which is widely used as an anti-epileptic drug, is immunologically safe.

Kainic acid 유발 간질 생쥐모델에서 소부혈(少府穴) 침치료의 해마 신경세포 보호효과연구 (The Neuroprotective Effect of Acupuncture Treatment at Shaofu (HT8) on Kainic Acid-induced Epilepsy Mouse Model.)

  • 김윤영;민상연;김지용;김장현
    • 대한한의학회지
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    • 제31권5호
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    • pp.167-178
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    • 2010
  • Objectives: The present study investigated the effects of acupuncture treatment and their mechanism by using the kainic acid (KA)-induced epilepsy mouse model. Materials and Methods: The seizure was induced by an intraperitoneal (i.p.) injection of 30 mg/kg KA, and the acupuncture treatment was subsequently administered to acupoint Shaofu(HT8) bilaterally with two pretreatment sessions before injection (total 3 times over 3 days). Twenty four hours after injection, we observed the survival of neuronal cells in the CA3 region of the hippocampus. In addition, the activation of microglia and astrocytes was observed by using CD11b and GFAP immunohistochemistry in the same region. Results: The results indicate that acupuncture treatment reduced the rate of neural cell death in the CA3 region of the hippocampus and decreased the activations of microglia and astrocytes in this region. Conclusion: These results demonstrate that acupuncture treatment protects hippocampal neuronal cell death from KA-induced epileptic seizure by inhibiting the activations of microglia and astrocytes.

Delayed Appearance of Radiologically Occult Cerebral Arteriovenous Malformation : A Case Report and Literature Review

  • Hangeul Park;Hyun-Seung Kang;Won-Sang Cho
    • Journal of Korean Neurosurgical Society
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    • 제66권2호
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    • pp.199-204
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    • 2023
  • It is critical to identify the ruptured cerebral arteriovenous malformations (AVMs) for secondary prevention. However, there are rare cases unidentified on the radiological evaluation. We report on a patient with the delayed appearance of radiologically occult AVM as a probable cause of the previous intracerebral hemorrhage (ICH). An 18-year-old male patient presented with a right temporal ICH. The preoperative radiological examination did not reveal any causative lesions. Because of the intraoperative findings suggesting an AVM, however, only hematoma was evacuated. Disappointedly, there were no abnormal findings on postoperative and follow-up radiographic examinations. Eleven years later, the patient presented with an epileptic seizure, and an AVM was identified in the right temporal lobe where ICH had occurred before. The patient underwent partial glue embolization followed by total surgical resection of the AVM and anterior temporal lobe. Based on the literature review published in the era of magnetic resonance imaging, common clinical presentation of radiologically occult AVMs included headache and seizure. Most of them were confirmed by pathologic examination after surgery. In cases of the ICH of unknown etiology in young patients, long-term follow-up should be considered.

경련 질환 환아의 정신병리와 신경학적 요인과의 관계에 대한 연구 (THE STUDY ON RELATIONSHIP BETWEEN PSYCHOPATHOLOGY AND NEUROLOGICAL FACTORS IN CHRONIC EPILEPTIC CHILDREN)

  • 김붕년;조수철;황용승
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • 제7권1호
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    • pp.92-109
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    • 1996
  • 본 연구에서는 정상 지능 범위의 만성 특발성 경련 질환으로 치료중인 40명의 환아군과, 나이, 성별, 학업 성적, 지능 지수를 일치시킨 30명의 대조군을 대상으로, 국내외를 통해 신뢰도 및 타당도가 확인된 평가 도구들인, 부모용 아동 행동 조사표(Child Behavior Checklist)의 한국판, DSM-III-R에 따른 파탄적 행동 장애 척도(Disruptive behavior disorders scale according to DBM-III-R)의 한국판, 예일 아동 평가표(Yale children's inventory)의 한국판, 소아 우울 척도(Children's Depression Inventory)의 한국촌, 소아용 상태 및 특성불안 척도(State-Trait Anxiety Inventory for children)의 한국판, 피어스-해리스 자기 개념 척도(Piers-Harris self-concept questionnaire)의 한국판. 가정 환경 척도(Family environment Scale)의 한국판, 간이 정신진단 검사(Symptom check-list-90)의 한국판, 경련질환에 대한 부모태도 척도(Parent's attitude to epilepsy questionnaire)의 한국판, 아동 의존척도(self-administered dependency questionnaire)의 한국판을 사용하였고, 이들 결과로 부터 얻은 자료의 일부인 환아의 정신병리 부분과 경련 질환의 신경과적인 변수들인 환아의 성별 및 나이, 경련 질환 발병시 나이와 유병기간, 경련질환의 임상적 유형, 뇌파의 유형 최근 6개월간의 경련 빈도, 항경련 약물 치료력과 그 반응등과의 관련성을 평가하였다. 위에서 얻은 자료들을 토대로 분석하여 다음과 같은 연구 결과를 얻었다. 환아의 우울과 관계된 위험 요인은, 조기 발병(early onset), 복합성 부분 간질(complex partial seizure), 뇌파상 편측성 측두엽 이상(lateralized temporal focal abnormality in EEG), 약물 병합 투여(drug polypharmacy), 고 빈도 경련(high seizure frequency)임을 알 수 있었고, 이들 위험요인들은 상호 연관되어 있었다. 불안에 영향을 미치는 요인은 높은 연령. 뇌파상 편측성 측두엽 이상, 고 빈도 경련이었고, 학습 및 언어적 문제와 관련이 있는 위험 요인은 환아의 어린나이, 조기 발병, 복합성 부분 간질, 고빈도 경련 등이었다. 주의력 결핍 과잉행동 장애와 반항 및 품행장애에 영향을 미치는 위험 요인은 남성, 어린 나이, 조기 발병, 뇌파상 편측성 측두엽 이상, 고 빈도 경련등이었다. 위의 결과를 종합하면, 우울, 불안, 품행장애 및 주의력 결핍 과잉 행동장애에 공통적으로 관계되는 위험요인은, 뇌파상 편측성 측두엽 이상, 고 빈도 경련이라는 겻을 알 수 있었다. 향후 연구를 통해서는 신경학적 요인이외에 가족 및 사회-인구학적 위험 요인을 찾는 연구가 지속되어야 하며, 이를 통해 종합적 위험 요인 평가 작업과 치료적 대안을 제시하는 후속 작업이 지속 되어야 할 것 이다.

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11세 여아의 심인성 발작 1례 (A CASE OF 11-YEAR-OLD GIRL WITH PSYCHOGENIC SEIZURE)

  • 노경선;손석한
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • 제11권1호
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    • pp.144-149
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    • 2000
  • 심인성 발작은 신경과 및 정신과 임상에서 가끔씩 접하게 되는 질환으로서 진성 간질성 발작과의 감별진단이 가장 중요하다고 하겠다. 특히 정신과의사는 면밀한 환자의 병력청취, 임상양상 관찰 등을 통하여 확진 전 단계에서 심인성 발작을 어느 정도 진단내릴 수 있다고 생각된다. 저자들은 11세 여아의 심인성 발작 증례를 경험했는데, 심리환경적 스트레스가 명확했고, 임상특징이 일치 했으며, 신속한 검사와 정신과적 중재에 의해서 좋은 결과를 얻었다. 본 증례로 볼 때 소아기 심인성 발작의 진단과 치료에 있어서 뇌파 검사 외에도 철저한 가족배경 조사 및 병력청취와 정신교육학적 중재가 중요하다고 생각된다.

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선천성 양측성 Sylvius 주위 피질 증후군의 병인론으로서의 뇌회반흔증에 대한 고찰 (A Study of Ulegyria as Pathognomonic Aspects of Congenital Bilateral Perisylvian Syndrome)

  • 김한웅;조규용;이민철;김형일;우영종;김명규
    • Journal of Korean Neurosurgical Society
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    • 제37권2호
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    • pp.124-128
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    • 2005
  • Objective: Congenital bilateral perisylvian syndrome(CBPS) has been defined as a characteristic malformative perisylvian polymicrogyria(PMG) in patients with clinical symptoms of pseudobulbar palsy and epileptic seizures. For the present study, we investigate clinicopathologic features of CBPS associated with timing of lesion formation. Methods: Clinicopathologic features of CBPS from 6 patients with surgical resection of the cerebral lesions due to medically intractable seizures were studied. Results: Seizure onset ranged from 1 to 10years (average 6.7years) of age, and average duration of seizure was 23years. All had complex partial seizures, and two patients had additional tonic clonic seizures. Magnetic resonance (MR) images showed polymicrogyria, atropic gyri with gliosis. In the histopathologic examination, the cortical lesions revealed features of ulegyria; atrophic and sclerotic gyri, laminar loss of neurons, extensive lobular gliosis throughout the gray and white matter, neuronoglial nodule formation, and many amyloid bodies. Unlayered or four-layered PMG was not identified. Conclusion: Above data suggest that CBPS might be caused by ulegyria resulting from developmental cortical defect during early fetal stage or acquired hypoxic/ischemic injury in prenatal or postnatal life.